This document outlines drugs classifications covered in the 5th semester DRUGS CLASSIFICATION module. It discusses cholinergic and anticholinergic drugs, adrenergic and adrenergic blocking agents, antispasmodic and anti-ulcer drugs, neuromuscular blocking agents, local anesthetics, antihistamines, and analgesic-antipyretic and non-steroidal anti-inflammatory agents. For each category, it lists examples of specific drugs and how they work.

2. DRUGS CLASSIFICATION 5th Sem
 MODULE 2
2.1.1 CHOLINERGIC & ANTICHOLINERGIC
2.1.2 ADRENERGIC & ADRENERGIC BLOCKING AGENTS
2.1.3 ANTISPASMODIC & ANTI-ULCER DRUGS
 MODULE 3
3.1.1 NEUROMUSCULAR BLOCKING AGENTS
3.1.2 LOCAL ANAESTHETICS
 MODULE 4
4.1.1 ANTIHISTAMINE
4.1.3 ANALGESIC-ANTIPYRETICS, NON-STEROIDAL ANTI INFLAMATORY AGENTS

3. CHOLINERGIC
DIRECTLY ACTING DRUGS:-
Choline Esters :-
Acetylcholine
Bethachol
Carbachol
Methacholine
Cholinomimetics Alkaloids :-
Muscarine
Pilocarpine
Nicotine
Lobeline
Arecholine
Oxotremonine
INDIRECTLY ACTING DRUGS:-
Reversible :-
(a) Lipid soluble :-
Physostigmine, Tacrine, Donepezil,
Rivastigmine, Galantanine
(b) Water soluble :-
Neostigmine, Pyridostigmine, Edrophonium
 Irreversible :-
(a) Organophosphates:-
Malathion, Parathion, Ecothiophate,
Tabun,
Sarin, Soman
(b) Carbamates:-
Carbaryl, Propoxur, Aldicarb

4. ANTICHOLINERGIC
(A) Natural:- Atropine & Hyoscine(scopolamine)
(B) Semisynthetic derivatives:- Homatropine, Methonitrate,
Ipratropium bromide, Tiotropium bromide
(C) Synthetic derivatives:-
(a) Mydriatics:- Cyclopentolate, Tropicamide
(b) Antisecretory-Antispasmodics:-
Quaternary amonium compounds:- Propantheline,
Oxyphenonium,
Clidinium, Pipenzolate, Methyl bromide, Glycopyrrolate,
Isopropamide
Tertiary Amines:- Diclomine, Valethamate, Piperazine
(c) Vasicoselective:- Oxybutynin, Falvoxate, Tolterodine

5. ADRENERGIC DRUGS
Catecholamine Non- Catecholamine Ephedrine, Pseudoephedrine
Dopamine Xylometazoline
Adrenaline Clonidine
Nor Adrenaline Phenylephrine
Salbutamol
Reuptake Inhibitor Acting by displacement
Cocaine Amphetamine
Directly Acting
Indirectly Acting Mixed Action

6. ADRENERGIC BLOCKING AGENTS
Prazosin Yohimbine
Terazosin
Reversible Irreversible Doxazosin
Phentolamine Phenoxybenzomine Tamsulosin
Tolazoline Alfuzosin
Alpha Blockers
Non-Selective(α1 & α2) blockers Selective α1 blockers Selective α2 blockers
Beta blockers
1st Generation 2nd Generation
3rd Generation
(Non Selective β blockers) (Selective β blockers)
(β blocker with additional
property
Propranolol, Sotalol,
Pindolol, Nadolol,
Penbutolol, Pindolol,
Timolol,
Levobunolol,Metipranolol
Metoprolol,
Atenolol,
Acebutolol,
Bisoprolol,
Esmolol
Non selective β1 selective
Labetalol,
Carvedilol,
Carteolol,
Bucindolol
Betaxolol,
Celiprolol,
Nebivolol

7. ANTISPASMODIC
1. Natural Alkaloids:-
 Spasmolytic:- Atropine (mydriatic)
 Antiemetic:- Hyoscine, Scopolamine
2. Semisynthetic derivatives:-
 Mydriatics:- Homatropine, Tropicamide
 GI spasmolytics:- Hyoscine butyl bromide
3. Synthetic Compounds:-
 GI spasmolytics:- Oxyphenonium
 Antiulcer drugs:- Pirenzepine(M- Blockers)
 Antiasthmatics:- Ipratropium & Tiotropium
 Urinary system:- Flavoxate, Oxybutynyne, Trospium
 Antiparkinsonian(Central M-Choinolytics):-
Benztropine,Biperiden,Trihexyphenidyl

8. ANTI ULCER
1. Reduction of Gastric Acid secretion:-
H2 Antihistamine:- Cimetidine, Ranitidine, Famotidine, Roxatidine, Loxatidine
Proton pump Inhibitors:- Omeprazole, Pantoprazole, Rabeprazole, Esmoprazole,
Lansoprazole, Dexrabeprazole
Anticholinergics:- Pirenzepine, Propantheline, Oxyphenonium
Prostaglandin analogues:- Misoprostol, Enaprostol, Rioprostol
2. Neutralization of Gastric Acid(Antacids):-
Systemic:- Sodium bicarbonate, Sodium Citrate
Non Systemic(Local):- Magnesium Hydroxide, Magnesium, Aluminium Hydroxide gel,
Calcium Carbonate
3. Ulcer protectives:- Sucralfate, CBS( Colloidal Bismuth Subcitrate)
4. Ulcer healing drugs:- Carbenoxolone sodium
5. Anti H. pyloric drugs:- Amoxicillin, Clarithromycin, Metronidazole,
Tinidazole

9. NEUROMUSCULAR BLOCKING AGENTS
Depolarising Non-Depolarising
Succinylcholine D-Tubocurarine
Gallamine
Pancuronium
Vecuronium
Rocuronium
Atracurium
Cisatracurium
Mivacurium

10. LOCAL ANAESTHETIC
Injectable Surface Anaesthetic
Soluble
Cocaine
Lidocaine
Tertracaine
Benoxinate
Insoluble
Benzocaine
Butylaminobenzoate
Oxethazine
Low potency, short duration
Proacine
Chloroprocaine
Intermediate potency &
duration
Lidocaine(Lignocaine)
Prilocaine
High potency, long duration
Tetracaine(Amethocaine)
Bupivacaine
Ropivacaine
Dibucaine(Cinchocaine)

11. ANTIHISTAMINE
1. H1 Antihistamine:-
 Highly Sedative:- Diphenyhydramine,
Dimenhydrinate, Promethazine, Hydoxyzine
 Moderately Sedative:- Pheniramine, Cyproheptadine,
Meclozine, Cinnarizine
 Mildly Sedative:- Chlorpheniramine,
Dexchlorpheniramine, Triprolidine, Clemastine
 Second Generation(nonsedative) anti histaminics:-
Fexofenadine, Loratadine, Desloratadine, Cetirizine,
Levocetirizine, Azelastine, Mizolastine, Ebastine
2. H2 Antihistamine:- Ranitidine, Famotidine,
Cimetidine, Roxatidine, Loxatidine

12. ANALGESIC/ANTIPYRETIC(NSAIDS)
(A) Non-Selective COX inhibitors:-
Salisylates :- Aspirin
Propionic Acid derivative :- Ibuprofen, Naproxifen, Ketoprofen, Flurbiprofen
Anthranilic Acid derivative :- Diclomine, Acelofenac
Oxicam :- Piroxicam, Tenoxicam
Pyrolo-pyrolle derivative :- Ketorolac
Indole derivative :- Indomethacin
Pyrozolone derivative :- Phenylbutazone, Oxyphenbutazone
(B) Preferentical COX-2 Inhibitors:-
Nimesulide, Meloxicam, Nabumetone
(C) Selective COX-2 Inhibitors:-
Celecoxib, Etoricoxib, Parecoxib
(D) Analgesic- Antipyretics:-
Paraminophenol:- Paracetamol
Pyrozolone derivative:- Metamizol, Propiphenazone