New PRRS disease phenotypes as vaccine and genetic improvement targets - Dr. Andrea Wilson, Roslin Institute, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. X.J. Meng - Designing PRRSV Vaccines for Heterologous ProtectionJohn Blue
Designing PRRSV Vaccines for Heterologous Protection - Dr. X.J. Meng, VA-MD College of Veterinary Medicine, Virginia Tech, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
Dr. Jack Dekkers and Dr. Bob Rowland - Introduction of the ProgramJohn Blue
Introduction of the Program - Dr. Jack Dekkers,Iowa State University, and Dr. Bob Rowland, Kansas State University, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. Hanchun Yang - Pathogenesis and control of Chinese highly pathogenic Porc...John Blue
Pathogenesis and control of Chinese highly pathogenic Porcine Reproductive & Respiratory Syndrome (PRRSV) - Dr. Hanchun Yang, China Agricultural University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Mike Roof - Impact of Porcine Reproductive & Respiratory Syndrome (PRRS) ...John Blue
Impact of Porcine Reproductive & Respiratory Syndrome (PRRS) vaccination on infectious load and implications for area control and eradication - Dr. Mike Roof, Boehringer Ingelheim, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Megan Niederwerder - The role of the microbiome in Porcine Reproductive &...John Blue
The role of the microbiome in Porcine Reproductive & Respiratory Syndrome (PRRS) - Dr. Megan Niederwerder, Diagnostic Medicine/Pathobiology, Kansas State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Meggan Bandrick - The latest on Porcine Epidemic Diarrhea Virus (PEDV)John Blue
The latest on Porcine Epidemic Diarrhea Virus (PEDV) - Dr. Meggan Bandrick, Zoetis, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. X.J. Meng - Designing PRRSV Vaccines for Heterologous ProtectionJohn Blue
Designing PRRSV Vaccines for Heterologous Protection - Dr. X.J. Meng, VA-MD College of Veterinary Medicine, Virginia Tech, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
Dr. Jack Dekkers and Dr. Bob Rowland - Introduction of the ProgramJohn Blue
Introduction of the Program - Dr. Jack Dekkers,Iowa State University, and Dr. Bob Rowland, Kansas State University, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. Hanchun Yang - Pathogenesis and control of Chinese highly pathogenic Porc...John Blue
Pathogenesis and control of Chinese highly pathogenic Porcine Reproductive & Respiratory Syndrome (PRRSV) - Dr. Hanchun Yang, China Agricultural University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Mike Roof - Impact of Porcine Reproductive & Respiratory Syndrome (PRRS) ...John Blue
Impact of Porcine Reproductive & Respiratory Syndrome (PRRS) vaccination on infectious load and implications for area control and eradication - Dr. Mike Roof, Boehringer Ingelheim, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Megan Niederwerder - The role of the microbiome in Porcine Reproductive &...John Blue
The role of the microbiome in Porcine Reproductive & Respiratory Syndrome (PRRS) - Dr. Megan Niederwerder, Diagnostic Medicine/Pathobiology, Kansas State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Meggan Bandrick - The latest on Porcine Epidemic Diarrhea Virus (PEDV)John Blue
The latest on Porcine Epidemic Diarrhea Virus (PEDV) - Dr. Meggan Bandrick, Zoetis, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Jack Dekkers - Update on the host genetics of resistance to porcine diseasesJohn Blue
Update on the host genetics of resistance to porcine diseases - Dr. Jack Dekkers, Animal Breeding and Genetics, Department of Animal Science, Iowa State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Tanja Opriessnig - Update on novel experimental pig vaccine approachesJohn Blue
Update on novel experimental pig vaccine approaches - Dr. Tanja Opriessnig, The Roslin Institute, University of Edinburgh and Iowa State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Daniel Linhares - Update on Porcine Reproductive & Respiratory Syndrome (...John Blue
Update on Porcine Reproductive & Respiratory Syndrome (PRRS) stability studies and flash updates on PRRS detection and biosecurity studies - Dr. Daniel Linhares, Iowa State University, Swine Health and Productivity, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. PH Rathkjen - Porcine Reproductive & Respiratory Syndrome (PRRS) around t...John Blue
Porcine Reproductive & Respiratory Syndrome (PRRS) around the World – What’s new regarding Global cross‐protection against PRRS - Dr. PH Rathkjen, Boehringer Ingelheim, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Andres Diaz - Dynamics of swine influenza in a wean-finish populationJohn Blue
Dynamics of swine influenza in a wean-finish population - Andres Diaz, University of Minnesota, College of Veterinary Medicine, from the 2013 Allen D. Leman Swine Conference, September 14-17, 2013, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2013-leman-swine-conference-material
Dr. Amy Vincent - H3N2 influenza A virus in swine and the human-animal interfaceJohn Blue
The growing diversity of H3N2 influenza A virus in swine and the impact on control in swine and at the human animal interface - Dr. Amy Vincent, Research Veterinary Medical Officer, National Animal Disease Center, USDA-ARS, from the 2013 Allen D. Leman Swine Conference, September 14-17, 2013, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2013-leman-swine-conference-material
Dr. Pete Lasley - The Dreaded Ps of Pork Production - PRRS and PEDVJohn Blue
The Dreaded Ps of Pork Production - PRRS and PEDV - Dr. Pete Lasley, Murphy-Brown of Missouri, LLC, from the 2014 Missouri Pork Expo , February 11 - 12, 2014, Columbia, MO, USA.
More presentations at http://www.swinecast.com/2014-missouri-pork-expo
Dr. Jeff Zimmerman - Developments in infectious disease surveillanceJohn Blue
Developments in infectious disease surveillance - Dr. Jeff Zimmerman, Vet Diagnostic and Production Animal Medicine, Veterinary Diagnostic Laboratory, Iowa State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Real-Time Genome Sequencing of Resistant Bacteria Provides Precision Infectio...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Real-Time Genome Sequencing of Resistant Bacteria Provides Precision Infection Control in an Institutional Setting. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management and GMI-9, 23-25 May 2016, Rome, Italy.
Dr. Randy Prather - Porcine Reproductive and Respiratory Syndrome Virus Resis...John Blue
Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs - Dr. Randy Prather, University of Missouri, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
Dr. Michael Murtaugh and Dr. Cheryl Dvorak - Natural Infection, Immunity & Pr...John Blue
Natural Infection, Immunity & Prevalence of PCV2 - Dr. Michael Murtaugh and Dr. Cheryl Dvorak, University of Minnesota, USA , from the Boehringer Ingelheim Pre-AASV Conference, February 28, 2014 - Dallas, TX
More presentations at http://www.swinecast.com/2014-boehringer-ingelheim-aasv
Dr. Jack Dekkers - Using genetic selection and genomics to combat infectious ...John Blue
Using genetic selection and genomics to combat infectious disease - Dr. Jack Dekkers, Iowa State University, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. Graham Plastow - Resilience and PRRS in a natural disease challenge modelJohn Blue
Resilience and PRRS in a natural disease challenge model - Dr. Graham Plastow, University of Alberta, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. Jack Dekkers - Update on the host genetics of resistance to porcine diseasesJohn Blue
Update on the host genetics of resistance to porcine diseases - Dr. Jack Dekkers, Animal Breeding and Genetics, Department of Animal Science, Iowa State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Tanja Opriessnig - Update on novel experimental pig vaccine approachesJohn Blue
Update on novel experimental pig vaccine approaches - Dr. Tanja Opriessnig, The Roslin Institute, University of Edinburgh and Iowa State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. Daniel Linhares - Update on Porcine Reproductive & Respiratory Syndrome (...John Blue
Update on Porcine Reproductive & Respiratory Syndrome (PRRS) stability studies and flash updates on PRRS detection and biosecurity studies - Dr. Daniel Linhares, Iowa State University, Swine Health and Productivity, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Dr. PH Rathkjen - Porcine Reproductive & Respiratory Syndrome (PRRS) around t...John Blue
Porcine Reproductive & Respiratory Syndrome (PRRS) around the World – What’s new regarding Global cross‐protection against PRRS - Dr. PH Rathkjen, Boehringer Ingelheim, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Andres Diaz - Dynamics of swine influenza in a wean-finish populationJohn Blue
Dynamics of swine influenza in a wean-finish population - Andres Diaz, University of Minnesota, College of Veterinary Medicine, from the 2013 Allen D. Leman Swine Conference, September 14-17, 2013, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2013-leman-swine-conference-material
Dr. Amy Vincent - H3N2 influenza A virus in swine and the human-animal interfaceJohn Blue
The growing diversity of H3N2 influenza A virus in swine and the impact on control in swine and at the human animal interface - Dr. Amy Vincent, Research Veterinary Medical Officer, National Animal Disease Center, USDA-ARS, from the 2013 Allen D. Leman Swine Conference, September 14-17, 2013, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2013-leman-swine-conference-material
Dr. Pete Lasley - The Dreaded Ps of Pork Production - PRRS and PEDVJohn Blue
The Dreaded Ps of Pork Production - PRRS and PEDV - Dr. Pete Lasley, Murphy-Brown of Missouri, LLC, from the 2014 Missouri Pork Expo , February 11 - 12, 2014, Columbia, MO, USA.
More presentations at http://www.swinecast.com/2014-missouri-pork-expo
Dr. Jeff Zimmerman - Developments in infectious disease surveillanceJohn Blue
Developments in infectious disease surveillance - Dr. Jeff Zimmerman, Vet Diagnostic and Production Animal Medicine, Veterinary Diagnostic Laboratory, Iowa State University, from the 2016 North American PRRS Symposium, December 3‐4, 2016, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2016-north-american-prrs-symposium
Real-Time Genome Sequencing of Resistant Bacteria Provides Precision Infectio...ExternalEvents
http://www.fao.org/about/meetings/wgs-on-food-safety-management/en/
Real-Time Genome Sequencing of Resistant Bacteria Provides Precision Infection Control in an Institutional Setting. Presentation from the Technical Meeting on the impact of Whole Genome Sequencing (WGS) on food safety management and GMI-9, 23-25 May 2016, Rome, Italy.
Dr. Randy Prather - Porcine Reproductive and Respiratory Syndrome Virus Resis...John Blue
Porcine Reproductive and Respiratory Syndrome Virus Resistant Pigs - Dr. Randy Prather, University of Missouri, from the 2015 North American PRRS Symposium, December 4 - 5, 2015, Chicago, IL, USA.
More presentations at http://www.swinecast.com/2015-north-american-prrs-symposium
Dr. Michael Murtaugh and Dr. Cheryl Dvorak - Natural Infection, Immunity & Pr...John Blue
Natural Infection, Immunity & Prevalence of PCV2 - Dr. Michael Murtaugh and Dr. Cheryl Dvorak, University of Minnesota, USA , from the Boehringer Ingelheim Pre-AASV Conference, February 28, 2014 - Dallas, TX
More presentations at http://www.swinecast.com/2014-boehringer-ingelheim-aasv
Dr. Jack Dekkers - Using genetic selection and genomics to combat infectious ...John Blue
Using genetic selection and genomics to combat infectious disease - Dr. Jack Dekkers, Iowa State University, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. Graham Plastow - Resilience and PRRS in a natural disease challenge modelJohn Blue
Resilience and PRRS in a natural disease challenge model - Dr. Graham Plastow, University of Alberta, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. Jay Calvert - Viral genetics and application to vaccine developmentJohn Blue
Viral genetics and application to vaccine development - Dr. Jay Calvert, Zoetis, Inc, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Dr. Stephanie Rossow - Applications of Next Generation SequencingJohn Blue
Applications of Next Generation Sequencing - Dr. Stephanie Rossow, College of Veterinary Medicine, University of Minnesota, from the 2016 Allen D. Leman Swine Conference, September 17-20, 2016, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2016-leman-swine-conference-material
Dr. Mike Roof - Current status - "State of the Union" - PRRS vaccine researchJohn Blue
Current status - State of the Union - PRRS vaccine research - Dr. Mike Roof, Boehringer Ingelheim Vetmedica, from the 2017 North American PRRS/National Swine Improvement Federation Joint Meeting, December 1‐3, 2017, Chicago, Illinois, USA.
More presentations at http://www.swinecast.com/2017-north-american-prrs-nsif-joint-meeting
Infectious disease emergencies are opportunities to test the efficacy of newly developed interventions (e.g. drugs, vaccines and treatment regimens), yet they raise many intertwined challenges of politics, logistics, ethics, and study design. Consistent with the efforts of CEPI, WHO, and others to encourage development and Phase I/II testing of candidate vaccines (the focus of this talk) in advance of emergencies, it is essential before the emergency strikes to advance the discussion of how such products can and should be tested. This can help to disentangle ethical from political and logistical concerns, reduce the time pressure to make a decision, and encourage rational deliberation by future stakeholders who at the time of deliberation do not know what role (which product, which field site) they may be supporting in an actual emergency.
At this luncheon, Professor Marc Lipsitch described his work on computer simulation of vaccine trials during epidemics to assess options for trial design, as well as some of his recent work on the ethics of trials in emergencies, with the aim to stimulate discussion on the intersection of these two topics.
For more, please see our website: http://petrieflom.law.harvard.edu/events/details/digital-health-harvard-series-november-2018
Matt Allerson - Swine influenza virus prevalence and risk factors in weaning-...John Blue
Swine influenza virus prevalence and risk factors in weaning-age pigs - Matt Allerson, University of Minnesota, College of Veterinary Medicine, from the 2013 Allen D. Leman Swine Conference, September 14-17, 2013, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2013-leman-swine-conference-material
Dr. Joel Nerem - Science and Practice - How does the Science of Antibiotic Re...John Blue
Science and Practice - How does the Science of Antibiotic Resistance and Use Get Applied in Veterinary and Farming Practices? - Dr. Eric Moore, Technical Director, Norbrook, Inc., Dr. H. Morgan Scott, Professor of Epidemiology, Texas A&M; Dr. Donna Carver, Extension Specialist, Poultry Veterinarian, North Carolina State University; Dr. Joel Nerem, Pipestone Veterinary Services, from the 2017 NIAA Antibiotic Symposium - Antibiotic Stewardship: Collaborative Strategy for Animal Agriculture and Human Health, October 31 - November 2, 2017, Herndon, Virginia, USA.
More presentations at http://www.swinecast.com/2017-niaa-antibiotic-symposium-antibiotic-stewardship
Professor Michael Levin's presentation at Meningitis Research Foundation's 2013 conference Meningitis & Septicaemia in Children & Adults www.meningitis.org/conference2013
The 'omics' revolution: How will it improve our understanding of infections a...WAidid
This slideset explains the ‘Omics’ technology and its role in the study of infections and vaccination. It is a revolution as it offers powerful tools to interrogate the animal / human immune response to vaccines and infections.
Dr. Mark Thurmond - Integrity of Risk Assessment Science Underlying USDA PolicyJohn Blue
Integrity of Risk Assessment Science Underlying USDA Policy - Dr. Mark Thurmond, Professor Emeritus, Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California, Davis, from the 2016 NIAA Annual Conference: From Farm to Table - Food System Biosecurity for Animal Agriculture, April 4-7, 2016, Kansas City, MO, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2016_niaa_farm_table_food_system_biosecurity
The views expressed in the presentations are that of the author and do not necessarily reflect the views of the Government of Canada. Presentations are shared in the original format received from the presenter.
Presentations given at the Conference to Develop a Federal Framework on Lyme Disease are the property of the author, unless otherwise cited. If you reference the author's work, you must give the author credit by naming the author and their work as well as the place and date it was presented.
For more information, contact the Lyme Disease Conference Secretariat at maladie_lyme_disease@phac-aspc.gc.ca
Dr. Robert Stout - Governmental Response to Equine Herpesvirus (EVH-1)John Blue
Governmental Response to Equine Herpesvirus (EVH-1) - Dr. Robert Stout, State Veterinarian, Kentucky Department of Agriculture, from the 2016 NIAA Annual Conference: From Farm to Table - Food System Biosecurity for Animal Agriculture, April 4-7, 2016, Kansas City, MO, USA.
More presentations at http://www.trufflemedia.com/agmedia/conference/2016_niaa_farm_table_food_system_biosecurity
Antibiotics in the ICU - when, what and how?scanFOAM
A presentation by Fredrik Sjövall at the 2017 meeting of the Scandinavian Society of Anaestesiology and Intensive Care Medicine.
All available content from SSAI2017: https://scanfoam.org/ssai2017/
Delivered in collaboration between scanFOAM, SSAI & SFAI.
Dr. Fabian Chamba - Incidence, Prevalence, Seasonality And Control Of Influen...John Blue
Incidence, Prevalence, Seasonality And Control Of Influenza Infections In Breeding Herds - Dr. Fabian Chamba, from the 2015 Allen D. Leman Swine Conference, September 19-22, 2015, St. Paul, Minnesota, USA.
More presentations at http://www.swinecast.com/2015-leman-swine-conference-material
Similar to Dr. Andrea Wilson - New PRRS disease phenotypes as vaccine and genetic improvement targets (20)
Jordan Hoewischer - OACI Farmer Certification ProgramJohn Blue
OACI Farmer Certification Program - Jordan Hoewischer, Ohio Farm Bureau, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Fred Yoder - No-till and Climate Change: Fact, Fiction, and IgnoranceJohn Blue
No-till and Climate Change: Fact, Fiction, and Ignorance - Fred Yoder, Former President, National Corn Growers Association, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. John Grove - Fifty Years Of No-till Research In KentuckyJohn Blue
Fifty Years Of No-till Research In Kentucky - Dr. John Grove, Univerity of Kentucky, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Warren Dick - Pioneering No-till Research Since 1962John Blue
Pioneering No-till Research Since 1962 - Dr. Warren Dick, OSU-OARDC (retired), from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Christine Sprunger - The role that roots play in building soil organic ma...John Blue
The role that roots play in building soil organic matter and soil health - Dr. Christine Sprunger, OSU - SENR, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Leonardo Deiss - Stratification, the Role of Roots, and Yield Trends afte...John Blue
Stratification, the Role of Roots, and Yield Trends after 60 years of No-till - Dr. Leonardo Deiss, OSU, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Steve Culman - No-Till Yield Data AnalysisJohn Blue
No-Till Yield Data Analysis - Dr. Steve Culman, OSU Soil Fertility Extension Specialist, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Alan Sundermeier and Dr. Vinayak Shedekar - Soil biological Response to BMPs John Blue
Soil biological Response to BMPs - Alan Sundermeier, OSU Extension, and Dr. Vinayak Shedekar, USDA-ARS, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Curtis Young - Attracting And Protecting PollinatorsJohn Blue
Attracting And Protecting Pollinators - Dr. Curtis Young, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Sarah Noggle - Cover Crop Decision Tool SelectorJohn Blue
Cover Crop Decision Tool Selector - Sarah Noggle, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Hemp Regulations - Jim Belt, ODA, Head of Hemp for Ohio, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
John Barker - UAVs: Where Are We And What's NextJohn Blue
UAVs: Where Are We And What's Next - John Barker, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Rajbir Bajwa - Medical uses of MarijuanaJohn Blue
Medical uses of Marijuana - Dr. Rajbir Bajwa, Coordinator of legal medical marijuana sales, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Jeff Stachler - Setting up a Corn and Soybean Herbicide Program with Cove...John Blue
Setting up a Corn and Soybean Herbicide Program with Cover Crops - Dr. Jeff Stachler, OSU Extension, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Chad Penn - Developing A New Approach To Soil Phosphorus Testing And Reco...John Blue
Developing A New Approach To Soil Phosphorus Testing And Recommendations - Dr. Chad Penn, USDA-ARS, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Jim Hoorman - Dealing with Cover Crops after Preventative PlantingJohn Blue
Dealing with Cover Crops after Preventative Planting - Jim Hoorman, Hoorman Soil Health Services, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Sjoerd Duiker - Dealing with Poor Soil Structure and Soil Compaction John Blue
Dealing with Poor Soil Structure and Soil Compaction - Dr. Sjoerd Duiker, Extension Agronomist, Penn State University, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Christine Brown - Canadian Livestock Producers Efforts to Improve Water QualityJohn Blue
Canadian Livestock Producers Efforts to Improve Water Quality - Christine Brown, Ontario Ministry of Agriculture, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Dr. Lee Briese - Details Matter (includes details about soil, equipment, cove...John Blue
Details Matter (includes details about soil, equipment, cover crops...) - Dr. Lee Briese, North Dakota, 2017 International Crop Adviser of the Year, from the 2020 Conservation Tillage and Technology Conference, held March 3-4, 2020, Ada, OH, USA.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
This presentation explores a brief idea about the structural and functional attributes of nucleotides, the structure and function of genetic materials along with the impact of UV rays and pH upon them.
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
Remote Sensing and Computational, Evolutionary, Supercomputing, and Intellige...University of Maribor
Slides from talk:
Aleš Zamuda: Remote Sensing and Computational, Evolutionary, Supercomputing, and Intelligent Systems.
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Inter-Society Networking Panel GRSS/MTT-S/CIS Panel Session: Promoting Connection and Cooperation
https://www.etran.rs/2024/en/home-english/
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Dr. Andrea Wilson - New PRRS disease phenotypes as vaccine and genetic improvement targets
1. New PRRS disease phenotypes
as vaccine & genetic
improvement targets
Andrea Doeschl-Wilson
Andrea.wilson@roslin.ed.ac.uk
2. Thanks to all collaborators & funders
Roslin Colleagues
• PhD students and post-docs in Wilson group
• Steve Bishop
External
• Jack Dekkers, A. Hess (ISU)
• H. Mulder, H. Rashidi (WUR, NL)
• I. Kyriazakis (Newcastle University, UK)
• S. Touzeau, C. Belloc (INRIA / INRA, France)
• P. Mathur (Topigs Norsvin, NL)
• G. Plastow (UAlberta), B. Kemp (PigGen), Canada
• J. Lunney (USDA), B. Rowland (KSU) & PHGC
3. -7 0 7 1
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4
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5
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8
Acclimation
Weight
Blood,
Tempus (RNA)
Weight
Blood
Tempus
Weight
Blood
Tempus
Weight
Blood
Tempus
Weight
Blood
Tempus
Weight
Blood
Tempus
Weight
Blood
Tempus
TonsilsBlood
Tempus
Infection
Acute Infection
Rebound
Persistence
Data source for this talk
Viremia Weight
‘PHGC Nursery model’
4. Outline
• Viremia profiles, Tolerance & Infectivity as new disease
phenotypes
– What are they and why do they matter?
• What do the PHGC challenge data tell us about these?
1. A statistical model of PRRS viremia profiles
New resistance & infectivity phenotypes
2. A mechanistic model of PRRS infection dynamics
Understanding rebound
3. A random regression model
Is there genetic variation in tolerance of pigs to PRRS?
5. Desirable target trait for maintaining high individual & herd health & performance
Nr 1 target trait: Resistance
• Virus load is a good resistance
phenotype for PRRS
Resistance:
= ability to block pathogen entry
or restrict pathogen replication
High resistance corresponds to:
• Low pathogen burden
• High health and production
• Low risk of transmission
6. Much is known about genetic resistance of pigs to PRRS
Resistance quantified
as the area under
the curve from 0 to
21 dpi
‘The WUR SNP’
7. Tolerance:
= ability of a host to limit
the detrimental impact of
infection on health /
performance,
without affecting
pathogen burden per se
Desirable target trait to maintain high performance
in the face of constant exposure to infection
2. Target trait: Tolerance
Do pigs differ genetically in tolerance to PRRS?
8. Virus load
GrowthSame tolerance
Virus load
Growth
Different tolerance
High tolerance
Low tolerance
Tolerance is the slope of the reaction-norm of health /
performance with respect to change in pathogen load
How to measure tolerance?
Tolerance
9. Tolerance:
Ability to limit impact
of infection on health /
performance
Resistance:
Ability to block infection /
limit pathogen replication
Resilience:
Ability to maintain high health /
performance whilst exposed to
infectious pathogens
10. Different epidemiological
outcomes
• Tolerant hosts do not reduce
pathogen spread
• Only improvement of resistance
can lead to disease eradication
Different evolutionary outcomes
• Tolerance may be less pathogen-
strain specific:
• multiple pathogen protection
• may not drive pathogen co-evolution
Why distinguish between Resistance & Tolerance?
11. Infectivity:
= ability of an infected individual
to transmit the infection
• Many recent epidemic outbreaks
attributed to ‘super-spreaders’:
• 20% individuals responsible for
80% of transmissions
3. Target trait: Infectivity
• Early identification & removal of most infectious individuals would be a very
effective disease control
• It is not known to what extent infectivity is genetically controlled
• Infectivity cannot be directly measured, but can be inferred from disease data
• Can’t be inferred from challenge experiments
12. Message 1
• Resistance, tolerance & infectivity
are important host target traits for
genetic improvement
• Understanding the genetic control
& relationship between these traits
is important for effective disease
control
13. Making more of the PHGC data: modelling virus load dynamics
• Large variation in viremia profiles
• How to describe these?
• Viremia rebound: prolonged
infectivity?
• Is it common, predictable &
genetically controlled?
Viremia rebound
14. Virusload[RT-PCRlog10]
1 1
1
b c t
y a t e
Woods function:
1 1 2
1 2 0max(0, ( )b c bt
y a t e a t t e
01 1 2 2 ( )
1 2 0max(0, ( ) )t tb c b ct
y a t e a t t e
Extended Woods function:
An individual’s viremia profile is fully specified by 3 (7) parameters
Islam et al. Plos ONE 2013
The (extended) Woods function describes all viremia profiles
15. Woods function advantages
• Smooth continuous profiles rather than
noisy discrete data
• Objective classification of pigs into
rebounder or non-rebounder
• New phenotypes for genetic analyses
based on viremia profile characteristics:
• Rebound (yes / no)
• Peak viral load
• Time to peak
• Rate of viral load decline
VPeak1
Tpeak
VPeak2
16. Some results: the good news
Hess et al. GSE 2016
Quantitative comparison of profile
characteristics for 2 viral strains:
• Most viremia profile
characteristics are heritable
• The WUR resistance SNP
confers a more desirable
phenotype for most profile
characteristics
• Effect is strain dependent
18. • Rebound is a common
phenomenon
• But apparently
• not heritable
• not predictable (no significant
differences in viremia profiles
within the first 21 dpi)
Some results: the bad news
Number of individuals
Non-Rebound Rebound
683 (78%) 191(22%)
Islam et al. Plos ONE 2013
19. Message 2
Viremia profiles of PRRSV infected pigs
can be modelled by Woods functions
• Most profile characteristics are heritable &
favourably influenced by the WUR SNP
• Viremia rebound is undesirable, common
& apparently not under host genetic control
20. Hypotheses for viremia rebound:
1. Virus characteristics (e.g. emergence of escape mutants)
– Emergence of escape variants
– Latent in tissues & spontaneous release into blood
2. Environmental characteristics
– Re-infection
3. Differences in immune responsiveness of pigs
– Could potentially be modified by genetic selection or vaccines
What causes viremia rebound?
21. Adapted from Go et al., PloS One 2014
Can this model reproduce the PHGC viremia profiles?
Can we use it to identify causative mechanisms for rebound?
A mechanistic model of the immune response of pigs
to PRRSV
23. Woods viremia profiles from the PHGC nursery pigs
Step 1: Select subset of viremia profiles that
have similar profile characteristics within 3 wpi
Step 1: Selection of datasets for model fitting
24. Step 2: Fit model to viremia data
The model can reproduce the observed large variation
in viremia profiles for both types of profiles
Apply a mathematical search algorithm to identify input
parameter values that reproduce the viremia data profiles
25. Step 3: Identify candidate mechanisms for rebound
Stronger
immune
response
activation
Faster
depletion of
target cells
Predominant
orientation
towards
antiviral
response
Lower CTL
& nAB
response
But which of these are causative?
Non-rebound
Rebound
26. Step 4 Validation: How to prevent or trigger rebound?
A simulated knock-out experiment:
• Can we prevent rebound by altering a specific mechanism?
• Can we trigger rebound by modulating the mechanism in the
opposite direction?
• Boosting cytolysis or
virus neutralization
prevents rebound
• Weak virus
neutralization alone
does not cause
rebound
ApoptosisInfection NK
cytolysis
NeutralizationLc
cytolysis
Go et al., PloS Comp. Biol. Under Review
27. • The model demonstrates that rebound can be caused
by differences in host immune competence alone
Preventable!!
• The model identified candidate immune mechanisms
that could cause or prevent rebound:
– (Target cell permissiveness, apoptosis of naïve target cells,
cytolysis of infected cells, virus neutralization)
Vaccine or gene editing targets?
Modelling conclusions
28. Genetics of rebound revisited:
WUR SNP protects from rebound
Woods viremia profiles
Logistic regression with WUR SNP fitted as fixed effect:
‘WUR resistant’ pigs are 2.4 x less likely to
experience viremia rebound
29. • Resistance, Tolerance & Infectivity as new
disease phenotypes
– What are they and why do they matter?
• What do the PHGC challenge data tell us
about these?
1. Statistical modelling of viremia profiles
New resistance & infectivity phenotypes
2. How to prevent viremia rebound? Evidence
from a mechanistic model of the immune
response of pigs to PRRSV
3. Is there genetic variation in tolerance of
pigs to PRRS, in addition to resistance?
Outline
30. PRRS as a case studyEvidence for phenotypic variation in PRRS tolerance
High tolerance
Low tolerance
• Is tolerance genetically controlled?
• What is the role of the WUR SNP on tolerance?
31. A: No genetic variation in
growth response to infection
Estimating genetic variation in tolerance
B: Genetic variation in growth
but not in tolerance
C: Genetic variation in
growth & tolerance
Statistical random regression sire model:
• Each line corresponds to one sire (54 sires)
• Estimated from measurements of at least 10
offspring per sire (~1300 pigs)
32. A: No genetic variation in
growth response to infection
B: Genetic variation in
growth but not tolerance
C: Genetic variation in
growth & tolerance
Model of best fit
True or statistical artefact?
Inconclusive evidence for genetic variation in tolerance
Lough et al. GSE 2017
33. A: No genetic variation in
growth response to infection
B: Genetic variation in
growth but not tolerance
C: Genetic variation in
growth & tolerance
True or statistical artefact?
Inconclusive evidence for genetic variation in tolerance
Lough et al. GSE 2017
Simulations show that measures of non-infected
relatives would provide accurate tolerance estimates
34. Message 4
• Estimating genetic effects for
tolerance is difficult
• Performance measures of
uninfected relatives would be
useful for estimating genetic
parameters of tolerance
35. Utilizing dynamic information
Split infection period into 3 distinct stages:
• Captures different sets of immune mechanisms
controlling resistance and tolerance
stronger genetic signal
• 3 growth and virus load measures per individual
greater statistical power
36. A: No genetic variation in
growth response to infection
B: Genetic variation in
growth but not tolerance
C: Genetic variation in
growth & tolerance
There is genetic variance in tolerance to PRRS
Lough et al., GSE 2017 & in prep.
• There is significant genetic variance in tolerance of pigs to PRRS
• WUR AB pigs are on avg. 1.6% more tolerant than AA pigs
38. Implications
• In principle, genetic selection of pigs with
desirable infection profiles & greater tolerance to
PRRS is possible
• In practice, this requires intense data collection
• Selecting on WUR genotype may
simultaneously improve resistance, tolerance
& prevent rebound
• In the future, we should assess the influence of
host genetics on disease spread & virus evolution
This requires new sets of data & models
41. • Pigs vary genetically in
resistance & tolerance to PRRS
• WUR resistance QTL also
confers differences in tolerance
42. • Resistance, tolerance & infectivity
are important host target traits for
genetic improvement
• Infectivity cannot be inferred from
challenge experiments
43. • Mathematical modelling of viremia
profiles characterises rebound &
shows that most profile characteristics
are under host genetic control
• The WUR resistance QTL has a
favourable effect on most viremia
profile characteristics
44. • Mechanistic models can identify
candidate immune mechanisms
underlying viremia rebound
• WUR resistance QTL appears to
reduce risk for rebound
Editor's Notes
PRRS Symposium Chicago 2017
We don’t want to accidentally create tolerant superspreaders
Read Carpenter paper about virus change in rebounders
The model desdribes the interaction between the virus and the host immune response at the cell level in the main infection site, the lung.
Binding of the virus and Tn either results in Tm that phagocytose the virus or in Ti in which new viral particles are generated.
The host responds with innate and then adaptive IR, which is represented by different types of cytokines which either amplify or inhibit diiffeent arms of immunity, such as ….
Create table of input parameters
Pig swith different input parameter values will produce different viremia or immuje profile
Filter
e.g. gene editidng that reduces target cell permissivientss is alrady effective for preventing rebound