Down syndrome, also known as trisomy 21, is a genetic disorder caused by a third copy of chromosome 21. It is associated with physical growth delays and distinctive facial features. People with Down syndrome typically have mild to moderate intellectual disabilities, with an average IQ of around 50. While Down syndrome is not caused by environmental factors or a parent's genetics, it can be identified during pregnancy through screening and testing. Individuals with Down syndrome often require regular health checks as they are at greater risk for health problems and have reduced life expectancy compared to the general population.