The document discusses the characteristics of a successful digital enterprise. It states that in the future, all companies will need to be digitized and use algorithms, sensors, and software. Leaders need to imagine how to use new technologies to create much larger market opportunities, as companies like Netflix, Google, and Amazon have done. A digital enterprise focuses on delivering the best possible customer experience through convenience, speed, and customization. It uses a flexible platform and algorithms at its core to gain insights from vast amounts of customer data. Such a company treats each customer individually, innovates continuously, and integrates new technologies and ways of working like flatter organizational structures and a focus on meaningful projects. The top leaders must have the skills to link digital
Big Data has become a bleeding edge technology from past few years in both industry and the research Community. Is it the diametrically opposed view or truth? Frankly speaking, think is startup’s succeeding with these solutions?
Big Data has become a bleeding edge technology from past few years in both industry and the research Community. Is it the diametrically opposed view or truth? Frankly speaking, think is startup’s succeeding with these solutions?
Proper forecasting is a key factor that decides a company's survival in the market. Companies that are good at forecasting can win over the market quickly because they are ready for every uncertain situation. Companies now have started relying on digital methods of forecasting for better and genuine results.
Machine First Approach Towards Digital Transformation of Businesses - TCSvishankjagtap
From this PDF by TCS understand the different ways of Machine First Approach towards digital transformation of businesses and what should be the approach of the CEOs towards competing in a world of abundant resources and opportunities. Click here to download and know more.
Digital Transformation: What it is and how to get thereEconsultancy
Digital Transformation: What it is and how to get there.
Authored by Econsultancy CEO Ashley Friedlein, this presentation on the topic of 'Digital Transformation', is broken down into six sections covering:
1. Digital Transformation - what it is and recent data and research on the topic
2. Strategy - what a digital strategy should include
3. Technology - the challenges of technology and the skills gap
4. People - looking at organisational structure, culture, roles & responsibilities, environment recquired
5. Process - how to address the speed, innovation and agility required
6. Business Transformation - how digital transformation is actually business transformation
How entrepreneurs can benefit from machine learning GlobalTechCouncil
A study released by Harvard Business Review revealed that AI allows humans to improve social skills, creativity, leadership, and teamwork.
Let’s see how machine learning can empower entrepreneurs to improve their productivity.
Vital Trends in Digital Experience and Transformation in 2016 | Dreamforce 20...Dion Hinchcliffe
Here's the deck I presented at the Emerging Tech Trends track at the Hilton Union Square at Dreamforce 2016 last week. Updates on trends from last year and new trends both are included. A thorough list of what your organization should be considering from both a technology standpoint and as a business.
Cognizant Community Europe 2017: Mastering Digital: Navigating the Shift to t...Cognizant
Executives gathered at Cognizant’s flagship European thought leadership conference heard how digital technologies in general and AI in particular are poised to generate significant economic growth.
Cloud Enabled Transformation In InsuranceCapgemini
Immature capabilities and growing market disruptors are compelling insurers to act swiftly and become fully customer centric. According to the World Insurance Report 2015 less than 30% of customers are having positive customer experiences globally forcing Insurers to reinvent their ability to deliver positive customer experience across the entire customer journey.
Capgemini's ACEs (All Channel Experience) for Insurance is built on Salesforce the leading CRM platform to help insurers improve their core capabilities and enrich customer experiences regardless of customer channel or device preferences.
Find out how Cloud-Enabled Transformation in Insurance from Capgemini and Salesforce is a faster and less disruptive way for insurers to rapidly evolve digital capabilities to achieve customer experiences that leave your customers wanting more!
Creating the Intelligence Driven Digital Enterprise Accenture
“Artificial Intelligence, Automation and Cognitive Enterprise are no Longer a Tech Dreamer’s Imagination” Keynote Presentation on the impact of AI and Robotics on businesses and society
Digital transformation sweet spot: Business operationsMarcel Santilli
Learn more: https://insights.hpe.com
Your enterprise can digitally transform by gaining insights from your data to improve the experience for your customers.
Enterprises need to make over all aspects of their business, because today’s customers expect frictionless experiences — and because new competitors launched with the latest technologies can change and respond to customers faster than mature companies.
Start with the fact that your enterprise has valuable assets that start-ups don’t — your customers. Fostering loyalty among these customers requires improving their interaction with not only your products and services, but also sales, billing, support and shipping operations. Successful companies count on digital technologies to transform the total customer experience. As consumers, we’ve come to expect digitally enabled products as the new normal. But what’s the next step for your enterprise? Find ways to translate into their business lives what people love and expect as consumers.
Enterprises can learn from the digital leaders who look for ways that apps and data can be added to products to create new value over time. Digital leaders use what they learn from the data to reshape core operations to drive the enterprise forward. What’s considered a core operation varies from industry to industry, but the common characteristic is that core operations make up a sizable portion of the enterprise budget. Gaining even a modest amount of efficiency through digital transformation can significantly impact the bottom line. Data also can be used to predict mechanical failure and to schedule preventive maintenance to avoid business disruptions.
Digital transformation begins with data. So how can your enterprise gain insights from your data to improve the experience for your customers?
Analyzing Gartner's CIO Study: Fliping to Digital Leadership HARMAN Services
Why CIOs Need To “Flip” From Old To New In Terms Of Information And Technology Leadership, Value Leadership And People Leadership. We analyzed and decoded Gartner's latest report to find out more!
Estimations are that by year 2025, the proliferation of virtual, augmented and mixed reality tools throughout everyday life and work will be similar to that of PC, web, and mobile today.
We are defining these experiential tools “Digital Reality” and they will drastically transform how we work, we communicate, we learn, and we create.
The Rise of the Chief Digital Officer in 2015Nick Benson
From CDO to CEO:
What’s Driving the Chief Digital Officer to CEO Carer Path?
For fast-growing companies, the Chief Digital Oficer is emerging as the new “it” positon. Gartner predicts that 25% of busineses wil have a CDO by 2015.
Digital Foundations to Transform Customer Experiences Through Process Optimiz...Jared Hill
The Urban Affairs Coalition (UAC) was looking to streamline their processes to save their nonprofit clients time and money, allowing them to have a greater impact. See how Lime Consulting Group helped (UAC) build a roadmap and a business case to gain the consensus they needed internally to secure funding to get started. By mapping business processes in Signavio, UAC was able to standardize the way they do business today, so that they can automate with the use of technology in the future.
Proper forecasting is a key factor that decides a company's survival in the market. Companies that are good at forecasting can win over the market quickly because they are ready for every uncertain situation. Companies now have started relying on digital methods of forecasting for better and genuine results.
Machine First Approach Towards Digital Transformation of Businesses - TCSvishankjagtap
From this PDF by TCS understand the different ways of Machine First Approach towards digital transformation of businesses and what should be the approach of the CEOs towards competing in a world of abundant resources and opportunities. Click here to download and know more.
Digital Transformation: What it is and how to get thereEconsultancy
Digital Transformation: What it is and how to get there.
Authored by Econsultancy CEO Ashley Friedlein, this presentation on the topic of 'Digital Transformation', is broken down into six sections covering:
1. Digital Transformation - what it is and recent data and research on the topic
2. Strategy - what a digital strategy should include
3. Technology - the challenges of technology and the skills gap
4. People - looking at organisational structure, culture, roles & responsibilities, environment recquired
5. Process - how to address the speed, innovation and agility required
6. Business Transformation - how digital transformation is actually business transformation
How entrepreneurs can benefit from machine learning GlobalTechCouncil
A study released by Harvard Business Review revealed that AI allows humans to improve social skills, creativity, leadership, and teamwork.
Let’s see how machine learning can empower entrepreneurs to improve their productivity.
Vital Trends in Digital Experience and Transformation in 2016 | Dreamforce 20...Dion Hinchcliffe
Here's the deck I presented at the Emerging Tech Trends track at the Hilton Union Square at Dreamforce 2016 last week. Updates on trends from last year and new trends both are included. A thorough list of what your organization should be considering from both a technology standpoint and as a business.
Cognizant Community Europe 2017: Mastering Digital: Navigating the Shift to t...Cognizant
Executives gathered at Cognizant’s flagship European thought leadership conference heard how digital technologies in general and AI in particular are poised to generate significant economic growth.
Cloud Enabled Transformation In InsuranceCapgemini
Immature capabilities and growing market disruptors are compelling insurers to act swiftly and become fully customer centric. According to the World Insurance Report 2015 less than 30% of customers are having positive customer experiences globally forcing Insurers to reinvent their ability to deliver positive customer experience across the entire customer journey.
Capgemini's ACEs (All Channel Experience) for Insurance is built on Salesforce the leading CRM platform to help insurers improve their core capabilities and enrich customer experiences regardless of customer channel or device preferences.
Find out how Cloud-Enabled Transformation in Insurance from Capgemini and Salesforce is a faster and less disruptive way for insurers to rapidly evolve digital capabilities to achieve customer experiences that leave your customers wanting more!
Creating the Intelligence Driven Digital Enterprise Accenture
“Artificial Intelligence, Automation and Cognitive Enterprise are no Longer a Tech Dreamer’s Imagination” Keynote Presentation on the impact of AI and Robotics on businesses and society
Digital transformation sweet spot: Business operationsMarcel Santilli
Learn more: https://insights.hpe.com
Your enterprise can digitally transform by gaining insights from your data to improve the experience for your customers.
Enterprises need to make over all aspects of their business, because today’s customers expect frictionless experiences — and because new competitors launched with the latest technologies can change and respond to customers faster than mature companies.
Start with the fact that your enterprise has valuable assets that start-ups don’t — your customers. Fostering loyalty among these customers requires improving their interaction with not only your products and services, but also sales, billing, support and shipping operations. Successful companies count on digital technologies to transform the total customer experience. As consumers, we’ve come to expect digitally enabled products as the new normal. But what’s the next step for your enterprise? Find ways to translate into their business lives what people love and expect as consumers.
Enterprises can learn from the digital leaders who look for ways that apps and data can be added to products to create new value over time. Digital leaders use what they learn from the data to reshape core operations to drive the enterprise forward. What’s considered a core operation varies from industry to industry, but the common characteristic is that core operations make up a sizable portion of the enterprise budget. Gaining even a modest amount of efficiency through digital transformation can significantly impact the bottom line. Data also can be used to predict mechanical failure and to schedule preventive maintenance to avoid business disruptions.
Digital transformation begins with data. So how can your enterprise gain insights from your data to improve the experience for your customers?
Analyzing Gartner's CIO Study: Fliping to Digital Leadership HARMAN Services
Why CIOs Need To “Flip” From Old To New In Terms Of Information And Technology Leadership, Value Leadership And People Leadership. We analyzed and decoded Gartner's latest report to find out more!
Estimations are that by year 2025, the proliferation of virtual, augmented and mixed reality tools throughout everyday life and work will be similar to that of PC, web, and mobile today.
We are defining these experiential tools “Digital Reality” and they will drastically transform how we work, we communicate, we learn, and we create.
The Rise of the Chief Digital Officer in 2015Nick Benson
From CDO to CEO:
What’s Driving the Chief Digital Officer to CEO Carer Path?
For fast-growing companies, the Chief Digital Oficer is emerging as the new “it” positon. Gartner predicts that 25% of busineses wil have a CDO by 2015.
Digital Foundations to Transform Customer Experiences Through Process Optimiz...Jared Hill
The Urban Affairs Coalition (UAC) was looking to streamline their processes to save their nonprofit clients time and money, allowing them to have a greater impact. See how Lime Consulting Group helped (UAC) build a roadmap and a business case to gain the consensus they needed internally to secure funding to get started. By mapping business processes in Signavio, UAC was able to standardize the way they do business today, so that they can automate with the use of technology in the future.
Failed Mega Events As Urban Development Engines?PaulTLevin
A case study of the construction of Hammarby Sjöstad, a planned Olympic village in Stockholm, Sweden. Why was this \'green\' district built even though the 2004 Games went to Athens? I focus on public management and urban planning lessons.
Scandinavia vs canada comparison of social and economic policiespaul young cpa, cga
This presentation discuss various policies like corporate taxation, personal taxation, valued-added taxation, poverty, income inequality, income distribution and other policies.
The focus is on countries like Norway, Sweden, Finland and Denmark. Canada has been told by many socialist that they should follow the Scandinavia model when it comes to taxation and social programs.
Smooth Operator – Managing an Operating Business SuccessfullyBoast Capital
You have founded your company and raised capital. Now it is time to operate your business. What are the legal aspects that you need to pay attention to? This webinar covers the knowledge and tools you need to make decisions and manage your business successfully.
Everything You Need to Know to Claim & Finance Your R&D Tax CreditsBoast Capital
Boast and Espresso have teamed up to host a webinar titled “Everything You Need to Know to Claim for, and Finance Your SR&ED Tax Credits”. During this webinar we will cover what type of work technically qualifies for the program, the types of expenditures that you can recover, as well as the potential returns you could receive. Espresso Capital will also speak about different financing options available to be able to realize your SR&ED return in a timely manner.
Final Year Project :The Beginning in becoming a programmerSuhailan Safei
The learning outcome of Final Year Project in Bachelor of Computer Science (Software Development) with Honours, Faculty of Informatics, Universiti Sultan Zainal Abidin, Malaysia.
Each CIO post description includes something resembling the 12 roles and requirements. This list outlines what CEOs are currently looking for in their CIOs. However, it's not necessarily what CEOs really need from their CIOs.
In the current data-driven economy, in which analytics and software have become the main factors in business, executives must reconsider the hierarchies and silos that fueled the business in the past. There is no longer a need for "technology people" who work independently of "data people" who work in isolation from "sales" people or from "finance." Instead, they need to manage organizations where every employee is embraced by technology and data as integral to their work.
They also require CIOs to guide them there. In this regard, redefining the business to accommodate the new data economy is the primary task executives have to today's top-of-the-line CIOs.
Here's how:
from Software and the Business to Software is the Business
When Cargill began to put IoT sensors in shrimp ponds, Chief Information Officer Justin Kershaw realised that the $130 billion agriculture business was evolving into a digital enterprise. To determine the point at which IT should stop and where IoT technology engineering needs to begin, Kershaw did not call CIOs from other food and agricultural companies to discuss their experiences. He contacted the CIOs of SAP and Microsoft as well as various other companies that use software. He was thinking about reimagining the world's biggest agricultural business as a software business.
Modern Delivery
Moving software from a supporting role to leading position is the why is the issue, then modern delivery is the way to do it. Modern delivery involves an approach to product (rather as project) management rapid development and small teams of cross-functional experts which co-create, as well as continuous integration and delivery, all with a brand new financial model that supports "value" not "projects."
However, don't try to build an modern SDLC. Instead, build a software development cycle (SDLC) on an industrial infrastructure. The architecture that is intended for this data-driven economy relies on platforms and cloud-connected, makes use of APIs that connect with an ecosystem outside and splits monolithic applications into microservices.
"A platforms model encompasses more than just an architecture. It's a mental model that allows us to consider how vertically we can provide the vet, farmer, or pet's owners, then expand to think horizontally about ways to make solutions adaptable, scalable and secure" claims Wafaa Mamilli Chief Information Officer and Digital Officer of global animal health firm Zoetis. "Platforms can be flexible, intelligent and run algorithms that let us rapidly change. If we did not adopt the platform model and approach, we'd be funding these massive programs."
The Democratisation of IT
If you gift someone an uncooked fish, they can take a bite for a few hours.
Digital has brought about change in everything we do.
Your business needs to adapt to changing customer
dynamics and respond to competitive forces in real-time.
Your customers, partners, and suppliers are on their toes
and they expect you to be up and running too.
Thus, IT leaders have to imbibe the concept of the platform ecosystem and think in terms of creating the “platforms that cohesively work internally and externally to enable a
multimodal connect for delivering digital enterprise.”
Take following steps to Platformize:
1. Build Contextual Process
Platform
2. Integrate mobility and social in
process applications
3. Deliver Process Experience
4. Elevate Orchestration
5. Loosely Couple resources
6. Create and Carry Process
Context
7. Practice Platform Governance
8. Think Big, Start Small, Earn
quick wins, Expand
9. Leverage Agile Methodology
and Accelerators
For more information visit: http://www.newgensoft.com/
BIG DATA is having an enormous impact on the profile of workforces around the world. If you've ever seen the technology and experienced the impact it has on the pace of innovation in a business then the predictations made by McKinsey Global Institute will come as no surprise ( and just in case you've been on holiday for around two years, McKinsey is suggesting that by 2018 the US will face a shortfall of close to 200,000 analysts and 1.5 million managers with the right skills. In this presentation I outline the impact of BIG DATA on workforce design. I hope you find it informative and fun to read. Ian.
The rising collection and analysis of data has shifted the way companies do business. Four key ingredients to develop a data strategy, how to leverage next-generation technologies, and three essential steps for rolling out implementation are included. The Data Ecosystem will show you how to develop and implement the strategies that will meet the needs of your business.
The Digital Enterprise Vol 5 - A Framework for TransformationStuart Lamb
We outline the many aspects of digital transformation and a roadmap for getting there. This issue of Perspectives exudes the enthusiasm and capabilities that TCS has in
supporting the transformation ahead.
People — Not Just Machines — Will Power Digital InnovationCognizant
As new technologies cause value chains to rapidly evolve and organizational boundaries to blur, human roles and tasks are also digitizing, as machines alter how knowledge work is performed.
Are you exploring the best way for your business to save expenses, enhance margin, or reinvest in the coming years? Check out the top technological advancements in business that are beneficial for business expansion and that result in a technology roadmap that has an impact on a number of the organization's strategic goals.
For more information, see: https://www.albiorixtech.com/blog/technology-trends-in-business/
#technology #technologytrends #webappdevelopment #mobileappdevelopment #softwaredevelopment
Accenture Technology Vision 2013: The Latest IT Trends and Innovations. Every business is now a digital business, and every executive needs to be able to understand the implications of technology trends and innovations for his or her company and industry. Without this insight, the company will not be well positioned to achieve high performance.
The Accenture Technology Vision 2013 identifies seven IT trends shaping technology—and thus business—into the future, making it required reading for everyone in the C-suite.
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
2. Contd…
Make no mistake that in the near future every successful company will be digitised.
They will be “math houses” that have at their core the use of algorithms, sensors
and sophisticated software. Leaders have to go on the offense by imagining how to
use new technologies and mathematical capabilities to create a market space that
is ten or even a hundred times larger. That’s what the likes of Netflix, Google and
Amazon have done. Leadership is no longer a matter of sensing secular, seasonal or
cyclical changes and anticipating bends in the road.
Is your business fit to compete in the new era? Here is my take on the
characteristics of a successful digital enterprise: A mindset focused on the “end-to-
end customer experience” permeates the company. Everyone in the enterprise
strives to deliver an experience that is more convenient, cheaper, faster, less time
consuming and more pleasurable. This may require a wholesale change in coaching
and training and perhaps the replacement of some people who cannot adapt. A top
team that sticks too long with the old mindset is at high risk, given the speed with
which destruction can come full force.
3. Contd…
The essence of the strategy is a platform, as at Amazon, Alibaba, Google and GE
digital, with algorithms at its center. The design of its software, data structure and
algorithms can capture and customise consumer experience in nanoseconds.
The platform is flexible and provides countless options for the company and
perhaps others to build on it. It can be modular and can incorporate artificial
intelligence. Core competence in designing and operating the platform makes it
possible to solve hitherto unsolvable problems and creates extraordinarily large
opportunities that can be converted into customer benefits and profits.
The top leaders have an ambitious imagination to conceive of serving an
exponentially bigger market by becoming a digital enterprise. They recognise that
problems that were too big to crack in the past can now be solved precisely
because of digitisation, algorithms and sensors. Witness the reality of the driverless
car, which not long ago was mere fantasy .
4. Contd…
The aim is to treat each customer as an individual. This can be achieved only
when the organisation is unshackled from the industrial hierarchical
structures that were created long before the advent of digital technology and
information transparency . These structures have outlived their usefulness
and are now a competitive disadvantage. Layers of de cision making create
“information filters” that distort consumer feedback.
They make the enterprise slower and less responsive and therefore
vulnerable to digital startups.
Innovation and experimentation are continuous as the enterprise seeks new
offerings the customer will find compelling.
Generating new ideas must be part of the company’s DNA in order to keep
pace with changes in consumer behaviour. Algorithms allow the testing of
ideas with statistical validity at low cost and high speed.
5. Contd…
Millennials are integrated into the organisation, and new organisation
structures and coordination mechanisms replace industrial hierarchical
layers. The organisation is project based, and has fewer layers (a maximum
of three, regardless of number of employees). Senior people must come to
grips with the presence of this new generation, who seek substantive growth
on meaningful projects and are unwilling to move up slowly through a dozen
organisational layers.
The ecosystem is reshaped and managed via digitisation. It adapts quickly to
external change. Some players may have to be eliminated and new
relationships formed.
A new breed of leader arises with skills in linking the customer experience
and a digital algorithmic platform. Digital natives such as Jeff Bezos of
Amazon and Sergey Brin and Eric Schmidt of Google grew up that way, but
others can learn. It is a mandatory skill at the very top.
6. For details and bookings contact:-
Parveen Kumar Chadha… THINK TANK
(Founder and C.E.O of Saxbee Consultants & Other-Mother
marketingandcommunicationconsultants.com)
Email :-saxbeeconsultants@gmail.com
Mobile No. +91-9818308353
Address:-First Floor G-20(A), Kirti Nagar, New Delhi India Postal Code-110015