The document discusses the function and configuration of a diverter valve in liquid chromatography mass spectrometry (LCMS). It highlights the importance of diverting un-retained components to waste to prevent contamination and emphasizes correct operation to avoid incorrect data. The valve can be set up in either injector mode or diverter mode, depending on the desired flow of the sample.

1. LCMS - Diverter Valve
C. P.Singh

2. Diverter Valve in LCMS
 A divert valve allows you to switch portions of the mobile phase to waste before the mass spectrometer.
 This is particularly important for the portion containing all the un-retained components – many of which are likely to be
involatile and contaminate the source. If you really want to keep things clean use a divert valve to divert everything to
waste except the compounds of interest.
 The integrated diverter valve, which is located next to the ion source, can be plumbed in injector mode or diverter mode.
 To configure the valve, access the Configuration tab and then make sure
that the Use integrated injector/diverter valve check box is selected.
 CAUTION: Potential Wrong Result. Do not press the diverter valve
button during a run. Doing so might result in incorrect data.

3. When the valve is in Position A, the sample flows through the external loop.
When the valve switches to Position B, the sample is injected.
Diverter Valve—Injector Mode Position A Diverter Valve—Injector Mode Position B
Item Description
1: Sample in
2: Waste out
3: Sample loop (ports 3 and 6)
4: Mobile phase in
5: To column (or to the mass spectrometer, if a column is not installed)
Plumb the valve for injector mode
Plumb the Diverter Valve in Injector Mode

4. Plumb the Diverter Valve in Diverter Mode
When the valve is in Position A, the flow goes to the mass spectrometer.
When the valve switches to Position B, the flow goes to waste.
Diverter Valve—Diverter Mode Position A Diverter Valve—Diverter Mode Position B
Item Description
1: To mass spectrometer
2: From column
3: Waste out
Plumb the valve for diverter mode

5. Thanks