This deck is from a presentation I gave on endogeneity and entrepreneurship research at the University of Nebraska. The presentation focuses mostly on dealing with endogeneity using latent variable structural equation modeling, but the content broadly applies to observed variable models.
This deck is from a presentation I gave on endogeneity and entrepreneurship research at the University of Nebraska. The presentation focuses mostly on dealing with endogeneity using latent variable structural equation modeling, but the content broadly applies to observed variable models.
A Fuzzy Mean-Variance-Skewness Portfolioselection Problem.inventionjournals
A fuzzy number is a normal and convex fuzzy subsetof the real line. In this paper, based on membership function, we redefine the concepts of mean and variance for fuzzy numbers. Furthermore, we propose the concept of skewness and prove some desirable properties. A fuzzy mean-variance-skewness portfolio se-lection model is formulated and two variations are given, which are transformed to nonlinear optimization models with polynomial ob-jective and constraint functions such that they can be solved analytically. Finally, we present some numerical examples to demonstrate the effectiveness of the proposed models
D. Mayo (Dept of Philosophy, VT)
Sir David Cox’s Statistical Philosophy and Its Relevance to Today’s Statistical Controversies
ABSTRACT: This talk will explain Sir David Cox's views of the nature and importance of statistical foundations and their relevance to today's controversies about statistical inference, particularly in using statistical significance testing and confidence intervals. Two key themes of Cox's statistical philosophy are: first, the importance of calibrating methods by considering their behavior in (actual or hypothetical) repeated sampling, and second, ensuring the calibration is relevant to the specific data and inquiry. A question that arises is: How can the frequentist calibration provide a genuinely epistemic assessment of what is learned from data? Building on our jointly written papers, Mayo and Cox (2006) and Cox and Mayo (2010), I will argue that relevant error probabilities may serve to assess how well-corroborated or severely tested statistical claims are.
In this video from PASC18, Jakub Tomczak from the University of Amsterdam presents: The Success of Deep Generative Models.
"Deep generative models allow us to learn hidden representations of data and generate new examples. There are two major families of models that are exploited in current applications: Generative Adversarial Networks (GANs), and Variational Auto-Encoders (VAE). The principle of GANs is to train a generator that can generate examples from random noise, in adversary of a discriminative model that is forced to confuse true samples from generated ones. Generated images by GANs are very sharp and detailed. The biggest disadvantage of GANs is that they are trained through solving a minimax optimization problem that causes significant learning instability issues. VAEs are based on a fully probabilistic perspective of the variational inference. The learning problem aims at maximizing the variational lower bound for a given family of variational posteriors. The model can be trained by backpropagation but it was noticed that the resulting
generated images are rather blurry. However, VAEs are probabilistic models, thus, they could be incorporated in almost any probabilistic framework. We will discuss basics of both approaches and present recent extensions. We will point out advantages and disadvantages of GANs and VAE. Some of most promising applications of deep generative models will be shown."
Watch the video: https://wp.me/p3RLHQ-iSX
Learn more: https://pasc18.pasc-conference.org/
Sign up for our insideHPC Newsletter: http://insidehpc.com/newsletter
On the Use of the Causal Analysis in Small Type Fit Indices of Adult Mathemat...QUESTJOURNAL
ABSTRACT: Model evaluation is one of the most important aspects of Structural Equation Modeling (SEM). Many model fit indices have been developed. It is not an exaggeration to say that nearly every publication using the SEM methodology has reported at least one fit index. Fit is the ability of a model to reproduce the data in the variance-covariance matrix form. A good fitting model is one that is reasonably consistent with the data and doesn’t require respecification and also its measurement model is required before estimating paths in a covariance structure model. A baseline model of four constructs together with a combination of none, one, two, three or four additional constructs was constructed with latent variables: educational performance, socioeconomic label, self concept and parental authority using dichotomous digits 0 or 1 for each additional construct. 16 progressively nested models were considered starting with baseline model using the mathematics adult learners data from the modeling sample and employing some small fit indexes which are commonly used (AIC, CAIC, RMR, SRMR, RMSEA, 2 / DF among others) [1] to test the fitness of the model. The measures of model fit based on results from analysis of the covariance structure model are presented.
A Fuzzy Mean-Variance-Skewness Portfolioselection Problem.inventionjournals
A fuzzy number is a normal and convex fuzzy subsetof the real line. In this paper, based on membership function, we redefine the concepts of mean and variance for fuzzy numbers. Furthermore, we propose the concept of skewness and prove some desirable properties. A fuzzy mean-variance-skewness portfolio se-lection model is formulated and two variations are given, which are transformed to nonlinear optimization models with polynomial ob-jective and constraint functions such that they can be solved analytically. Finally, we present some numerical examples to demonstrate the effectiveness of the proposed models
D. Mayo (Dept of Philosophy, VT)
Sir David Cox’s Statistical Philosophy and Its Relevance to Today’s Statistical Controversies
ABSTRACT: This talk will explain Sir David Cox's views of the nature and importance of statistical foundations and their relevance to today's controversies about statistical inference, particularly in using statistical significance testing and confidence intervals. Two key themes of Cox's statistical philosophy are: first, the importance of calibrating methods by considering their behavior in (actual or hypothetical) repeated sampling, and second, ensuring the calibration is relevant to the specific data and inquiry. A question that arises is: How can the frequentist calibration provide a genuinely epistemic assessment of what is learned from data? Building on our jointly written papers, Mayo and Cox (2006) and Cox and Mayo (2010), I will argue that relevant error probabilities may serve to assess how well-corroborated or severely tested statistical claims are.
In this video from PASC18, Jakub Tomczak from the University of Amsterdam presents: The Success of Deep Generative Models.
"Deep generative models allow us to learn hidden representations of data and generate new examples. There are two major families of models that are exploited in current applications: Generative Adversarial Networks (GANs), and Variational Auto-Encoders (VAE). The principle of GANs is to train a generator that can generate examples from random noise, in adversary of a discriminative model that is forced to confuse true samples from generated ones. Generated images by GANs are very sharp and detailed. The biggest disadvantage of GANs is that they are trained through solving a minimax optimization problem that causes significant learning instability issues. VAEs are based on a fully probabilistic perspective of the variational inference. The learning problem aims at maximizing the variational lower bound for a given family of variational posteriors. The model can be trained by backpropagation but it was noticed that the resulting
generated images are rather blurry. However, VAEs are probabilistic models, thus, they could be incorporated in almost any probabilistic framework. We will discuss basics of both approaches and present recent extensions. We will point out advantages and disadvantages of GANs and VAE. Some of most promising applications of deep generative models will be shown."
Watch the video: https://wp.me/p3RLHQ-iSX
Learn more: https://pasc18.pasc-conference.org/
Sign up for our insideHPC Newsletter: http://insidehpc.com/newsletter
On the Use of the Causal Analysis in Small Type Fit Indices of Adult Mathemat...QUESTJOURNAL
ABSTRACT: Model evaluation is one of the most important aspects of Structural Equation Modeling (SEM). Many model fit indices have been developed. It is not an exaggeration to say that nearly every publication using the SEM methodology has reported at least one fit index. Fit is the ability of a model to reproduce the data in the variance-covariance matrix form. A good fitting model is one that is reasonably consistent with the data and doesn’t require respecification and also its measurement model is required before estimating paths in a covariance structure model. A baseline model of four constructs together with a combination of none, one, two, three or four additional constructs was constructed with latent variables: educational performance, socioeconomic label, self concept and parental authority using dichotomous digits 0 or 1 for each additional construct. 16 progressively nested models were considered starting with baseline model using the mathematics adult learners data from the modeling sample and employing some small fit indexes which are commonly used (AIC, CAIC, RMR, SRMR, RMSEA, 2 / DF among others) [1] to test the fitness of the model. The measures of model fit based on results from analysis of the covariance structure model are presented.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Cancer cell metabolism: special Reference to Lactate PathwayAADYARAJPANDEY1
Normal Cell Metabolism:
Cellular respiration describes the series of steps that cells use to break down sugar and other chemicals to get the energy we need to function.
Energy is stored in the bonds of glucose and when glucose is broken down, much of that energy is released.
Cell utilize energy in the form of ATP.
The first step of respiration is called glycolysis. In a series of steps, glycolysis breaks glucose into two smaller molecules - a chemical called pyruvate. A small amount of ATP is formed during this process.
Most healthy cells continue the breakdown in a second process, called the Kreb's cycle. The Kreb's cycle allows cells to “burn” the pyruvates made in glycolysis to get more ATP.
The last step in the breakdown of glucose is called oxidative phosphorylation (Ox-Phos).
It takes place in specialized cell structures called mitochondria. This process produces a large amount of ATP. Importantly, cells need oxygen to complete oxidative phosphorylation.
If a cell completes only glycolysis, only 2 molecules of ATP are made per glucose. However, if the cell completes the entire respiration process (glycolysis - Kreb's - oxidative phosphorylation), about 36 molecules of ATP are created, giving it much more energy to use.
IN CANCER CELL:
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
Unlike healthy cells that "burn" the entire molecule of sugar to capture a large amount of energy as ATP, cancer cells are wasteful.
Cancer cells only partially break down sugar molecules. They overuse the first step of respiration, glycolysis. They frequently do not complete the second step, oxidative phosphorylation.
This results in only 2 molecules of ATP per each glucose molecule instead of the 36 or so ATPs healthy cells gain. As a result, cancer cells need to use a lot more sugar molecules to get enough energy to survive.
introduction to WARBERG PHENOMENA:
WARBURG EFFECT Usually, cancer cells are highly glycolytic (glucose addiction) and take up more glucose than do normal cells from outside.
Otto Heinrich Warburg (; 8 October 1883 – 1 August 1970) In 1931 was awarded the Nobel Prize in Physiology for his "discovery of the nature and mode of action of the respiratory enzyme.
WARNBURG EFFECT : cancer cells under aerobic (well-oxygenated) conditions to metabolize glucose to lactate (aerobic glycolysis) is known as the Warburg effect. Warburg made the observation that tumor slices consume glucose and secrete lactate at a higher rate than normal tissues.
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
(May 29th, 2024) Advancements in Intravital Microscopy- Insights for Preclini...Scintica Instrumentation
Intravital microscopy (IVM) is a powerful tool utilized to study cellular behavior over time and space in vivo. Much of our understanding of cell biology has been accomplished using various in vitro and ex vivo methods; however, these studies do not necessarily reflect the natural dynamics of biological processes. Unlike traditional cell culture or fixed tissue imaging, IVM allows for the ultra-fast high-resolution imaging of cellular processes over time and space and were studied in its natural environment. Real-time visualization of biological processes in the context of an intact organism helps maintain physiological relevance and provide insights into the progression of disease, response to treatments or developmental processes.
In this webinar we give an overview of advanced applications of the IVM system in preclinical research. IVIM technology is a provider of all-in-one intravital microscopy systems and solutions optimized for in vivo imaging of live animal models at sub-micron resolution. The system’s unique features and user-friendly software enables researchers to probe fast dynamic biological processes such as immune cell tracking, cell-cell interaction as well as vascularization and tumor metastasis with exceptional detail. This webinar will also give an overview of IVM being utilized in drug development, offering a view into the intricate interaction between drugs/nanoparticles and tissues in vivo and allows for the evaluation of therapeutic intervention in a variety of tissues and organs. This interdisciplinary collaboration continues to drive the advancements of novel therapeutic strategies.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
1. Bayesian Restricted Likelihood Methods:
A discussion
Christian P. Robert
(Paris Dauphine PSL & Warwick U.
&Università Ca’Foscari Venezia)
Bayesian Analysis webinar, 09/02/22
2. When you cannot trust the likelihood
I Model defined by moment conditions
I Use of empirical likelihood Bayesian tools
I Use of scoring rules
I Use of ABC as robustification
I Cut models
I non-parametric component
[Bissiri et al., 2016; Jacob et al., 2018; Frazier et al., 2019]
“...the prior distribution, the loss function, and the likelihood or
sampling density (...) a healthy skepticism encourages us to
question each of them”
3. When you cannot trust the likelihood
I Model defined by moment conditions
I Use of empirical likelihood Bayesian tools
I Use of scoring rules
I Use of ABC as robustification
I Cut models
I non-parametric component
[Bissiri et al., 2016; Jacob et al., 2018; Frazier et al., 2019]
“...the prior distribution, the loss function, and the likelihood or
sampling density (...) a healthy skepticism encourages us to
question each of them”
4. Empirical likelihood
Given dataset x1, . . . , xn and moment constraints
E[g(X, θ)] = 0
empirical likelihood defined as
`emp
(θ|y) =
n
Y
i=1
p̂i
with (p̂1, . . . , p̂n) minimising
n
X
i=1
pi log(pi)
under the constraint
n
X
i=1
pig(xi, θ) = 0
[Owen, 1988]
6. Not all misspecified models are created outlying
I Convenient mixture representation
I Original model relevant for part of the sample
I Is there such a thing as ‘good data’?
I Lower likelihood input through ‘safe Bayes’
[Rousseau and Robert, 2000; Kamary et al., 2014; Grünwald, 2018]
“The literature on robust methods is replete with examples
described in terms of ‘outliers’ where the central problem is
model misspecification.”
7. Not all misspecified models are created outlying
I Convenient mixture representation
I Original model relevant for part of the sample
I Is there such a thing as ‘good data’?
I Lower likelihood input through ‘safe Bayes’
[Rousseau and Robert, 2000; Kamary et al., 2014; Grünwald, 2018]
“The literature on robust methods is replete with examples
described in terms of ‘outliers’ where the central problem is
model misspecification.”
8. Insufficient statistic is the solution?
”...for a variety of conditioning statistics with non-trivial
regularity conditions on prior, model, and likelihood, the
posterior distribution resembles the asymptotic sampling
distribution of the conditioning statistic.”
I Motivations for choice of T(·) and post-choice reassessment
I Sufficient and almost sufficiency irrelevant in misspecified
settings
I Degree of robustness to misspecification?
I Workhorse of ABC
I Sufficiency may prove an hindrance in ABC model choice
[Robert et al., 2011; Fearnhead & Prangle, 2021; Frazier et al.,2018]
9. On ABC
”Acceptance rates of this [ABC] algorithm can be intolerably low
(...) especially problematic in high-dimensional settings since
generating high-dimensional statistics that are close to the
observed values is difficult.”
I Comparison of MCMC and ABC rarely relevant
I Why ”ABC with = 0 ??
I Plus, = 0 is suboptimal for ABC
I Turner and van Zandt (2014) exploits likelihood-free
hierarchical conditionals to run semi-ABC
I Clarté et al. (2020) extend ABC-Gibbs to general setup
and point out potential inconsistencies
[Turner and van Zandt, 2014; Frazier et al., 2018; Clarté et al., 2020]
10. MCMC on manifolds
”...deliberate choice of an insufficient statistic T(y) guided by
targeted inference is sound practice.”
I Simulation of y conditional on T(y) not useful for inference
I Measure-theoretic difficulties with use of density on Rp
against density on manifold as in e.g.
Z
A
f(y|θ) dy
I Exploitation of the location scale structure to the uttermost
I What is a general strategy?
I Example of Bayesian empirical likelihood
[Byrne Girolami, 2013; Florens Simoni, 2015; Bornn al., 2019]