The document describes the diagnosis of pregnancy through various signs and symptoms. It distinguishes between possible/presumptive signs (based on a woman's subjective reports), probable signs (combining subjective and objective findings), and positive signs (conclusive proof of pregnancy). Possible signs include missed period, morning sickness, breast changes, frequent urination, and quickening. Probable signs involve pelvic exam findings, abdominal enlargement, and ballottement. Positive signs are fetal heart tones, palpation of the fetus, ultrasound examination, and fetal movement. Diagnosis progresses from possible to probable to positive as the pregnancy advances.
Raynaud's disease, also known as Raynaud's phenomenon or Raynaud's syndrome, is a condition that affects blood flow to certain parts of the body—usually the fingers and toes. In Raynaud's disease, smaller arteries that supply blood to the skin constrict excessively in response to cold or stress, limiting blood supply to affected areas (vasospasm). This can lead to numbness, tingling, and color changes in the affected areas, typically turning them white or blue.
Raynaud's disease, also known as Raynaud's phenomenon or Raynaud's syndrome, is a condition that affects blood flow to certain parts of the body—usually the fingers and toes. In Raynaud's disease, smaller arteries that supply blood to the skin constrict excessively in response to cold or stress, limiting blood supply to affected areas (vasospasm). This can lead to numbness, tingling, and color changes in the affected areas, typically turning them white or blue.
Normal vs cryptic pregnancy Noaman Ali studyNomanRaj1
Use for knowledge only. In this presentation discussion with patients and use of articles cases, you tube videos how the cryptic pregnancy take time what is the reason of behind the cryptic pregnancy. In my knowledge readout after the articles all conclusion in this presentation . You can get more knowledge when you read the ppt. it's presentation makes only discussion with patients and study different types of articles and you tube. Thanks
Wondering if you could be pregnant? Do you even know the presumptive, probable and positive signs of pregnancy? After a couple of weeks since you did lovemaking and now can’t wait for the confirmation, you’re confuse and still holding with the feeling of being pregnant. Can you distinguish those signs and symptoms? Are you familiar with their differences? Let’s find out each distinction.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Normal vs cryptic pregnancy Noaman Ali studyNomanRaj1
Use for knowledge only. In this presentation discussion with patients and use of articles cases, you tube videos how the cryptic pregnancy take time what is the reason of behind the cryptic pregnancy. In my knowledge readout after the articles all conclusion in this presentation . You can get more knowledge when you read the ppt. it's presentation makes only discussion with patients and study different types of articles and you tube. Thanks
Wondering if you could be pregnant? Do you even know the presumptive, probable and positive signs of pregnancy? After a couple of weeks since you did lovemaking and now can’t wait for the confirmation, you’re confuse and still holding with the feeling of being pregnant. Can you distinguish those signs and symptoms? Are you familiar with their differences? Let’s find out each distinction.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
The Gram stain is a fundamental technique in microbiology used to classify bacteria based on their cell wall structure. It provides a quick and simple method to distinguish between Gram-positive and Gram-negative bacteria, which have different susceptibilities to antibiotics
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Basavarajeeyam is an important text for ayurvedic physician belonging to andhra pradehs. It is a popular compendium in various parts of our country as well as in andhra pradesh. The content of the text was presented in sanskrit and telugu language (Bilingual). One of the most famous book in ayurvedic pharmaceutics and therapeutics. This book contains 25 chapters called as prakaranas. Many rasaoushadis were explained, pioneer of dhatu druti, nadi pareeksha, mutra pareeksha etc. Belongs to the period of 15-16 century. New diseases like upadamsha, phiranga rogas are explained.
Basavarajeeyam - Ayurvedic heritage book of Andhra pradesh
Diagnosis.pptx
1. Diagnosis of pregnancy
By Ritbano Ahmed(BSc, MSc)
Assistant professor of maternity nursing
November, 2022
2. Objectives
At the end of this session, the students will be able to
• Describe diagnosis of pregnancy
• Differentiate sign and symptom of pregnancy
3. Diagnosis of pregnancy
• Many changes women experience during pregnancy are
used to diagnose the pregnancy itself.
• Sign and symptom of pregnancy can be classified in to
three
1. Possible/Presumptive (Based on what the mother will
recognize)
2. Probable (Based on both what the mother will recognize
and what you will find)
3. Positive (No doubt of pregnancy)
4. • Means a symptom of pregnancy, when it is impossible to
confirm pregnancy with certainness (sure)
• i.e. Many other DDx other than pregnancy can be sited as
a possible cause
• The possible symptoms means changes in her body
that a woman can identify for herself and tell you
about.
• But they could also be caused by something else
1. A possible (presumptive) symptoms
5. 1. A possible……
• In the possible symptoms you only have the
woman’s subjective report on which to base
your diagnosis
• Possible symptoms sometimes also called
‘presumptive signs’ because pregnancy is often
‘presumed/assumed’ by the health professional on
the basis subjective reports from the mother
6. • Is a sign and symptoms which often but not always
is present when the woman is pregnant
• i.e. Other DDx is possible
• The probable signs and symptoms some of
these indicators are reported by the woman
(symptoms), but also see by the examiner (sign)
• For Dx of pregnancy you based both subjective
report and objective findings
2. Probable sign and symptoms
7. 3. A positive signs
• Completely objective can not be confused with
pathologic states and offer conclusive proof of
pregnancy
1. Fetal Heart Tones (FHTs)
2. Palpation of Fetus
3. Ultrasound Examination of Fetus
4. Fetal movement
8. Possible (presumptive) symptoms
1. Missing a Menstrual Period (Amenorrhea)
2. Morning sickness
3. Breast changes
4. Urinary frequency
5. Quickening
6. Fatigue
9. 1.1. Missing a Menstrual Period (Amenorrhea)
Amenorrhea is often the first symptom that women
notice when they become pregnant
Other possible causes of amenorrhea are:
• Poor nutrition
• Emotional tension
• Menopause
• Endocrine disorders
• Obesity
• Chronic disease
• Infection……
10. • Is a common symptom occurs in appr. 50% of
pregnancies during the first three months
• More often in the first pregnancy than in the subsequent
one
• It is usually most severe in the morning, which is why
this feeling is often called morning sickness
• But it can occur at any time and may be stimulated by
cooking odours and spicy smells
• DDx- PUD, gastritis, parasites, Cerebral irritation
1.2. Morning Sickness
12. • Is experienced during the first trimester as enlarged
uterus exerts pressure on the bladder
• The increased vascularization and pelvic congestion
that occur in each pregnancy can also cause frequent
voiding
• This symptom decrease during the second trimester
when the uterus is an abdominal organ but reappears
during third trimester when the presenting part
descends in to the pelvis.
1.3. Urinary frequency
13. • Pregnant women may report feelings of breast
tenderness, fullness, tingling and enlargement
and darkening of the areola
• But other DDx is possible that breasts often get
bigger just:
• Before the monthly menstruation in women who
are not pregnant
• And also a change who took a contraceptives
1.4. Breast changes
14. Breast changes…..
The changes on the breasts during pregnancy are:
• 3-4 weeks: tingling sensation to pain caused by
hormonal responses of the mammary ducts and alveolar
system
• 6th –8th weeks –enlargement and tenderness of the
breast and visible surface veins appear.
• 12 week: Primary areola becomes darker
• 16 week: Colostrum's can be expressed
• 20 week: Appearance of secondary areola
16. • Women start to feel their baby moving very lightly before
they are half-way through the pregnancy
• This feeling is known as ‘quickening’ that is the first fetal
movement felt by the mother
• Multigravida mothers are sensitive to these tiny movements
sooner than primigravida mothers
• Quickening usually occurs at 18–20 weeks in primigravida
and 16–18 weeks in multigravida
• DDX----Intestinal peristalsis
1.5. Quickening
17. 2. Probable Signs and Symptoms of Pregnancy
1. Change in the pelvic organs
2. Abdominal enlargement
3. Braxton-Hicks contractions
4. External ballottement
5. Internal ballottement
6. Immunological test
7. Skin change
18. 2.1. Change in the pelvic organs
• Caused by increased vascular congestion are the only
physical signs detectable with in the first 3 months of
pregnancy
• This changes are noted on pelvic examination
• Softening of cervix- Goodell’s sign
• Chadwick’s(Jacquemiers )sign is the deep red to purple
or bluish discoloration of mucus membrane of cervix, due
to increased vasocongestion of the pelvic vessels
19. 2.1. Change in the pelvic organs….
• Hegar’s sign is softening of the isthmus of the uterus
weeks (6-12 weeks)
• On bimanual examination (two fingers in the anterior
vaginal fornix and the abdominal fingers behind the
uterus), the abdominal and vaginal fingers seem to
appose below the body of the uterus
20. 2.1. Change in the pelvic organs….
Hegar’s sign…….
• Due to the softening of the lower segments of the
uterus and to the fact that the ovum does not fill
the lower uterine cavity at this stage
• An empty space in the lower part is detected
• This sign is based on the fact that:
• Upper part of the body of the uterus is occupied by the
growing embryo
• Lower part of the body is empty and extremely soft
• The cervix is comparatively firm
22. 2.2. Enlargement of the abdomen
• There is progressive enlargement of the abdomen
(belly) from 9 to 28 weeks of pregnancy
• At 16 to 22 weeks, growth may appear more rapid as
the uterus rises higher into the abdomen
• The uterus is enlarged to the size of:
• A hen’s egg at 6th week
• A cricket ball at 8th week
• A fetal head by 12th week
24. 2.3. Braxton hicks contraction—16wks
• BH Contractions are Irregular, painless and occur
intermittently that throughout pregnancy
• It facilitate uterine blood flow through the intervillous
spaces of the placenta and thereby promote o2 to the
fetus
• They usually begin at about 16 weeks' gestation and
increase in regularity.
• These contractions usually disappear with walking or
exercise, whereas true labor contractions become
more intense
25. 2.4. Uterine souffle
• Soft, blowing sound made by the blood in the arteries
of the pregnant uterus
• It is the same (synchronous) rate as the maternal
pulse
• This may be confused with FHB
• DDX—increased BF to the uterus, uterine myoma and
ovarian tumours
26. 2.5. Funic or fetal souffle
• Is due to rush of blood through the umbilical arteries
• It is a soft, blowing murmur synchronous with the
fetal heart sounds
• This may also confused with FHB
27. 2.6. Ballottement
A. Internal Ballottement
• Maybe felt by the 16th week on an examination
carried out by the doctor
• Passive fetal movement elicited by pushing up
against the cervix with two fingers
• This pushes the fetal body up and as it falls back
the examiner feel rebound
(Fig. B and C)
28. 2.6. Ballottement ….
B. External Ballottement
• Maybe felt by the 16th week on an examination carried
out by the doctor
• Two examining hands kept to the side of the mother
abdomen externally (Parallel)
• One examining hand pushes the contents of the
uterine cavity to the opposite hand
• Immediately a bound of fetus on the opposite hand
is felt (Fig. A)
30. 2.7. Skin change
• Chloasma (Or the ‘Mask of Pregnancy’)
• Darkening of the skin over the forehead, bridge of
the nose, or cheekbones, is called chloasma
• Signs of chloasma usually occur after 16 weeks
gestation
• Are also intensified by exposure to sunlight
32. 2.7. Skin change ….
• Stretch Marks or striae of the breast and
abdomen:
• Are caused by separation of the underlying collagen tissue
and appear as irregular scars
• In addition to stretching this is probably due to response of
ACTH (Aldosterone)
• These marks generally appear later in pregnancy when the
skin is under greater tension
33. 2.7. Skin change ….
Linea Nigra
• Is darkening of lower midline of the abdomen
from the umbilicus to the pubis (darkening of the
linea alba)
• The basis of these changes is stimulation of the
melanophores by an increase in melanocyte-
stimulating hormone
35. 2.7. Pregnancy test
• Are based on analysis of maternal blood or urine for detection
of HCG
• This test are not considered positive signs of pregnancy because
similarity of HCG and the luteinizing hormone (LH)
occasionally result in cross reaction
• In addition certain conditions other than the pregnancy can cause
elevated levels of HCG
• Earliest biochemical marker for pregnancy.
• Production of β-hcG begins as early as the day of implantation
and can be detected as early as 7 to 10 days
37. 3. Diagnostic ( positive changes)
3.1. Visualization of gestational sack by:
Transvaginal ultrasound------4.5wks
Transabdominal U/S-----------5.5wks
Visualization of fetus by x ray
16wks +
38. 3. Diagnostic …….
3.2. The fetal heart beat
• FHBs is the most conclusive clinical sign of pregnancy
• Detected with fetoscope by approximately 20 -24weeks
• With the electronic Doppler device it is possible to detect
10-12 weeks
• Ultrasound – 6 weeks +
• Rate 120-160 beat per minute
39. Two other sounds are confused with fetal heart
sounds. These are:
A. Uterine soufflé:
• Is a soft blowing and systolic murmur heard low down at
the sides of the uterus, best on the left side
• The sound is synchronous with the maternal pulse
• It can be heard in big uterine fibroid
B. Funic or fetal soufflé:
• Is due to rush of blood through the umbilical arteries
• It is a soft blowing murmur synchronous with the fetal
heart sounds
3. Diagnostic …….
40. 3. Diagnostic …….
3.3. Fetal movement
• Palpable 22 weeks +
• Visible late pregnancy
Fetal part
• Fetal part palpated 24 weeks
43. Reference Books
1. DC Dutta’s Text books of Obstetrics 7th edition
2. Current text book of obstetrics and gynecology
24th edition
3. Blueprints Obstetrics & gynecology 6th Edition
4. Gabbe: Obstetrics: Normal and Problem
Pregnancies, 5th ed.
5. Williams Obstetrics 24thEdition
44. Quiz 1
1. List subjective, probable and objective signs of
pregnancy
2. Discuss the difference b/n subjective and sure signs
of pregnancy
10 minutes only
Editor's Notes
List the subjective, objective and diagnostic sign of pregnancy
Describe the difference between subjective , objective , diagnostic sign of pregnancy
Subjective ( or presumptive ) changes
Objective (or probable) changes and
Diagnostic or positive changes of pregnancy
Subjective (presumptive) changes
Caused by other conditions and therefore cannot be considered proof of pregnancy.
Can be the diagnostic clues when other signs and symptoms of pregnancy are present.
How ever subjectivity is greater than objectivity
Probable Signs and Symptoms of Pregnancy
An examiner can perceive objective changes that occur in pregnancy.
However their presence does not offers a definite diagnosis of pregnancy
Diagnostic ( positive changes)
They cannot generally be detected until after the first 3 months of pregnancy
These are absolute proof (surest) of pregnancy, based on objective findings that detected by the examiner
i.e. There is definitive evidence of pregnancy and other causes are not possible
Amenorrhea(fairly reliable sign of conception in women with regular menstrual cycles)
Nausea and vomiting of pregnancy
Excessive fatigue
Quickening
amenorrhea is a fairly reliable sign of conception in women with regular menstrual cycles. In women with irregular cycles, amenorrhea is not a reliable sign
Excessive fatigue
May be noted within a few weeks after the first missed menstrual period and may persist throughout the first trimester
Fatigue is a frequent symptom which may occur early in pregnancy
Amenorrhea---4wke+
Earliest symptom of pregnancy in a healthy woman whose menstrual cycle are regular missing one or more menstrual period leads to the consideration of pregnancy.
Delayed menses may also be caused by other factors such as emotional tension, chronic disease, opioid and dopaminergic medications, endocrine disorders, and certain genitourinary tumors.
Is a fairly reliable sign of conception in women with regular menstrual cycles. In women with irregular cycles, amenorrhea is not a reliable sign.
DDx. Hormonal imbalance, emotional stress and illness
Nausea and vomiting of pregnancy
Half of all pregnancy during the first 3 months result from elevated HCG level and changed carbohydrate metabolism
This gastrointestinal disturbance usually appear about 4/6 weeks after the first day of LMP and usually disappears spontaneously 6 to 12 weeks later although it may be prolonged in some instance
Some pregnant women feel nauseous all day
Fatigue and Tiredness
The extra progesterone in a woman's body during pregnancy may cause her to feel fatigued and tired, and the need for naps increases. By the second trimester, energy levels usually rise again.
Frequent Urination
Pregnant women often report needing to urinate more frequently particularly during the first three months and the last one or two months of pregnancy
Is quite troublesome symptom during 8–12th week of pregnancy
It is due to:
The urge to urinate more frequently starts about six weeks into pregnancy, thanks to the hormone human chorionic gonadotrophin (hCG), which causes increased blood flow to the pelvic area and can stimulate the urge to urinate. Later in pregnancy, the urge to urinate may be increased by the growing baby in the enlarging uterus putting pressure on the bladder.
Resting of the bulky uterus on the fundus of the bladder because of exaggerated anteverted position of the uterus (8–12th week)
Congestion of the bladder mucosa
Change in maternal osmoregulation causing increased thirst and polyuria
As the uterus straightens up after 12th week, the symptom disappears
Other possible causes of this symptom are stress, a bladder infection, or diabetes
Melasma (Darkening of the Skin)
The breasts may feel full or heavy, and the area around the nipple (areola) may darken.
colostrum (known colloquially as beestings, bisnings or first milk) is the first form of milk produced by the mammary glands of mammals (including many humans) immediately following delivery of the newborn
Quickening-----16-20wks
The first recognition of fetal movements, or ‘feeling life’ Or the mother perception of fetal movement occurs about 18-20 weeks after LMP in primigravida( women who has pregnant for the first time )
May occur as early as 16 week in multigravida ( a woman who has been pregnant more than once )
Maternal perception of fetal movement; usually occurs between weeks 16 and 20 of gestation
Another possible cause of this symptom is gas in the belly
The rise in progesterone during pregnancy can also cause abdominal bloating, fullness, and gas. The weight gain in the first trimester is usually minimal, but cramping and bloating may make you feel as if you have gained more than the typical one pound per month.Osianders Sign
Change in the vagina
Is the increased pulsation felt on the lateral vaginal fornix due to marked vascularity from 8th week onwards
2.12. Chadwick's Sign Is a bluish discoloration of the cervix, vagina, and labia caused by the hormone estrogen which results in venous congestion
It can be observed as early as 6–8 weeks after conception
Softening of the lower segments of the uterus/isthmus(6-12 weeks)
At 6th to 12th week is one of the early sign and detected by an examination carried out by the doctor
is softening of the isthmus of the uterus weeks (6-12 weeks)
Blueing of vagina (Jacquemier’s sign)
Softening of the lower segments of the uterus/isthmus
At 6th to 12th week is one of the early sign and detected by an examination carried out by the doctor
On bimanual examination (two fingers in the anterior vaginal fornix and the abdominal fingers behind the uterus), the abdominal and vaginal fingers seem to appose below the body of the uterus
Due to the softening of the lower segments of the uterus and to the fact that the ovum does not fill the lower uterine cavity at this stage
An empty space in the lower part is detected
Pelvic changes:
- Chadwick’s sign: bluish discoloration of vagina & cervix
- Goodell’s sign: Cyanosis and softening of cervix- 4 weeks
- Hegar’s sign: widening of softened area of isthmus giving a compressibility of isthmus-6-8 weeks
Goodell’s sign
It is softening of the cervix
Felt from the 10th week
Normally non pregnant cervix felt like cartilage (Tip of nose)
Cervix becomes soft, a little earlier in multipara
The pregnant cervix feels like the lips of the mouth, while in the non-pregnant state, like that of tip of the nose
2.10. Von - Fernwald’s sign
Localized softening of uterine fundus over the site of placental implantation
Change in the pelvic organs
Caused by increased vascular congestion are the only physical signs detectable with in the first 3 months of pregnancy
This changes are noted on pelvic examination
Softening of cervix- Goodell’s sign
Chadwick’s sign is the deep red to purple or bluish coloration of mucus membrane of cervix, due to increased vasocongestion of the pelvic vessels
BH Contractions are Irregular, painless and occur intermittently that throughout pregnancy
It facilitate uterine blood flow through the intervillous spaces of the placenta and thereby promote o2 to the fetus
They usually begin at about 16 weeks' gestation and increase in regularity.
These contractions usually disappear with walking or exercise, whereas true labor contractions become more intense
May be heard when auscultating the abdomen over the uterus
2.5. Uterine Souffle
From the 16th week is a soft blowing and systolic murmur heard low down at the sides of the uterus, best on the left side
Is due to increase in blood flow through the dilated uterine vesselsIt is soft blowing sound at the same rate as the maternal pulse and is due to increased uterine vascularization and the blood pulsating through the placenta
This may be confused with FHB
soft, blowing sound made by the blood in the arteries of the pregnant uterus and synchronous with the maternal pulse
After the examining finger inserted in to the vagina the fetus is displaced by a light tap immediately a rebound of fetus felt on the examining finger
Ballottement—16-28 wks
During the first trimester, the skin on the forehead, bridge of the nose, upper lip, or cheekbones may darken. This is often referred to as the "mask of pregnancy," and the medical term is melasma or chloasma. It is more common in darker skinned women and those with a family history of melasma.
Striae gravidrum/stretch marks/: seen over lower abdomen)
May be caused by action of adrenocorticosteroids.
These slightly depressed steaks tend to occur over areas of maximum stretch(i.e, abdomen, thighs, and breast)
The striae appears pinkish on a woman with light skin and are lighter than surrounding skin in dark skinned woman.
sign)
Spider Telangiectases:
Are common skin lesions that result from high levels of circulating estrogen
A pigmented area on the skin formed by dilated capillaries or arterioles radiating from a central point like the legs of a spider — called also spider angioma
1.7.
During pregnancy pigmentation increase change to Linea nigra
In primigravidas the extension of the linea nigra, beginning in the 3rd month.
In multigravidas, appears earlier than the 3rd month.
Not all pregnant women develop linea nigra.
Molar pregnancy,
Pregnancy Test or immunological tests for HCG
The hCG produced by the syncytiotrophoblast of the placenta and secreted into the blood of both mother and fetus
Pregnancy tests is detection of an antigen (hCG) present in the maternal urine or serum with hCG antibody available commercially
In most cases, the testing kits may give a false result, especially if they have not been stored properly, or are out of date
Presence of HCG in while the cervix is still firm
Positive or absolute signs
Palpation of fetal parts and perception of active fetal movements by the examiner at about 20th week
Auscultation of fetal heart sounds
Ultrasound evidence of embryo as early as 6th week and later on the fetus
Radiological demonstration of the fetal skeleton at 16th week and onwards