Intrauterine fetal death (IUFD) refers to fetal death occurring during pregnancy or labor of a fetus weighing 500g or more. Causes of IUFD include maternal factors (5-10%), placental factors (20-35%), fetal factors (25-40%), and unknown causes (25-35%). Diagnosis is confirmed through repeated examinations showing absence of fetal movement and heartbeat. Management involves expectant care for up to 2 weeks if no complications, or early medical induction using prostaglandins or oxytocin if indicated to prevent infections and complications.
The increased cardiac output related to pregnancy can lead to heart failure, and the increased heart rate in the third trimester can lead to ischemic events. The potential obstetrical complications include preeclampsia or other hypertensive related disorders, premature birth, and small-for-gestational-age births.
INTRODUCTION
DEFINITION
TYPES
CAUSES
MANAGEMENT-Management of 3rd stage bleeding
Actual management
MANAGEMENT OF 3RD STAGE BLEEDING
Steps of management
1. Placental site bleeding-
To palpate the fundus and massage the uterus to make it hard. The massage is to be done by placing four fingers behind the uterus and thumb in front.
To start crystalloid solution (NS or RL) with oxytocin (1L with 20 units) at 60 drops per minute and to arrange for blood transfusion if necessary.
Oxytocin 10 unit IM or methergine 0.2 mg is given intravenously.
To catheterize the bladder.
To give antibiotics (Ampicillin 2gm and Metronidazole 500mg IV)
2. Management of traumatic bleed
The uterovaginal canal is to be explored under general anesthesia after the placenta is expelled and haemostatic sutures are placed on the offending sites.
STEPS OF MANUAL REMOVAL OF PLACENTA
The patient is placed in lithotomy position. With all aseptic measures, the bladder is catheterized.
One hand is introduced into the uterus in cone shaped manner following the cord. While introducing the hand, the labia are separated by the fingers at the other hand.
Counter pressure on the uterine fundus is applied by the hand placed over the abdomens. The abdominal hand should steady the fundus and guide the movement of the fingers inside the uterine cavity till the placenta is completely separated.
According to the International Federation of Gynaecology and Obstetrics (FIGO), prolonged pregnancy is defined as any pregnancy that exceeds 42wks (294 days) from the first day of the LMP in a woman with regular 28-day cycles.
Hydatidiform Mole (HM) is a rare mass or growth that forms inside the uterus at the beginning of a pregnancy. It is a type of gestational trophoblastic disease (GTD).
When a normal sperm cell fertilizes one of these oocytes, the resulting embryo has only one set of chromosomes. Because the embryo has no genes from the mother, the pregnancy cannot develop normally, resulting in a hydatidiform mole.
The increased cardiac output related to pregnancy can lead to heart failure, and the increased heart rate in the third trimester can lead to ischemic events. The potential obstetrical complications include preeclampsia or other hypertensive related disorders, premature birth, and small-for-gestational-age births.
INTRODUCTION
DEFINITION
TYPES
CAUSES
MANAGEMENT-Management of 3rd stage bleeding
Actual management
MANAGEMENT OF 3RD STAGE BLEEDING
Steps of management
1. Placental site bleeding-
To palpate the fundus and massage the uterus to make it hard. The massage is to be done by placing four fingers behind the uterus and thumb in front.
To start crystalloid solution (NS or RL) with oxytocin (1L with 20 units) at 60 drops per minute and to arrange for blood transfusion if necessary.
Oxytocin 10 unit IM or methergine 0.2 mg is given intravenously.
To catheterize the bladder.
To give antibiotics (Ampicillin 2gm and Metronidazole 500mg IV)
2. Management of traumatic bleed
The uterovaginal canal is to be explored under general anesthesia after the placenta is expelled and haemostatic sutures are placed on the offending sites.
STEPS OF MANUAL REMOVAL OF PLACENTA
The patient is placed in lithotomy position. With all aseptic measures, the bladder is catheterized.
One hand is introduced into the uterus in cone shaped manner following the cord. While introducing the hand, the labia are separated by the fingers at the other hand.
Counter pressure on the uterine fundus is applied by the hand placed over the abdomens. The abdominal hand should steady the fundus and guide the movement of the fingers inside the uterine cavity till the placenta is completely separated.
According to the International Federation of Gynaecology and Obstetrics (FIGO), prolonged pregnancy is defined as any pregnancy that exceeds 42wks (294 days) from the first day of the LMP in a woman with regular 28-day cycles.
Hydatidiform Mole (HM) is a rare mass or growth that forms inside the uterus at the beginning of a pregnancy. It is a type of gestational trophoblastic disease (GTD).
When a normal sperm cell fertilizes one of these oocytes, the resulting embryo has only one set of chromosomes. Because the embryo has no genes from the mother, the pregnancy cannot develop normally, resulting in a hydatidiform mole.
Adv. biopharm. APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMSAkankshaAshtankar
MIP 201T & MPH 202T
ADVANCED BIOPHARMACEUTICS & PHARMACOKINETICS : UNIT 5
APPLICATION OF PHARMACOKINETICS : TARGETED DRUG DELIVERY SYSTEMS By - AKANKSHA ASHTANKAR
Integrating Ayurveda into Parkinson’s Management: A Holistic ApproachAyurveda ForAll
Explore the benefits of combining Ayurveda with conventional Parkinson's treatments. Learn how a holistic approach can manage symptoms, enhance well-being, and balance body energies. Discover the steps to safely integrate Ayurvedic practices into your Parkinson’s care plan, including expert guidance on diet, herbal remedies, and lifestyle modifications.
Muktapishti is a traditional Ayurvedic preparation made from Shoditha Mukta (Purified Pearl), is believed to help regulate thyroid function and reduce symptoms of hyperthyroidism due to its cooling and balancing properties. Clinical evidence on its efficacy remains limited, necessitating further research to validate its therapeutic benefits.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of the physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar lead (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
6. Describe the flow of current around the heart during the cardiac cycle
7. Discuss the placement and polarity of the leads of electrocardiograph
8. Describe the normal electrocardiograms recorded from the limb leads and explain the physiological basis of the different records that are obtained
9. Define mean electrical vector (axis) of the heart and give the normal range
10. Define the mean QRS vector
11. Describe the axes of leads (hexagonal reference system)
12. Comprehend the vectorial analysis of the normal ECG
13. Determine the mean electrical axis of the ventricular QRS and appreciate the mean axis deviation
14. Explain the concepts of current of injury, J point, and their significance
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. Chapter 3, Cardiology Explained, https://www.ncbi.nlm.nih.gov/books/NBK2214/
7. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
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2. Definition :
Intrauterine fetal death (IUD) embraces all fetal death
weighing 500 gm or more occurring both during pregnancy
(antepartum death) or during labour (intrapartum).
Thus, Antepartum death occurring beyond the period
of viability is termed as intrauterine death.
WHO definition:
Fetal death means death prior to complete expulsion
or extraction of mother of a fetus irrespective of duration of
pregnancy and which is not an induced termination
pregnancy.
4. 1.Maternal 5-10%
Hypertensive disorder in pregnancy.
Diabetes in pregnancy.
Infections(malaria,hepatitis, influenza, toxoplasma&syphili
Hyperpyrexia
Antiphospholipid syndrome
Thrombophilis
Abnormal labour
Post term pregnancy
Systemic lupus erythematosus.
2.Fetal25-40%
Chromosomal abnormalities
Major structural anomalies
Infections
Rh- incompatibility
Non immune hydrops
Growth restriction
5. 3.Placental20-35%
Antepartum haemorrhage.
Cord accident
Placental insufficiency
Twin transfusion syndrome(TTTS)
4.Iatrogenic
Beyond dose.
External cephalic version
Drugs.
5.Idiopathic 25-35%
Causes remains unknown even with through clinical
examination and investigations.
6. DIGNOSIS:
Repeated examination are often
required to confirm the diagnosis.
SYMPTOMS:
Absence of fetal movements which
were previously noted by the
patient.
7. SIGNS: retrogression of the positive breast changes that occur
during pregnancy is evident after variable period following
death of the fetus.
Per abdomen:
Gradual retrogression of the fundal height and it becomes
smaller than the period of amenorrhoea.
Uterine tone is diminished and the uterus feels flaccid.
Braxton-Hicks contraction is not easily felt.
Fetal movements are not felt during palpation
.Fetal heart sound is absent. Doppler ultrasound is better than
the stethoscope.
Egg-shell crackling feel of the fetal head is late feature.
8. INVESTIGATION:
Sonography:
Earliest diagnosis is possible with Sonography.
The evidences are:
Lack of all fetal motions during a 10minute period of
careful observation with a real-time sonar is a strong
presumptive evidence of fetal death.
Gradually, oligohydramnios and collapsed cranial bones
are evident.
9. Straight X-ray abdomen: Rarely done at present .
The following features may be found in varying
degree either singly or in combination.
Spalding sign –
The irregular overlapping of the cranial bones on
one another is due to liquefaction of the brain
matter & softening of the ligamentous structures
supporting the vault. It usually appears 7 days
after death.
Similar features may be found in extra-uterine
pregnancy with the fetus alive
10.
11. Hyperflexion of the spine is more common. In some
cases hyperextension of the neck is seen.
Crowding of the ribs shadow with loss of normal
parallelism.
Roberts sign : Appearance of gas shadow in the
chambers of the heart and great vessels may appear as
12 hours but difficult tointerpret. When detected provides
conclusive evidence.
Blood: To estimate the blood fibrinogen level and
partial thromboplastin time periodically, when the fetus
is retained for more then 2 weeks
12. COMPLICATION:
Psychological Upset often becomes a problem.
Infection: so long as the membranes rupture infection especially by
gas forming organisms like Cl.welchii may occur. The dead tissue
favours their growth with disastrous consequences.
Blood coagulation disorders are rare. If the fetus is retained for
more than 4 weeks(10- 20%),there is a possibility of defibrination
from silent disseminated intravascular coagulopathy (DIC).It is due to
gradual absorption of thromboplastin, liberated from the dead
placenta and decidua, into the maternal circulation.
13. During labor:Uterine inertia, retained placenta and
postpartum haemorrhage.
PPH (postpartum hemorrhage)
Placental abruption
Shock, renal failure
Sepsis
Maternal death
14. MANAGEMENT
Prevention : the overall risk of recurrence of still birth
varies between 0-8%. The conditions that run the risks
of recurrence are:
hereditary disorders
diabetes
hypertension
thrombophilias
placental abruption
fetal congenital malformation
15. pre-conceptional counselling and care.
Pre-natal diagnosis
To screen the “at-risk mothers” during antenatal
care. Carefull assessment of fetal well being and to
terminate pregnancy with the earliest evidence of
fetal compromise.
16. EXPECTANT ATTITUDE NON INTERFERENCE:
In about 80% of cases, spontaneous expulsion
occurs within 2 weeks of death.
Fibrinogen estimation should be done weekly.
REASONS FOR EARLY DELIVERY:
Reliable diagnosis could be made with real time
ultrasonography quickly.
Prostaglandins are available for effective induction.
Complication should be avoided.
17. INDICATIONS OF EARLY INTERFERE:
Psychological upset of the patient.
Manifestation of uterine infection
Tendency of prolongation of pregnancy beyond 2 weeks.
Falling fibrinogen level.
METHODS OF DELIVERY: The delivery should always
be done by medical induction.
OXYTOCIN INFUSION :Very effective in cases where
the cervix is favourable
*5-10units with 500ml of Ringer’s solution is
administered through intravenous infusion drip.
* 20units with 500ml of Ringer’s solution and run
with 30drops in case of failure
*if the uterus still remains refractory, the same
procedure is repeated after vaginal administration of
prostaglandin gel.
18. Prostaglandins: Vaginal administration of
prostaglandin (PGE2) gel or lipid pessary high in
the posterior fornix is very effective for induction
where the cervix is unfavourable .
It is repeated after 6-8 hours and may be
supplemented with oxytocin infusion.
Misoprostol (PGE1):
25-50µ either vaginally or orally is also found
effective.
Vaginal route use is more effective compared to
oral route. May be repeated for every 4 hours.