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DIABETIC KETOACIDOSIS Dr.Padmesh. V Dept of Pediatrics Dr.SMCSI Medical College, Karakonam,  Trivandrum
DKA ,[object Object],[object Object],[object Object]
DKA :definition ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Physiology of carbohydrate metabolism ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
To develop DKA there must be both  a relative  lack of insulin  and  a relative  overactivity of counter-regulatory hormones ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Physiology
Physiology of DKA ,[object Object],[object Object]
Physiology of carbohydrate metabolism ,[object Object],[object Object],[object Object],[object Object],To develop DKA there must be both    a relative  lack of insulin  and    a relative  overactivity of counter-regulatory hormones
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology of DKA ,[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object]
Potassium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Pathophysiology of Potassium loss ,[object Object],[object Object],[object Object],[object Object],[object Object]
Sodium ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
CLINICAL FEATURES ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Lab Abnormalities and Diagnosis   ,[object Object],[object Object],[object Object],[object Object],[object Object]
Laboratory Abnormalities and Diagnosis ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],Should be re-checked after rehydration
[object Object],[object Object],[object Object]
To summarize..
In short…
[object Object],[object Object]
Aims of management: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
TREATMENT OF DKA  (Milwaukee DKA PROTOCOL) ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],* *
[object Object],[object Object],[object Object],[object Object],IV rate =  85ml/kg  + maintenance – bolus 23 hr
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cautious rehydration : ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Complications of DKA ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cerebral edema ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cerebral Edema – Clinical Features: ,[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object],[object Object]
Cerebral edema –Treatment : ,[object Object],[object Object],[object Object],[object Object],[object Object]
[object Object],[object Object]
 

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