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Diabetes Mellitus
Diabetes Mellitus (DM) - FACTS
 Condition where blood glucose/blood sugar, is higher than normal limits
In General:
 Our body utilises blood glucose to generate energy.
 This glucose comes from the food that we eat, digested and broken down.
 The glucose is then absorbed into our bloodstream to be utilised by metabolically active cells
like muscles, brain etc.
 Pancreas is the main power house for the production of hormones regulating blood glucose
level, i.e. Insulin and Glucagon.
 Insulin allows glucose in the bloodstream to be transported into the cell for utilisation, thus
decreasing glucose flowing through the blood.
 Glucagon, on the other hand, increases blood glucose level through several metabolic process.
Diabetes Mellitus (DM) - FACTS
 Either the insulin production is not enough
or
 The target cells are not responding adequately to insulin.
 Both these pathological processes cause a spike in blood glucose level.
 Too much glucose in your blood can cause health problems.
SYMPTOMS
 Feeling thirsty easily
 Feeling very hungry
 Feeling very tired
 Passing urine in increased frequency
 Losing weight unintentionally
 Sores or wounds that heal slowly
 Dry, itchy skin especially of the limbs
 Feeling of pins and needles in your feet or hands
 Losing sensation over your feet or hands
 Eyesight blurring
TYPES OF DIABETES MELLITUS
 3 common types of DM
 Type 1 Diabetes mellitus or Juvenile diabetes
 Type 2 Diabetes mellitus or Adult-onset
Diabetes
 Gestational Diabetes Mellitus
TYPE 1 DIABETES MELLITUS
 Common in young people
 The body does not produce enough insulin from the pancreas due to autoimmunity
 Immune system itself attacks the glands that produce insulin and destroys them.
TREATMENT for TYPE 1 DIABETES
 Regular subcutaneous injection of insulin (usually artificial insulin)
 Lifestyle changes including healthy food choices and regular exercise
 Medications may also be used to control blood pressure and cholesterol levels if
these were found to be abnormal.
TYPE 2 DIABETES MELLITUS
 In type 2, there is insulin resistance – meaning the target cells (fat, muscle and liver)
do not respond to insulin stimulation to take up glucose from the bloodstream as
effective anymore.
 This causes the pancreas to produce even more insulin to counter the resistance.
 Over time, the pancreas just fails to produce as much and each time after a meal, there
will be a spike in blood glucose
Treatment for Type 2 diabetes:
 Medications can be used to control blood glucose level. Your doctor will prescribe the
most suitable drug accordingly.
 Lifestyle changes such as healthy food choices and regular exercise
 Also take steps to control your blood pressure and cholesterol levels as these usually go
hand-in-hand
Gestational Diabetes Mellitus
 Encountered in pregnant women
 During pregnancy, there are changes in hormonal secretion and some of these hormones
interact with insulin, causing insulin resistance.
 If the pancreas does not meet the demand for insulin, gestational diabetes develops.
 Overweight or obese mothers are usually at higher risk.
 Most of the time, gestational diabetes resolves within 6 weeks post-partum (i.e. after delivery).
But keep in mind that studies have shown that those who have had gestational diabetes are at
risk of developing Type 2 Diabetes Mellitus later in life. Also, babies who are born to mothers
having gestational diabetes while pregnant are also more likely to develop obesity and Type 2
Diabetes.
 If the blood glucose level is not controlled during the pregnancy, complications can occur -
polyhydramnios (too much amniotic fluid), a large baby, etc.
Gestational Diabetes Mellitus - Complications
 Heart disease
 Stroke
 Peripheral arterial disease that could lead to amputation of toes, feet or leg
 Kidney failure
 Eye problems – Cataract, diabetic retinopathy, neovascular glaucoma
 Nervous system problem – Losing sensation of the hands and feet (aka glove and stocking
distribution)
Remember, diabetes mellitus is treatable and manageable. Do not fall into despair with the
diagnosis of diabetes mellitus. With proper care and control, most patients can still lead a
normal life and achieve life satisfaction.
Reference: http://www.mmgazette.com/how-to-know-if-i-have-
diabetes-dr-adeline-carol-peters/
Diabetes Mellitus

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Diabetes Mellitus

  • 2. Diabetes Mellitus (DM) - FACTS  Condition where blood glucose/blood sugar, is higher than normal limits In General:  Our body utilises blood glucose to generate energy.  This glucose comes from the food that we eat, digested and broken down.  The glucose is then absorbed into our bloodstream to be utilised by metabolically active cells like muscles, brain etc.  Pancreas is the main power house for the production of hormones regulating blood glucose level, i.e. Insulin and Glucagon.  Insulin allows glucose in the bloodstream to be transported into the cell for utilisation, thus decreasing glucose flowing through the blood.  Glucagon, on the other hand, increases blood glucose level through several metabolic process.
  • 3. Diabetes Mellitus (DM) - FACTS  Either the insulin production is not enough or  The target cells are not responding adequately to insulin.  Both these pathological processes cause a spike in blood glucose level.  Too much glucose in your blood can cause health problems.
  • 4. SYMPTOMS  Feeling thirsty easily  Feeling very hungry  Feeling very tired  Passing urine in increased frequency  Losing weight unintentionally  Sores or wounds that heal slowly  Dry, itchy skin especially of the limbs  Feeling of pins and needles in your feet or hands  Losing sensation over your feet or hands  Eyesight blurring
  • 5. TYPES OF DIABETES MELLITUS  3 common types of DM  Type 1 Diabetes mellitus or Juvenile diabetes  Type 2 Diabetes mellitus or Adult-onset Diabetes  Gestational Diabetes Mellitus
  • 6. TYPE 1 DIABETES MELLITUS  Common in young people  The body does not produce enough insulin from the pancreas due to autoimmunity  Immune system itself attacks the glands that produce insulin and destroys them. TREATMENT for TYPE 1 DIABETES  Regular subcutaneous injection of insulin (usually artificial insulin)  Lifestyle changes including healthy food choices and regular exercise  Medications may also be used to control blood pressure and cholesterol levels if these were found to be abnormal.
  • 7. TYPE 2 DIABETES MELLITUS  In type 2, there is insulin resistance – meaning the target cells (fat, muscle and liver) do not respond to insulin stimulation to take up glucose from the bloodstream as effective anymore.  This causes the pancreas to produce even more insulin to counter the resistance.  Over time, the pancreas just fails to produce as much and each time after a meal, there will be a spike in blood glucose Treatment for Type 2 diabetes:  Medications can be used to control blood glucose level. Your doctor will prescribe the most suitable drug accordingly.  Lifestyle changes such as healthy food choices and regular exercise  Also take steps to control your blood pressure and cholesterol levels as these usually go hand-in-hand
  • 8. Gestational Diabetes Mellitus  Encountered in pregnant women  During pregnancy, there are changes in hormonal secretion and some of these hormones interact with insulin, causing insulin resistance.  If the pancreas does not meet the demand for insulin, gestational diabetes develops.  Overweight or obese mothers are usually at higher risk.  Most of the time, gestational diabetes resolves within 6 weeks post-partum (i.e. after delivery). But keep in mind that studies have shown that those who have had gestational diabetes are at risk of developing Type 2 Diabetes Mellitus later in life. Also, babies who are born to mothers having gestational diabetes while pregnant are also more likely to develop obesity and Type 2 Diabetes.  If the blood glucose level is not controlled during the pregnancy, complications can occur - polyhydramnios (too much amniotic fluid), a large baby, etc.
  • 9. Gestational Diabetes Mellitus - Complications  Heart disease  Stroke  Peripheral arterial disease that could lead to amputation of toes, feet or leg  Kidney failure  Eye problems – Cataract, diabetic retinopathy, neovascular glaucoma  Nervous system problem – Losing sensation of the hands and feet (aka glove and stocking distribution) Remember, diabetes mellitus is treatable and manageable. Do not fall into despair with the diagnosis of diabetes mellitus. With proper care and control, most patients can still lead a normal life and achieve life satisfaction.