1. Occlusion refers to the relationship between the teeth of the upper and lower jaws during normal function. Proper occlusion develops through growth of jaws and synchronous eruption of teeth. 2. From birth through adulthood, there are four periods of occlusal development: the neonatal period, primary dentition period, mixed dentition period, and permanent dentition period. Each period involves changes to the gums, eruption of specific teeth, and shifting relationships between teeth. 3. During the mixed dentition period, as permanent teeth erupt to replace primary teeth, the occlusion transitions through three phases involving early and late shifts in molar and canine relationships to achieve optimal occlusion. Space management and sequencing of