This Power Point presentation deals with the Dengue virus its cause and mechanism. How the virus infects the host and how the host immune cells kill the virus. vaccines against this virus and the recent advances related to these virus.
Vaccine discovery
DNA vaccine, mechanism
methods of delivery
Main concerns: do DNA vaccines cause insertional mutation and elicit anti-DNA antibodies in the body?
completed and ongoing trials.
new strategies: Prime Boost vaccines
Future prospects
Vaccine discovery
DNA vaccine, mechanism
methods of delivery
Main concerns: do DNA vaccines cause insertional mutation and elicit anti-DNA antibodies in the body?
completed and ongoing trials.
new strategies: Prime Boost vaccines
Future prospects
To create awareness from trial and error method of medical science to proper effective treatment at right time , right dosage and with reduced side effects. To create healthy world.
Antiviral Drugs – A Brief (Classification & Mechanism of Actions)Parth Thosani
This presentation gives you an overview of antiviral agents (both retro and non-retro viruses), focusing on the sites of actions, classification and class-wise mechanism of actions.
host pathogen interaction, Mechanism of pathogenesis rashmi816961
-What is host - pathogen interaction?
-Define terms includes pathogenicity, lethal dose, infection etc.
-Duration of symptom
- Pathogens and steps involved in mechanism of pathogenesis
1. Microbial adherence
2. Invasion
3. Colonization
4. Evasion
5. Damage to host
6. Exiting the host
7. Survival outside the host
8. Transmission
- Host -pathogen interaction in plants and animals
- Defence system in plants and animals
Overview of vaccine and vaccination, types of vaccines with examples, vaccine production technique, adverse effects of vaccination, precautions
Email: jeevan@smail.nchu.edu.tw
this is ppt of viral emerging and re-emerging diseases....pls comment for any doubts, pls follow for more ppts regarding health, heatl care and medical field..thank you
Features, Evaluation and Treatment Coronavirus (COVID-19)
The WHO and other organizations have issued the following general recommendations:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash your hands frequently, especially after contact with infected people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Strengthen, in particular, in emergency medicine departments, the application of strict hygiene measures for the prevention and control of infections.
Individuals that are immunocompromised should avoid public gatherings.
Patients and families should receive instruction to:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash their hands frequently, especially after contact with sick people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Immunocompromised patients should avoid public exposure and public gatherings. If an immunocompromised individual must be in a closed space with multiple individuals present, such as a meeting in a small room; masks, gloves, and personal hygiene with antiseptic soap should be undertaken by those in close contact with the individual. In addition, prior room cleaning with antiseptic agents should be undertaken and performed before exposure. However, considering the danger involved to these individuals, exposure should be avoided unless a meeting, group event, etc. is a true emergency.
Strict personal hygiene measures are necessary for the prevention and control of this infection.
To create awareness from trial and error method of medical science to proper effective treatment at right time , right dosage and with reduced side effects. To create healthy world.
Antiviral Drugs – A Brief (Classification & Mechanism of Actions)Parth Thosani
This presentation gives you an overview of antiviral agents (both retro and non-retro viruses), focusing on the sites of actions, classification and class-wise mechanism of actions.
host pathogen interaction, Mechanism of pathogenesis rashmi816961
-What is host - pathogen interaction?
-Define terms includes pathogenicity, lethal dose, infection etc.
-Duration of symptom
- Pathogens and steps involved in mechanism of pathogenesis
1. Microbial adherence
2. Invasion
3. Colonization
4. Evasion
5. Damage to host
6. Exiting the host
7. Survival outside the host
8. Transmission
- Host -pathogen interaction in plants and animals
- Defence system in plants and animals
Overview of vaccine and vaccination, types of vaccines with examples, vaccine production technique, adverse effects of vaccination, precautions
Email: jeevan@smail.nchu.edu.tw
this is ppt of viral emerging and re-emerging diseases....pls comment for any doubts, pls follow for more ppts regarding health, heatl care and medical field..thank you
Features, Evaluation and Treatment Coronavirus (COVID-19)
The WHO and other organizations have issued the following general recommendations:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash your hands frequently, especially after contact with infected people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Strengthen, in particular, in emergency medicine departments, the application of strict hygiene measures for the prevention and control of infections.
Individuals that are immunocompromised should avoid public gatherings.
Patients and families should receive instruction to:
Avoid close contact with subjects suffering from acute respiratory infections.
Wash their hands frequently, especially after contact with sick people or their environment.
Avoid unprotected contact with farm or wild animals.
People with symptoms of acute airway infection should keep their distance, cover coughs or sneezes with disposable tissues or clothes and wash their hands.
Immunocompromised patients should avoid public exposure and public gatherings. If an immunocompromised individual must be in a closed space with multiple individuals present, such as a meeting in a small room; masks, gloves, and personal hygiene with antiseptic soap should be undertaken by those in close contact with the individual. In addition, prior room cleaning with antiseptic agents should be undertaken and performed before exposure. However, considering the danger involved to these individuals, exposure should be avoided unless a meeting, group event, etc. is a true emergency.
Strict personal hygiene measures are necessary for the prevention and control of this infection.
Morphology, Classification, Cultivation and Replication of VirusKrutika Pardeshi
This presentation is Useful for B. Pharmacy SEM III Students to study the Topic Fungi According to PCI Syllabus.
It Consist of Morpholoy of Fungi, Cultivation , Replication and Classification of Virud
A brief exploration of the way some modern viruses act and ancient viruses have acted to benefit their hosts - particularly humans - today and through evolutionary history, by various means (such as targeted destruction of pathogenic bacteria and introduction of new genetic material).
HIV is a lentivirus which can not only infect actively dividing cells but also non-dividing cells such as macrophages. AIDS is the last stage of HIV infection. HIV primarily attacks T- helper cells resulting into low activated T-cytotoxic cells and suppression of immune system. thus leading to AIDS.
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LGBTQ+ Adults: Unique Opportunities and Inclusive Approaches to CareVITASAuthor
This webinar helps clinicians understand the unique healthcare needs of the LGBTQ+ community, primarily in relation to end-of-life care. Topics include social and cultural background and challenges, healthcare disparities, advanced care planning, and strategies for reaching the community and improving quality of care.
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Stem Cell Solutions: Dr. David Greene's Path to Non-Surgical Cardiac CareDr. David Greene Arizona
Explore the groundbreaking work of Dr. David Greene, a pioneer in regenerative medicine, who is revolutionizing the field of cardiology through stem cell therapy in Arizona. This ppt delves into how Dr. Greene's innovative approach is providing non-surgical, effective treatments for heart disease, using the body's own cells to repair heart damage and improve patient outcomes. Learn about the science behind stem cell therapy, its benefits over traditional cardiac surgeries, and the promising future it holds for modern medicine. Join us as we uncover how Dr. Greene's commitment to stem cell research and therapy is setting new standards in healthcare and offering new hope to cardiac patients.
Dr. David Greene R3 stem cell Breakthroughs: Stem Cell Therapy in CardiologyR3 Stem Cell
Dr. David Greene, founder and CEO of R3 Stem Cell, is at the forefront of groundbreaking research in the field of cardiology, focusing on the transformative potential of stem cell therapy. His latest work emphasizes innovative approaches to treating heart disease, aiming to repair damaged heart tissue and improve heart function through the use of advanced stem cell techniques. This research promises not only to enhance the quality of life for patients with chronic heart conditions but also to pave the way for new, more effective treatments. Dr. Greene's work is notable for its focus on safety, efficacy, and the potential to significantly reduce the need for invasive surgeries and long-term medication, positioning stem cell therapy as a key player in the future of cardiac care.
Trauma Outpatient Center is a comprehensive facility dedicated to addressing mental health challenges and providing medication-assisted treatment. We offer a diverse range of services aimed at assisting individuals in overcoming addiction, mental health disorders, and related obstacles. Our team consists of seasoned professionals who are both experienced and compassionate, committed to delivering the highest standard of care to our clients. By utilizing evidence-based treatment methods, we strive to help our clients achieve their goals and lead healthier, more fulfilling lives.
Our mission is to provide a safe and supportive environment where our clients can receive the highest quality of care. We are dedicated to assisting our clients in reaching their objectives and improving their overall well-being. We prioritize our clients' needs and individualize treatment plans to ensure they receive tailored care. Our approach is rooted in evidence-based practices proven effective in treating addiction and mental health disorders.
Under Pressure : Kenneth Kruk's StrategyKenneth Kruk
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Cold Sores: Causes, Treatments, and Prevention Strategies | The Lifesciences ...The Lifesciences Magazine
Cold Sores, medically known as herpes labialis, are caused by the herpes simplex virus (HSV). HSV-1 is primarily responsible for cold sores, although HSV-2 can also contribute in some cases.
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Feeding plate for a newborn with Cleft Palate.pptxSatvikaPrasad
A feeding plate is a prosthetic device used for newborns with a cleft palate to assist in feeding and improve nutrition intake. From a prosthodontic perspective, this plate acts as a barrier between the oral and nasal cavities, facilitating effective sucking and swallowing by providing a more normal anatomical structure. It helps to prevent milk from entering the nasal passage, thereby reducing the risk of aspiration and enhancing the infant's ability to feed efficiently. The feeding plate also aids in the development of the oral muscles and can contribute to better growth and weight gain. Its custom fabrication and proper fitting by a prosthodontist are crucial for ensuring comfort and functionality, as well as for minimizing potential complications. Early intervention with a feeding plate can significantly improve the quality of life for both the infant and the parents.
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2. What is Dengue Virus
• Dengue Virus is a RNA Virus that is transmitted by a mosquito.
• This Virus is a member of Flavivirus genus.
• These Viruses effect the central nervous system and also cause Visceral
diseases in humans.
• The Dengue Virus infects nearly 390 million people each year in more then
100 countries.
3. Dengue Virus
• The Dengue Virus is 50 nm Spherical Virion that is comprised of structural proteins.
• The 3 structural proteins are capsid, membrane and the envelope also with 10.7 kb capped
RNA.
• The two mosquito vectors of Dengue Virus are Aedes albopictus / Ades aegypti and Humans.
• The 4 Dengue virus stereotypes that can cause the disease are DENV1, DENV2, DENV3,
DENV4.
• The difference in these stereotypes are 25% to 40% and these differences occur at the
amino acid level.
4. Mechanism of Dengue Virus to cause infection
• Dengue virus binds to the target cells by the help of structurally diverse
group of attachment factors.
• The bound Virions internalize with the help of Catherin which are then
transported to the endosome.
• The fusion of the viral and the host membranes occur by the structural
rearrangement of the E Protein.
• Penetration of the nucleocaspid takes place then the Viral RNA genome is
translated into the single polyprotein.
6. Mechanism of Dengue Virus to cause infection
(continued)
• This polyprotein is then cleaved into 3 structural and 7 non structural proteins.
• Synthesis of negative strand viral RNA occur and the leads to the synthesis of
Positive strand Viral RNA.
• The Positive strand RNA is packaged and form immature virions.
• The maturation of Virions occur in Trans Golgi network by the action of Furin
proteases.
7. Targets for antibody neutralizations
• Virion Maturity – The partially synthesized virus can also cause infection.
The cleavage of the structural proteins prM on newly synthesized virus are
required for infectivity. The uncleaved prM is recognized by the poorly
neutralizing antibodies.
• Structural heterogeneity- The Exposure of the DENV-2 to the normal
temperature of the human body can result in increase of structural
heterogeneity of the virus populations.
8. Immunity Against the Dengue Virus
• The Dengue virus infects and replicates inside the Langerhans Cells (these
cells display the antigen on their surface). Immune system gets activated and
innate immunity is triggered.
• Monocytes and macrophages ingest the virus but they also get infected.
• The infected cells release small proteins called interferon's (Part of Large
group of proteins called cytokines) they have the ability to interfere with the
viral replication and they interfere both adaptive and innate immunity.
• As the immune system fights with the infection the person experiences fever.
10. Immunity Against the Dengue Virus
(continued)
• The B cells produce IgM and igG that recognize and neutralize the dengue
viral particles.
• The cytotoxic T cells recognize and kill the cells that are infected with the
virus.
• The innate immune cells activates complement system which helps the
antibodies and white blood cells to remove the virus.
• The immune system of the body thus neutralizes the dengue infection.
11. Dengue virus Vaccine
• The presence of 4 different stereotypes of Dengue viruses are a great
challenge for the synthesis of vaccine as an incompletely induced vaccine
immunity may predispose an individual to a severe disease when gets
encountered to a natural infection.
• DENVax is a live –attenuated tetravalent vaccine composed of a infectious
clone derived attenuated DENV-2 strain and three chimeric viruses that
incorporate the structural genes of other three stereotypes.
12. Advanced Research in Dengue Virus
• High throughput antiviral drugs are being discovered for the identification of
inhibitors of the fusogenic viral envelope proteins, integral membrane proteins,
protease and helicase proteins and the RNA Dependent RNA polymerases .
• Many Drugs are prepared that target the steps in DENV pathogenesis.
• Progressive discoveries are there on reducing the transmission of the DENV by
limiting the infection in the mosquito host.
• There are advances in the DENV biology in areas of host-pathogen-vector
interactions, structural biology, genetic variability, commensal biology.