The rapid pace of technological advancement and an increasingly volatile business environment causes pharma industry players to face three main challenges. The first challenge is to develop the critical ability to create and maintain a common view on the big picture of the organization’s architecture and environment. Linked to this is the challenge of making it decisible, which actions must be taken on strategical, business and technological level. The last challenge consists in identifying/considering the best architectural approach and solution on a fine-grained level. This may include answer on question such as “Which approach we choose to implement a read replica in the cloud (transactional replication using publish-subscribe between relational database systems, stream into a Redis Cache, …)?” We develop a digitalization RA for pharma industry and incorporate three main areas, Internet of Things (IoT), Cognitive Computing (CC), and Augmented Reality (AR). Digitalization is horizontally divisible into four sequentially arranged domains that can be understood as the stages of digitalization: Tag, Sense and Wire (1), Ingest (2), Analyze and Prepare (3), and Utilize (4). Technology components may be used across different industries. Applications developed and running in different industries may both interact or be integrated with each other and exchange data through these industry-specific applications (cool chain monitoring while transportation, healthcare research data for public, origination & distribution information for authorities). For this reason, our frame possesses a third dimension: connected industries (in pharma these include transportation & logistics and the public sector). This approach generates a big picture that transparently illustrates the pharma RA for digitalization including its stages, architecture layers and connections between building blocks across organizational boundaries and different industries. Author of paper and presentation: Eldar Sultanow, Carsten Brockmann, Levent Sözer, Capgemini Germany