vector born diseases
malaria facts
Malaria; One of the world’s deadliest vectorborne diseases
Global malaria scenario; As for World
Malaria report 2020
Current Malaria scenario in INDIA
malaria vector control
prevention
SEIR Model and Simulation for Controlling Malaria Diseases Transmission witho...ijtsrd
In this study we have develop a basic deterministic mathematical model to investigate SEIR Model and Simulation for controlling malaria Diseases Transmission without Intervention Strategies. The model has seven non linear differential equations which describe the spread of malaria with three state variables for mosquitoes populations and four state variables for humans population and to introduce the model without intervention strategies. The models are analyzed qualitatively to determine criteria for control of a malaria transmission, and are used to calculate the basic reproduction R 0. The equilibria of malaria models are determined. In addition to having a disease free equilibrium, which is locally asymptotically stable when the R 0 1, the basic malaria model manifest ones possession of a quality of the phenomenon of backward bifurcation where a stable disease free equilibrium co exists at the same time with a stable endemic equilibrium for a certain range of associated reproduction number less than one. The results also designing the effects of some model parameters, the infection rate and biting rate. The numerical analysis and numerical simulation results of the model suggested that the most effective strategies for controlling or eradicating the spread of malaria were suggest to use insecticide treated bed nets, indoor residual spraying, prompt effective diagnosis and treatment of infected individuals. Fekadu Tadege Kobe "SEIR Model and Simulation for Controlling Malaria Diseases Transmission without Intervention Strategies" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25235.pdf Paper URL: https://www.ijtsrd.com/mathemetics/applied-mathamatics/25235/seir-model-and-simulation-for-controlling-malaria-diseases-transmission-without-intervention-strategies/fekadu-tadege-kobe
Statistical analysis on household factors influencing annual episodes of malariacimran15
Malaria is responsible for about 66 per cent of all clinic visits in Nigeria. It accounts for 25% of under-5 mortality, 30% childhood mortality and 11% maternal mortality. At least 50% of the population will have at least one episode of malaria annually. Moreover, environment dictates the incidence and prevalence of diseases all over the world and if timely action is not taken, it may lead to diseases. Three (3) out of six (6) major towns in Ido local government area are considered and accumulated one hundred and ninety one (191) individuals as respondents using haphazard non probability sampling technique for selection. The obtained data through questionnaire was presented on frequency table and charts while inferential statistics were analysed using dummy variables in regression. It was revealed that majority of the respondents suffered from one or more incidences of malaria in a year, where female had the higher percentage of the incidence and there was high incidence of malaria among the adult ages 30years and above. The qualitative predictor variable in regression analysis revealed significant relationship between annual episode of malaria and number of members of household, toilet type, absent ceiling, building type, disposable site and source of domestic water. The ANOVA, F – test was significant for all predicted factors. Conclusively, in the view of the discovery, it was therefore recommended that people need awareness on densely populated area / household are more prone to experience more episodes of malaria incidence than sparsely populated one, encouragement on utilization of closed domestic water system instead of open system to avoid reservoir for mosquito, enlightenment on type toilet used and avoid absence ceiling to prevent being a breeding site for mosquitoes, government to stage more campaign against malaria especially for adult not for children under 5year alone and create a task force officer/ sanitary inspectors to checkmate sanitation of our environment to avoid unkempt toilet habit which serves as breeding site for mosquitoes.
SEIR Model and Simulation for Controlling Malaria Diseases Transmission witho...ijtsrd
In this study we have develop a basic deterministic mathematical model to investigate SEIR Model and Simulation for controlling malaria Diseases Transmission without Intervention Strategies. The model has seven non linear differential equations which describe the spread of malaria with three state variables for mosquitoes populations and four state variables for humans population and to introduce the model without intervention strategies. The models are analyzed qualitatively to determine criteria for control of a malaria transmission, and are used to calculate the basic reproduction R 0. The equilibria of malaria models are determined. In addition to having a disease free equilibrium, which is locally asymptotically stable when the R 0 1, the basic malaria model manifest ones possession of a quality of the phenomenon of backward bifurcation where a stable disease free equilibrium co exists at the same time with a stable endemic equilibrium for a certain range of associated reproduction number less than one. The results also designing the effects of some model parameters, the infection rate and biting rate. The numerical analysis and numerical simulation results of the model suggested that the most effective strategies for controlling or eradicating the spread of malaria were suggest to use insecticide treated bed nets, indoor residual spraying, prompt effective diagnosis and treatment of infected individuals. Fekadu Tadege Kobe "SEIR Model and Simulation for Controlling Malaria Diseases Transmission without Intervention Strategies" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-3 | Issue-6 , October 2019, URL: https://www.ijtsrd.com/papers/ijtsrd25235.pdf Paper URL: https://www.ijtsrd.com/mathemetics/applied-mathamatics/25235/seir-model-and-simulation-for-controlling-malaria-diseases-transmission-without-intervention-strategies/fekadu-tadege-kobe
Statistical analysis on household factors influencing annual episodes of malariacimran15
Malaria is responsible for about 66 per cent of all clinic visits in Nigeria. It accounts for 25% of under-5 mortality, 30% childhood mortality and 11% maternal mortality. At least 50% of the population will have at least one episode of malaria annually. Moreover, environment dictates the incidence and prevalence of diseases all over the world and if timely action is not taken, it may lead to diseases. Three (3) out of six (6) major towns in Ido local government area are considered and accumulated one hundred and ninety one (191) individuals as respondents using haphazard non probability sampling technique for selection. The obtained data through questionnaire was presented on frequency table and charts while inferential statistics were analysed using dummy variables in regression. It was revealed that majority of the respondents suffered from one or more incidences of malaria in a year, where female had the higher percentage of the incidence and there was high incidence of malaria among the adult ages 30years and above. The qualitative predictor variable in regression analysis revealed significant relationship between annual episode of malaria and number of members of household, toilet type, absent ceiling, building type, disposable site and source of domestic water. The ANOVA, F – test was significant for all predicted factors. Conclusively, in the view of the discovery, it was therefore recommended that people need awareness on densely populated area / household are more prone to experience more episodes of malaria incidence than sparsely populated one, encouragement on utilization of closed domestic water system instead of open system to avoid reservoir for mosquito, enlightenment on type toilet used and avoid absence ceiling to prevent being a breeding site for mosquitoes, government to stage more campaign against malaria especially for adult not for children under 5year alone and create a task force officer/ sanitary inspectors to checkmate sanitation of our environment to avoid unkempt toilet habit which serves as breeding site for mosquitoes.
The more i study and search about HIV and AIDS, the more deep its becomes. I discovered that HIV and AIDS is the highest killing machine of our time. silently reducing world population. many countries don't want to talk about HIV, some religious countries felt that HIV is a taboo and should not be talked about in any case. so they ignore the myths and the truth about HIV and is killing their citizen gradually, spreading drastically. HIV/ AIDS IS REAL AND THAT IS THE TRUTH.
Malaria history in Sri Lanka has many milestones. There was a period when thousands of people died due to malaria. At that time, Sri Lanka started official malaria control program and achieved almost eradication in 1960.
Malaria status & challenges of the epidemicGreenFacts
Malaria is one of the most common infectious diseases and a great public health problem worldwide. About one million people die each year from malaria, and half of the world's population lives in areas where there is a risk of getting the disease through the bites of infected mosquitoes.
What is being done to control the spread of malaria? Can the disease be eradicated?
Ceva's CEO, Marc Prikazsky, addressed Animal Health Investment Asia in Beijing, China setting out how partnerships can stimulate innovation and create value. Ultimately the major global health challenges we face are to great for any one country or company to address alone. Working together, but with the Power of One is therefore essential. #One Health.
https://www.indezine.com/bank/aids.html -- Download the presentation
You can download the template used from http://www.indezine.com/powerpoint/templates/categories/medicalmedicine/aids.html
Both downloads require free Indezine membership.
A backgrounder presentation on AIDS.
WHO Reported 28% Reduction in Malaria Cases in India Last Yearvipul srivastava
According to a new World Health Organization (WHO) report, out of the 11 countries with the world’s highest malaria burdens, India was one of only two countries to reduce malaria cases. Achieving a 28% reduction in malaria cases between 2017 and 2018.
The more i study and search about HIV and AIDS, the more deep its becomes. I discovered that HIV and AIDS is the highest killing machine of our time. silently reducing world population. many countries don't want to talk about HIV, some religious countries felt that HIV is a taboo and should not be talked about in any case. so they ignore the myths and the truth about HIV and is killing their citizen gradually, spreading drastically. HIV/ AIDS IS REAL AND THAT IS THE TRUTH.
Malaria history in Sri Lanka has many milestones. There was a period when thousands of people died due to malaria. At that time, Sri Lanka started official malaria control program and achieved almost eradication in 1960.
Malaria status & challenges of the epidemicGreenFacts
Malaria is one of the most common infectious diseases and a great public health problem worldwide. About one million people die each year from malaria, and half of the world's population lives in areas where there is a risk of getting the disease through the bites of infected mosquitoes.
What is being done to control the spread of malaria? Can the disease be eradicated?
Ceva's CEO, Marc Prikazsky, addressed Animal Health Investment Asia in Beijing, China setting out how partnerships can stimulate innovation and create value. Ultimately the major global health challenges we face are to great for any one country or company to address alone. Working together, but with the Power of One is therefore essential. #One Health.
https://www.indezine.com/bank/aids.html -- Download the presentation
You can download the template used from http://www.indezine.com/powerpoint/templates/categories/medicalmedicine/aids.html
Both downloads require free Indezine membership.
A backgrounder presentation on AIDS.
WHO Reported 28% Reduction in Malaria Cases in India Last Yearvipul srivastava
According to a new World Health Organization (WHO) report, out of the 11 countries with the world’s highest malaria burdens, India was one of only two countries to reduce malaria cases. Achieving a 28% reduction in malaria cases between 2017 and 2018.
Covid 19 spreading in rural india a geospatial study of villages, semi-urban ...Mohd Akhter Ali
The COVID-19 pandemic is considered as the most critical global health disaster of the century and the greatest challenge that the human civilization faced since the 2nd World War.
It has rapidly spread around the world, posing enormous health, economic, environmental and social challenges to the whole human population
Burden of Vector Borne Diseases Past, Present & FuturePradip Awate
Bharati Vidyapeeth Pune has recently organized National CME on VBDs. I delivered a speech on " Burden of Vector Borne Diseases Past, Present & Future".
This presentation deals with burden of prominent VBDs globally & in India with special reference to Maharashtra.
National framework for malaria elimination in indiaAparna Chaudhary
outlines India’s strategy for elimination of the disease by 2030. The framework has been developed with a vision to eliminate malaria from the country and contribute to improved health and quality of life and alleviation of poverty.
Effectiveness of tuberculosis screening among a high-risk population: recomme...Георги Календеров
Tuberculosis (TB) is an infectious disease caused by Mycobacterium tuberculosis most commonly affecting lungs. Due to the low detection, possible drug-resistance and coinfections with other diseases, it remains one of the largest global public health problem. TB is considered as a disease of poverty and health inequalities, often associated with HIV infections.
Iveta Angelova Nikolova, PhD
University of architecture, civil engineering and geodesy, Sofia
Indian Governance on SARS-COV2 Viral Outbreak – A Chronology. International J...Premier Publishers
The world is now facing an unprecedented crisis due to the novel coronavirus. The disease has spread around 210 countries and territories around the globe and infected (confirmed) more than twelve million people (09/07/2020). The global death rate due to coronavirus was around 584k, respectively. This intense situation emerges the necessity of drug discovery and vaccination against SARS-COV2. The total (cumulative) number of confirmed infected people is 767K until now across India (09 JUL 2020). Most of the research and newspaper articles focus on the number of infected people over the countries. In the absence of a vaccine, the preventive measures of maintaining basic personal hygiene and large-scale social distancing appears to be most effective against SARS-COV2 causing infection. The effect of preventing actions and lockdown was observed that the count was in control during the lockdown period. Complete unlocking protocols may elevate the possibility of viral spread. A sustained lockdown with considerable relaxation is suggested. This article discusses the timeline events and guidance of Indian governance on this pandemic 2020. Additionally, it also covers the graphical growth curvature of Morbidity and Mortality rate, centre’s accomplishments, economical inspection, and exponential growth.
Find the Key biopsychosocial factors contributing to HIV. Suppor.docxbryanwest16882
Find the Key biopsychosocial factors contributing to HIV. Support the following information. Please use APA style.
Description of the Issue.
HIV stands for human immunodeficiency virus and it impacts people in the United States and countries around the world. HIV attacks and destroys the infection-fighting CD4 Cells of the immune system (CDC, 2019). The loss of CD4 cells makes it difficult for the body to fight off infections and certain cancers. Without treatment, HIV can gradually destroy the immune system and advance to AIDS (AIDS, 2019). HIV is spread through contact with the blood, semen, pre-seminal fluid, rectal fluids, vaginal fluids, or breast milk of a person with HIV. Although there has been a decrease in numbers of HIV incidence, transmission of this disease ranges in age groups, male & female sex, race, ethnicity, and area of residence (HIV Survailance Report, 2018).
In 2017, gay and bisexual men accounted for 66% of all HIV diagnoses in the United States and 6 dependent areas. In the same year, individuals who got HIV infection through heterosexual sex made up 24% of all HIV diagnoses. If we look at HIV diagnoses by race and ethnicity, we see that African Americans are most affected by HIV. In 2017, African Americans accounted for 43% of all new HIV diagnoses. Additionally, Hispanic/Latinos are also strongly affected. They accounted for 26% of all new HIV diagnoses(CDC, 2019). HIV does not discriminate and any race, gender and age are affected. Even children are being diagnosed with this disease. In 2018 there were 37.9 million people living with HIV and out of those, 36.2 were adults and 1.7 million were children under the age of 15 ("The Global HIV/AIDS Epidemic", 2019). There is an equal divide between male and females that are affected by HIV. Women compose 50% of all adults living with HIV worldwide ("The Global HIV/AIDS Epidemic", 2019). This tells us that there is no discrimination with this disease and men are just as susceptible to get infected.
HIV disease continues to be a serious health issue for parts of the world. Worldwide, there were about 1.8 million new cases of HIV in 2017. About 36.9 million people were living with HIV around the world in 2017, and 21.7 million of them were receiving medicines to treat HIV, called antiretroviral therapy (ART). From 2017 to 2018, the number of HIV infected people has increased by 1 million. That is an alarming number for the span of one year. Additionally, an estimated 940,000 people died from AIDS-related illnesses in 2017 (CDC, 2019). However, the number of deaths has also decreased due to the advances made in treatment. In 2018, the number of deaths decreased by 170,000 and instead there were an estimated 770,000 deaths from AIDS due in part to antiretroviral therapy ("The Global HIV/AIDS Epidemic", 2019). Although deaths have decreased, there are still many people who don’t know they have HIV. About one in five with HIV (21%) are unaware that they even have it ("T.
impact of metropolitanization on covid 19 cases in india using entropy weight...ijtsrd
The global pandemic COVID 19 which was started early this year spreading rapidly in developed countries as all well as developing countries of the world. The noticeable fact is that most of the metropolitan cities of the world are severely affected by Corona pandemic and toped in their respective country among the COVID cases. The impact of the metropolitan city on COVID 19 cases, example can be cited around every corner of the world, From Wuhan to New York, Mumbai to Sao Paulo and Moscow to Madrid the Metropolitan cities of the world’s come out as deep rooted hotspots of novel coronavirus pandemic. Mumbai, Delhi, Chennai, and Kolkata are the leading metropolis in India also leading in COVID 19 cases it can be explained by their connectivity to the rest of the world by the people and products. Therefore this article aims to summerise the impact of six metropolitan cities on the total COVID 19 cases of their states and try to find out which city have best suited in the concept of the Metropolitanization of COVID 19 cases. Entropy based TOPSIS methods are applied to compare the dataset of six metropolitan cities of India, and try to find out which city best fitted in the concept of metropolitanization of COVID 19 cases. Seven factors are chosen to analyze the impact of metropolitan cities on COVID 19 cases such as city population, percentage of slum population, number of COVID cases, airport traffic movement, relative humidity, and temperature. Entropy methods applied to weights the criterion for finding which criteria have maximum influence on COVID 19 cases. After that on the basis of Entropy weights, the TOPSIS method has been used to evaluate the dataset of six cities to track down the relative position of cities on the concentration of COVID 19 cases. After comparing the alternatives in TOPSIS method i.e those six cities , Delhi came in the first position, followed by Mumbai 2nd , Chennai 3rd , Kolkata 4th , Ahmedabad 5th , Hyderabad 6th based on the concentration of COVID 19 cases in the metropolitan cities. Sanu Dolui | Sayani Chakraborty "Impact of Metropolitanization on Covid-19 Cases in India using Entropy Weights Based Topsis Approach" Published in International Journal of Trend in Scientific Research and Development (ijtsrd), ISSN: 2456-6470, Volume-4 | Issue-5 , August 2020, URL: https://www.ijtsrd.com/papers/ijtsrd32929.pdf Paper Url :https://www.ijtsrd.com/other-scientific-research-area/enviormental-science/32929/impact-of-metropolitanization-on-covid19-cases-in-india-using-entropy-weights-based-topsis-approach/sanu-dolui
How far has Africa gone in achieving the zero hunger target? Evidence from Ni...Olutosin Ademola Otekunrin
Sustainable Development Goal 2 is hinged on achieving zero hunger, worldwide, by the year 2030. Many developing countries, especially African countries, are faced with extreme hunger often caused or compounded by bad governance, conflicts and climate change. In this paper, we review patterns of Global Hunger Index scores across Africa from 2000 to 2018 noting advances and setbacks in the fight against hunger in relation to the underlying causes of hunger in these nations, using Nigeria, the poverty capital of the world, as a case study. We also review selected policies of the Nigerian government and development partners aimed at reducing hunger in Nigeria and proffer solutions that can help actualise the target of zero hunger by 2030.
UNDERSTANDING THE INVOLVEMENT OF N-TERMINAL DOMAIN OF FATS IN INTERACTION WIT...Santosh Kumar Sahoo
Fat family members (FAT1, FAT2, FAT3, and FAT4) are human homologs of Drosophila Fat and are implicated in tumour suppression and planar cell polarity. Cellular homeostasis is largely maintained at the cellular level via transcription regulation, which can vary in response to physiological alterations. FAT atypical cadherin 1 (FAT1), which encodes a protocadherin, is one of the most frequently mutated genes in human cancer. FAT1 is thought to play a vital role in the maintenance of organ and cellular homeostasis, as well as activating a number of signalling pathways via protein-protein interactions, such as the Wnt/catenin, Hippo, and MAPK/ERK signaling pathways. Unregulated FAT1 expression can cause cancer and have a negative impact on prognosis. In this study, we focused on the structural and functional aspects of various domains and motifs of FAT1. Global bioinformatic databases resulted in streamlining a list of putative protein associates of FAT1. Since FAT1-mediated structural and functional alterations, as well as variations in FAT1 expression, contribute to disturbances in cellular homeostasis and result in patho-physiological disorders including cancer, we essentially focused on cancer-related genes functionally related to the FAT1. FAT1 is a huge protein composed of 4588 amino acid residues. By mutational analysis and further protein-protein docking studies using multiple bioinformatic tools it was confirmed that the C-terminus 4204-4214 and 4300-4400 amino acid residues are critical for interaction with cancer-related genes including Tumor necrosis factor, Myc proto-oncogene and Rela proto-oncogene. Interestingly, it was found that the small peptides corresponding to the C-terminus domain 4204-4214 and 4300-4400 of FAT1 effectively interact with tumor-suppressor genes. These evidences widens up the possibility of administering potential peptides when the FAT1 expression is inhibited. Our preliminary results will pave way forward in improving the prognosis and treatment of patients with cancer.
Polymerase Chain Reaction
History of PCR
Instrumentation of PCR
Principle of PCR
Components of PCR
Steps of PCR
Optimal PCR Factors
Applications of PCR
Introduction
Fish Health Management GOALS
Principles of fish health management
Factors affecting fish health
Common symptoms of diseases
General preventive measures
Proper Health Management through manipulating the disease triangle
Conclusion
References
NCBI; Introduction, Homepage and about
Tools and database of NCBI
BLAST; Introduction, Homepage and types of BLAST
Some databases of NCBI
References
Acknowledgements
Fatty acid oxidation
Types of fatty acid oxidation
Overview of fatty acid oxidation
Beta-Oxidation of fatty acid
Steps in Beta-Oxidation of fatty acid
Stoichiometry of Beta oxidation
Reference
Introduction
Fish Health Management GOALS
Principles of fish health management
Factors affecting fish health
Common symptoms of diseases
General preventive measures
Proper Health Management through Manipulating the disease triangle
Conclusion
References
Professional air quality monitoring systems provide immediate, on-site data for analysis, compliance, and decision-making.
Monitor common gases, weather parameters, particulates.
Observation of Io’s Resurfacing via Plume Deposition Using Ground-based Adapt...Sérgio Sacani
Since volcanic activity was first discovered on Io from Voyager images in 1979, changes
on Io’s surface have been monitored from both spacecraft and ground-based telescopes.
Here, we present the highest spatial resolution images of Io ever obtained from a groundbased telescope. These images, acquired by the SHARK-VIS instrument on the Large
Binocular Telescope, show evidence of a major resurfacing event on Io’s trailing hemisphere. When compared to the most recent spacecraft images, the SHARK-VIS images
show that a plume deposit from a powerful eruption at Pillan Patera has covered part
of the long-lived Pele plume deposit. Although this type of resurfacing event may be common on Io, few have been detected due to the rarity of spacecraft visits and the previously low spatial resolution available from Earth-based telescopes. The SHARK-VIS instrument ushers in a new era of high resolution imaging of Io’s surface using adaptive
optics at visible wavelengths.
The increased availability of biomedical data, particularly in the public domain, offers the opportunity to better understand human health and to develop effective therapeutics for a wide range of unmet medical needs. However, data scientists remain stymied by the fact that data remain hard to find and to productively reuse because data and their metadata i) are wholly inaccessible, ii) are in non-standard or incompatible representations, iii) do not conform to community standards, and iv) have unclear or highly restricted terms and conditions that preclude legitimate reuse. These limitations require a rethink on data can be made machine and AI-ready - the key motivation behind the FAIR Guiding Principles. Concurrently, while recent efforts have explored the use of deep learning to fuse disparate data into predictive models for a wide range of biomedical applications, these models often fail even when the correct answer is already known, and fail to explain individual predictions in terms that data scientists can appreciate. These limitations suggest that new methods to produce practical artificial intelligence are still needed.
In this talk, I will discuss our work in (1) building an integrative knowledge infrastructure to prepare FAIR and "AI-ready" data and services along with (2) neurosymbolic AI methods to improve the quality of predictions and to generate plausible explanations. Attention is given to standards, platforms, and methods to wrangle knowledge into simple, but effective semantic and latent representations, and to make these available into standards-compliant and discoverable interfaces that can be used in model building, validation, and explanation. Our work, and those of others in the field, creates a baseline for building trustworthy and easy to deploy AI models in biomedicine.
Bio
Dr. Michel Dumontier is the Distinguished Professor of Data Science at Maastricht University, founder and executive director of the Institute of Data Science, and co-founder of the FAIR (Findable, Accessible, Interoperable and Reusable) data principles. His research explores socio-technological approaches for responsible discovery science, which includes collaborative multi-modal knowledge graphs, privacy-preserving distributed data mining, and AI methods for drug discovery and personalized medicine. His work is supported through the Dutch National Research Agenda, the Netherlands Organisation for Scientific Research, Horizon Europe, the European Open Science Cloud, the US National Institutes of Health, and a Marie-Curie Innovative Training Network. He is the editor-in-chief for the journal Data Science and is internationally recognized for his contributions in bioinformatics, biomedical informatics, and semantic technologies including ontologies and linked data.
Introduction:
RNA interference (RNAi) or Post-Transcriptional Gene Silencing (PTGS) is an important biological process for modulating eukaryotic gene expression.
It is highly conserved process of posttranscriptional gene silencing by which double stranded RNA (dsRNA) causes sequence-specific degradation of mRNA sequences.
dsRNA-induced gene silencing (RNAi) is reported in a wide range of eukaryotes ranging from worms, insects, mammals and plants.
This process mediates resistance to both endogenous parasitic and exogenous pathogenic nucleic acids, and regulates the expression of protein-coding genes.
What are small ncRNAs?
micro RNA (miRNA)
short interfering RNA (siRNA)
Properties of small non-coding RNA:
Involved in silencing mRNA transcripts.
Called “small” because they are usually only about 21-24 nucleotides long.
Synthesized by first cutting up longer precursor sequences (like the 61nt one that Lee discovered).
Silence an mRNA by base pairing with some sequence on the mRNA.
Discovery of siRNA?
The first small RNA:
In 1993 Rosalind Lee (Victor Ambros lab) was studying a non- coding gene in C. elegans, lin-4, that was involved in silencing of another gene, lin-14, at the appropriate time in the
development of the worm C. elegans.
Two small transcripts of lin-4 (22nt and 61nt) were found to be complementary to a sequence in the 3' UTR of lin-14.
Because lin-4 encoded no protein, she deduced that it must be these transcripts that are causing the silencing by RNA-RNA interactions.
Types of RNAi ( non coding RNA)
MiRNA
Length (23-25 nt)
Trans acting
Binds with target MRNA in mismatch
Translation inhibition
Si RNA
Length 21 nt.
Cis acting
Bind with target Mrna in perfect complementary sequence
Piwi-RNA
Length ; 25 to 36 nt.
Expressed in Germ Cells
Regulates trnasposomes activity
MECHANISM OF RNAI:
First the double-stranded RNA teams up with a protein complex named Dicer, which cuts the long RNA into short pieces.
Then another protein complex called RISC (RNA-induced silencing complex) discards one of the two RNA strands.
The RISC-docked, single-stranded RNA then pairs with the homologous mRNA and destroys it.
THE RISC COMPLEX:
RISC is large(>500kD) RNA multi- protein Binding complex which triggers MRNA degradation in response to MRNA
Unwinding of double stranded Si RNA by ATP independent Helicase
Active component of RISC is Ago proteins( ENDONUCLEASE) which cleave target MRNA.
DICER: endonuclease (RNase Family III)
Argonaute: Central Component of the RNA-Induced Silencing Complex (RISC)
One strand of the dsRNA produced by Dicer is retained in the RISC complex in association with Argonaute
ARGONAUTE PROTEIN :
1.PAZ(PIWI/Argonaute/ Zwille)- Recognition of target MRNA
2.PIWI (p-element induced wimpy Testis)- breaks Phosphodiester bond of mRNA.)RNAse H activity.
MiRNA:
The Double-stranded RNAs are naturally produced in eukaryotic cells during development, and they have a key role in regulating gene expression .
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
This pdf is about the Schizophrenia.
For more details visit on YouTube; @SELF-EXPLANATORY;
https://www.youtube.com/channel/UCAiarMZDNhe1A3Rnpr_WkzA/videos
Thanks...!
Seminar of U.V. Spectroscopy by SAMIR PANDASAMIR PANDA
Spectroscopy is a branch of science dealing the study of interaction of electromagnetic radiation with matter.
Ultraviolet-visible spectroscopy refers to absorption spectroscopy or reflect spectroscopy in the UV-VIS spectral region.
Ultraviolet-visible spectroscopy is an analytical method that can measure the amount of light received by the analyte.
Multi-source connectivity as the driver of solar wind variability in the heli...Sérgio Sacani
The ambient solar wind that flls the heliosphere originates from multiple
sources in the solar corona and is highly structured. It is often described
as high-speed, relatively homogeneous, plasma streams from coronal
holes and slow-speed, highly variable, streams whose source regions are
under debate. A key goal of ESA/NASA’s Solar Orbiter mission is to identify
solar wind sources and understand what drives the complexity seen in the
heliosphere. By combining magnetic feld modelling and spectroscopic
techniques with high-resolution observations and measurements, we show
that the solar wind variability detected in situ by Solar Orbiter in March
2022 is driven by spatio-temporal changes in the magnetic connectivity to
multiple sources in the solar atmosphere. The magnetic feld footpoints
connected to the spacecraft moved from the boundaries of a coronal hole
to one active region (12961) and then across to another region (12957). This
is refected in the in situ measurements, which show the transition from fast
to highly Alfvénic then to slow solar wind that is disrupted by the arrival of
a coronal mass ejection. Our results describe solar wind variability at 0.5 au
but are applicable to near-Earth observatories.
Richard's aventures in two entangled wonderlandsRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
4. Malaria; One of the world’s deadliest vector-
borne diseases
More than 400 different species of Anopheles mosquito and approximately 61 different
anopheline mosquito species have been reported till date to occur in India.
..
6. Current Malaria scenario in INDIA
The World Malaria Report (WMR) 2020 released by WHO
indicates that India has made considerable progress in
reducing its malaria burden.
India is the only high endemic country which has reported a
decline of 17.6% in 2019 as compared to 2018.
The Annual Parasitic Incidence (API) reduced by 27.6%
in 2018 compared to 2017 and by 18.4% in 2019 as compared
to 2018. India has sustained API less than one since year
2012.
India has also contributed to the largest drop in cases region-
wide, from approximately 20 million to about 6
million. The percentage drop in the malaria cases was
71.8% and deaths was 73.9% between 2000 to 2019.
India achieved a reduction of 83.34% in malaria
morbidity and 92% in malaria mortality between the
year 2000 (20,31,790 cases, 932 deaths) and 2019 (3,38,494
cases, 77 deaths).