Cooking reduces antimicrobial residues in meat through degradation. The degree of reduction depends on factors like cooking method, temperature, and drug properties. Tetracyclines generally show high reduction (35-94%) through methods like boiling, roasting and microwaving. β-lactams are unstable at high heat but stable at 65°C. Macrolides and chloramphenicol also degrade with increased temperature and time. Regulations in India establish tolerance limits and withdrawal periods but national surveillance programs are still needed to monitor antimicrobial usage and resistance.
Dr. Randy Singer - The Impact on Public Health of Environmental Contamination...John Blue
"The Impact on Public Health of Environmental Contamination with Antimicrobial Residues - Dr. Randy Singer, University of Minnesota, from the 2012 NIAA One Health Approach to Antimicrobial Resistance and Use Symposium, October 26-27, 2012, Columbus, OH, USA.
More presentations at:
http://www.trufflemedia.com/agmedia/conference/2012-one-health-to-approach-antimicrobial-resistance-and-use"
Coccidiosis is caused by protozoan parasites of the genera Eimeria or Isospora that infect the intestinal tract. It causes damage to the intestinal mucosa and is an important disease affecting poultry and livestock production. Clinical signs include vomiting, diarrhea, weight loss, and decreased egg production. Treatment involves the use of anticoccidial drugs like ionophores, amprolium, sulphonamides, and quinolones. Proper management practices to control environmental contamination with parasite oocysts are also important to control coccidiosis on farms.
Unusual causes of emergence of antimicrobial drug resistanceBhoj Raj Singh
Overuse and misuse of antibiotics have long been believed to fuel antimicrobial resistance (AMR), but new research shows that simply lowering consumption is not enough. Poor sanitation, corruption and low public health spending have a bigger role in pushing up drug-resistant infections in low- and middle-income countries, including India.
Respiratory problems application of vaccinesFaisalakram75
This document discusses respiratory problems in poultry and the application of vaccines. It describes the respiratory system of chickens and lists various non-viral and viral respiratory diseases such as mycoplasmosis, Newcastle disease, infectious bronchitis, and avian influenza. It provides details on the symptoms, transmission, and diagnosis of these diseases. It also discusses the types of vaccines available for bacterial diseases and mycoplasmosis, as well as viral diseases like Newcastle disease and infectious bronchitis.
The document defines various terms related to antibiotics such as antimicrobials, bacteriostatic, bactericidal, and antibiotic resistance. It describes different types of antibiotics like narrow and broad spectrum and discusses minimum inhibitory concentration. It provides historical context on the discovery of penicillin and discusses the classification, mechanisms of action, uses, and development of resistance for penicillins and cephalosporins. [/SUMMARY]
Avian influenza virus vaccines: the use of vaccination in poultry productionHarm Kiezebrink
This document discusses avian influenza virus vaccines. It describes the ideal characteristics of avian influenza vaccines and factors that can limit vaccine protection in the field. Common vaccine types include inactivated whole virus vaccines and attenuated live vaccines, with various limitations discussed. Newer vaccine approaches explored include vector vaccines using viruses like fowlpox virus or infectious laryngotracheitis virus to deliver avian influenza antigens, as well as replication-competent vaccines using these virus vectors. The development of reverse genetics has enabled generation of recombinant attenuated vaccines, though live H5/H7 vaccines still carry risks and limitations.
updated statistics about antimicrobial resistance,causes and mechanism of antimicrobial resistances, national antimicrobial policy, national antimicrobial surveillance, new delhi b metallo-lactamase-1 bacteria
Dr. Randy Singer - The Impact on Public Health of Environmental Contamination...John Blue
"The Impact on Public Health of Environmental Contamination with Antimicrobial Residues - Dr. Randy Singer, University of Minnesota, from the 2012 NIAA One Health Approach to Antimicrobial Resistance and Use Symposium, October 26-27, 2012, Columbus, OH, USA.
More presentations at:
http://www.trufflemedia.com/agmedia/conference/2012-one-health-to-approach-antimicrobial-resistance-and-use"
Coccidiosis is caused by protozoan parasites of the genera Eimeria or Isospora that infect the intestinal tract. It causes damage to the intestinal mucosa and is an important disease affecting poultry and livestock production. Clinical signs include vomiting, diarrhea, weight loss, and decreased egg production. Treatment involves the use of anticoccidial drugs like ionophores, amprolium, sulphonamides, and quinolones. Proper management practices to control environmental contamination with parasite oocysts are also important to control coccidiosis on farms.
Unusual causes of emergence of antimicrobial drug resistanceBhoj Raj Singh
Overuse and misuse of antibiotics have long been believed to fuel antimicrobial resistance (AMR), but new research shows that simply lowering consumption is not enough. Poor sanitation, corruption and low public health spending have a bigger role in pushing up drug-resistant infections in low- and middle-income countries, including India.
Respiratory problems application of vaccinesFaisalakram75
This document discusses respiratory problems in poultry and the application of vaccines. It describes the respiratory system of chickens and lists various non-viral and viral respiratory diseases such as mycoplasmosis, Newcastle disease, infectious bronchitis, and avian influenza. It provides details on the symptoms, transmission, and diagnosis of these diseases. It also discusses the types of vaccines available for bacterial diseases and mycoplasmosis, as well as viral diseases like Newcastle disease and infectious bronchitis.
The document defines various terms related to antibiotics such as antimicrobials, bacteriostatic, bactericidal, and antibiotic resistance. It describes different types of antibiotics like narrow and broad spectrum and discusses minimum inhibitory concentration. It provides historical context on the discovery of penicillin and discusses the classification, mechanisms of action, uses, and development of resistance for penicillins and cephalosporins. [/SUMMARY]
Avian influenza virus vaccines: the use of vaccination in poultry productionHarm Kiezebrink
This document discusses avian influenza virus vaccines. It describes the ideal characteristics of avian influenza vaccines and factors that can limit vaccine protection in the field. Common vaccine types include inactivated whole virus vaccines and attenuated live vaccines, with various limitations discussed. Newer vaccine approaches explored include vector vaccines using viruses like fowlpox virus or infectious laryngotracheitis virus to deliver avian influenza antigens, as well as replication-competent vaccines using these virus vectors. The development of reverse genetics has enabled generation of recombinant attenuated vaccines, though live H5/H7 vaccines still carry risks and limitations.
updated statistics about antimicrobial resistance,causes and mechanism of antimicrobial resistances, national antimicrobial policy, national antimicrobial surveillance, new delhi b metallo-lactamase-1 bacteria
E. coli diagnosis in broiler and layer bird.Abdullah Masud
Hi,this is Abdullah Al Masud's presentation.Microbiological and pathological characteristics of E. coli in birds has shown here. It was made as assignment on my masters work in microbiology.
DNA Gyrase Inhibitors -quinolones and Fluoroquinolones.pptxVijay Salvekar
DNA gyrase inhibitors of synthetic origin. Fluoroquinolones have been the most successful antibacterial agents targeting DNA gyrase. These compounds have been extensively explored and researched to improve spectrum of activity, potency and bacterial resistance.
Wild birds act as a natural reservoir for all influenza A subtypes. There are currently two influenza A subtypes (H1N1 and H3N2) and two influenza B lineages circulating among humans. Neuraminidase inhibitors like oseltamivir are recommended for treating influenza. They work by preventing the virus from being released from infected cells. Early treatment within 48 hours of symptoms provides the greatest benefit in shortening illness duration and reducing complications.
Antifungal Strategies in the Intensive Care UnitsYazan Kherallah
Discuss the different anti-fungal treatment strategies for suspected systemic candidiasis in the intensive care units: prophylaxis, preemptive, empiric and definitive.
Tuberculosis, or TB, is caused by bacteria that usually affect the lungs. It can be spread through the air when someone with active TB coughs or sneezes. There are two types of TB infection - latent TB, where the bacteria remain inactive in the body, and active TB, where the bacteria are causing symptoms and can be transmitted. To prevent the spread of TB, it is important to avoid exposure to those with active infections, get tested if exposed, and begin treatment right away if diagnosed with latent TB.
This document discusses Avian Reo Virus. It begins with an introduction to the virus's discovery and economic impacts, including weight suppression and viral arthritis. It then covers the virus's characteristics such as being non-enveloped with 10 segments of dsRNA. Transmission occurs horizontally through feces or respiratory routes or vertically at low rates. Clinical signs include lameness, joint swelling, and malabsorption syndrome. Treatment is not possible but vaccination of breeders can help reduce problems in progeny.
Toxicology of drugs and pesticides classification,history,mechanism of actio...Muhammad Amir Sohail
Organophosphate pesticides work by overstimulating the nervous system through excess acetylcholine. This can cause symptoms like headaches, convulsions, and potentially coma. Long-term exposure is also linked to reproductive effects like reduced semen quality in men and menstrual issues in women. DDT was widely used as an insecticide but bioaccumulates in animals and causes eggshell thinning, among other issues. Pesticide residues remain on foods and can build up in the body over time.
Clostridium tetani is an anaerobic, spore-forming bacterium found in soil and the intestines of animals that produces a neurotoxin causing the serious disease tetanus. It enters the body through wounds and produces a potent toxin called tetanospasmin that causes painful muscle spasms by blocking inhibitory motor nerve signals in the central nervous system. Symptoms include lockjaw, arched back, and risus sardonicus. Treatment involves wound cleaning, antibiotics, tetanus antitoxin, and vaccination to stimulate protective antibodies against the toxin.
This document provides information on Brucella, the causative agent of brucellosis. It discusses the classification of Brucella as an alpha Proteobacteria. The main Brucella species that infect humans are B. melitensis, B. abortus, and B. suis, which are transmitted through contact with infected animals. The document outlines the morphology, culture characteristics, pathogenicity, diagnosis, treatment and prevention of Brucella infections. Brucellosis is a widespread zoonotic disease that can cause acute or chronic infections in humans.
Comparative antimicrobial activity of aspirin, paracetamol, flunixin meglumin...Bhoj Raj Singh
• Some of the tested drugs (NSAIDs including aspirin, diclofenac, meloxicam & flunixin meglumine) possess broad-spectrum antimicrobial activity but not in therapeutically achievable non-toxic concentrations in the body. Paracetamol was the least effective as antimicrobial similar to pheniramine maleate.
• A few of the NSAIDs may be evaluated as topical use antimicrobials (aspirin, diclofenac & flunixin) being microbial growth inhibitors at 0.128% concentration, similar levels of antimicrobial drugs including antibiotics are often used in topical antiseptic preparations (gels/ ointments/creams/powders/ lotions).
• Studies should be conducted on synergism/ antagonism of NSAIDs with commonly used antibiotics and herbal antimicrobials so that antimicrobial potential of NSAIDs can be therapeutically utilized.
• Susceptibility of bacteria to NSAIDs may be an aid in the differentiation of a few bacteria like Klebsiella and Raoultella; Enterococcus and Streptococcus (meloxicam); Bacillus and Paenibacillus (Diclofenac). However, multicentric studies on a greater number of strains are essential to establish the difference.
Bordetella is a genus of Gram-negative bacteria that includes three human pathogens: B. pertussis, B. parapertussis, and B. bronchiseptica. B. pertussis causes pertussis (whooping cough) in humans. The bacteria are small, aerobic, non-fermentative, and fastidious. They produce several virulence factors like pertussis toxin and filamentous hemagglutinin that contribute to pathogenesis. Pertussis has an incubation period of 1-2 weeks and presents as a catarrhal stage followed by paroxysmal coughing spells characterized by a "whoop". It is highly contagious and vaccine-preventable
At the four front of flu vaccination - Quadrivalent Flu Vaccination in India ...Gaurav Gupta
Is flu vaccination needed in India? Is there any benefits of Quadrivalent Flu vaccination over Trivalent Flu vaccination? Any safety & efficacy data about Vaxiflu 4 by Zydus Vaccines. All discussed in a Presentation in Panchkula, in September 2019
This document discusses avian parasitic diseases. It begins by outlining the economic importance of parasitic diseases in poultry, noting they can cause direct disease, transmit other pathogens, decrease production, and stunt growth. It then examines factors affecting incidence such as breed, age, season, nutrition, housing system, and management practices. The document categorizes parasitic diseases and describes various nematodes, cestodes, trematodes, protozoa, ectoparasites, and their lifecycles, transmission methods, clinical signs, treatment and more. In closing, it provides detailed information on several common parasitic infections in poultry.
Vaccination failures in poultry can be caused by many factors beyond just vaccine quality. The bird's immune system, including maternal antibodies and stress, influence the effectiveness of vaccination. Proper handling, storage, and administration of vaccines according to the vaccination program are also critical. Other issues like disease challenges, poor management, and immunosuppression can reduce vaccine protection. To prevent failures, it is important to maintain the cold chain, vaccinate only healthy birds, and implement good hygiene and biosecurity practices.
This document discusses Mycoplasma gallisepticum infection in poultry farms. Some key points:
- M. gallisepticum is a highly successful pathogen that causes chronic respiratory disease in chickens and turkeys. Once infected, the infection remains for life.
- It is transmitted both horizontally between flocks through contact/aerosols and vertically from parent to offspring through eggs.
- Clinical signs include coughing, sneezing, and reduced egg production. Post-mortem lesions include sinusitis, tracheitis, and airsacculitis.
- Diagnosis involves isolation of the bacteria or serological tests like ELISA. Treatment includes antibiotics like tetracyclines and tylos
This document discusses prevention of coccidia in poultry. It begins with an outline of the topics to be covered, which include the coccidia life cycle, anticoccidial drugs and their use, classification of anticoccidial drugs, resistance to anticoccidials, and overcoming resistance. It then provides details on the coccidia life cycle, anticoccidial use for prophylaxis, common anticoccidial drugs and their mechanisms of action, classification of drugs into ionophores and chemicals, examples of specific drugs, and issues of resistance. The document focuses on anticoccidial drugs used in poultry production to control coccidiosis.
Foot and mouth disease preventive and epidemiological aspectsBhoj Raj Singh
FMD: Menace in India
Discusses problems of FMD Control in India like:
Lack of faith in farmers and veterinarians that FMD can be controlled with vaccination (due to repeated failure of vaccines in quality and vaccination failures resulting in FMD outbreaks).
Lack of infrastructure facilities for maintaining the cold chain and efficient transport to the vaccination site.
Lack of human resources for handling/ vaccinating livestock.
Needs for further researches on diagnosis (Pen-side), disinfection, vaccines and vaccination (affording at least a year immunity, quality vaccine etc.) and control strategies.
No-timely investigation or excessively delayed investigation of FMD outbreaks especially those occurring after vaccination.
Transparency in vaccine quality monitoring and vaccine purchases.
Fear in veterinarians for reporting FMD in their area of operation.
False statistics of the disease and vaccination.
No legal punitive action against suppliers of substandard FMD vaccines even after the supply of multiple substandard batches of vaccine.
Foot and mouth disease: An Indian perspectiveBhoj Raj Singh
FMD is an economically important disease of cloven-footed animals. It causes an estimated loss of Rs. 20-22 thousand crores per year to livestock owners in India. To control the disease, DAHDF of India launched a National FMD Control Program (FMD-CP) in 2003 with an outlay of about Rs. 500 crores a year by Central Government and each state government also invested an equally good amount of money. The program is ongoing all over India. However, results are humiliating and harassing. We are almost at the same spot from where we started 15 years back in 2003.
El documento repite la palabra "HOME" y las frases "Kembali ke soal 1-2", "Kembali ke soal 3-5", "Kembali ke soal 6-8" y "Kembali ke soal 9-10" varias veces sin otra información relevante.
Zummi and his friends travel across a high bridge that Zummi is afraid of, carrying him when he is too scared to move. They enter Duke Iggy's land where there are ogres, finding a locked big door that they hope to open with Zummi's magic spell or their Gummi medal, though it is dark and they need light.
E. coli diagnosis in broiler and layer bird.Abdullah Masud
Hi,this is Abdullah Al Masud's presentation.Microbiological and pathological characteristics of E. coli in birds has shown here. It was made as assignment on my masters work in microbiology.
DNA Gyrase Inhibitors -quinolones and Fluoroquinolones.pptxVijay Salvekar
DNA gyrase inhibitors of synthetic origin. Fluoroquinolones have been the most successful antibacterial agents targeting DNA gyrase. These compounds have been extensively explored and researched to improve spectrum of activity, potency and bacterial resistance.
Wild birds act as a natural reservoir for all influenza A subtypes. There are currently two influenza A subtypes (H1N1 and H3N2) and two influenza B lineages circulating among humans. Neuraminidase inhibitors like oseltamivir are recommended for treating influenza. They work by preventing the virus from being released from infected cells. Early treatment within 48 hours of symptoms provides the greatest benefit in shortening illness duration and reducing complications.
Antifungal Strategies in the Intensive Care UnitsYazan Kherallah
Discuss the different anti-fungal treatment strategies for suspected systemic candidiasis in the intensive care units: prophylaxis, preemptive, empiric and definitive.
Tuberculosis, or TB, is caused by bacteria that usually affect the lungs. It can be spread through the air when someone with active TB coughs or sneezes. There are two types of TB infection - latent TB, where the bacteria remain inactive in the body, and active TB, where the bacteria are causing symptoms and can be transmitted. To prevent the spread of TB, it is important to avoid exposure to those with active infections, get tested if exposed, and begin treatment right away if diagnosed with latent TB.
This document discusses Avian Reo Virus. It begins with an introduction to the virus's discovery and economic impacts, including weight suppression and viral arthritis. It then covers the virus's characteristics such as being non-enveloped with 10 segments of dsRNA. Transmission occurs horizontally through feces or respiratory routes or vertically at low rates. Clinical signs include lameness, joint swelling, and malabsorption syndrome. Treatment is not possible but vaccination of breeders can help reduce problems in progeny.
Toxicology of drugs and pesticides classification,history,mechanism of actio...Muhammad Amir Sohail
Organophosphate pesticides work by overstimulating the nervous system through excess acetylcholine. This can cause symptoms like headaches, convulsions, and potentially coma. Long-term exposure is also linked to reproductive effects like reduced semen quality in men and menstrual issues in women. DDT was widely used as an insecticide but bioaccumulates in animals and causes eggshell thinning, among other issues. Pesticide residues remain on foods and can build up in the body over time.
Clostridium tetani is an anaerobic, spore-forming bacterium found in soil and the intestines of animals that produces a neurotoxin causing the serious disease tetanus. It enters the body through wounds and produces a potent toxin called tetanospasmin that causes painful muscle spasms by blocking inhibitory motor nerve signals in the central nervous system. Symptoms include lockjaw, arched back, and risus sardonicus. Treatment involves wound cleaning, antibiotics, tetanus antitoxin, and vaccination to stimulate protective antibodies against the toxin.
This document provides information on Brucella, the causative agent of brucellosis. It discusses the classification of Brucella as an alpha Proteobacteria. The main Brucella species that infect humans are B. melitensis, B. abortus, and B. suis, which are transmitted through contact with infected animals. The document outlines the morphology, culture characteristics, pathogenicity, diagnosis, treatment and prevention of Brucella infections. Brucellosis is a widespread zoonotic disease that can cause acute or chronic infections in humans.
Comparative antimicrobial activity of aspirin, paracetamol, flunixin meglumin...Bhoj Raj Singh
• Some of the tested drugs (NSAIDs including aspirin, diclofenac, meloxicam & flunixin meglumine) possess broad-spectrum antimicrobial activity but not in therapeutically achievable non-toxic concentrations in the body. Paracetamol was the least effective as antimicrobial similar to pheniramine maleate.
• A few of the NSAIDs may be evaluated as topical use antimicrobials (aspirin, diclofenac & flunixin) being microbial growth inhibitors at 0.128% concentration, similar levels of antimicrobial drugs including antibiotics are often used in topical antiseptic preparations (gels/ ointments/creams/powders/ lotions).
• Studies should be conducted on synergism/ antagonism of NSAIDs with commonly used antibiotics and herbal antimicrobials so that antimicrobial potential of NSAIDs can be therapeutically utilized.
• Susceptibility of bacteria to NSAIDs may be an aid in the differentiation of a few bacteria like Klebsiella and Raoultella; Enterococcus and Streptococcus (meloxicam); Bacillus and Paenibacillus (Diclofenac). However, multicentric studies on a greater number of strains are essential to establish the difference.
Bordetella is a genus of Gram-negative bacteria that includes three human pathogens: B. pertussis, B. parapertussis, and B. bronchiseptica. B. pertussis causes pertussis (whooping cough) in humans. The bacteria are small, aerobic, non-fermentative, and fastidious. They produce several virulence factors like pertussis toxin and filamentous hemagglutinin that contribute to pathogenesis. Pertussis has an incubation period of 1-2 weeks and presents as a catarrhal stage followed by paroxysmal coughing spells characterized by a "whoop". It is highly contagious and vaccine-preventable
At the four front of flu vaccination - Quadrivalent Flu Vaccination in India ...Gaurav Gupta
Is flu vaccination needed in India? Is there any benefits of Quadrivalent Flu vaccination over Trivalent Flu vaccination? Any safety & efficacy data about Vaxiflu 4 by Zydus Vaccines. All discussed in a Presentation in Panchkula, in September 2019
This document discusses avian parasitic diseases. It begins by outlining the economic importance of parasitic diseases in poultry, noting they can cause direct disease, transmit other pathogens, decrease production, and stunt growth. It then examines factors affecting incidence such as breed, age, season, nutrition, housing system, and management practices. The document categorizes parasitic diseases and describes various nematodes, cestodes, trematodes, protozoa, ectoparasites, and their lifecycles, transmission methods, clinical signs, treatment and more. In closing, it provides detailed information on several common parasitic infections in poultry.
Vaccination failures in poultry can be caused by many factors beyond just vaccine quality. The bird's immune system, including maternal antibodies and stress, influence the effectiveness of vaccination. Proper handling, storage, and administration of vaccines according to the vaccination program are also critical. Other issues like disease challenges, poor management, and immunosuppression can reduce vaccine protection. To prevent failures, it is important to maintain the cold chain, vaccinate only healthy birds, and implement good hygiene and biosecurity practices.
This document discusses Mycoplasma gallisepticum infection in poultry farms. Some key points:
- M. gallisepticum is a highly successful pathogen that causes chronic respiratory disease in chickens and turkeys. Once infected, the infection remains for life.
- It is transmitted both horizontally between flocks through contact/aerosols and vertically from parent to offspring through eggs.
- Clinical signs include coughing, sneezing, and reduced egg production. Post-mortem lesions include sinusitis, tracheitis, and airsacculitis.
- Diagnosis involves isolation of the bacteria or serological tests like ELISA. Treatment includes antibiotics like tetracyclines and tylos
This document discusses prevention of coccidia in poultry. It begins with an outline of the topics to be covered, which include the coccidia life cycle, anticoccidial drugs and their use, classification of anticoccidial drugs, resistance to anticoccidials, and overcoming resistance. It then provides details on the coccidia life cycle, anticoccidial use for prophylaxis, common anticoccidial drugs and their mechanisms of action, classification of drugs into ionophores and chemicals, examples of specific drugs, and issues of resistance. The document focuses on anticoccidial drugs used in poultry production to control coccidiosis.
Foot and mouth disease preventive and epidemiological aspectsBhoj Raj Singh
FMD: Menace in India
Discusses problems of FMD Control in India like:
Lack of faith in farmers and veterinarians that FMD can be controlled with vaccination (due to repeated failure of vaccines in quality and vaccination failures resulting in FMD outbreaks).
Lack of infrastructure facilities for maintaining the cold chain and efficient transport to the vaccination site.
Lack of human resources for handling/ vaccinating livestock.
Needs for further researches on diagnosis (Pen-side), disinfection, vaccines and vaccination (affording at least a year immunity, quality vaccine etc.) and control strategies.
No-timely investigation or excessively delayed investigation of FMD outbreaks especially those occurring after vaccination.
Transparency in vaccine quality monitoring and vaccine purchases.
Fear in veterinarians for reporting FMD in their area of operation.
False statistics of the disease and vaccination.
No legal punitive action against suppliers of substandard FMD vaccines even after the supply of multiple substandard batches of vaccine.
Foot and mouth disease: An Indian perspectiveBhoj Raj Singh
FMD is an economically important disease of cloven-footed animals. It causes an estimated loss of Rs. 20-22 thousand crores per year to livestock owners in India. To control the disease, DAHDF of India launched a National FMD Control Program (FMD-CP) in 2003 with an outlay of about Rs. 500 crores a year by Central Government and each state government also invested an equally good amount of money. The program is ongoing all over India. However, results are humiliating and harassing. We are almost at the same spot from where we started 15 years back in 2003.
El documento repite la palabra "HOME" y las frases "Kembali ke soal 1-2", "Kembali ke soal 3-5", "Kembali ke soal 6-8" y "Kembali ke soal 9-10" varias veces sin otra información relevante.
Zummi and his friends travel across a high bridge that Zummi is afraid of, carrying him when he is too scared to move. They enter Duke Iggy's land where there are ogres, finding a locked big door that they hope to open with Zummi's magic spell or their Gummi medal, though it is dark and they need light.
Zummi practices a magic spell that allows him to light a candle on fire. Cavin compliments Zummi and they decide to show the others. However, Grammi is angry because Tummi was not helping as he should have been, which led to them running out of water. Gruffi says he can fix the problem and gets shovels to take everyone to the water station.
This document appears to be a list of Indonesian terms related to education including subject knowledge and development indicators, course materials, and evaluation. It contains repetition of the word "HOME" multiple times at the end with no other context provided.
Dokumen tersebut memberikan informasi tentang materi pengenalan perangkat keras dan sistem yang digunakan dalam program presentasi PowerPoint 2007. Dokumen tersebut menjelaskan langkah-langkah dasar dalam membuat presentasi baru, mengatur layout slide, mengganti tema, menambahkan dan mengatur teks, serta menyisipkan gambar dan clip art. Dokumen tersebut juga berisi soal latihan dan kunci jawaban yang terkait dengan materi pengenalan fitur-fitur dasar Power
The document discusses containerizing MPI workloads using Docker and QNIBTerminal. It provides an overview of Docker, describes the QNIBTerminal testbed which runs an HPCG benchmark on multiple Linux distributions within Docker containers, and presents results showing a low performance overhead for containerized workloads compared to bare metal. Future work is discussed around optimizing containers for HPC and benchmarking real-world applications.
QNIBTerminal: Understand your datacenter by overlaying multiple information l...QNIB Solutions
Today's data center managers are burdened by a lack of aligned information of multiple layers. Work-flow events like 'job starts' aligned with performance metrics and events extracted from log facilities are low-hanging fruit that is on the edge to become use-able due to open-source software like Graphite, StatsD, logstash and alike.
This talk aims to show off the benefits of merging multiple layers of information within an InfiniBand cluster by using use-cases for level 1/2/3 personnel.
Este documento establece los procedimientos administrativos para obtener derechos de uso de agua en Perú. Describe los tipos de procedimientos como la obtención de licencias de agua superficial y subterránea, así como permisos y autorizaciones. Explica los requisitos para iniciar cada procedimiento, incluyendo la solicitud, anexos, publicaciones y opiniones requeridas de otras entidades. El objetivo es regular de manera uniforme el otorgamiento de derechos de uso de agua en el país.
The Gummi bears help their friend Cavin who is in trouble. They make a plan using Zummi's magic which works but Gruffi becomes invisible and is caught by an ogre. Cavin drinks Gummi berry juice which makes him strong enough to lift the ogre. Duke Iggy then steals and drinks the juice, becoming strong too. The Gummis try to stop Iggy's catapult from launching as it moves but Cavin is stuck on it. It crashes but Cavin survives, and the King and Princess thank the Gummis for saving the day.
Meat in Human Diet: Balance between nutrition and health
Limitations of prospective cohort studies and epidemiological studies and with respect to less meat affluent countries
Preservation of Meat Using High Pressure Processingnavi04vet
This document discusses the use of high pressure processing (HPP) to preserve meat. It begins with an introduction to food preservation methods and a brief history of HPP. The working principles of HPP are then explained. The document outlines various effects of HPP on physico-chemical properties of meat including tenderization, water retention, microbial inactivation, and oxidation. It provides examples of HPP applications for different meat products and major HPP industries worldwide. In conclusion, HPP is presented as a promising preservation method that extends shelf life without compromising nutrition, though it can impact color and enhance oxidation requiring added antioxidants.
Benefits of forage systems on product quality: mechanisms and implications - ...Sustainable Food Trust
Kevin J Shingfield's presentation from the Sustainable Food Trust's meeting: What role for grazing livestock in a world of climate change and diet-related disease?
The rising global human population and the improving general human welfare standards comes with an increasing demand for animal proteins. According to an outlook report by the Organisation for Economic Co-operation and Development (OECD) and the Food and Agriculture Organisation of the United Nations (FAO), the poultry meat production will grow over the next 10 years at around 2.3 percent annually to around 134.5 million tonnes of meat making it the largest meat sector from 2020 onwards.
High Pressure Processing for Preservation of Meatnavi04vet
This document outlines the use of high pressure processing (HPP) to preserve meat. It discusses the history, working principles, and effects of HPP on various physico-chemical properties of meat. HPP can tenderize meat, improve water retention and cooking yield, and significantly reduce microbial levels. While it maintains sensory and nutritional quality, HPP may accelerate oxidation at higher pressures. The document reviews applications of HPP for different meat products and major HPP industries globally and in India.
The Effects of Different Levels Aqueous Extract of Fenugreek (Trigonella foen...Ali Olfati
This study examined the effects of different levels of fenugreek extract in drinking water on performance and immune response in laying hens. 240 laying hens were given 0, 5, 10, or 15 ml/L of fenugreek extract in their water for 6 weeks. Higher levels of fenugreek extract improved egg production, egg mass, and feed conversion ratio. The 15 ml/L treatment significantly increased performance over other treatments. Fenugreek extract also enhanced immune response, with the highest antibody titer seen in hens given 15 ml/L. In conclusion, fenugreek extract supplementation of laying hen drinking water effectively improved both production performance and immune system functioning.
This study evaluated the effects of graded levels of the dietary probiotic Hydroyeast Aquaculture on growth performance of adult Nile tilapia (Oreochromis niloticus). Fish were fed diets containing 0, 5, 10 or 15 g of probiotic per kg of feed. Results showed that supplemental probiotic significantly improved final weight, weight gain, daily gain, and growth rates in both male and female fish in a dose-dependent manner compared to the control group. The highest growth performance was observed in fish fed 10 g or 15 g of probiotic per kg of diet. The study suggests that dietary probiotic can be used to enhance growth of adult tilapia.
Antibiotic-free broiler meet production in indiaMilindNande2
This document discusses sustainable antibiotic-free broiler meat production. It begins with a history of antibiotic use in poultry farming and the development of antibiotic resistance. Regulations in India regarding antibiotic use are outlined. Alternatives to antibiotic growth promoters that could be used include probiotics, prebiotics, organic acids, enzymes, and phytogenic feed additives. These alternatives can improve growth performance, gut health, and immune function. While consumer demand exists for antibiotic-free meat, producing it profitably remains challenging. Strict regulations and awareness programs are needed to combat antibiotic resistance and facilitate a transition to sustainable antibiotic-free broiler production.
3. Antibiotic Concerns Prompt a Different Approach by Dr. Sirish NigamInayath Ulla Khan
Antibiotic concerns have prompted a different approach to animal feeding in Europe. The use of antibiotics as growth promoters was banned in the EU in 2006 due to concerns about antibiotic resistance. This has led to increased focus on non-antibiotic alternatives like improving feed quality, adding enzymes, probiotics, prebiotics, organic acids, and secondary plant compounds. Feeding fermentable fibers through processes like LTCL that modify starch and structural carbohydrates can support gut health and performance in broilers without the use of antibiotics.
Presentation for first doctoral seminar on Advances in poultry nutrition.pptxPallaviMali14
Due to ban on use of antibiotics, introduction of probiotics/ prebiotics
/synbiotic (combination of pro-prebiotic) / organic
acids in poultry nutrition as replacement for
antibiotics.
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Let’s start with the segment. What will be your marketing and brand positioning? It depends on what menu items you serve. What type of cooking methods and equipment will you use? GUEST EXPERIENCE = FACILITY (Space) DESIGN + MENU + SERVPOINTS™
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Effective food packaging provides number of purposes. It functions as a container to hold and transport the food product, as well as a barrier to protect the food from outside contamination such as water, light, odours, bacteria, dust, and mechanical damage by maintaining the food quality. The package may also include barriers to keep the product's moisture content or gas composition consistent. Furthermore, convenience is vital role in packaging, and the desire for quick opening, dispensing, and resealing packages that maintain product quality until fully consumed is increasing. To facilitate trading, encourage sales, and inform on content and nutritional attributes, the packaging must be communicative. For storage of food there is huge scope for modified atmosphere packaging, intelligent packaging, active packaging, and controlled atmosphere packaging. Active packaging has a variety of uses, including carbon dioxide absorbers and emitters, oxygen scavengers, antimicrobials, and moisture control agents. Smart packaging is another term for intelligent packaging. Edible packaging, self-cooling and self-heating packaging, micro packaging, and water-soluble packaging are some of the advancements in package material.
NANOTECHNOLOGY IN FOOD PACKAGING (FOOD TECHNOLOGY)
Credit sem ppt
1. 6 July 2015
Effect of cooking on antimicrobial residues
in meat and meat products
Major Advisor
Dr.V.N.Vasudevan
Assistant Professor
Department of Livestock Products
Technology
Prajwal. S (14-MVM-49)
Excellence in Meat Science
College of veterinary and Animal Sciences, Mannuthy
2. Outline
oIntroduction
oUses of antimicrobials
oCauses for occurrence and Impact on human health
oHeat stability of antimicrobials
oStability of antimicrobials during cooking
oRegulations and laws on antimicrobial residues in India
oFuture perspectives and Conclusion
6 July 2015 1
3. Introduction
Antimicrobial drugs
oNaturally occurring, semi-synthetic or synthetic compounds with
antimicrobial activity
oAdministered orally, parenterally or topically
oUsed to treat prevent disease of human and veterinary medicine,
and growth promotion (Barton, 2000)
oPotential for antimicrobial resistant bacteria to spread from
treated animals via the food chain (Swann, 1969)
6 July 2015 2
4. Use of antimicrobials in food animals and
poultry
oTherapy/Treatment
oPrevention/Prophylaxis
oGrowth promotion
6 July 2015 3
5. Causes for occurrence of antimicrobial residues
oPoor treatment records
oFailure to identify treated animals
oLack of advice on withdrawal periods by veterinarians
oOff label use of antimicrobials
oAvailability of antimicrobials to lay men
oLack of enforcement of laws to use antimicrobials
oLack of consumer awareness
(CAC, 2001)
6 July 2015 4
6. Impact of antimicrobial residue on human
oIncreased microbial resistance (Butaye et al., 2001)
oResistant strains can cause failure of antimicrobial therapy in
clinical situations (Nisha, 2008)
6 July 2015 5
7. Impact of antimicrobial residue on human
cont’d…
Antimicrobial Pathological effects
Sulphamethazine, Oxytetracycline
and Furazolidone
Immuno-pathological effects,
Autoimmunity, Carcinogenicity
Gentamicin Mutagenicity, Nephropathy
Chloramphenicol Hepatotoxicity, Reproductive
disorders, Bone marrow toxicity
Penicillin Allergy
(Nisha, 2008; Demoly and Romano, 2005)
6 July 2015 6
8. Heat stability of antimicrobial drugs
o Different heat stabilities depending on different types of matrices
and heating treatments involved (Rose et al., 1996)
6 July 2015 7
Heat stable Heat liable Partially heat liable
Sulfamethazine, Oxacillin,
Chloramphenicol,
Aminoglycosides,
Quinolones, Clindamycin
and Trimethoprim
Oxytetracycline and
Erythromycin
Penicillin G, Ampicillin and
Amoxycillin
9. Stability of antimicrobial drugs during cooking
oResidues of veterinary antimicrobials show varying degrees of
stability during cooking
oCooking influences the level of risk exposed to consumers
(Rose et al., 1999)
Factors affecting degradation of antimicrobial drugs
oDrug formulation and Pharmacodynamics
oCooking temperature and time
oShape and thickness of cooked tissues (O'Brien et al., 1981)
6 July 2015 8
10. Stability of tetracyclines
oCooking processes such as mocrowaving, boiling, roasting,
grilling, braising and frying bring about 35-94% reduction in
tetracycline residues in beef, mutton and cow liver (Rose et al., 1996)
oCuring of meat with sodium nitrate which has synergic effect
with cooking is facilitating the reduction of oxytetracyclin residue
(Fedeniuk et al., 1997)
oWithin the tetracycline group, doxycycline is heat stable and
oxytetracycline is heat labile (Abou-Raya et al., 2013)
6 July 2015 9
11. Stability of tetracyclines cont’d…
o90% reduction of tetracyclines in leg piece and breast of chicken
by microwave cooking for 23.9 min, boiling for 53.2 min and
roasting for 101.6 minute (Abou-Raya et al., 2013)
oDuring cooking tetracyclines degrade to anhydrotetracycline and
4-epianhydrotetracycline. Toxic effects of such metabolites on the
consumers not studied (Kuhne et al., 2011)
6 July 2015 10
12. Tetracycline reduction in pork
0
10
20
30
40
50
60
Boiling 100°C(9 m) Deepfrying140°C(9m) Microwaving (1m)
6 July 2015 11
45-67%
38-66%
38-48%
Tetracyclinereduction%
(VanHue Nguyen et al., 2013)
13. Stability of β- lactam group of antimicrobials
o Benzyl penicillin was not stable to cooking, losses being
proportional to the harshness of the cooking regime
oBenzyl penicillin was stable at 650C but not stable at higher
temperatures
(Rose et al., 1997)
6 July 2015 12
14. Stability of β- lactam group of antimicrobials
cont’d…
oDuring cooking residues leach out into fluids
oDiscarding the juice can reduce exposure to residues of benzyl
penicillin
oPotential threat in the Indian custom of cooking meat (meat with
gravy or stewing)
(Rose et al., 1997)
6 July 2015 13
15. Stability of macrolides
oHigher reduction in tylosin and tilmicosin residues with increased
time and temperature during boiling and microwave cooking of
chicken
oReduction in tylosin residues during deep frying increased with
temperature, time and size of the meat sample
(Heshmati et al., 2015)
6 July 2015 14
16. Stability of amphenicols
oEmulsifying and curing of meat partially degrade
chloramphenicol and total degradation by pre-heat treatment
during canning
(Epstein et al., 1988)
6 July 2015 15
18. Stability of nitrofurazone
oNitrofurans are metabolized rapidly by animals in vivo
(McCracken et al., 1995)
oMetabolites are bound to tissues which may be released by mild
acid hydrolysis and used as marker detection residues
oFurazolidone degrade to 3-amino-2-oxazolidinone
oFuraltadone degrade to 3-amino-5-morpholinomethyl-2-
oxazolidone
oNitrofurazone degrade to semicarbazide (Hoogenboom et al., 1991)
6 July 2015 17
19. Stability of nitrofurazone cont’d…
o67-100% nitrofurazone remains during frying, grilling, roasting
and microwaving of pork and liver of pig
(Cooper and Kennedy, 2007)
6 July 2015 18
20. Stability of quinolone
oCooking mixture of meat, liver and kidney at 134 °C for 20 min,
68% of enroflaxocin was reduced (Van Egmond et al., 2000)
Heat stable quinolones in fish
oOxolinic acid
oFlumequinein
oEnrofloxacin
oCiprofloxacin
oNot degraded by any cooking methods(Botsoglou and Fletouris, 2001)
6 July 2015 19
21. Stability of quinolone cont’d…
oCooking of chicken leg piece and breast results in reduction of
enrofloxacin residues and release of residues to cook out fluid
oResidues levels were almost unaltered in roasting, grilling and
microwaving (Lolo et al., 2006)
oCooking and roasting of chicken, gizzard, liver show reduction of
enrofloxacin residue (Javedi et al., 2009)
6 July 2015 20
23. Stability of sulfanamides cont’d…
Reduction of sulfonamide residue in chicken meat during frying
was influenced by
Internal temperature of meat ball
Size of meat ball
oSulfamonomethoxine (SMX)
oSulfadiazine (SDZ)
oSulfaquinoxaline (SQ)
oSulfamethoxazole (SMZ)
6 July 2015 22
24. Sulfonamide in chicken meat ball
0
5
10
15
20
25
30
35
40
45
SMX SDZ SQ SMZ
reduce during fryingSulfonamidereduction(%)
6 July 2015 23
25. Regulations and laws for antimicrobial
residues in India
oTolerance limit for antimicrobials and other pharmacologically
active substances has been established only for sea foods
oContainer of medicines used in food animals and poultry should
be labeled with the withdrawal period for the species on which it
is intended to be used
oIf specific withdrawal period not mentioned, a period not less
than 28 days should be practiced
(FSSAI, 2011)
6 July 2015 24
27. Withdrawal period for commonly used
antimicrobials
Antimicrobials Pre-slaughter withdrawal time(days)
Ampicillin 06
Procaine penicillin G 05
Dihydro streptomycin sulfate 30
Erythromycin 14
Oxytetrcycline Hydrochloride 03
Sulfadimethoxime 07
Sulfamethoxy Pyridazine 16
Sulfamethazine 10
Tylosin 08
6 July 2015 26
28. Regulations and laws for antimicrobials
residues in India cont’d…
oExport Inspection Council of India (EIC) has Residue Monitoring
Plan (RMP) for export of poultry meat and meat products to
European Union (EU)
oEIC has adopted the EU council directive regulations and
Maximum residue limit (MRL) for different antibiotics
oEIC has not set any RMP for sale of poultry meat and meat
products in India
(EIC, 2012)
6 July 2015 27
29. Future perspectives
oNeed to study toxicologic effects of antimicrobial metabolites in
the human being
oEstablish national surveillance programme of antimicrobial usage
on the food animals and poultry
oEstablish surveillance programme on antimicrobial resistance in
bacteria
6 July 2015 28
30. Future perspectives cont’d…
oSensitivity and resistance by veterinary antimicrobials have to be
study
oEstablish universally accepted standards for the maximum
antimicrobial residues in animal tissues
oDevelopment of simple and economic field test to identify drug
residue in edible animal products
6 July 2015 29
31. Conclusion
oCombination of time and temperature of cooking influence loss
of antimicrobial residue
oTetracycline’s show notable decrease in their amount
oNitrofurzone is most heat stable compound
oDiscarding any juices it can reduce exposure to residues
6 July 2015 30
32. Conclusion cont’d…
oNeed to study toxicologic effects of antimicrobial metabolites in
the human being
oWithdrawal periods should be strictly followed
oStrictly enforce rules pertaining to antimicrobial residue
6 July 2015 31
33. References
oAbou-Raya, S., Shalaby, A.R., Salamal, N.A., Emam, W.H. and Mehaya, F.M. 2013. Effect
of ordinary cooking procedures on tetracycline residues in chicken meat. J. Food Drug
Analysis. 21: 80-86.
oAnon, 2002. USFDA improvises testing for chloramphenicol in seafood. Seafood Export
J. 10: 5.
oBarton, M.D. 2000. Antibacterial use in animal feed and its impact on human health.
Nutr. Res. Rev. 13: 279-299.
oButaye, P., Devriese, L. A. and Haesebrouck, F. 2001. Differences in antibacterial
resistance patterns of Enterococcus faecalis and Enterococcus faecium strains isolated
from farm and pet animals. Antimicrob. Agents Chemther. 45: 1374-1378.
6 July 2015 32
34. References cont’d…
oCAC. 2001. Codex Alimentarius Commission. Committee on residues of veterinary drugs
in foods, document control of veterinary drug residues in milk and milk products. Joint
Food and Agriculture Organization of the United Nations/World Health Organization
Food Standards Programme, Rome
oEIC. 2012. Export inspection council of India. 2012. Ministry of Commerce. Govt.
ofIndia.Avialable:http://www.eicindia.gov.in/services/PreCompliance/ResidueMonitori
ng Plans.aspx [6 June 2015].
oEpstein, R.L., Randecker, V., Corrao, P., Keeton, J.T., and Cross H.R. 1988. Influence of
heat and cure preservatives on residues of sulfamethazine, chloramphenicol, and
cyromazine in muscle tissue. J. Agri. Food Chem. 36: 1009-1012.
6 July 2015 33
35. References cont’d…
oFAO/WHO. 2002. Evaluation of certain veterinary drug residues in food: fifty eighth
report of the Joint FAO/WHO Expert Committee on Food Additives, WHO technical
report series, No. 911. FAO, Rome, pp. 33.
oFedeniuk R.W., Shand P.J. and Mccurdy A.R. 1997. Effect of thermal processing and
additives on the kinetics of oxytetracycline degradation in pork muscle. J. Agri. Food
Chem. 45: 2252-2257.
oFSSAI. 2011. Food Safety Standards (Contaminants, Toxins and Residues) Regulations.
2011. Ministry of Health and Family Welfare. Govt of India. Available:
http://www.fssai.gov.in/Food safety and standards contaminants, toxins and residues
regulation. 2011.[6 June 2015]
6 July 2015 34
36. References cont’d…
oSettepani, J.A. 1984. The hazard of using chloramphenicol in food animals. J. Am. Vet.
Med. Ass. 184: 30-39.
oShakila, R.J., Vyla, S.A.P., Saravana, K.R., Jeyasekaran, G and Indra, J.G. 2006. Stability of
chloramphenicol residues in shrimp subjected to heat processing treatments. Food Micro.
23: 47-51.
oSmit, L.A., Hoogenboom, L.A.P., Berghmans, M.C., Haagsma, N. 1994. Stability of
sulfadimidine during raw fermented sausage preparation. Zeitschrift fir Lebensmittel-
Untersuchung und- Forschung. [online] 198: 480-485.
Available:http://www.researchgate.net/publication/225601494. [6 June.2015]
6 July 2015 35
37. 6 July 2015 36
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