This document discusses craniospinal irradiation (CSI) techniques. It defines CSI as radiation delivered to the entire cranial-spinal axis. The document outlines the indications for CSI including various types of brain tumors. It then discusses the challenges of CSI due to the large irregular target volume and proximity to critical structures. The document focuses on the 3D conformal technique in supine position used at the author's department. It describes patient positioning, immobilization, simulation, target and organ at risk delineation, and treatment planning. Complications of CSI and the role of chemotherapy are also reviewed. Alternative CSI techniques like IMRT and proton therapy are mentioned but have limitations. Dosimetric studies find modern
This presentation is intended to refer while doing planning of SBRT Prostate for all practical aspects from Simulation - contouring - planning - treatment. I am sure it will be very useful presentation for any radiation oncologist who are willing to start workflow of SBRT Prostate in the department of radiation oncology
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This presentation is intended to refer while doing planning of SBRT Prostate for all practical aspects from Simulation - contouring - planning - treatment. I am sure it will be very useful presentation for any radiation oncologist who are willing to start workflow of SBRT Prostate in the department of radiation oncology
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Very beggining of my post graduation journey I prepared it for weekly presentation in my oncology department RAJSHAHI MEDICAL COLLEGE. sharing here if anyone get any help who r begginer in this field. Thank you.
— Treatment of nasopharyngeal carcinoma is done by advanced radiotherapy techniques like VMAT (Volumetric Modulated Arc Therapy) where dose to critical organs around tumour is of concern. Present study aimed to describe radiation dose to critical organs in nasopharyngeal cancer patients using VMAT technique. Study was conducted on 10 carcinoma nasopharynx patients treated by VMAT technique at a super-specialty cancer institute in Rajasthan. The structures were contoured using RTOG (Radiation Therapy Oncology Group) guidelines and dose prescription to PTV (Planning Target Volume) was such that 95% iso-dose covered 100% of PTV. Constraints to the OARs (Organs at risk) were as per QUANTEC (Quantitative Analysis of Normal Tissue Effects in the Clinic). VMAT planning was done by double arc using Eclipse (v 10.0.42) treatment planning system. Mean dose to brain stem, spinal cord and optic chiasma were 51.79 Gy, 45.92 Gy and 18.8 Gy respectively. Mean dose to left and right temporal lobes was 22.7Gy and 24.3Gy. Dose to right and left eye were 20.6 Gy and 19.2 Gy while dose to right and left lenses were 5.9Gy and 5.8 Gy respectively. Dose to brain stem, spinal cord, optic chiasma, eyes, lens and temporal lobes were below the dose constraints. VMAT is an effective way to deliver maximum radiation to tumour tissue while providing better sparing of normal tissue and less doses to OARs in carcinoma nasopharynx.
Assessment of Intrafraction Motion during real-time tracking in the treatment...Subrata Roy
In our experience, intrafraction motion for intracranial targets treated with fiducial free, frameless cranial SRS / SRT on CyberKnife with 6-D skull tracking, is within the acceptable range, and can be reliably detected and corrected. A PTV margin of 1 mm appears adequate to account for most of the intrafraction motion in this situation. However, significant intrafraction motion occurs during treatment delivery when mask based immobilization is used, and hence the same should be accounted for, in situations where intrafraction imaging is not being practiced. Owing to the highest level of precision, excellent automation, ease of treatment planning and delivery and avoidance of anaesthesia, CyberKnife Stereotactic Radiosurgery / Radiotherapy is highly recommended as an alternative to complex cranial neurosurgical procedures.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
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5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
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Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
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Prix Galien International 2024 Forum ProgramLevi Shapiro
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Tom Selleck Health: A Comprehensive Look at the Iconic Actor’s Wellness Journeygreendigital
Tom Selleck, an enduring figure in Hollywood. has captivated audiences for decades with his rugged charm, iconic moustache. and memorable roles in television and film. From his breakout role as Thomas Magnum in Magnum P.I. to his current portrayal of Frank Reagan in Blue Bloods. Selleck's career has spanned over 50 years. But beyond his professional achievements. fans have often been curious about Tom Selleck Health. especially as he has aged in the public eye.
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Introduction
Many have been interested in Tom Selleck health. not only because of his enduring presence on screen but also because of the challenges. and lifestyle choices he has faced and made over the years. This article delves into the various aspects of Tom Selleck health. exploring his fitness regimen, diet, mental health. and the challenges he has encountered as he ages. We'll look at how he maintains his well-being. the health issues he has faced, and his approach to ageing .
Early Life and Career
Childhood and Athletic Beginnings
Tom Selleck was born on January 29, 1945, in Detroit, Michigan, and grew up in Sherman Oaks, California. From an early age, he was involved in sports, particularly basketball. which played a significant role in his physical development. His athletic pursuits continued into college. where he attended the University of Southern California (USC) on a basketball scholarship. This early involvement in sports laid a strong foundation for his physical health and disciplined lifestyle.
Transition to Acting
Selleck's transition from an athlete to an actor came with its physical demands. His first significant role in "Magnum P.I." required him to perform various stunts and maintain a fit appearance. This role, which he played from 1980 to 1988. necessitated a rigorous fitness routine to meet the show's demands. setting the stage for his long-term commitment to health and wellness.
Fitness Regimen
Workout Routine
Tom Selleck health and fitness regimen has evolved. adapting to his changing roles and age. During his "Magnum, P.I." days. Selleck's workouts were intense and focused on building and maintaining muscle mass. His routine included weightlifting, cardiovascular exercises. and specific training for the stunts he performed on the show.
Selleck adjusted his fitness routine as he aged to suit his body's needs. Today, his workouts focus on maintaining flexibility, strength, and cardiovascular health. He incorporates low-impact exercises such as swimming, walking, and light weightlifting. This balanced approach helps him stay fit without putting undue strain on his joints and muscles.
Importance of Flexibility and Mobility
In recent years, Selleck has emphasized the importance of flexibility and mobility in his fitness regimen. Understanding the natural decline in muscle mass and joint flexibility with age. he includes stretching and yoga in his routine. These practices help prevent injuries, improve posture, and maintain mobilit
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
1. Dr Mohammad Abu Ashour
Radiation Oncology Resident
Jordanian Royal Medical Services
الرحمن هللا بسم
الرحيم
2. CONTENT
Definition
Anatomy
Indication of CSI
Doses of CSI .
Technique ( 3D – conformal in supine position )
Complications
Rule of CTX in CSI
Other technique of CSI.
3. Definition
CSI is a technique used in radiation
therapy to deliver a prescribed dose to
the entire cranial-spinal axis .
CSI : treat anywhere CSF flows ( sub
arachnoid space ).
7. Indications
Medulloblastoma.
Primitive neuroectodermal tumour.
Atypical teratoid/rhabdoid tumour.
Pineoblastoma.
Epenedymoma with evidence of CSF involvement ,
anaplastic type.
CNS Germ cell tumor with neuroaxis invlvment .
Primary CNS lymphoma with leptomeninigeal
involvment
8. What makes CSI challenging ??
Patient position and immobilization difficult
especially in pediatric cases ( may require
anaesthsia).
Large , irregular target volume.
Critical structure with special importance to
pediatric cases who are potential long term
survivor .
Problem of matching junctions between the fields .
9. CSI can be done with photon , proton ,3D
conformal IMRT , VMAT or Tomotherapy.
Every technique has advantages and
disadvantages .
In this lecture we will focus on the 3D –
conformal in supine position as we use this
technique in our department .
10. Doses of CSI
Average risk Medulloblastoma :
CSI 23.4 Gy/13 fx with weekly concurrent
vincristine
Posterior Fossa As per recent ACNS 0331
results, boost I.F (rather than entire PF) to
54–55.8 Gy
11. High risk*
CSI 36 Gy/20 fx with weekly concurrent
vincristine
Boost PF to 54–55.8 Gy**
Post-RT CHT
13. A simple technique for craniospinal radiotherapy
in the supine position
William A. Parkera,*, Carolyn R. Freemanb
Department of Medical Physics, and Department of
Radiation Oncology, McGill University Health
Centre, Montreal, Canada
14. Methods: The patient is CT scanned and treated in the
supine position. The clinical target volume and relevant
critical structures are outlined on a planning CT scan.
Half beam blocked lateral fields with a collimator rotation
are used to match the beam divergence from the superior
border of the spinal field at the C2 vertebral body.
The shielding for the cranial fields is generated
automatically, and the dose distribution is calculated using
a 3D treatment planning system.
The position of the isocenter of the spine field is always a
fixed longitudinal distance from the isocenter of the brain
fields. If multiple posterior fields are required, the
isocenter of the second spine field is always a fixed
longitudinal distance from that of the first.
15. the gap between the fields is determined
using virtual simulation and feathered
during treatment using the asymmetric jaws
of the linear accelerator.
this technique requires only longitudinal
couch motions, and is simple to plan and
easy to incorporate into the workload of a
busy radiotherapy department
18. Prone Position:
*Advantages :
Good alignment of the spine
Direct visualization of the field junctions.
*Disadvantages :
Uncomfortable
Technically difficult to reproduce.
Difficult anesthetic maneuvers
19. Supine position
Supine
More comfortable.
Better reproducibility
Safer for general anesthesia
BUT
Direct visualization of spinal field is not possible
22. Simulation
CT simulation
3mm slice thickness
Simulation from top of the head to below the end of
sacral area with arms down. The neck is
hyperextended so that spine fields do not exit through
the patient’s mouth .
One iso reference .
23. Target Volume and OAR:
Entire brain and its meningeal
coverings with the CSF.
Spinal cord and the leptomeninges
with CSF.
24.
25. The CSF space around the cribriform plate , optic
nerves are critical and should be included in CTV.
For the inferior extent of the spine fields, must be
below the bottom of the thecal sac. The thecal sac
can often be seen on both finer cut CT imaging in
soft tissue windows and sagittal MRI imaging.
The thecal sac typically ends between S1 and S3.
Nerve roots. The CTV should include the
neuroforamina at all levels of the spine.
26.
27.
28.
29. Treatment Planning
two parallel opposed lateral cranial fields matched
with the posterior spinal field to cover the entire
length of the spinal cord
Fixed field parameters are used.
Since the patient is treated in the supine position, the
posterior fields are difficult to visualize on the patient.
The setup is therefore based on anterior setup fields
with the same isocenters and field dimensions as the
treatment fields.
32. Junction shift
The junctions between the fields are feathered during
the course of treatment by using the asymmetric jaws.
The jaw defining the inferior limit of the brain fields is
opened by 1 cm every 9 Gy, while the superior limit of
the spinal field abutting the brain fields is decreased
by 1 cm.
If a second spine field is required, the inferior limit of
the superior field is decreased by 1 cm, and the
superior limit of the inferior field is increased by 1 cm
33. Portal imaging
All fields are imaged on a daily basis
during the first week of treatment, and
once a week (following each junction
change) thereafter. The portal images
are compared to simulation DRRs.
35. Factors for decline in IQ after CSI
Factors for decline in IQ after CSI:
Age <7 yrs (most important)
Higher dose (36 Gy vs. 23.4 Gy)
Higher IQ at baseline
Female sex
(Ris MD et al., JCO 2001)
36. What is the annual IQ drop after
full PF boost in MB pts younger and
older than 7 yrs? What structure is
most important?
IQ drop of 5 points/yr if <7 yo and 1 point/yr if >7
yo. The dose to the supratentorial brain (temporal
lobes) is most important.
37. Rule of CTX in CSI
Attempts to reduce CSI dose
and its associated growth and
neurocognitive toxicities have
been facilitated by optimized
CHT regimens.
38. Chemotherapy can also be given for
younger patients in order to delay
RT, as the high toxicity profile for
patients
39. In standard risk patients several strategies
were used to decrease the craniospinal
radiation (CSI) dose and to increase overall
survival. Deutsch et al. decreased the CSI
dose to 23.4 Gy but in their early report they
observed an increased rate of CNS failure
compared to 36 Gy
40. Packer et al. combined chemotherapy with
23.4 Gy CSI and reported a 5 year event free
survival rate of 90% Studies conducted by
the International Society of Pediatric
Oncology (SIOP) and the Children’s
Oncology Group supported the use of 23.4–
24 Gy CSI with adjuvant chemotherapy
41. Medulloblastoma in adult
Brandes, 2007. Low-risk disease given CSI to
36 Gy, then boost PF 18.8 Gy to total 54.8 Gy.
High-risk pts received combination chemo +
RT. PFS and OS at 5 years were 72% and 75%
for all pts.
We can omit CTX in adult patients .
42. Proton Treatment
Protons have the distinct advantage of
minimal dose deposition beyond the Bragg
peak. This allows dose to be limited to the
anterior aspect of the vertebral bodies with
minimal dose extending into the more
anterior structures. This should, ideally,
limit late complications of treatment but the
proton treatment is not available in Jordan
and is significantly more expensive.
43. IMRT
Delivery of CSI with IMRT delivers
conformal high doses to the spine and
brain, but low dose radiation is
delivered to a large volume due to the
multiple beam angles.
44. VMAT
There are some concerns about increased
risk of secondary malignancies in patients
treated receiving craniospinal irradiation
with volumetric arc therapy compared to 3D
conformal therapy
45.
46. Dosimetric comparison of five different
techniques for craniospinal irradiation
across 15 European centers: analysis on
behalf of the SIOPE- BTG
(radiotherapy working group)
47. Purpose:
Conventional techniques (3D-CRT) for craniospinal
irradiation (CSI) are still widely used . Modern
techniques (IMRT, VMAT, TomoTherapy , proton
pencil beam scanning [PBS]) are applied in a limited
number of centers. For a 14-year-old patient, we aimed
to compare dose distributions of five CSI techniques
applied across Europe and generated according to the
participating institute protocols, therefore
representing daily practice.
48. Results:
The modern radiotherapy techniques investigated
resulted in superior conformity/homogeneity and
demonstrated a decreased dose to the thyroid,
heart, esophagus and pancreas. Dose reductions of
>10.0 Gy were observed with Proton compared to
modern photon techniques for parotid glands,
thyroid and pancreas.
49. Conclusions:
The investigated modern radiotherapy techniques
demonstrate superior dosimetric results compared
to 3D-CRT. The lowest mean dose for organs at risk
is obtained with proton therapy. However, for a
large number of organs ranges in mean doses were
wide and overlapping between techniques making
it difficult to recommend one radiotherapy
technique over another.