The keynote presentation by Everett McKay focuses on the importance of courageous design in UX/UI, emphasizing that great design requires intelligent risks rather than consensus-driven compromise. Key concepts include user-centered design, the impact of team culture on design decisions, and the role of data in guiding design while maintaining a balance between safety and creativity. McKay concludes by urging designers to strive for greatness in their work, challenging the prevailing mediocrity in organizational cultures.