Chronic obstructive pulmonary disease (COPD) is the 3rd leading cause of death in Bangladesh, affecting over 6 million people. The primary cause is tobacco smoke. COPD is diagnosed through spirometry showing airflow limitation. Management includes smoking cessation, vaccinations, medications like bronchodilators and steroids, pulmonary rehabilitation, oxygen therapy, and surgery in severe cases. Exacerbations are acute worsening of symptoms and managed with oxygen, steroids, and antibiotics. Hospital admission is needed for severe exacerbations or inadequate response to home treatment.
Chronic Obstructive Pulmonary Disease BY
Dr Akram Yousuf
Resident Internal Medicine
Liaquat University of Medical Health and Sciences Jamshoro Pakistan
Chronic Obstructive Pulmonary Disease BY
Dr Akram Yousuf
Resident Internal Medicine
Liaquat University of Medical Health and Sciences Jamshoro Pakistan
COPD, EMPHYSEMA, CHRONIC BRONCHITIS,LUNG DISEASE, OBSTRUCTIVE LING DISEASE, PHYSIOLOGY, KINGS COLLEGE,DPT DEPARTMENT ALL necessary information regarding lung disease which you should know
At the end of this lecture student able to:
Define COPD
List causes of COPD
List risk factors of COPD
List signs and symptoms of COPD
List diagnostic measures
Describe treatment of COPD
Identify complications of COPD
Use nursing process
Discuss relevant patient / family education
\It is a condition of the lung characterized by permanent dilatation of the air spaces distal to the terminal bronchioles with destruction of the walls of these airways.
Chronic Bronchitis
It is a disease characterized by daily cough with sputum for at least 3 months of the year for at least 2 consecutive years and airway obstruction which is irreversible.
COPD is a chronic respiratory illness that is associated with an abnormal inflammatory response of the lungs to noxious particles and gases. Severe COPD can lead to respiratory failure, repeated hospitalization and death. One of the most important risk factors for COPD is tobacco smoking.
COPD, EMPHYSEMA, CHRONIC BRONCHITIS,LUNG DISEASE, OBSTRUCTIVE LING DISEASE, PHYSIOLOGY, KINGS COLLEGE,DPT DEPARTMENT ALL necessary information regarding lung disease which you should know
At the end of this lecture student able to:
Define COPD
List causes of COPD
List risk factors of COPD
List signs and symptoms of COPD
List diagnostic measures
Describe treatment of COPD
Identify complications of COPD
Use nursing process
Discuss relevant patient / family education
\It is a condition of the lung characterized by permanent dilatation of the air spaces distal to the terminal bronchioles with destruction of the walls of these airways.
Chronic Bronchitis
It is a disease characterized by daily cough with sputum for at least 3 months of the year for at least 2 consecutive years and airway obstruction which is irreversible.
COPD is a chronic respiratory illness that is associated with an abnormal inflammatory response of the lungs to noxious particles and gases. Severe COPD can lead to respiratory failure, repeated hospitalization and death. One of the most important risk factors for COPD is tobacco smoking.
These lecture notes were prepared by Dr. Hamdi Turkey- Pulmonologist- Department of internal medicine - Taiz university
It contains :
- The new GOLD classification of severity
- The new GOLD treatment guidelines for the treatment of
COPD
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A common, preventable and treatable disease, characterized by persistent respiratory symptoms and airflow limitation that are usually progressive and associated with an enhanced chronic inflammatory response in the airways and/or alveoli due to significant exposure to noxious particles or gases. (Vogelmeier et al., 2017).
Presentation on Treatment of Bronchial Asthma | Jindal Chest ClinicJindal Chest Clinic
Bronchial asthma is a lung disease characterized by inflammation, narrowing, swelling of airways, and increased mucus production, making it difficult to breathe. This Presentation gives an overview on "Treatment of Bronchial Asthma" including management, diagnosis, symptoms, Complications, etc. For more information, please contact us: 9779030507.
Leading the Way in Nephrology: Dr. David Greene's Work with Stem Cells for Ki...Dr. David Greene Arizona
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Struggling with intense fears that disrupt your life? At Renew Life Hypnosis, we offer specialized hypnosis to overcome fear. Phobias are exaggerated fears, often stemming from past traumas or learned behaviors. Hypnotherapy addresses these deep-seated fears by accessing the subconscious mind, helping you change your reactions to phobic triggers. Our expert therapists guide you into a state of deep relaxation, allowing you to transform your responses and reduce anxiety. Experience increased confidence and freedom from phobias with our personalized approach. Ready to live a fear-free life? Visit us at Renew Life Hypnosis..
We understand the unique challenges pickleball players face and are committed to helping you stay healthy and active. In this presentation, we’ll explore the three most common pickleball injuries and provide strategies for prevention and treatment.
India Clinical Trials Market: Industry Size and Growth Trends [2030] Analyzed...Kumar Satyam
According to TechSci Research report, "India Clinical Trials Market- By Region, Competition, Forecast & Opportunities, 2030F," the India Clinical Trials Market was valued at USD 2.05 billion in 2024 and is projected to grow at a compound annual growth rate (CAGR) of 8.64% through 2030. The market is driven by a variety of factors, making India an attractive destination for pharmaceutical companies and researchers. India's vast and diverse patient population, cost-effective operational environment, and a large pool of skilled medical professionals contribute significantly to the market's growth. Additionally, increasing government support in streamlining regulations and the growing prevalence of lifestyle diseases further propel the clinical trials market.
Growing Prevalence of Lifestyle Diseases
The rising incidence of lifestyle diseases such as diabetes, cardiovascular diseases, and cancer is a major trend driving the clinical trials market in India. These conditions necessitate the development and testing of new treatment methods, creating a robust demand for clinical trials. The increasing burden of these diseases highlights the need for innovative therapies and underscores the importance of India as a key player in global clinical research.
The dimensions of healthcare quality refer to various attributes or aspects that define the standard of healthcare services. These dimensions are used to evaluate, measure, and improve the quality of care provided to patients. A comprehensive understanding of these dimensions ensures that healthcare systems can address various aspects of patient care effectively and holistically. Dimensions of Healthcare Quality and Performance of care include the following; Appropriateness, Availability, Competence, Continuity, Effectiveness, Efficiency, Efficacy, Prevention, Respect and Care, Safety as well as Timeliness.
Medical Technology Tackles New Health Care Demand - Research Report - March 2...pchutichetpong
M Capital Group (“MCG”) predicts that with, against, despite, and even without the global pandemic, the medical technology (MedTech) industry shows signs of continuous healthy growth, driven by smaller, faster, and cheaper devices, growing demand for home-based applications, technological innovation, strategic acquisitions, investments, and SPAC listings. MCG predicts that this should reflects itself in annual growth of over 6%, well beyond 2028.
According to Chris Mouchabhani, Managing Partner at M Capital Group, “Despite all economic scenarios that one may consider, beyond overall economic shocks, medical technology should remain one of the most promising and robust sectors over the short to medium term and well beyond 2028.”
There is a movement towards home-based care for the elderly, next generation scanning and MRI devices, wearable technology, artificial intelligence incorporation, and online connectivity. Experts also see a focus on predictive, preventive, personalized, participatory, and precision medicine, with rising levels of integration of home care and technological innovation.
The average cost of treatment has been rising across the board, creating additional financial burdens to governments, healthcare providers and insurance companies. According to MCG, cost-per-inpatient-stay in the United States alone rose on average annually by over 13% between 2014 to 2021, leading MedTech to focus research efforts on optimized medical equipment at lower price points, whilst emphasizing portability and ease of use. Namely, 46% of the 1,008 medical technology companies in the 2021 MedTech Innovator (“MTI”) database are focusing on prevention, wellness, detection, or diagnosis, signaling a clear push for preventive care to also tackle costs.
In addition, there has also been a lasting impact on consumer and medical demand for home care, supported by the pandemic. Lockdowns, closure of care facilities, and healthcare systems subjected to capacity pressure, accelerated demand away from traditional inpatient care. Now, outpatient care solutions are driving industry production, with nearly 70% of recent diagnostics start-up companies producing products in areas such as ambulatory clinics, at-home care, and self-administered diagnostics.
CHAPTER 1 SEMESTER V PREVENTIVE-PEDIATRICS.pdfSachin Sharma
This content provides an overview of preventive pediatrics. It defines preventive pediatrics as preventing disease and promoting children's physical, mental, and social well-being to achieve positive health. It discusses antenatal, postnatal, and social preventive pediatrics. It also covers various child health programs like immunization, breastfeeding, ICDS, and the roles of organizations like WHO, UNICEF, and nurses in preventive pediatrics.
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Antibiotic Stewardship by Anushri Srivastava.pptxAnushriSrivastav
Stewardship is the act of taking good care of something.
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
WHO launched the Global Antimicrobial Resistance and Use Surveillance System (GLASS) in 2015 to fill knowledge gaps and inform strategies at all levels.
ACCORDING TO apic.org,
Antimicrobial stewardship is a coordinated program that promotes the appropriate use of antimicrobials (including antibiotics), improves patient outcomes, reduces microbial resistance, and decreases the spread of infections caused by multidrug-resistant organisms.
ACCORDING TO pewtrusts.org,
Antibiotic stewardship refers to efforts in doctors’ offices, hospitals, long term care facilities, and other health care settings to ensure that antibiotics are used only when necessary and appropriate
According to WHO,
Antimicrobial stewardship is a systematic approach to educate and support health care professionals to follow evidence-based guidelines for prescribing and administering antimicrobials
In 1996, John McGowan and Dale Gerding first applied the term antimicrobial stewardship, where they suggested a causal association between antimicrobial agent use and resistance. They also focused on the urgency of large-scale controlled trials of antimicrobial-use regulation employing sophisticated epidemiologic methods, molecular typing, and precise resistance mechanism analysis.
Antimicrobial Stewardship(AMS) refers to the optimal selection, dosing, and duration of antimicrobial treatment resulting in the best clinical outcome with minimal side effects to the patients and minimal impact on subsequent resistance.
According to the 2019 report, in the US, more than 2.8 million antibiotic-resistant infections occur each year, and more than 35000 people die. In addition to this, it also mentioned that 223,900 cases of Clostridoides difficile occurred in 2017, of which 12800 people died. The report did not include viruses or parasites
VISION
Being proactive
Supporting optimal animal and human health
Exploring ways to reduce overall use of antimicrobials
Using the drugs that prevent and treat disease by killing microscopic organisms in a responsible way
GOAL
to prevent the generation and spread of antimicrobial resistance (AMR). Doing so will preserve the effectiveness of these drugs in animals and humans for years to come.
being to preserve human and animal health and the effectiveness of antimicrobial medications.
to implement a multidisciplinary approach in assembling a stewardship team to include an infectious disease physician, a clinical pharmacist with infectious diseases training, infection preventionist, and a close collaboration with the staff in the clinical microbiology laboratory
to prevent antimicrobial overuse, misuse and abuse.
to minimize the developme
1. Presented by
Dr. Ajay Kumar Agarwala
Resident (Neurology)
Bangabandhu Sheikh Mujib Medical University,
Dhaka, Bangladesh.
CHRONIC OBSTRUCTIVE
PULMONARY DISEASE
OVERVIEW & UPDATE
2. Key facts
90% of COPD deaths occur in low- and middle-income
countries
The primary cause of COPD is tobacco smoke
The disease now affects men and women almost equally
Not curable, but treatment can slow the progression
2
Chronic obstructive pulmonary disease
(COPD)
3. 3rd leading cause
death in developing world
Prevalence in Bangladesh
21.25% (above 40 year age)
Currently total burden about
6 million in BD
(Worldwide 80 million) 3
Picture in Bangladesh
Top 10 Causes of Death
Cancer 13%
Lower Respiratory Infections 7%
Chronic Obstructive Pulmonary
Disease 7%
Ischemic Heart Disease 6%
Stroke 5%
Preterm Birth Complications 4%
Tuberculosis 3%
Neonatal Encephalopathy 3%
Diabetes 3%
Cirrhosis 3%
Source: https://www.cdc.gov/globalhealth/countries/banglade
sh/
4. It is characterized by Progressive air way limitation
that is not fully reversible.
Emphysema
Chronic Bronchitis
Small airway disease
4
What is COPD?
7. Risk factors
HOST FACTORS
Genes
Male sex
Ethnicity (Caucasians)
Airway hyper-
responsiveness
Poor lung development/
poor growth
EXPOSURE FACTORS
Tobacco smoke (Unusual if
< 10 pack years)
Occupational-
dust/fumes/Smokes
Air pollution
Persistent Infections
(adenovirus, HIV)
Low Socioeconomic status
7
8. • Pink puffer
Type A- Emphysema Predominant
• Blue bloater
Type B- Chronic Bronchitis Predominant
Type C- Mixed (MOST COMMON)
8
Types
9. Abnormal permanent dilatation of airspaces distal to
terminal bronchioles (resp. bronchioles, alveolar
ducts and alveoli)
Emphysema
9
10. 10
Pathology of emphysema
Cigarette leads to inflammatory and immune cell
recruitment within the terminal air spaces < 2mm
Release elastolytic and other proteinases that damage
the ECM
Cell death (Endothelial and Epithelial)
Ineffective repair of elastin and other
ECM leads to airspace enlargement
11. Small Airways
• Airway inflammation & edema, fibrosis, cellular
infiltration and destruction of elastic fibers of
respiratory bronchiole and alveolar ducts
• Goblet metaplasia and mucus plugs
• Reduce surfactant leads to airway narrowing and
collapse
• Smooth muscle hypertrophy
• Increased airway resistance
• Narrowing and drop out of small airway
Lung Parenchymal Destruction
• Loss of alveolar attachments
• Perforated alveoli coalesce to form large air spaces
• Decrease of elastic recoil
Airway limitation
Decrease pulmonary
and chest wall
compliance
Airway
hyperinflation
Poor gas exchange
Respiratory failure
12. Bronchitis is inflammation of the inner lining of the
Bronchi ( Cough & Sputum for most of the days for 3 months
for consecutive 2 years)
Bronchitis
Enlargement of mucus-secreting glands &
goblet cells mainly in large airway
Inflammatory cell infiltrate
(Neutorphil elastase)
Smooth muscle hypertrophy & bronchial
hyper-responsiveness
Increased sputum production and
airway limitation
14. COPD Comorbidities
Increased risk of:
Cardiovascular diseases Cardioselective beta-blockers are not
contraindicated in COPD
Osteoporosis
Respiratory infections
Anxietyand Depression
Diabetes
Lung cancer
These comorbid conditions may influence mortality and
hospitalizations and should be looked for routinely, and
treated appropriately.
15. HISTORY
Dyspnoea
Fatigue, Morning headache (hypercapnia)
Cough, Sputum +/-
Frequent respiratory infection
Risk exposure (Smoke, pollution etc.)
Family history
15
How to diagnose?
16. PHYSICAL EXAMINATION
Pursed lip breathing and use of accessory
respiratory muscles
“ Paradoxical inward movement of the lower rib
cage during inspiration: Hoovers sign”
Rhonchi, Prolonged expiration, Crackles (if
infection)
Decreased intensity of breath and heart sound
Polycythemia, Cyanosis, Digital clubbing
(Malignancy), dependent pitting edema
16
Diagnosis…..(cont.)
17. Thin with a barrel chest
Little or no cough or expectoration
pursed lips and use of accessory
respiratory muscles
patients may adopt the tripod sitting
position
The chest may be hyper-resonant &
wheezing may be heard
Heart sounds are very distant
Maintain normal PaC02 until late
stage
17
Emphysema PINK
PUFFER
18. Patients may be obese
Frequent cough and
expectoration are typical
Coarse Ronchi and
wheezing may be present
Earlier hypercapnia so
early secondary
Polycythemia
Patient may have edema
and cyanosis
18
Chronic
bronchitis BLUE
BLOATER
19. 19
INVESTIGATION
The global initiative for chronic obstructive lung disease
(GOLD) used severity staging based on air flow
limitation.
stage I: MILD, FEV1 > 80% of normal
stage II: MODERATE, FEV1 = 50-79% of normal
stage III: SEVERE, FEV1 = 30-49% of normal
stage IV: VERY SEVERE, FEV1 <30% of normal or
<50% of normal with presence of chronic respiratory
failure present
The FEV1:FVC ratio should be <0.70 for all stages
(Post-bronchodilator)
Spirometry
must to
establish
diagnosis
25. Centrilobular (centriacinar)
primarily the upper lobes
Occurs with loss of the
respiratory bronchioles in the
proximal portion of the acinus,
with sparing of distal alveoli.
This pattern is most typical for
smokers
25
26. 26
Panlobular emphysema permanent destruction of the entire
acinus distal to the respiratory bronchioles with no "obvious"
associated fibrosis. Usually affect basal part. Common in patient
with Alpha 1 AT deficiency.
28. 1. Assessment of COPD
2. Relief of symptoms
3. Prevent frequency and severity of exacerbations
4. Improve quality of life
5. Reduce mortality
28
Goals of management
29. Modified MRC dyspnoea scale
Six-minute walk test
Exercise Oximetry
COPD assessment test (CAT)
29
Assessment of COPD
34. A B
DC
Gold stage Ⅰ
Gold stage Ⅲ
Gold stage Ⅳ
Combined COPD Assessment (Airway limitation GOLD
assessment + Exacerbation risk + breathlessness)
≥2 episode in
last one 1
year or
≥1 episode
leading to
hosp
admission
≤ 1episode
not leading to
hosp
admission
Gold stage Ⅱ
mMRC 0-1 mMRC ≥ 2
Low risk, Less symptom
High risk, More symptomHigh risk, Less symptom
Low risk, More symptom
35. Patient Characteristic SpirometricClas
sification
Exacerbations
per year
mMRC CAT
A Low Risk
Less Symptoms
GOLD 1-2 ≤ 1 0-1 < 10
B Low Risk
More Symptoms
GOLD 1-2 ≤ 1 >2 ≥ 10
C High Risk
Less Symptoms
GOLD 3-4 >2 0-1 < 10
D High Risk
More Symptoms
GOLD 3-4 >2 >2 ≥ 10
Combined Assessment of COPDWhen assessing risk, choose the highest risk according to GOLD grade
or exacerbation history
36. Patient
category
First recommendation Alternative recomm.
A
Short acting anticholinergic
or Short acting beta2 agonist
as per need (pro re nata)
-Long acting anticholinergic or
-Long acting beta2 agonist or
-Short acting anticholinergic and
Short acting beta2 agonist
B
Long acting anticholinergic
or Long acting beta2 agonist
Long acting anticholinergic and Long
acting beta2 agonist
C
Inhaled corticosterLong
+
Long acting anticholinergic
or Long acting beta2 agonist
-Long acting anticholinergic and
Long acting beta2 agonist or
-LAanticholinergic +PDE4 inhibitor
or
-LAbeta2agonist+ PDE4 inhibitor
D
Inhaled corticosteroid
+
Long acting anticholinergic
and/or Long acting beta2
agonist
LTOT /SURGERY
Inhaled corticosteroid
+
Long acting anticholinergic and Long
acting beta2 agonist or
-LAanticholinergic +PDE4 inhibitor or
-LAbeta2agonist+ PDE4 inhibitor
36
Pharmacotherapy
38. Ultra short acting b2 agonist- Indacaterol
Long acting muscarinic antagonist- Glycopyronium
bromide
Phosphodiesterase 4 inhibitor- Roflumilast and
Cilomilast
Newer generation phosphodiesterase inhibitors-
Doxyphyllin
Mucolytic and anti-oxidant agent- N acetylcysteine
38
Newer drugs
39. During exercise
During exacerbation
During air travel
Category D disease (Severe) - LTOT
39
02 Therapy
Temporary Need based
40. For continuous use at home in patients with chronic
hypoxaemia
15 to 19 hours per day including sleeping periods
2-4 L/min For at least 30 days
Goal: Increase baseline
Pa02 > 60 mmHg
Sa02 > 90%
40
Long term oxygen therapy
(LTOT)
42. Category C and D disease
In Category B if steroid shows responsiveness
Severe exacerbation of COPD
Frequent exacerbation
Oral Steroid Trial
Differentiation of COPD from Asthma of ACOS
Can it predicts responsiveness to inhaled corticosteroid?
42
When to use inhaled steroid
43. Smoking cessation & Reduce exposure to noxious
stimuli
Vaccination (pneumococcal and Influenza vaccine)
Exercise training & Breathing exercise
Nutritional and Psychological counseling
Palliation (Morphine for breathlessness and
Addressing End of life issue)
Pulmonary rehabilitation (A holistic multidisciplinary
approach for patients with chronic respiratory
impairment) 43
Other mode of management
44. Influenza vaccines can reduce serious illness.
Pneumococcal polysaccharide vaccine is
recommended for COPD patients 65 years and older
and for COPD patients younger than age 65 with an
FEV1< 40% predicted.
vaccines
45. Brief Strategies to Help the
Patient Willing to Quit Smoking
ASSIST For the patient willing to make a quit
ttempt,
offer medication and provide or refer for
counseling or additional treatment to help
the patient quit. For patients unwilling to
quit at the time, provide interventions
designed to increase future quit attempts.
ARRANGE For the patient willing to make a quit
attempt, arrange for followup contacts,
46.
47. Lung volume reduction surgery
Bullectomy
Lung transplantation
47
Surgery
49. Def: Acute change in baseline dyspnoea, cough and/or
sputum that is beyond normal day to day variation
Cause: 1. Infection 2. pollution 3. unknown (66% cases)
Types:
Type1: Mild exace. (Risk factor for poor outcome-
)
(H. Influenzae, S. Pneumoniae, Chlamydia, Viruses)
Type2: Moderate exace. (Risk factor for poor outcome +)
(Type 1 plus Presence of resistant organism)
Type3: Severe exace. (Risk factor for poor outcome +)
(Type 2 plus P. aeruginose, Actinobactor)
Exacerbations
50. 50
Exacerbations
Investigation:
Chest x ray, ECG, Pulse oximetry, ABG
Sputum for gram stain and C/S
CBC, B. Urea, S. Creatinine S. Electrolytes, B. Sugar
Management: 1. Home-based 2. Hospital-based
Controlled oxygen: at 24% or 28% should be used with the aim of
PaO2above 60 mmHg or an SaO2 between 88% and 92%
without worsening acidosis
Systemic steroid: If baseline FEV1 is <50 % predicted….30-40 mg
of prednisolone for 7-10 day (Nebulized budesonide if risk of
hyperglycaemia or other steroid side effects)
Antibiotic: Aminopenicillin or a Macrolide. Co-amoxiclav if β-
lactamase-producing organisms are known to be common
51. Increased intensity or resting dyspnoea
New sign appearance (cyanosis, edema, arrhythmia)
Severe underlying disease
Significant co-morbidities
Frequent admission
Diagnostic uncertainty
Older age
Inadequate home support
51
Indication for Hospital
admission in exacerbation
52. Inadequate response to initial emergency therapy
Change in mental status (lethargy, confusion, coma)
Persistent of worsening parameters despite oxygen
and Non-invasive ventilation
Hypoxemia (Pa02) ….less than 40 mmHg
Hypercapnia (PaC02)…..more than 60 mmHg
Respiratory acidosis…..pH <7.35
Need for invasive ventilation
Haemodynamic instability needing vasopressor
52
Indication for
ICU admission
53. Able to use long acting bronchodilators
Need for short acting b2 agonist not more than every 4
hour
Patient can walk, eat and sleep without awakening by
dyspnoea
Clinically stable for 12-24 hours
Fully understand the use of medication
Good support at home
Follow up plan home care arrangement completed
53
Discharge criteria
54. Maintenance pharmacotherapy regimen for home
Inhaler technique
Instruction regarding completion of steroid and
antibiotic therapy
Assess for long term oxygen therapy
Provide management plan for Comorbidities
Assurance of a follow up visit within 4-6 weeks
54
Assessment at time of discharge
55. Measurement of FEV1
Inhaler technique
Ability to cope in usual environment
Understanding recommended treatment regimen
55
Items to assess at F/U visit
59. 59
Predictors of
BAD prognosis
1) Increased age
2) Declined Post-bronchodilator FEV1
3) Weight loss (Cachexia)
4) Pulmonary hypertension
60. Body mass index
Obstruction of airflow
Dyspnoea
measurement
Exercise capacity
60
BODE index
BODE score of 0-2 has a mortality rate of around 10% at 52 months, When
BODE score 7-10 mortality rate around 80% at 52 months
61. 61
Distinguishing Asthma From COPD
Lung function test:
Airway hyper responsiveness (Methacholin challenge test)
Arterial blood gas (Chronically abnormal in COPD)
DLCO (reduced in COPD)
PEFR (Diurnal variation less in COPD)
Inflammatory Biomarkers:
Skin prick tests for atopy,
Ig E in blood,
Blood eosinophilia,
Suptum cell analysis
Imaging :
Chest X ray
HRCT
62. Differential Diagnosis:
COPD and Asthma
COPD ASTHMA
Onset in mid-life
Symptoms slowly
progressive
Long smoking history
Dyspnea during exercise
Largely irreversible
airflow limitation
Onset early in life (often childhood)
Symptoms vary from day to day
Symptoms at night/early morning
Allergy, rhinitis, and/or eczema also present
Family history of asthma
Largely reversible airflow limitation
63.
64. Increased but not complete reversibility of the airway obstruction.
2 major and 2 minor required
67. PLoS One. 2014 Nov 26;9(11):e113048. doi: 10.1371/journal.pone.0113048. eCollection 2014.
Beta-blockers reduced the risk of mortality and
exacerbation in patients with COPD: a meta-analysis
of observational studies.
Du Q1, Sun Y1, Ding N1, Lu L1, Chen Y1.
An extensive search of the EMBASE, MEDLINE and Cochrane was performed to retrieve the
studies of beta-blockers treatment in patients with COPD. The random effects model meta-
analysis was used to evaluate effect on overall mortality and exacerbation of COPD.
Fifteen original observational cohort studies with a follow-up time from 1 to 7.2 years
were included. The results revealed that beta-blockers treatment significantly decreased
the risk of overall mortality and exacerbation of COPD. The relative risk (RR) for overall
mortality was 0.72 (0.63 to 0.83), and for exacerbation of COPD was 0.63 (0.57 to 0.71). In
subgroup analysis of COPD patients with coronary heart disease or heart failure, the risk
for overall mortality was 0.64 (0.54-0.76) and 0.74 (0.58-0.93), respectively.
The findings of this meta-analysis confirmed that beta-blocker use in patients
with COPD may not only decrease the risk of overall mortality but also reduce
the risk of exacerbation of COPD. Beta-blocker prescription for cardiovascular
diseases needs to improve in COPD patients.
Beta-blocker use in patients with COPD may not only decrease the risk of overall
mortality but also reduce the risk of exacerbation of COPD.
69. Abstract
In order to clarify the possible role of N-acetylcysteine (NAC) in the treatment of patients with
chronic bronchitis and chronic obstructive pulmonary disease (COPD), we have carried out a
meta-analysis testing the available evidence that NAC treatment may be effective in preventing
exacerbations of chronic bronchitis or COPD and evaluating whether there is a substantial
difference between the responses induced by low (≤600 mg per day) and high (>600 mg per
day) doses of NAC.
The results of the present meta-analysis (13 studies, 4155 COPD patients, NAC n=1933; placebo or
controls n=2222) showed that patients treated with NAC had significantly and consistently
fewer exacerbations of chronic bronchitis or COPD (relative risk 0.75, 95% CI 0.66–0.84;
p<0.01), although this protective effect was more apparent in patients without evidence of
airway obstruction. However, high doses of NAC were also effective in patients suffering from
COPD diagnosed using spirometric criteria (relative risk 0.75, 95% CI 0.68–0.82; p=0.04). NAC
was well tolerated and the risk of adverse reactions was not dose-dependent (low doses
relative risk 0.93, 95% CI 0.89–0.97; p=0.40; high doses relative risk 1.11, 95% CI 0.89–1.39;
p=0.58).
The strong signal that comes from this meta-analysis leads us to state that if a patient suffering
from chronic bronchitis presents a documented airway obstruction, NAC should be
administered at a dose of ≥1200 mg per day to prevent exacerbations, while if a patient suffers
from chronic bronchitis, but is without airway obstruction, a regular treatment of 600 mg per
day seems to be sufficient.
69
Influence of N-acetylcysteine on chronic bronchitis or COPD exacerbations: a
meta-analysis Mario Cazzola1 , Luigino Calzetta1 , Clive Page2 , Josè Jardim3 ,
Alexander G. Chuchalin4 , Paola Rogliani1 and Maria Gabriella Matera5
patient suffering from chronic bronchitis with documented airway obstruction,
NAC should be administered at a dose of ≥1200 mg per day to prevent
exacerbations, while if a patient suffers from chronic bronchitis, but is without
airway obstruction, a regular treatment of 600 mg per day seems to be sufficient.
71. Harrison's Principles of Internal Medicine .19th E
Davidson's principles and practice of medicine. 22nd E
National guideline on Asthma and COPD. 5th E
71
References