This document provides information on chronic obstructive pulmonary disease (COPD) including its definition, risk factors, pathophysiology, clinical manifestations, medical management, nursing management, and surgical options. COPD is characterized by persistent airflow limitation that is not fully reversible. It is mostly caused by smoking and results in changes like thickening of the airways and inflammation that narrow the lungs over time. Management involves treatments to improve ventilation and remove secretions, as well as strategies to prevent complications and promote overall health.
Asthma is a condition in which your airways narrow and swell and produce extra mucus. This can make breathing difficult and trigger coughing, wheezing and shortness of breath. For some people, asthma is a minor nuisance
Asthma is a condition in which your airways narrow and swell and produce extra mucus. This can make breathing difficult and trigger coughing, wheezing and shortness of breath. For some people, asthma is a minor nuisance
Module: Pharmacology and Therapeutics III, (Therapeutics part)
Coordinator: Dr. Arwa M. Amin Mostafa
Academic Level: Undergraduate, B.Pharmacy
School: Dubai Pharmacy College
Year of first presented in Class: 2018
This presentation is for Educational purpose. It has no commercial value associated with it.
Dr. Md. Khairul Hassan Jessy
Associate Professor, Respiratory Medicine
National Institute of Diseases of the Chest and Hospital (NIDCH), Mohakhali, Dhaka.
Acknowledment:
Davidson’s Principles and Practice of Medicine
Module: Pharmacology and Therapeutics III, (Therapeutics part)
Coordinator: Dr. Arwa M. Amin Mostafa
Academic Level: Undergraduate, B.Pharmacy
School: Dubai Pharmacy College
Year of first presented in Class: 2018
This presentation is for Educational purpose. It has no commercial value associated with it.
Dr. Md. Khairul Hassan Jessy
Associate Professor, Respiratory Medicine
National Institute of Diseases of the Chest and Hospital (NIDCH), Mohakhali, Dhaka.
Acknowledment:
Davidson’s Principles and Practice of Medicine
This presentation introduces the readers to Word Power Made Easy Chapter 1 words using ready visuals.
For more such visual presentations, please visit www.greogeek.com
Chronic obstructive pulmonary disease (COPD) is a preventable and treatable disease characterized by persistent airflow limitation that is slowly progressive. It is also known as Chronic obstructive lung disease. “(COLD)”
It refers to Chronic Bronchitis and emphysema, a pair of two commonly coexisting disease of the lungs in which the airways become narrowed.
Reading material on COPD (CHRONIC OBSTRUCTIVE PULMONARY DISEASE) for Nursing students and teachers. It tells pathophysiology, clinical manifestations, diagnostic evaluations, medical and nursing management of COPD.
chronic obstructive pulmonary disease and its management
chronic obstructive pulmonary disease is a chronic inflammatory lung disease that causes obstructed airflow from the lungs.
COPD typically has a clear cause and a clear path of prevention, and there are ways to slow the progression of the disease.
\It is a condition of the lung characterized by permanent dilatation of the air spaces distal to the terminal bronchioles with destruction of the walls of these airways.
Chronic Bronchitis
It is a disease characterized by daily cough with sputum for at least 3 months of the year for at least 2 consecutive years and airway obstruction which is irreversible.
Chronic obstructive pulmonary disease (COPD)- Preeti sharmaEducate with smile
COPD is a type of obstructive lung disease and related conditions. it is very helpful presentation to you about information of COPD.
It includes all things that is definition, causes, symptoms, pathophysiology, diagnostic evaluation, types, treatment and role of nurses for COPD patient.
Local Advanced Lung Cancer: Artificial Intelligence, Synergetics, Complex Sys...Oleg Kshivets
Overall life span (LS) was 1671.7±1721.6 days and cumulative 5YS reached 62.4%, 10 years – 50.4%, 20 years – 44.6%. 94 LCP lived more than 5 years without cancer (LS=2958.6±1723.6 days), 22 – more than 10 years (LS=5571±1841.8 days). 67 LCP died because of LC (LS=471.9±344 days). AT significantly improved 5YS (68% vs. 53.7%) (P=0.028 by log-rank test). Cox modeling displayed that 5YS of LCP significantly depended on: N0-N12, T3-4, blood cell circuit, cell ratio factors (ratio between cancer cells-CC and blood cells subpopulations), LC cell dynamics, recalcification time, heparin tolerance, prothrombin index, protein, AT, procedure type (P=0.000-0.031). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and N0-12 (rank=1), thrombocytes/CC (rank=2), segmented neutrophils/CC (3), eosinophils/CC (4), erythrocytes/CC (5), healthy cells/CC (6), lymphocytes/CC (7), stick neutrophils/CC (8), leucocytes/CC (9), monocytes/CC (10). Correct prediction of 5YS was 100% by neural networks computing (error=0.000; area under ROC curve=1.0).
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/kqbnxVAZs-0
- Video recording of this lecture in Arabic language: https://youtu.be/SINlygW1Mpc
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
share - Lions, tigers, AI and health misinformation, oh my!.pptxTina Purnat
• Pitfalls and pivots needed to use AI effectively in public health
• Evidence-based strategies to address health misinformation effectively
• Building trust with communities online and offline
• Equipping health professionals to address questions, concerns and health misinformation
• Assessing risk and mitigating harm from adverse health narratives in communities, health workforce and health system
Here is the updated list of Top Best Ayurvedic medicine for Gas and Indigestion and those are Gas-O-Go Syp for Dyspepsia | Lavizyme Syrup for Acidity | Yumzyme Hepatoprotective Capsules etc
DISSERTATION on NEW DRUG DISCOVERY AND DEVELOPMENT STAGES OF DRUG DISCOVERYNEHA GUPTA
The process of drug discovery and development is a complex and multi-step endeavor aimed at bringing new pharmaceutical drugs to market. It begins with identifying and validating a biological target, such as a protein, gene, or RNA, that is associated with a disease. This step involves understanding the target's role in the disease and confirming that modulating it can have therapeutic effects. The next stage, hit identification, employs high-throughput screening (HTS) and other methods to find compounds that interact with the target. Computational techniques may also be used to identify potential hits from large compound libraries.
Following hit identification, the hits are optimized to improve their efficacy, selectivity, and pharmacokinetic properties, resulting in lead compounds. These leads undergo further refinement to enhance their potency, reduce toxicity, and improve drug-like characteristics, creating drug candidates suitable for preclinical testing. In the preclinical development phase, drug candidates are tested in vitro (in cell cultures) and in vivo (in animal models) to evaluate their safety, efficacy, pharmacokinetics, and pharmacodynamics. Toxicology studies are conducted to assess potential risks.
Before clinical trials can begin, an Investigational New Drug (IND) application must be submitted to regulatory authorities. This application includes data from preclinical studies and plans for clinical trials. Clinical development involves human trials in three phases: Phase I tests the drug's safety and dosage in a small group of healthy volunteers, Phase II assesses the drug's efficacy and side effects in a larger group of patients with the target disease, and Phase III confirms the drug's efficacy and monitors adverse reactions in a large population, often compared to existing treatments.
After successful clinical trials, a New Drug Application (NDA) is submitted to regulatory authorities for approval, including all data from preclinical and clinical studies, as well as proposed labeling and manufacturing information. Regulatory authorities then review the NDA to ensure the drug is safe, effective, and of high quality, potentially requiring additional studies. Finally, after a drug is approved and marketed, it undergoes post-marketing surveillance, which includes continuous monitoring for long-term safety and effectiveness, pharmacovigilance, and reporting of any adverse effects.
ABDOMINAL TRAUMA in pediatrics part one.drhasanrajab
Abdominal trauma in pediatrics refers to injuries or damage to the abdominal organs in children. It can occur due to various causes such as falls, motor vehicle accidents, sports-related injuries, and physical abuse. Children are more vulnerable to abdominal trauma due to their unique anatomical and physiological characteristics. Signs and symptoms include abdominal pain, tenderness, distension, vomiting, and signs of shock. Diagnosis involves physical examination, imaging studies, and laboratory tests. Management depends on the severity and may involve conservative treatment or surgical intervention. Prevention is crucial in reducing the incidence of abdominal trauma in children.
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
3. 3
MEANING
OF
CHRONIC OBSTRUCTIVE PULMONARY
DISEASE
• .
• Chronic obstructive pulmonary disease is a
group of progressive obstructive lung disorder
where airway resistance is increased with
reduced airflow ;may include diseases that
cause airflow limitation (eg emphysema
,chronic bronchitis , bronchiectasis )or a
combination of this disorder.[older definition]
4. MEANINGMEANING
OFOF
CHRONIC OBSTRUCTIVE PULMONARY DISEASECHRONIC OBSTRUCTIVE PULMONARY DISEASE
Chronic obstructive pulmonary disease isChronic obstructive pulmonary disease is
a disease state characterrised by airflowa disease state characterrised by airflow
limitation that is not fullyreversible.limitation that is not fullyreversible.
(NIH,2001 and GOLD 2002)(NIH,2001 and GOLD 2002)
( Newer definition)( Newer definition)
4
5. RISK FACTORS FOR CHRONICRISK FACTORS FOR CHRONIC
OBSTRUCTIVE PULMONARY DISEASE.OBSTRUCTIVE PULMONARY DISEASE.
Exposure to tobacco smoke accounts forExposure to tobacco smoke accounts for
estimated 80% tp 90% of COPD).estimated 80% tp 90% of COPD).
Passive smoking.Passive smoking.
Occupational exposure.Occupational exposure.
Ambient air pollution.Ambient air pollution.
Genetic abnormalities, including a deficiencyGenetic abnormalities, including a deficiency
of alfhpa1- antitrypsin,an enzyme inhibitorof alfhpa1- antitrypsin,an enzyme inhibitor
that normally counteracts the destruction ofthat normally counteracts the destruction of
lung tissue by certain other enzymeslung tissue by certain other enzymes
5
7. 77
PathophysiologyPathophysiology
Pathologic changes in the lung consists of:Pathologic changes in the lung consists of:
1.1. Hyperplasia of mucous secreting glandsHyperplasia of mucous secreting glands
in the trachea and bronchiin the trachea and bronchi
2.2. Disappearance of ciliaDisappearance of cilia
3.3. Chronic inflammatory changes andChronic inflammatory changes and
narrowing of small airways.narrowing of small airways.
4.4. Altered function of alveolar macrophagesAltered function of alveolar macrophages
leading to increased bronchial infections.leading to increased bronchial infections.
8. 8
CLINICAL MANIFESTATIONSCLINICAL MANIFESTATIONS
► Frequent productive coughFrequent productive cough
► Broncho -spasm occur at the end of paroxysm ofBroncho -spasm occur at the end of paroxysm of
coughing.coughing.
► Frequent respiratory infectionsFrequent respiratory infections
► Dyspnea on exertionDyspnea on exertion
► Weight- normal or heavy setWeight- normal or heavy set
► Hypoxemia and hypercapniaHypoxemia and hypercapnia
► Blue bloaterBlue bloater
► PolycythemiaPolycythemia
► cyanosiscyanosis
11. 1111
Medical management of COPDMedical management of COPD
Treatment goals:Treatment goals:
1.1. Improve ventilationImprove ventilation
2.2. To facilitate the removal of bronchialTo facilitate the removal of bronchial
secretionssecretions
3.3. To prevent complicationsTo prevent complications
4.4. To slow the progression of clinicalTo slow the progression of clinical
manifestations.manifestations.
5.5. To promote health maintenanceTo promote health maintenance
12. 1212
Improve ventilationImprove ventilation
• 1. Pharmaco therapy
a) Broncho dilators
b) Cortico steroids
c) Antibiotics
d) Influenza and pneumococcal vaccines
e) Alpha 1 Antitrypsin therapy
f) Psycho active agents
g) Oxygen
15. 1515
Control complicationsControl complications
Edema and cor pulmonale areEdema and cor pulmonale are
treated with diuretics and digitalistreated with diuretics and digitalis
Phlebotomy to reduce blood volumePhlebotomy to reduce blood volume
16. 16
Improve general health
Stop smoking
Minimize exposure to allergens
Avoid high altitudes
Adequate nutrition
22. 2222
Nursing managementNursing management
1. Nursing Assessment:1. Nursing Assessment:
Subjective data (health information,Subjective data (health information,
functional health pattern)functional health pattern)
Objective data (Head to foot examination)Objective data (Head to foot examination)
23. 2323
Nursing diagnosis & interventionsNursing diagnosis & interventions
1.1. In effective air way clearance R/TIn effective air way clearance R/T
expiratory air flow obstruction.expiratory air flow obstruction.
Maintain adequate hydrationMaintain adequate hydration
Effective coughing techniques.Effective coughing techniques.
24. 24
Nsg. management cont….
2. Impaired gas exchange R/T
decreased ventilation and mucus
plugs.
Monitor client’s respiratory rate,
pattern, ABG results
Administer low flow oxygen
High fowlers position
Administer broncho dilators
25. 25
Cont..Cont..
► Teach s/s and consequences of hyper capniaTeach s/s and consequences of hyper capnia
► Avoid CNS depressant drugsAvoid CNS depressant drugs
3. Anxiety R/T acute breathing difficulty.3. Anxiety R/T acute breathing difficulty.
Remain with the client during the episodes ofRemain with the client during the episodes of
breathing difficultybreathing difficulty
Provide calm, quiet environment.Provide calm, quiet environment.
Ensure ventilationEnsure ventilation
Administer sedatives with caution (nonAdminister sedatives with caution (non
pharmaceutical methods of anxiety reduction)pharmaceutical methods of anxiety reduction)
26. 2626
Nursing Mx.cont….Nursing Mx.cont….
4. Activity intolerance R/T inadequate4. Activity intolerance R/T inadequate
oxygenation and dyspnea.oxygenation and dyspnea.
Monitor the severity of dyspnea and O2Monitor the severity of dyspnea and O2
saturation following activity.saturation following activity.
Stop or slow activity that leads to significantStop or slow activity that leads to significant
change in respiration.change in respiration.
Maintain supplemental O2Maintain supplemental O2
Schedule active exercise after resp. therapy.Schedule active exercise after resp. therapy.
27. 27
Cont…
Assist the client in scheduling gradual
increase in daily activities.
Avoid conditions that increase O2
demand.
Teach effective breathing techniques.
Instruct the client in energy
conservation techniques.
28. 2828
Cont….Cont….
5. Altered nutrition less than body5. Altered nutrition less than body
requirements R/T reduced appetite,requirements R/T reduced appetite,
decreased energy level and dyspnea.decreased energy level and dyspnea.
Mouth care before meals.Mouth care before meals.
Small, frequent meals high in protein &Small, frequent meals high in protein &
calories.calories.
Avoid gas producing foodAvoid gas producing food
Monitor the clients food intake, weight andMonitor the clients food intake, weight and
serum Hb, albumin levels.serum Hb, albumin levels.
29. 2929
Cont…Cont…
6. Disturbed sleep pattern R/T dyspnea and6. Disturbed sleep pattern R/T dyspnea and
external stimuli.external stimuli.
Promote relaxation.Promote relaxation.
Schedule care activities to allow periods ofSchedule care activities to allow periods of
uninterrupted sleep.uninterrupted sleep.
Avoid use of sleeping pills.Avoid use of sleeping pills.
Avoid stimulants e.g. caffeineAvoid stimulants e.g. caffeine
Maintain a consistent bed time and aMaintain a consistent bed time and a
regular bed time routine.regular bed time routine.
Recliner chair may be better in dyspnea.Recliner chair may be better in dyspnea.
30. 3030
Cont….Cont….
7. Interrupted family process R/T chronic illness of a7. Interrupted family process R/T chronic illness of a
family member.family member.
Encourage participation of family members in theEncourage participation of family members in the
planning process.planning process.
Family counseling if needed.Family counseling if needed.
Encourage social support network.Encourage social support network.
Provide family with anticipatory guidance.Provide family with anticipatory guidance.
31. 3131
Cont…Cont…
8. Risk for infection R/T ineffective8. Risk for infection R/T ineffective
pulmonary clearance.pulmonary clearance.
Hand washing after contacting withHand washing after contacting with
the potentially infectious material.the potentially infectious material.
Teach the client how to care forTeach the client how to care for
respiratory equipments used atrespiratory equipments used at
home.home.
Teach the client and the family theTeach the client and the family the
manifestations of pulmonarymanifestations of pulmonary
infections.infections.
32. 3232
Cont…..Cont…..
9. Sexual dysfunction R/T dyspnea, reduced
energy.
Provide opportunity for the client to
discuss concerns.
Suggest measures that may facilitate
sexual activity
Encourage alternative forms of sexual
expression
33. 3333
Cont…..Cont…..
10. Decisional conflict R/T smoking10. Decisional conflict R/T smoking
cessationcessation
Assess clients readiness to atop smokingAssess clients readiness to atop smoking
Counseling and pharmaco therapyCounseling and pharmaco therapy
Arrange follow up care.Arrange follow up care.
34. 3434
Cont….Cont….
11. Impaired physical mobility R/T de-11. Impaired physical mobility R/T de-
conditioning.conditioning.
Use adaptive breathing techniqueUse adaptive breathing technique
during activity to decrease the workduring activity to decrease the work
of breathing.of breathing.
Space the activities.Space the activities.
Gradual increase of activities.Gradual increase of activities.
Methods of conserving energy.Methods of conserving energy.
Active and passive exercise toActive and passive exercise to
maintain adequate muscle mass.
35. 3535
Patient education and homecare.Patient education and homecare.
1.1. Teach adaptive breathing techniquesTeach adaptive breathing techniques
2.2. Airway clearance techniqueAirway clearance technique
3.3. Avoid contact with persons who haveAvoid contact with persons who have
URTI.URTI.
4.4. Importance of prescribed medicationsImportance of prescribed medications
5.5. Teach the family how to manage duringTeach the family how to manage during
acute attacks of dyspnea.acute attacks of dyspnea.
6.6. Report any change in the health status.Report any change in the health status.
36. 3636
Cont….Cont….
7.7. Avoid dust producing articles at homeAvoid dust producing articles at home
and stop smoking.and stop smoking.
8.8. Adequate fluid intakeAdequate fluid intake
9.9. Food choice modificationFood choice modification
37. 37
Complications of COPDComplications of COPD
1)1) Cor pulmonaleCor pulmonale
2)2) Acute exacerbation of Chronic BronchitisAcute exacerbation of Chronic Bronchitis
3)3) Peptic ulcer and gastro-esophagealPeptic ulcer and gastro-esophageal
refluxreflux
4)4) Acute respiratory failureAcute respiratory failure
38. 3838
Nursing interventionsNursing interventions
Promote effective airway clearance and gasPromote effective airway clearance and gas
exchangeexchange
Prevent complications of immobilityPrevent complications of immobility
Monitoring and documenting altered tissueMonitoring and documenting altered tissue
perfusionperfusion
Promote effective breathing patternPromote effective breathing pattern
Reduce anxietyReduce anxiety
Promote comfort.Promote comfort.