4. CLASSIFICATION OF X-RAY CONTRAST MEDIUM (CM) Negative CM Positive Cm Gases -air BaSO4 Iodinated CM -CO2 Triiodobenzoic acid Water-insoluble CM Oily CM derivertives -aqueous suspensions -diiodopyridine Monomeric ionic cM Dimeric ionic CM Monomeric nonionic Cm Dimeric nonionic CM
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8. DIODONE NEOIPAX N I I O CH 2 COO (Methylglucamine) + Diiodinated pyridine compounds from 1930-1950 N O CH 3 COO - Na + Na + COO - I I
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11. 1 2 3 4 5 6 COO - I NHCOCH 3 I CH 3 COHN I “ 1955” “ Diatrizoic acid” Angiographin urografin Urorison Hypaque Renografin
12. 1 2 3 4 5 6 COO - I CONHCH 2 CH 2 OH I CH 3 COHN I Ioxithalamate Telebrix
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15. C I O NH NHCOCH 3 I N CH 3 CO CH 3 I CONHCHCH 2 OH CH 2 OH I I I CONHCHCH 2 OH CH 2 OH CH 3 CHCONH OH OH OH OH O CH 2 OH Metrizamide Iopamidol
16. I I I I R 3 COO - R 2 R 1 I I Ionic monoacid dimeric compound Ioxalic acid
17. Osmolality of ionic and nonionic CM mgI/ml Osmolality mosm/kg water Blood 290 Ionic monomeric CM Urografin 30% (sod-meg diatrizoate) 146 710 45% 219 1050 60% 292 1500 76% 370 2100 Angiografin (meg diatrizoate) 306 1530 Telebrix 38 (sod-meg ioxithalamate) 380 2100