This document provides an overview of congenital cardiopathy, including its causes, classifications, and types. It discusses how congenital heart diseases result from abnormal embryonic development and have multifactorial etiologies involving genetic and environmental factors. The document classifies congenital heart diseases as either acyanotic or cyanotic and describes common types such as atrial septal defects, ventricular septal defects, patent ductus arteriosus, coarctation of the aorta, tetralogy of Fallot, and transposition of the great vessels. Treatment options like surgical closure or angioplasty are mentioned for some conditions.
Austin Journal of Clinical Cardiology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of cardiology and angiology. The aim of the journal is to provide a forum for cardiologists, researchers, physicians, and other health professionals to find most recent advances in the areas of cardiology and cardiovascular diseases.
Austin Journal of Clinical Cardiology accepts original research articles, review articles, case reports, clinical images and rapid communication on all the aspects of cardiology and circulatory system.
Austin Journal of Clinical Cardiology strongly supports the scientific upgradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Journal of Clinical Cardiology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of cardiology and angiology
Austin Journal of Clinical Cardiology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of cardiology and angiology. The aim of the journal is to provide a forum for cardiologists, researchers, physicians, and other health professionals to find most recent advances in the areas of cardiology and cardiovascular diseases.
Austin Journal of Clinical Cardiology accepts original research articles, review articles, case reports, clinical images and rapid communication on all the aspects of cardiology and circulatory system.
Austin Journal of Clinical Cardiology strongly supports the scientific upgradation and fortification in related scientific research community by enhancing access to peer reviewed scientific literary works. Austin Publishing Group also brings universally peer reviewed journals under one roof thereby promoting knowledge sharing, mutual promotion of multidisciplinary science.
Austin Journal of Clinical Cardiology is an open access, peer reviewed, scholarly journal dedicated to publish articles in all areas of cardiology and angiology
A vivid description of the anaesthetic management in a case of congenital heart disease posted for non cardiac surgery.Briefing of the various CHD'S from basics.Clear description of the pathophysiology,Illustrated with flowcharts and understanding of the complex modified circulatory states.Completely discussed with Head Of the Department and Cardiac Anaesthetic.
The lecture is for medical student. It is from Dr RUSINGIZA Emmanuel, MD, senior lecture at UR( UNIVERSITY OF RWANDA) .
It will help to understand heart diseases in newborn, infants and children.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
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- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
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Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
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This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
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Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
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Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
1. UNIVERSIDAD TECNICA DE MACHALA
ACADEMIC UNIT OF CHEMICAL
SCIENCES AND HEALTH
MEDICINE SCHOOL
ENGLISH
CONGENITAL
CARDIOPATHY
STUDENTS
William Cruz
Kevin Herrera
TEACHER:
Mgs. Barreto Huilcapi Lina Maribel
CLASS:
EIGHTH SEMESTER ‘’A’’
Machala, El Oro
2018
2. CONGENITAL CARDIOPATHY
Introduction.- Congenital heart diseases are structural defects of the
heart and of the great vessels resulting from an altered embryonic
development.
Etiology.- The majority of congenital heart diseases have a
multifactorial etiology, with a complex interaction between genetic and
environmental factors.
1. Genetic syndromes and inheritance.- Mutations of isolated genes (2%)
or chromosomal anomalies (8%) have been found in less than 10% of
congenital heart diseases.
2. Maternal and environmental factors - fetuses exposed to alcohol,
cocaine and other drugs, as well as drugs such as thalidomine, lithium,
glucocorticoids, antiepileptics, warfarin, etc., have a higher incidence of
congenital heart disease. So also viral diseases that affect the mother such
as toxoplasmosis, rubella, etc.
3. Fetal circulation and transition to postnatal circulation. - The
persistence of short circuits such as atrioventricular communication.
ANOMALIES IN EMBIROLOGICAL DEVELOPMENT
3. Cardiac malpositions
Abnormalities of the primitive tube torsion (atrioventricular inversion)
Defects of cardiac septation
Obstructive lesions and short circuits
Classification of congenital heart diseases. - Congenital acianotic heart
disease-Cyanotic congenital cardiopathies.
Congenital acyanotic heart disease
Cardiopathy with left to right shunt. - It is the largest group of
congenital heart diseases and accounts for about 50% of them; a) atria:
(CIA), b) ventricles (CIV), c) atria and ventricles (A-V)
Pathophysiology.- The blood recirculates through the lungs without
entering the peripheral systemic arterial circulation. The
physiopathological and clinical consequences of short circuit I-D, which
depend on the magnitude of this and the anatomical place where they
occur are: pulmonary hyperflow, volume overload and cardiac cavities
dilation. In general, cardiopathies with short circuit I-D are symptomatic
when 50% or more of the flow that reaches the left side of the heart
deviates to the right.
Interauricular communication.- corresponds to 10% of congenital heart
diseases and predominates in women. The most common anatomical form
is the ostium secundum type (70%), located in the oval fossa. Less
frequent are the ostium primum or partial AV canal (20%), and venous
sinus (10%). Clinical picture.- Large or medium defects may occur in the
first years of life with retarded growth and repeated respiratory infections,
which are due to lobar or segmental atelectasis and bronchial
hypersecretion secondary to extrinsic compression of the bronchus by
dilated pulmonary vessels .
Treatment.- surgical closure.
Interventricular communication.- is the most frequent congenital heart
defect (25% to 30% of congenital heart diseases as an isolated defect).
These defects can be of different sizes and be located in any area of the
4. interventricular septum; Perimembranous communications are more
frequent.
Clinical picture.- The restrictive VSD is asymptomatic. Non-restrictive
VSD can cause severe heart failure, especially during the second or third
month of life. In large VSD, there is biventricular cardiomegaly and
pulmonary plethora on chest radiography.
Treatment.- Surgical intervention is indicated in older children and adults
with symptoms attributable to the short circuit of I-D.
Complete atrioventricular canal.- is characterized by the presence of a
ring and a common AV valve. In the complete form there is a septal defect
in the cruxcordis, which extends to the inter-ventricular and
interventricular septums; In the partial form, the two AV holes, right and
left, are separated and the septal defect can affect only the interventricular
septum of entry or the interatrial septum.
Ductus arteriosus persistent - is an arteriovenous fistula that sends blood
to the lungs throughout the cardiac cycle.
Congenital obstruction of the left heart.- These are lesions that extend
from the left ventricular-anatomic tract to the descending portion of the
aortic arch and prevent the normal dynamics of left ventricular ejection.
They can be located at the valvular, subvalvular or supravalvular level and
the obstruction can be total (atresia) or partial (stenosis). In cases of very
severe atresia or stenosis, aberrant flow patterns that occur during
intrauterine life influence the normal structural and functional
development of the left heart (hypoplastic left heart syndrome, SCIH). In
cases of stenosis, the cavities that precede the obstruction raise its pressure
to maintain cardiac output.
TYPES:
Coarctation of the aorta.- Constriction of the light of the aorta, it is a
relatively frequent congenital malformation and constitutes 7-9% of them;
more in males; this defect is almost always located at the junction of the
distal aortic arch and the thoracic aorta.
5. Treatment.- All patients must undergo surgical resection or percutaneous
angioplasty.
Subaortic stenosis. - It is a fixed character lesion and congenital etiology,
which can be localized (fibrous membrane or fibromuscular impeller) or
tunneling; It is usually associated with other congenital malformations
such as IVC (35%). Surgical repair is indicated with gradients greater than
30-50 mm Hg, depending on the age of the patient.
CYANOTIC CONGENITAL HEART DISEASE
Congenital cyanotic cardiopathies with increased pulmonary flow
(plethora) .- Transposition of the great vessels: the desaturated blood that
returns through the venae cava to the right atrium, returns to the aorta,
which originates in the right ventricle, without having passed through the
pulmonary circulation. Oxygenated blood that returns through the
pulmonary veins to the left atrium, returns to the lungs through the
pulmonary artery, which originates in the left ventricle.
Congenital cyanotic cardiopathies with reduced pulmonary flow
(ischemia) .- in this group are all simple or complex cardiac defects
associated with obstruction to pulmonary flow and with a septal defect that
allows the short circuit D-I.
TYPES:
Tetralogy of Fallot.-most frequent after 1 year of life; characterized by:
obstruction to the exit of the right ventricle, VSD, overlapping of the aorta
and hypertrophy of the RV.
Sx. From Eisenmenger.- systemic-pulmonary communication, with bi-
directional or predominantly D-I short circuit, with Qp / Qs less than 1,
secondary to pulmonary hypertension.
Cyanotic congenital cardiopathies with total mixture. - Single
ventricle. Fontan Circulation: single double-ventricle ventricular, tricuspid
atresia, stenosis or mitral atresia and heterotaxis.There are several possible
situations: Non-restrictive pulmonary output tract; Moderately restrictive
6. pulmonary outflow tract and balanced circulation; Very restrictive exit
tract and palliative surgical intervention in childhood.
BIBLIOGRAPHY REFERENCE
Gallego García de Vinuesa, P. "Cardiopathies Congenital", Farreras, V.
Rozman, C. Internal Medicine, Barcelona-Spain, Elsevier, 2016, Vol.1, pg. 542-
553.