SlideShare a Scribd company logo
Congenital anomalies of the
larynx
DR SUNITHA
ENT PG
DEPT OF ENT
AJIMS
MANGALORE
CLASSIFICATION
1..CARTILAGINOUS ANOMALIES-
A. SUPRA GLOTTIC ANOMALIES
- Laryngomalacia
- Epiglottic anomalies (absent or bifid )
B. GLOTTIC ANOMALIES
-Atresia
- Laryngeal cleft
C. SUBGLOTTIC ANOMALIES
- Stenosis
- Atresia
2. SOFT TISSUE ANOMALIES
A. Cyst and Laryngoceles
B. Tracheoesophageal fistula
C. Webs and Stenosis
D. Reduplication
3. COMBINED ANOMALIES
A. Atresia
4. NEUROLOGICALANOMALIES
A. Vocal cord palsy
5. HAMARTOMATOUS ANOMALIES
A. Haemangioma
B. Lymphangioma
LARYNGOMALACIA
 Also known as Congenital laryngeal stridor.
 Most common cause of stridor in infants.
 Occurence ratio- M:F -2:1.
 Theories of Causation –
-Congenital malformation of the larynx associated with abnormal f
flaccidity of laryngeal cartilage resulting in stridor.
- Delayed development of neuromuscular control leading to laryngeal hypotonia.
- Anatomical abnormality .
Pathophysiology of Laryngomalacia
 Softness or lack of consistency of laryngeal
tissue
 Hypocellularity of laryngeal tissue
 Wrinkled loose mucosa
 Ary epiglottic fold is short antero posteriorly
 80% of cases are associated with GERD
Clinical features
 Inspiratory stridor, high pitch type within few
days of birth, more in 8months (9-12 months)
 Cry is clear, strong and normal
 Cyanotic attacks are uncommon
Airway obstructive symptoms
Clinical features
 Prolonged feeding time
 Emesis
 Choking
 Coughing
 Weight loss
Feeding symptoms
Investigations
Specific investigations
 Flexible fibro optic laryngoscopy
 Sleep study- to document the duration of apnoea and
severity of laryngomalacia
Investigations to rule out other co existing
conditions
 Video fluoroscopy
 X ray chest
 Esophagogram
 Bronchoscopy
Treatment
Medical management
 Empiric reflux acid suppression – H2 blockers, PPI
 Feeding modulation – thickened formula feeds, small formula feeds
 Posture- upright
Surgical management
 Supraglottoplasty
 Epiglottoplexy
 Tracheostomy
Complications
 Life threatening airway obstruction
 Failure to thrive
 Recurrent upper respiratory tract infection
 GERD
 Sleep apnoea
 Pulmonary hypertension
 Developmental delay
 Cardiac failure
 Death
BIFID EPIGLOTTIS
 Congenital bifid epiglottis is a rare congenital laryngeal anomaly
 Epiglottis fails to fuse in midline resulting in cleft extending down to its
tubercle
 Presents as laryngomalacia with inspiratory stridor and airway obstruction.
 Bifid epiglottis may be associated with congenital syndromes most commonly
Pallister-Hall syndrome.
 Patients with bifid epiglottis should undergo an endocrine evaluation because of
the possibility of associated hypothyroidism or hypothalamic abnormalities.
Investigations
 Flexible endoscopy
Treatment
 In cases of severe airway obstruction, surgical management is necessary.
 Endoscopic removal of the malacic portion of the bifid epiglottis
 CO2 laser to relieve the airway obstruction.
LARYNGEAL ATRESIA
 Rare lesion.
 Arise from premature arrest of normal
epithetial ingrowth into the larynx.
 Atresia occurs when laryngeal opening fails to
develop and obstruction is created at or near
the glottis.
 Tracheoesophageal fistulae are frequently
associated with this condition and usually
arise at tracheal bifurcation.
 Symptoms- child becomes markedly cyanotic when umbilical cord is clamped .
 Child does not cry or manifest any stridor.
 Investigation made before birth by ultrasonography by noting enlarged oedematous lungs, compressed
fetal heart, severe ascites and fetal hydrops.
 Extracorporeal tracheostomy can be done during caesarean section .
LARYNGEAL CLEFT
 Posterior laryngeal cleft or laryngotracheal esophageal cleft, is an uncommon congenital laryngeal
anomaly
 Typically presents with aspiration, stridor, and weak cry at birth.
 Posterior laryngeal cleft (PLC) may be an isolated laryngeal anomaly or associated with other
congenital anomalies.
 Tracheoesophageal fistula
 Esophageal atresia
 Cleft lip and palate
 Congenital heart defects (transposition of great vessels)
 Gastrointestinal anomalies (imperforate anus, rectal stenosis, Meckel's diverticulum)
 Genitourinary anomalies ( hypoplastic kidneys)
 Subglottic stenosis
 The embryologic defect that causes an abnormal opening in the posterior larynx
or posterior trachea results from a failure of fusion of the tracheoesophageal
septum and of the dorsal laminae of the cricoid cartilage
 The failure of fusion may result in an abnormal communication limited just to the
larynx itself, or extending into the cervical and, possibly, thoracic trachea
Benjamin and Inglis classification
 Type I Supraglottic, interarytenoid cleft
 Type I1 Partial cricoid cleft
 Type I11 Complete cricoid cleft with or without extension into part of trachea-
esophageal wall
 Type IV Laryngotracheal esophageal cleft
Signs and symptoms
 Aspiration
 Choking and cyanosis on feeding
 Stridor
Investigations
 Endoscopy
 Fluroscopy
 Chest xray and xray neck
 Laryngoscopy
 Functional endoscopic evaluation of swallowing
 CT neck
Treatment
 Type 1 : No surgical intervention
 Type 2 : Repair endoscopically followed by NG feeds
 Type 3 : Low tracheostomy and laryngofissure approach
 Type 4 : Endotracheal intubation for 10 days
 Short cleft : cervical approach
 Long cleft : lateral cervical approach with tracheostomy or cervicothoracic
approach with medial sternotomy
SUBGLOTTIC STENOSIS
 Narrowing of less than 4mm at the subglottic region
 3rd most common congenital anomaly
 More common in males
 Subglottic stenosis may be associated with other congenital anomalies, such as
vocal cord paralysis or congenital syndromes, such as Down syndrome
Types
Based on position
 Circumferential
 Eccentric
Based on type
 Membranous
 Cartilagenous
Classification
Myer cotton endoscopic
grading system
Signs and symptoms
 Stridor
 Harsh and barking cough
 Hoarse cry
 Persistant or recurrent croup
Differential diagnosis
 Glottic web
 Laryngeal hemangioma
 Laryngeal cyst
 Tracheomalacia
 Bronchomalacia
Investigations
 Xray neck
 Microlaryngoscopy
 Bronchoscopy
 3 D CT scan navigator
 MRI
Treatment
 Grade 1: wait and watch
50% - dilatation / laser
 Grade 2 : Tracheostomy / laryngotracheoplasty with anterior cricoid splint
 Grade 3 : tracheostomy / laryngotracheoplasty with anterior and posterior cricoid splint and
placement of stent
 Grade 4 : partial crico tracheal resection
LARYNGEAL CYST
Originate from minor salivary glands within the mucosa of the larynx
Classification
De Santo
 Saccular cyst
 Ductal cyst
 Thyroid cartilage foraminal cyst
Newmann
 Epithelial cyst : ductal/ saccular
 Tonsillar cyst
 Oncocystic cyst
Investigations and treatment
 Xray neck
 Endoscopy
Laryngocoele
TRACHEOESOPHAGEAL FISTULA
Tracheo-oesophageal fistula is an abnormal connection between the
trachea and the oesophagus
 Type A: In this type, there is Oesophagal Atresia and proximal and distal
segments of oesophagus are blind. There is no communication between trachea
and oesophagus. This type is present in 3-7 % of cases
 Type B: In this type, Oesophagal Atresia is present and the blind proximal
segment of oesophagus connects with trachea by a fistula. The distal end of
oesophagus is blind. This type is present in 0.8 % cases.
 Type C: In this type, Oesophagal Atresia is present. The proximal end of
oesophagus is a blind pouch and distal segment of oesophagus is connected by
fistula to trachea. This is the commonest type, present in about 87 % cases.
 Type D: It is the rarest type that occurs in 0.7 % cases. In this type, both upper
and lower segments of oesophagus communicate with trachea.
 Type E: In this type, oesophagus and trachea are normal and completely formed
but are connected by a fistula. This type is also known as ‘H’ type and is present
4.2% cases.
Clinical Features
 Disorder is usually detected soon after birth when feeding is attempted on the
basis of following :
1. Violent response occurs on feeding
2.Infant coughs and chokes
3.Fluid returns through nose and mouth.
4.Cyanosis occur
5.The infant struggles
 Excessive secretions coming out of nose and constant drooling of saliva.
 Abdominal distension occurs in presence of type III, IV and V fistula.
 Intermittent unexplained cyanosis and laryngospasm, caused by aspiration of
accumulated saliva in blind oesophageal pouch.
 Pneumonia may occur due to overflow of milk and saliva from oesophagus
through fistula into the lungs
 TEF may be suspected prenatally if
Ultrasound examination reveals polyhydramnios, absence of a fluid-filled stomach,
a small abdomen, lower-than expected fetal weight, and a distended esophageal
pouch.
 TEF may be detected postnatally by
X-ray taken with radiopaque catheter placed in esophagus to check for obstruction;
standard chest X- ray shows a dilated air-filled upper esophageal pouch and can
demonstrate pneumonia.
Inability to pass a NG tube into stomach because it meets resistance
Bronchoscopy visualizes fistula between trachea and esophagus
 The management of tracheaoesophageal fistula is mainly surgical. Surgical
intervention depends on the distance between proximal and distal pouch of
oesophagus, type of defect.
 If distance between upper and lower oesophageal segments is less than 2.5 cm
and if the condition of infant is good, primary repair is done by division and
ligation of the fistula along with end-to-end anastomosis of proximal and distal
segments of oesophagus.
CONGENITAL VOCAL CORD PALSY
 Third most common congenital laryngeal anomaly causing stridor.
 Unilateral & Bilateral (1:1) .
 50% are associated to other anomalies
 Acquired paralysis
- 70% association to congenital neurologic abnormalities or neurosurgical
procedure.
-Unilateral are associated to cardiovascular anomalies (PDA) and left side is more
common.
 Symptoms –
Bilateral - High-pitched inspiratory stridor
- Inspiratory cry
-Paradoxical function (pressure changes)
-close during inspiration and open during expiration.
Unilateral – weak cry .
- Feeding difficulties secondary to laryngeal
penetration and aspiration.
 Awake flexible fiberoptic laryngoscopy
 Direct laryngoscopy
 Imaging of head (MRI) and chest to evaluate for associated abnormalities
(Neurologic & CV)
 Wait and watch
70% of idiopathic unilateral VC paralysis resolve spontaneously
Most within 6 month
 Speech therapy
 Rare surgical management
Bilateral VC Paralysis treatment
 Tracheostomy may be necessary (50%)
 Lateralizing one or both paralyzed vocal cords
 Excisional procedure -Tissue removed from posterior glottis
 Endoscopic technique with laser
 More consistent results are achieved by external approach
LARYNGEAL WEBS
 Uncommon
 Failure of laryngeal recanalization
 Most common site - glottic (75%)
 Symptoms
Vocal dysfunction
Hoarseness
Aphonia
Airway obstruction (if severe)
 Complete laryngeal atresia is incompatible with life and need emergency tracheostomy
Laryngeal Web Diagnosis
 Flexible laryngoscopy
 Direct Laryngoscopy
 Airway films if subglottic or cricoid pathology are present
Treatment
 Mild form requires no treatment.
 Web is divided endoscopically along the margin of one vocal cord with a knife ,
scissors or laser.
LARYNGEAL HEMANGIOMA
 Benign vascular malformations
 Subglottic haemangiomas is most common neoplasm of infant airway.
 Female predominance 2:1
 Asymptomatic at birth
Stridor presents by 6 months (85%)
 Associated cutaneous hemangioma (50%)
 Rapid growth phase in the 1st year followed by slow resolution
 Most have complete resolution by 5 years
 30-70% mortality rate if untreated
 Priority is to maintain the airway while minimizing potential long term sequelae
Diagnosis
 Direct Laryngoscopy –
unilateral, asymmetric, sub mucosal reddish mass
in subglottic area.
 CT & MRI
Treatment
 Systemic steroids (principal)
Partial regression in most patients (82-97%)
Risk of growth retardation and increase susceptibility to infection
Risk is reduced by alternate-day dosing regimen in the smallest doses
Also intralesion corticosteroids has been employed with successful avoidance of
tracheotomy
 Interferon alpha-2a
50% or greater regression of lesion in 73% of patients
It requires prolonged therapy, blocks various steps of angiogenesis
Side effects neuromuscular impairment, skin slough, fever and liver enzyme elevation
Treatment (contd)..
 Tracheostomy
Bypass the obstructing lesion
Waiting for the expected involution
Risks of tracheostomy as well as delay in speech and language
 Laser CO2 and KTP
associated with a significant risk of inducing subglottic stenosis in up to 20%
THANK YOU

More Related Content

What's hot

Eustachian tube disorders by Dr. Krishna Koirala
Eustachian tube disorders by Dr. Krishna Koirala Eustachian tube disorders by Dr. Krishna Koirala
Eustachian tube disorders by Dr. Krishna Koirala
Dr Krishna Koirala
 
Thyroplasty
ThyroplastyThyroplasty
Physilogy of phonation by Dr.Ashwin Menon
Physilogy of phonation by Dr.Ashwin MenonPhysilogy of phonation by Dr.Ashwin Menon
Physilogy of phonation by Dr.Ashwin Menon
Dr.Ashwin Menon
 
Congenital lesions of larynx
Congenital lesions of larynx Congenital lesions of larynx
Congenital lesions of larynx
drahme
 
Spaces of middle ear and their surgical importance
Spaces of middle ear  and their surgical importanceSpaces of middle ear  and their surgical importance
Spaces of middle ear and their surgical importance
Dr Soumya Singh
 
OME-Otitis Media with effusion in children
OME-Otitis Media with effusion in childrenOME-Otitis Media with effusion in children
OME-Otitis Media with effusion in children
Razal M
 
Stroboscopy
StroboscopyStroboscopy
Stroboscopy
ArjunSuresh60
 
SUBGLOTTIC STENOSIS.pptx
SUBGLOTTIC STENOSIS.pptxSUBGLOTTIC STENOSIS.pptx
SUBGLOTTIC STENOSIS.pptx
shankarnaikvarthya
 
Development of ear ppt
Development of ear pptDevelopment of ear ppt
Development of ear ppt
Dr Safika Zaman
 
Phonosurgery
PhonosurgeryPhonosurgery
Phonosurgery
Saurabh Gupta
 
Granulomatous diseases of the larynx
Granulomatous diseases of the larynxGranulomatous diseases of the larynx
Granulomatous diseases of the larynx
Sayan Banerjee
 
Endoscopic anatomy of Retrotympanum; Middle ear
Endoscopic anatomy of Retrotympanum; Middle earEndoscopic anatomy of Retrotympanum; Middle ear
Endoscopic anatomy of Retrotympanum; Middle ear
Prasanna Datta
 
Septoplasty
SeptoplastySeptoplasty
Septoplasty
Dr. Nitin taba
 
8737 Coclia 84 Glottic Ans Subglottic Stenosis
8737 Coclia 84 Glottic Ans Subglottic Stenosis8737 Coclia 84 Glottic Ans Subglottic Stenosis
8737 Coclia 84 Glottic Ans Subglottic StenosisMedicineAndHealthResearch
 
Benign disorders of larynx
Benign disorders of larynxBenign disorders of larynx
Benign disorders of larynx
11032013
 
Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...
Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...
Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...
social service
 
Vocal fold paralysis/ Paresis full
Vocal fold paralysis/ Paresis fullVocal fold paralysis/ Paresis full
Vocal fold paralysis/ Paresis full
SREENIVAS KAMATH
 
Cavity obliteration @ sayan
Cavity obliteration  @ sayanCavity obliteration  @ sayan
Cavity obliteration @ sayan
IPGMER
 
Fess part 2,3,4,5
Fess part 2,3,4,5Fess part 2,3,4,5
Fess part 2,3,4,5
drmhndalali
 

What's hot (20)

Eustachian tube disorders by Dr. Krishna Koirala
Eustachian tube disorders by Dr. Krishna Koirala Eustachian tube disorders by Dr. Krishna Koirala
Eustachian tube disorders by Dr. Krishna Koirala
 
Thyroplasty
ThyroplastyThyroplasty
Thyroplasty
 
Physilogy of phonation by Dr.Ashwin Menon
Physilogy of phonation by Dr.Ashwin MenonPhysilogy of phonation by Dr.Ashwin Menon
Physilogy of phonation by Dr.Ashwin Menon
 
Congenital lesions of larynx
Congenital lesions of larynx Congenital lesions of larynx
Congenital lesions of larynx
 
Spaces of middle ear and their surgical importance
Spaces of middle ear  and their surgical importanceSpaces of middle ear  and their surgical importance
Spaces of middle ear and their surgical importance
 
OME-Otitis Media with effusion in children
OME-Otitis Media with effusion in childrenOME-Otitis Media with effusion in children
OME-Otitis Media with effusion in children
 
Stroboscopy
StroboscopyStroboscopy
Stroboscopy
 
SUBGLOTTIC STENOSIS.pptx
SUBGLOTTIC STENOSIS.pptxSUBGLOTTIC STENOSIS.pptx
SUBGLOTTIC STENOSIS.pptx
 
Development of ear ppt
Development of ear pptDevelopment of ear ppt
Development of ear ppt
 
Phonosurgery
PhonosurgeryPhonosurgery
Phonosurgery
 
Granulomatous diseases of the larynx
Granulomatous diseases of the larynxGranulomatous diseases of the larynx
Granulomatous diseases of the larynx
 
Endoscopic anatomy of Retrotympanum; Middle ear
Endoscopic anatomy of Retrotympanum; Middle earEndoscopic anatomy of Retrotympanum; Middle ear
Endoscopic anatomy of Retrotympanum; Middle ear
 
Septoplasty
SeptoplastySeptoplasty
Septoplasty
 
8737 Coclia 84 Glottic Ans Subglottic Stenosis
8737 Coclia 84 Glottic Ans Subglottic Stenosis8737 Coclia 84 Glottic Ans Subglottic Stenosis
8737 Coclia 84 Glottic Ans Subglottic Stenosis
 
Benign disorders of larynx
Benign disorders of larynxBenign disorders of larynx
Benign disorders of larynx
 
Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...
Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...
Eustachian tube final PP ANATOMY,EMBRYOLOGY,FUNCTIONS,DYSFUNCTIONS TREATMENT,...
 
Vocal fold paralysis/ Paresis full
Vocal fold paralysis/ Paresis fullVocal fold paralysis/ Paresis full
Vocal fold paralysis/ Paresis full
 
Cavity obliteration @ sayan
Cavity obliteration  @ sayanCavity obliteration  @ sayan
Cavity obliteration @ sayan
 
Fess part 2,3,4,5
Fess part 2,3,4,5Fess part 2,3,4,5
Fess part 2,3,4,5
 
Vocal cord granuloma
Vocal cord granulomaVocal cord granuloma
Vocal cord granuloma
 

Similar to Congenital anomalies of the larynx

Esophageal atresia
Esophageal atresiaEsophageal atresia
Esophageal atresia
Silah Aysha
 
Esophageal atresia & tracheo-esophageal fistula
Esophageal atresia & tracheo-esophageal fistulaEsophageal atresia & tracheo-esophageal fistula
Esophageal atresia & tracheo-esophageal fistula
zanzibul tareq
 
Pediatric stridor
Pediatric stridorPediatric stridor
Pediatric stridor
Shivram Gautaam
 
Presentation1.pptx, radiological imaging of the larngeal diseases.
Presentation1.pptx, radiological imaging of the larngeal diseases.Presentation1.pptx, radiological imaging of the larngeal diseases.
Presentation1.pptx, radiological imaging of the larngeal diseases.Abdellah Nazeer
 
Theosophical fistula and esophageal atresia
Theosophical fistula and esophageal atresiaTheosophical fistula and esophageal atresia
Theosophical fistula and esophageal atresia
Arpan Pandya
 
Tracheo oesophageal fistula
Tracheo oesophageal fistulaTracheo oesophageal fistula
Tracheo oesophageal fistulaNavjyot Singh
 
esophageal atresia
esophageal atresiaesophageal atresia
esophageal atresia
طالبه جامعيه
 
Laryngomalagia
LaryngomalagiaLaryngomalagia
Laryngomalagia
DiNa Maklad
 
E.N.T 5th year, 4th lecture (Dr. Sherko)
E.N.T 5th year, 4th lecture (Dr. Sherko)E.N.T 5th year, 4th lecture (Dr. Sherko)
E.N.T 5th year, 4th lecture (Dr. Sherko)
College of Medicine, Sulaymaniyah
 
Special situations in tonsil and Adenoid disorder Special situations in ton...
Special situations in tonsil and Adenoid disorder 	 Special situations in ton...Special situations in tonsil and Adenoid disorder 	 Special situations in ton...
Special situations in tonsil and Adenoid disorder Special situations in ton...MedicineAndHealthResearch
 
Tracheo Esophageal Fistula and Anesthesia
Tracheo Esophageal Fistula and AnesthesiaTracheo Esophageal Fistula and Anesthesia
Tracheo Esophageal Fistula and Anesthesia
Dr.S.N.Bhagirath ..
 
Tef ppt new
Tef ppt newTef ppt new
Tef ppt new
Shivangi sharma
 
Tracheo oesophageal fistula atresia Everything
Tracheo oesophageal fistula atresia Everything Tracheo oesophageal fistula atresia Everything
Tracheo oesophageal fistula atresia Everything
abhinavslideshar
 
42.upper airway obstructions
42.upper airway obstructions42.upper airway obstructions
42.upper airway obstructions
solomondemeke6
 
Anomalies of the Gastrointestinal Tract and Anterior Abdominal.ppt
Anomalies of the Gastrointestinal Tract and Anterior Abdominal.pptAnomalies of the Gastrointestinal Tract and Anterior Abdominal.ppt
Anomalies of the Gastrointestinal Tract and Anterior Abdominal.ppt
hendra472440
 
1. Respiratory disorders and infections - Copy.pptx
1. Respiratory disorders and infections - Copy.pptx1. Respiratory disorders and infections - Copy.pptx
1. Respiratory disorders and infections - Copy.pptx
ManmeetKaur216
 
Anorectal conditions
Anorectal conditionsAnorectal conditions
Anorectal conditions
Nicholaus Mabongo
 
Esophageal atresia with or without tracheoesophageal fistula
Esophageal atresia with or without tracheoesophageal fistulaEsophageal atresia with or without tracheoesophageal fistula
Esophageal atresia with or without tracheoesophageal fistulaMohsin Ali
 

Similar to Congenital anomalies of the larynx (20)

Esophageal atresia
Esophageal atresiaEsophageal atresia
Esophageal atresia
 
Esophageal atresia & tracheo-esophageal fistula
Esophageal atresia & tracheo-esophageal fistulaEsophageal atresia & tracheo-esophageal fistula
Esophageal atresia & tracheo-esophageal fistula
 
Pediatric stridor
Pediatric stridorPediatric stridor
Pediatric stridor
 
Presentation1.pptx, radiological imaging of the larngeal diseases.
Presentation1.pptx, radiological imaging of the larngeal diseases.Presentation1.pptx, radiological imaging of the larngeal diseases.
Presentation1.pptx, radiological imaging of the larngeal diseases.
 
1.pptx
1.pptx1.pptx
1.pptx
 
Theosophical fistula and esophageal atresia
Theosophical fistula and esophageal atresiaTheosophical fistula and esophageal atresia
Theosophical fistula and esophageal atresia
 
Tracheo oesophageal fistula
Tracheo oesophageal fistulaTracheo oesophageal fistula
Tracheo oesophageal fistula
 
esophageal atresia
esophageal atresiaesophageal atresia
esophageal atresia
 
Laryngomalagia
LaryngomalagiaLaryngomalagia
Laryngomalagia
 
E.N.T 5th year, 4th lecture (Dr. Sherko)
E.N.T 5th year, 4th lecture (Dr. Sherko)E.N.T 5th year, 4th lecture (Dr. Sherko)
E.N.T 5th year, 4th lecture (Dr. Sherko)
 
Special situations in tonsil and Adenoid disorder Special situations in ton...
Special situations in tonsil and Adenoid disorder 	 Special situations in ton...Special situations in tonsil and Adenoid disorder 	 Special situations in ton...
Special situations in tonsil and Adenoid disorder Special situations in ton...
 
Tracheo Esophageal Fistula and Anesthesia
Tracheo Esophageal Fistula and AnesthesiaTracheo Esophageal Fistula and Anesthesia
Tracheo Esophageal Fistula and Anesthesia
 
Tef ppt new
Tef ppt newTef ppt new
Tef ppt new
 
Tracheo oesophageal fistula atresia Everything
Tracheo oesophageal fistula atresia Everything Tracheo oesophageal fistula atresia Everything
Tracheo oesophageal fistula atresia Everything
 
2)acute &chronic pharyngeal abscess
2)acute &chronic pharyngeal abscess2)acute &chronic pharyngeal abscess
2)acute &chronic pharyngeal abscess
 
42.upper airway obstructions
42.upper airway obstructions42.upper airway obstructions
42.upper airway obstructions
 
Anomalies of the Gastrointestinal Tract and Anterior Abdominal.ppt
Anomalies of the Gastrointestinal Tract and Anterior Abdominal.pptAnomalies of the Gastrointestinal Tract and Anterior Abdominal.ppt
Anomalies of the Gastrointestinal Tract and Anterior Abdominal.ppt
 
1. Respiratory disorders and infections - Copy.pptx
1. Respiratory disorders and infections - Copy.pptx1. Respiratory disorders and infections - Copy.pptx
1. Respiratory disorders and infections - Copy.pptx
 
Anorectal conditions
Anorectal conditionsAnorectal conditions
Anorectal conditions
 
Esophageal atresia with or without tracheoesophageal fistula
Esophageal atresia with or without tracheoesophageal fistulaEsophageal atresia with or without tracheoesophageal fistula
Esophageal atresia with or without tracheoesophageal fistula
 

Recently uploaded

The Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdfThe Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdf
kaushalkr1407
 
Operation Blue Star - Saka Neela Tara
Operation Blue Star   -  Saka Neela TaraOperation Blue Star   -  Saka Neela Tara
Operation Blue Star - Saka Neela Tara
Balvir Singh
 
Francesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptxFrancesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptx
EduSkills OECD
 
Additional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdfAdditional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdf
joachimlavalley1
 
Honest Reviews of Tim Han LMA Course Program.pptx
Honest Reviews of Tim Han LMA Course Program.pptxHonest Reviews of Tim Han LMA Course Program.pptx
Honest Reviews of Tim Han LMA Course Program.pptx
timhan337
 
Home assignment II on Spectroscopy 2024 Answers.pdf
Home assignment II on Spectroscopy 2024 Answers.pdfHome assignment II on Spectroscopy 2024 Answers.pdf
Home assignment II on Spectroscopy 2024 Answers.pdf
Tamralipta Mahavidyalaya
 
Introduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp NetworkIntroduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp Network
TechSoup
 
Acetabularia Information For Class 9 .docx
Acetabularia Information For Class 9  .docxAcetabularia Information For Class 9  .docx
Acetabularia Information For Class 9 .docx
vaibhavrinwa19
 
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
Levi Shapiro
 
Unit 2- Research Aptitude (UGC NET Paper I).pdf
Unit 2- Research Aptitude (UGC NET Paper I).pdfUnit 2- Research Aptitude (UGC NET Paper I).pdf
Unit 2- Research Aptitude (UGC NET Paper I).pdf
Thiyagu K
 
1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx
JosvitaDsouza2
 
Polish students' mobility in the Czech Republic
Polish students' mobility in the Czech RepublicPolish students' mobility in the Czech Republic
Polish students' mobility in the Czech Republic
Anna Sz.
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
Atul Kumar Singh
 
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
EugeneSaldivar
 
Guidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th SemesterGuidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th Semester
Atul Kumar Singh
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
Vivekanand Anglo Vedic Academy
 
Model Attribute Check Company Auto Property
Model Attribute  Check Company Auto PropertyModel Attribute  Check Company Auto Property
Model Attribute Check Company Auto Property
Celine George
 
special B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdfspecial B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdf
Special education needs
 
2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...
Sandy Millin
 
The geography of Taylor Swift - some ideas
The geography of Taylor Swift - some ideasThe geography of Taylor Swift - some ideas
The geography of Taylor Swift - some ideas
GeoBlogs
 

Recently uploaded (20)

The Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdfThe Roman Empire A Historical Colossus.pdf
The Roman Empire A Historical Colossus.pdf
 
Operation Blue Star - Saka Neela Tara
Operation Blue Star   -  Saka Neela TaraOperation Blue Star   -  Saka Neela Tara
Operation Blue Star - Saka Neela Tara
 
Francesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptxFrancesca Gottschalk - How can education support child empowerment.pptx
Francesca Gottschalk - How can education support child empowerment.pptx
 
Additional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdfAdditional Benefits for Employee Website.pdf
Additional Benefits for Employee Website.pdf
 
Honest Reviews of Tim Han LMA Course Program.pptx
Honest Reviews of Tim Han LMA Course Program.pptxHonest Reviews of Tim Han LMA Course Program.pptx
Honest Reviews of Tim Han LMA Course Program.pptx
 
Home assignment II on Spectroscopy 2024 Answers.pdf
Home assignment II on Spectroscopy 2024 Answers.pdfHome assignment II on Spectroscopy 2024 Answers.pdf
Home assignment II on Spectroscopy 2024 Answers.pdf
 
Introduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp NetworkIntroduction to AI for Nonprofits with Tapp Network
Introduction to AI for Nonprofits with Tapp Network
 
Acetabularia Information For Class 9 .docx
Acetabularia Information For Class 9  .docxAcetabularia Information For Class 9  .docx
Acetabularia Information For Class 9 .docx
 
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
June 3, 2024 Anti-Semitism Letter Sent to MIT President Kornbluth and MIT Cor...
 
Unit 2- Research Aptitude (UGC NET Paper I).pdf
Unit 2- Research Aptitude (UGC NET Paper I).pdfUnit 2- Research Aptitude (UGC NET Paper I).pdf
Unit 2- Research Aptitude (UGC NET Paper I).pdf
 
1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx1.4 modern child centered education - mahatma gandhi-2.pptx
1.4 modern child centered education - mahatma gandhi-2.pptx
 
Polish students' mobility in the Czech Republic
Polish students' mobility in the Czech RepublicPolish students' mobility in the Czech Republic
Polish students' mobility in the Czech Republic
 
Language Across the Curriculm LAC B.Ed.
Language Across the  Curriculm LAC B.Ed.Language Across the  Curriculm LAC B.Ed.
Language Across the Curriculm LAC B.Ed.
 
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...TESDA TM1 REVIEWER  FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
TESDA TM1 REVIEWER FOR NATIONAL ASSESSMENT WRITTEN AND ORAL QUESTIONS WITH A...
 
Guidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th SemesterGuidance_and_Counselling.pdf B.Ed. 4th Semester
Guidance_and_Counselling.pdf B.Ed. 4th Semester
 
The French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free downloadThe French Revolution Class 9 Study Material pdf free download
The French Revolution Class 9 Study Material pdf free download
 
Model Attribute Check Company Auto Property
Model Attribute  Check Company Auto PropertyModel Attribute  Check Company Auto Property
Model Attribute Check Company Auto Property
 
special B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdfspecial B.ed 2nd year old paper_20240531.pdf
special B.ed 2nd year old paper_20240531.pdf
 
2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...2024.06.01 Introducing a competency framework for languag learning materials ...
2024.06.01 Introducing a competency framework for languag learning materials ...
 
The geography of Taylor Swift - some ideas
The geography of Taylor Swift - some ideasThe geography of Taylor Swift - some ideas
The geography of Taylor Swift - some ideas
 

Congenital anomalies of the larynx

  • 1. Congenital anomalies of the larynx DR SUNITHA ENT PG DEPT OF ENT AJIMS MANGALORE
  • 2. CLASSIFICATION 1..CARTILAGINOUS ANOMALIES- A. SUPRA GLOTTIC ANOMALIES - Laryngomalacia - Epiglottic anomalies (absent or bifid ) B. GLOTTIC ANOMALIES -Atresia - Laryngeal cleft C. SUBGLOTTIC ANOMALIES - Stenosis - Atresia
  • 3. 2. SOFT TISSUE ANOMALIES A. Cyst and Laryngoceles B. Tracheoesophageal fistula C. Webs and Stenosis D. Reduplication 3. COMBINED ANOMALIES A. Atresia 4. NEUROLOGICALANOMALIES A. Vocal cord palsy 5. HAMARTOMATOUS ANOMALIES A. Haemangioma B. Lymphangioma
  • 4. LARYNGOMALACIA  Also known as Congenital laryngeal stridor.  Most common cause of stridor in infants.  Occurence ratio- M:F -2:1.  Theories of Causation – -Congenital malformation of the larynx associated with abnormal f flaccidity of laryngeal cartilage resulting in stridor. - Delayed development of neuromuscular control leading to laryngeal hypotonia. - Anatomical abnormality .
  • 5.
  • 6. Pathophysiology of Laryngomalacia  Softness or lack of consistency of laryngeal tissue  Hypocellularity of laryngeal tissue  Wrinkled loose mucosa  Ary epiglottic fold is short antero posteriorly  80% of cases are associated with GERD
  • 7.
  • 8. Clinical features  Inspiratory stridor, high pitch type within few days of birth, more in 8months (9-12 months)  Cry is clear, strong and normal  Cyanotic attacks are uncommon Airway obstructive symptoms
  • 9. Clinical features  Prolonged feeding time  Emesis  Choking  Coughing  Weight loss Feeding symptoms
  • 10. Investigations Specific investigations  Flexible fibro optic laryngoscopy  Sleep study- to document the duration of apnoea and severity of laryngomalacia
  • 11. Investigations to rule out other co existing conditions  Video fluoroscopy  X ray chest  Esophagogram  Bronchoscopy
  • 12. Treatment Medical management  Empiric reflux acid suppression – H2 blockers, PPI  Feeding modulation – thickened formula feeds, small formula feeds  Posture- upright
  • 13. Surgical management  Supraglottoplasty  Epiglottoplexy  Tracheostomy
  • 14. Complications  Life threatening airway obstruction  Failure to thrive  Recurrent upper respiratory tract infection  GERD  Sleep apnoea  Pulmonary hypertension  Developmental delay  Cardiac failure  Death
  • 15. BIFID EPIGLOTTIS  Congenital bifid epiglottis is a rare congenital laryngeal anomaly  Epiglottis fails to fuse in midline resulting in cleft extending down to its tubercle  Presents as laryngomalacia with inspiratory stridor and airway obstruction.
  • 16.  Bifid epiglottis may be associated with congenital syndromes most commonly Pallister-Hall syndrome.  Patients with bifid epiglottis should undergo an endocrine evaluation because of the possibility of associated hypothyroidism or hypothalamic abnormalities.
  • 17. Investigations  Flexible endoscopy Treatment  In cases of severe airway obstruction, surgical management is necessary.  Endoscopic removal of the malacic portion of the bifid epiglottis  CO2 laser to relieve the airway obstruction.
  • 18. LARYNGEAL ATRESIA  Rare lesion.  Arise from premature arrest of normal epithetial ingrowth into the larynx.  Atresia occurs when laryngeal opening fails to develop and obstruction is created at or near the glottis.  Tracheoesophageal fistulae are frequently associated with this condition and usually arise at tracheal bifurcation.
  • 19.  Symptoms- child becomes markedly cyanotic when umbilical cord is clamped .  Child does not cry or manifest any stridor.  Investigation made before birth by ultrasonography by noting enlarged oedematous lungs, compressed fetal heart, severe ascites and fetal hydrops.  Extracorporeal tracheostomy can be done during caesarean section .
  • 20. LARYNGEAL CLEFT  Posterior laryngeal cleft or laryngotracheal esophageal cleft, is an uncommon congenital laryngeal anomaly  Typically presents with aspiration, stridor, and weak cry at birth.
  • 21.  Posterior laryngeal cleft (PLC) may be an isolated laryngeal anomaly or associated with other congenital anomalies.  Tracheoesophageal fistula  Esophageal atresia  Cleft lip and palate  Congenital heart defects (transposition of great vessels)  Gastrointestinal anomalies (imperforate anus, rectal stenosis, Meckel's diverticulum)  Genitourinary anomalies ( hypoplastic kidneys)  Subglottic stenosis
  • 22.  The embryologic defect that causes an abnormal opening in the posterior larynx or posterior trachea results from a failure of fusion of the tracheoesophageal septum and of the dorsal laminae of the cricoid cartilage  The failure of fusion may result in an abnormal communication limited just to the larynx itself, or extending into the cervical and, possibly, thoracic trachea
  • 23. Benjamin and Inglis classification  Type I Supraglottic, interarytenoid cleft  Type I1 Partial cricoid cleft  Type I11 Complete cricoid cleft with or without extension into part of trachea- esophageal wall  Type IV Laryngotracheal esophageal cleft
  • 24. Signs and symptoms  Aspiration  Choking and cyanosis on feeding  Stridor
  • 25. Investigations  Endoscopy  Fluroscopy  Chest xray and xray neck  Laryngoscopy  Functional endoscopic evaluation of swallowing  CT neck
  • 26. Treatment  Type 1 : No surgical intervention  Type 2 : Repair endoscopically followed by NG feeds  Type 3 : Low tracheostomy and laryngofissure approach  Type 4 : Endotracheal intubation for 10 days  Short cleft : cervical approach  Long cleft : lateral cervical approach with tracheostomy or cervicothoracic approach with medial sternotomy
  • 27. SUBGLOTTIC STENOSIS  Narrowing of less than 4mm at the subglottic region  3rd most common congenital anomaly  More common in males  Subglottic stenosis may be associated with other congenital anomalies, such as vocal cord paralysis or congenital syndromes, such as Down syndrome
  • 28. Types Based on position  Circumferential  Eccentric Based on type  Membranous  Cartilagenous
  • 30. Signs and symptoms  Stridor  Harsh and barking cough  Hoarse cry  Persistant or recurrent croup
  • 31. Differential diagnosis  Glottic web  Laryngeal hemangioma  Laryngeal cyst  Tracheomalacia  Bronchomalacia
  • 32. Investigations  Xray neck  Microlaryngoscopy  Bronchoscopy  3 D CT scan navigator  MRI
  • 33. Treatment  Grade 1: wait and watch 50% - dilatation / laser  Grade 2 : Tracheostomy / laryngotracheoplasty with anterior cricoid splint  Grade 3 : tracheostomy / laryngotracheoplasty with anterior and posterior cricoid splint and placement of stent  Grade 4 : partial crico tracheal resection
  • 34. LARYNGEAL CYST Originate from minor salivary glands within the mucosa of the larynx Classification De Santo  Saccular cyst  Ductal cyst  Thyroid cartilage foraminal cyst Newmann  Epithelial cyst : ductal/ saccular  Tonsillar cyst  Oncocystic cyst
  • 35. Investigations and treatment  Xray neck  Endoscopy
  • 37.
  • 38.
  • 39. TRACHEOESOPHAGEAL FISTULA Tracheo-oesophageal fistula is an abnormal connection between the trachea and the oesophagus
  • 40.  Type A: In this type, there is Oesophagal Atresia and proximal and distal segments of oesophagus are blind. There is no communication between trachea and oesophagus. This type is present in 3-7 % of cases  Type B: In this type, Oesophagal Atresia is present and the blind proximal segment of oesophagus connects with trachea by a fistula. The distal end of oesophagus is blind. This type is present in 0.8 % cases.  Type C: In this type, Oesophagal Atresia is present. The proximal end of oesophagus is a blind pouch and distal segment of oesophagus is connected by fistula to trachea. This is the commonest type, present in about 87 % cases.
  • 41.  Type D: It is the rarest type that occurs in 0.7 % cases. In this type, both upper and lower segments of oesophagus communicate with trachea.  Type E: In this type, oesophagus and trachea are normal and completely formed but are connected by a fistula. This type is also known as ‘H’ type and is present 4.2% cases.
  • 42. Clinical Features  Disorder is usually detected soon after birth when feeding is attempted on the basis of following : 1. Violent response occurs on feeding 2.Infant coughs and chokes 3.Fluid returns through nose and mouth. 4.Cyanosis occur 5.The infant struggles
  • 43.  Excessive secretions coming out of nose and constant drooling of saliva.  Abdominal distension occurs in presence of type III, IV and V fistula.  Intermittent unexplained cyanosis and laryngospasm, caused by aspiration of accumulated saliva in blind oesophageal pouch.  Pneumonia may occur due to overflow of milk and saliva from oesophagus through fistula into the lungs
  • 44.  TEF may be suspected prenatally if Ultrasound examination reveals polyhydramnios, absence of a fluid-filled stomach, a small abdomen, lower-than expected fetal weight, and a distended esophageal pouch.
  • 45.  TEF may be detected postnatally by X-ray taken with radiopaque catheter placed in esophagus to check for obstruction; standard chest X- ray shows a dilated air-filled upper esophageal pouch and can demonstrate pneumonia. Inability to pass a NG tube into stomach because it meets resistance Bronchoscopy visualizes fistula between trachea and esophagus
  • 46.  The management of tracheaoesophageal fistula is mainly surgical. Surgical intervention depends on the distance between proximal and distal pouch of oesophagus, type of defect.  If distance between upper and lower oesophageal segments is less than 2.5 cm and if the condition of infant is good, primary repair is done by division and ligation of the fistula along with end-to-end anastomosis of proximal and distal segments of oesophagus.
  • 47. CONGENITAL VOCAL CORD PALSY  Third most common congenital laryngeal anomaly causing stridor.  Unilateral & Bilateral (1:1) .  50% are associated to other anomalies  Acquired paralysis - 70% association to congenital neurologic abnormalities or neurosurgical procedure. -Unilateral are associated to cardiovascular anomalies (PDA) and left side is more common.
  • 48.
  • 49.  Symptoms – Bilateral - High-pitched inspiratory stridor - Inspiratory cry -Paradoxical function (pressure changes) -close during inspiration and open during expiration. Unilateral – weak cry . - Feeding difficulties secondary to laryngeal penetration and aspiration.
  • 50.  Awake flexible fiberoptic laryngoscopy  Direct laryngoscopy  Imaging of head (MRI) and chest to evaluate for associated abnormalities (Neurologic & CV)
  • 51.  Wait and watch 70% of idiopathic unilateral VC paralysis resolve spontaneously Most within 6 month  Speech therapy  Rare surgical management
  • 52. Bilateral VC Paralysis treatment  Tracheostomy may be necessary (50%)  Lateralizing one or both paralyzed vocal cords  Excisional procedure -Tissue removed from posterior glottis  Endoscopic technique with laser  More consistent results are achieved by external approach
  • 53. LARYNGEAL WEBS  Uncommon  Failure of laryngeal recanalization  Most common site - glottic (75%)  Symptoms Vocal dysfunction Hoarseness Aphonia Airway obstruction (if severe)  Complete laryngeal atresia is incompatible with life and need emergency tracheostomy
  • 54. Laryngeal Web Diagnosis  Flexible laryngoscopy  Direct Laryngoscopy  Airway films if subglottic or cricoid pathology are present
  • 55. Treatment  Mild form requires no treatment.  Web is divided endoscopically along the margin of one vocal cord with a knife , scissors or laser.
  • 56. LARYNGEAL HEMANGIOMA  Benign vascular malformations  Subglottic haemangiomas is most common neoplasm of infant airway.  Female predominance 2:1  Asymptomatic at birth Stridor presents by 6 months (85%)  Associated cutaneous hemangioma (50%)
  • 57.  Rapid growth phase in the 1st year followed by slow resolution  Most have complete resolution by 5 years  30-70% mortality rate if untreated  Priority is to maintain the airway while minimizing potential long term sequelae
  • 58. Diagnosis  Direct Laryngoscopy – unilateral, asymmetric, sub mucosal reddish mass in subglottic area.  CT & MRI
  • 59. Treatment  Systemic steroids (principal) Partial regression in most patients (82-97%) Risk of growth retardation and increase susceptibility to infection Risk is reduced by alternate-day dosing regimen in the smallest doses Also intralesion corticosteroids has been employed with successful avoidance of tracheotomy  Interferon alpha-2a 50% or greater regression of lesion in 73% of patients It requires prolonged therapy, blocks various steps of angiogenesis Side effects neuromuscular impairment, skin slough, fever and liver enzyme elevation
  • 60. Treatment (contd)..  Tracheostomy Bypass the obstructing lesion Waiting for the expected involution Risks of tracheostomy as well as delay in speech and language  Laser CO2 and KTP associated with a significant risk of inducing subglottic stenosis in up to 20%