The document defines computer-mediated communication (CMC) as communication that occurs between humans using computers. CMC takes place synchronously or asynchronously through various mediums like text, audio, or video. Synchronous CMC allows for real-time interaction through applications like instant messaging, Skype video calls, or chat rooms. Asynchronous CMC occurs over different times through email, online forums, text messages, or video sharing websites. The document discusses examples of synchronous and asynchronous applications and how CMC plays an important role in distance learning environments.