Colistin is a last resort drug for the treatment of infection caused by multidrug-resistant Gram-negative bacteria. Different studies have uncovered the negative impact of colistin consumption in animals. Therefore, it has become essential to monitor the dosing regimens of colistin and assess their negative effects. Besides this, regular monitoring, strong legislation and creating awareness among the farmers, and the sellers is important to stop its haphazard uses as growth promoter in livestock.