This document summarizes key points from a CMS 2015 Advance Notice regarding changes that will impact Medicare Advantage plans. It discusses factors that will continue to put downward pressure on plan revenues, such as normalization factors, benchmark trends, and quality rating adjustments. It provides examples of how these changes could impact two hypothetical plans differently, with estimated revenue impacts ranging from a 0.4% increase to over a 10% decrease. The document also examines areas of uncertainty around the new requirements for risk adjustment diagnoses.
Effective risk management needs effective risk identification, assessment, planning, tracking and controlling in Clinical Trials. Considering the importance of risk management in efficient management of clinical trials, this webinar by DDismart will provide more insight on Clinical RBM.
The State of Clinical Outsourcing: Managing Risk in Outsourced Clinical Trials
Interactive Discussion Based on Data from Avoca’s 2013 Industry Research DIA Forum
June 24, 2013
The World Congress Summit on Risk-Based Monitoring and the Quality Risk Manag...WorldCongress
This Summit offers pharmaceutical and medical device delegates concrete examples of how to build a framework and methodology for a risk-based monitoring (RBM) program that is part of an overall risk management approach to study planning and oversight. One of the biggest challenges of implementation is overcoming resistance to change as no organization wants to be the first. For that reason, Summit faculty share change management strategies for people, processes, and technology that led to the effective implementation of their RBM programs. The Site’s perspective, assessing readiness for change and providing support during the change process must not be overlooked. Strategies to partner with Sites to achieve stronger connectivity will also be discussed.
The Risk-Based Monitoring (RBM) discussion is moving away from one focused on changing monitoring methods and reducing source document verification (SDV) to 'intelligent monitoring.' Learn why here!
Medicare Advantage is a well-known program, but perhaps not so well-known in its details. In this webinar, we get into the nuts and bolts of how the program works, including a case study with practical examples. If you’d like to offer or improve a Medicare Advantage plan at your facility, this is a good place to start.
Medicare Advantage is one of the few areas your clinic can generate risk scores. Learn the basics of the program, strategies to increase your reimbursement processes to monitor compliance with 5 star and tools available on the market to help your physicians.
Effective risk management needs effective risk identification, assessment, planning, tracking and controlling in Clinical Trials. Considering the importance of risk management in efficient management of clinical trials, this webinar by DDismart will provide more insight on Clinical RBM.
The State of Clinical Outsourcing: Managing Risk in Outsourced Clinical Trials
Interactive Discussion Based on Data from Avoca’s 2013 Industry Research DIA Forum
June 24, 2013
The World Congress Summit on Risk-Based Monitoring and the Quality Risk Manag...WorldCongress
This Summit offers pharmaceutical and medical device delegates concrete examples of how to build a framework and methodology for a risk-based monitoring (RBM) program that is part of an overall risk management approach to study planning and oversight. One of the biggest challenges of implementation is overcoming resistance to change as no organization wants to be the first. For that reason, Summit faculty share change management strategies for people, processes, and technology that led to the effective implementation of their RBM programs. The Site’s perspective, assessing readiness for change and providing support during the change process must not be overlooked. Strategies to partner with Sites to achieve stronger connectivity will also be discussed.
The Risk-Based Monitoring (RBM) discussion is moving away from one focused on changing monitoring methods and reducing source document verification (SDV) to 'intelligent monitoring.' Learn why here!
Medicare Advantage is a well-known program, but perhaps not so well-known in its details. In this webinar, we get into the nuts and bolts of how the program works, including a case study with practical examples. If you’d like to offer or improve a Medicare Advantage plan at your facility, this is a good place to start.
Medicare Advantage is one of the few areas your clinic can generate risk scores. Learn the basics of the program, strategies to increase your reimbursement processes to monitor compliance with 5 star and tools available on the market to help your physicians.
Purpose of the Call:
Call attendees will learn:
•About the importance of participating in MedRec Quality Audit Month
•How to participate in MedRec Quality Audit Month
•About the use of the MedRec Quality Audit tool (i.e. who should use it and how)
•Tips on the proper use of the tool and the Patient Safety Metrics System
•Where they can access MedRec Quality Audit Month tools and resources
Access the webinar: http://bit.ly/1xVtmDn
Grounded in personal experience and expertise as a Trial Manager at Sponsors managing outsourced clinical trials, and as a CRO Trial Manager, this overview presentation builds on this background with the current landscape of managing trials for quality using an extended team.
This is one session in the 1-2 day course I teach on CRO-Clinical Vendor Management that includes Quality by Design and Quality Oversight of your vendors.
This course is provided to Sponsors and CROs who use sub-contractors for their client work.
Description of the Call:
Objectives:
•To review the results of the Canadian Falls Audit Month 2015
•To discuss lessons learned from the audit month – strengths and areas for improvement
•To gather ideas about how to improve the information submitted on falls prevention
WATCH: http://bit.ly/1RkG84k
CRO/Vendor oversight should support sponsor regulatory requirements and cost containment.Quality Management in clinical operations are Centralized Monitoring, Study Quality Metrics and CRO Oversight.
This Risk Based Monitoring - Impact on Sites overview presentation, on targeted topics, was delivered to the ACRP Raleigh - Durham Chapter's Annual Conference in 2013.
Kuala Lumpur - PMI Global Congress 2009 - Risk ManagementTorsten Koerting
Presentation on Risk Management Tools, like Risk Register, Risk Profile Presentation Options, How to facilitate a Risk Assessment and effective Processes for day to day application of Risk Management in your Project
Enhance your audiences knowledge with this well researched complete deck. Showcase all the important features of the deck with perfect visuals. This deck comprises of total of thirty one slides with each slide explained in detail. Each template comprises of professional diagrams and layouts. Our professional PowerPoint experts have also included icons, graphs and charts for your convenience. All you have to do is DOWNLOAD the deck. Make changes as per the requirement. Yes, these PPT slides are completely customizable. Edit the colour, text and font size. Add or delete the content from the slide. And leave your audience awestruck with the professionally designed Risk Identification Powerpoint Presentation Slides complete deck.
Making CJR Work for You: A Roadmap for Successful Implementation of Medicare ...Wellbe
This presentation will describe a structured approach to successfully launching a program for the Comprehensive Care for Joint Replacement (CJR) Model. Based on years of experience with bundled programs, this roadmap provides the basis for developing a targeted plan for your organization as the April 1, 2016 deadline for CJR rapidly approaches.
Key topics to be addressed include:
• Overview of CJR rules and program requirements
• CJR implications for your organization
• Bundle evaluation – financial and clinical issues
• Gainsharing considerations with program collaborators
• Designing an effective post-acute care network
• Using analytics to develop and monitor your program
• Key “must-dos” for an April 1, 2016 launch
Learning Objectives:
1. Describe the rules and requirements of CJR
2. Assess the key success drivers in bundle performance
3. Evaluate where and why organizations fail in bundles
4. Develop strategies and tactics to create a post-acute partnership
5. Illustrate risk stratification factors in bundle design
About the Speaker:
Sheldon Hamburger is an Alternative Payment Model advisor for hospitals and healthcare firms nationally. With a focus on program implementation, he brings extensive knowledge and experience gained from more than 25 years of healthcare financial consulting, technology design and development, and sales & marketing strategy for Fortune 1000 clients. He is a frequently sought-after speaker and writer on regulatory and technology trends affecting hospital operations, provider reimbursement issues, BPCI / CJR, programs and regulations, medical expense strategies and payer-provider dynamics. Residing in Raleigh, he is an active member of HIMSS, HFMA, & ACHE. He earned his B.S.E. in Computer Engineering from the University of Michigan.
Purpose of the Call:
Call attendees will learn:
•About the importance of participating in MedRec Quality Audit Month
•How to participate in MedRec Quality Audit Month
•About the use of the MedRec Quality Audit tool (i.e. who should use it and how)
•Tips on the proper use of the tool and the Patient Safety Metrics System
•Where they can access MedRec Quality Audit Month tools and resources
Access the webinar: http://bit.ly/1xVtmDn
Grounded in personal experience and expertise as a Trial Manager at Sponsors managing outsourced clinical trials, and as a CRO Trial Manager, this overview presentation builds on this background with the current landscape of managing trials for quality using an extended team.
This is one session in the 1-2 day course I teach on CRO-Clinical Vendor Management that includes Quality by Design and Quality Oversight of your vendors.
This course is provided to Sponsors and CROs who use sub-contractors for their client work.
Description of the Call:
Objectives:
•To review the results of the Canadian Falls Audit Month 2015
•To discuss lessons learned from the audit month – strengths and areas for improvement
•To gather ideas about how to improve the information submitted on falls prevention
WATCH: http://bit.ly/1RkG84k
CRO/Vendor oversight should support sponsor regulatory requirements and cost containment.Quality Management in clinical operations are Centralized Monitoring, Study Quality Metrics and CRO Oversight.
This Risk Based Monitoring - Impact on Sites overview presentation, on targeted topics, was delivered to the ACRP Raleigh - Durham Chapter's Annual Conference in 2013.
Kuala Lumpur - PMI Global Congress 2009 - Risk ManagementTorsten Koerting
Presentation on Risk Management Tools, like Risk Register, Risk Profile Presentation Options, How to facilitate a Risk Assessment and effective Processes for day to day application of Risk Management in your Project
Enhance your audiences knowledge with this well researched complete deck. Showcase all the important features of the deck with perfect visuals. This deck comprises of total of thirty one slides with each slide explained in detail. Each template comprises of professional diagrams and layouts. Our professional PowerPoint experts have also included icons, graphs and charts for your convenience. All you have to do is DOWNLOAD the deck. Make changes as per the requirement. Yes, these PPT slides are completely customizable. Edit the colour, text and font size. Add or delete the content from the slide. And leave your audience awestruck with the professionally designed Risk Identification Powerpoint Presentation Slides complete deck.
Making CJR Work for You: A Roadmap for Successful Implementation of Medicare ...Wellbe
This presentation will describe a structured approach to successfully launching a program for the Comprehensive Care for Joint Replacement (CJR) Model. Based on years of experience with bundled programs, this roadmap provides the basis for developing a targeted plan for your organization as the April 1, 2016 deadline for CJR rapidly approaches.
Key topics to be addressed include:
• Overview of CJR rules and program requirements
• CJR implications for your organization
• Bundle evaluation – financial and clinical issues
• Gainsharing considerations with program collaborators
• Designing an effective post-acute care network
• Using analytics to develop and monitor your program
• Key “must-dos” for an April 1, 2016 launch
Learning Objectives:
1. Describe the rules and requirements of CJR
2. Assess the key success drivers in bundle performance
3. Evaluate where and why organizations fail in bundles
4. Develop strategies and tactics to create a post-acute partnership
5. Illustrate risk stratification factors in bundle design
About the Speaker:
Sheldon Hamburger is an Alternative Payment Model advisor for hospitals and healthcare firms nationally. With a focus on program implementation, he brings extensive knowledge and experience gained from more than 25 years of healthcare financial consulting, technology design and development, and sales & marketing strategy for Fortune 1000 clients. He is a frequently sought-after speaker and writer on regulatory and technology trends affecting hospital operations, provider reimbursement issues, BPCI / CJR, programs and regulations, medical expense strategies and payer-provider dynamics. Residing in Raleigh, he is an active member of HIMSS, HFMA, & ACHE. He earned his B.S.E. in Computer Engineering from the University of Michigan.
Hospital and Healthcare System Strategic Planning and Financial ForecastingAxiom EPM
Given the level of uncertainty in the healthcare industry and all of the external factors that impact healthcare provider organizations today, strategic planning has become an increasingly complex function. The process is no longer a simple financial forecasting exercise. Instead, it has evolved into a more integrated financial and operational planning activity that touches the entire organization. The process of defining a multi-year financial forecast is now predicated on the modeling of individual business initiatives focused on cost reduction or revenue growth. These slides present four factors vital to establishing more agile strategic planning models. You'll learn techniques to incorporate financial and service line-based analytics to enable efficient ‘what-if’ modeling, scenario analysis and initiative-based modeling and tracking.
Managing Risk: Maximizing Opportunities in the MAPD MarketCognizant
The Medicare Advantage (MAPD) marketplace is growing as memberships and revenue potential increase. At the same time, it is marked by risks associated with healthcare reform, continuing cost pressures, and healthcare consumerism. To operate and compete successfully, payers will have to find new and better ways to sharpen their strategies, integrate systems, increase collaboration and optimize processes.
Performance and Reimbursement under MIPS for OrthopedicsWellbe
The 2015 MACRA legislation fundamentally changed the way in which providers are paid for their services. It also provides some relief from the “all or nothing” approach used by Meaningful Use.
This session, a review of the Final Rule published on Oct 14, 2016, conveys a practical approach to maximizing reimbursement under MIPS while reducing burden on clinical staff.
After this session, attendees will have a firm grasp of:
– the major components of the Quality Payment Program
– operational strategies for measure selection
– orthopedic-specific quality measures
About the Speaker:
karenclarkKaren R. Clark is chief information officer for OrthoTennessee, where she has worked since 1998. In that role, she serves on national committees for the Healthcare Information Management Systems Society (HIMSS.) A HIMSS Fellow and Certified Professional in Healthcare Information and Management Systems, her current HIMSS committee is the HIT User Experience, which focuses on clinician experience with health information technology.
She has spoken at the AAOE, AAOS and OrthoForum conferences on both information security and the 2015 MACRA legislation, specifically on the Merit Based Incentive Payment System (MIPS.). She is a member of the College of Healthcare Information Management Executives (CHIME) as well as the CIO/CMIO Council with the American Medical Group Association.
After graduating from American University with a degree in marketing in 1979, she joined Brooks Brothers in New York, where she was a buyer. She earned her MBA in finance from Fordham University in 1984. She moved to Knoxville in 1988 and joined Watson’s as director of planning and distribution when her husband, Brooks, was recruited from Sports Illustrated to Whittle Communications. They have two adult daughters, Isabel, and Olivia.
Hospitals and health systems are struggling to maximize the benefits of innovative technology to better manage uncompensated care and revenue integrity, suggests a HFMA/Navigant survey of 125 provider CFOs and revenue cycle management executives.
This slideshow is about P4P model in health care and how it can transform the health care sector. It also talks about what is P4P it origin, budgeting methods, and how can it transform health care
ATTENTION SNF OPERATORS: Find out how how your facility’s rehospitalization rates will determine how you are reimbursed moving forward.
Are you ready for a Big Game Changer? Health care reform mandates will directly impact your bottom line starting January 2017. As CMS rolls out the “SNF VBP Program,” SNFs nationwide may find themselves scrambling to protect 2% revenue.
This presentation is supplemental material to RadioRev episode 1: Understanding Medicare Star Ratings with Sara Ratner. We cover everything from the nuts and bolts of Medicare Star Ratings, what they are, why they matter, and who should care about them. Plus, we look to the future and learn everything you need to know for what's on the horizon in 2019.
Webinar: “While You Were Sleeping…Proposed Rule Positioned to Significantly I...PYA, P.C.
You likely know from the headlines that the 2021 Medicare Physician Fee Schedule (MPFS) Proposed Rule slashes payments for surgical specialists. But the impact of the Proposed Rule is far broader, reflecting a fundamental realignment driven by the transition to value-based payments. In our webinar, “While You Were Sleeping…Proposed Rule Positioned to Significantly Impact Physician Compensation,” PYA experts addressed these proposals, helping you understand and prepare for the changes ahead.
Following this presentation, attendees were able to:
Understand how a handful of wRVU changes would alter Medicare reimbursement for nearly all physicians.
Appreciate the operational impact of these changes.
Recognize the challenges to existing physician compensation models.
Identify strategies and tactics to prepare for and manage these impacts.
Presenters include PYA Principals Angie Caldwell, Martie Ross, and Valerie Rock. The webinar took place Thursday, September 10 and was hosted in conjunction with the Florida Hospital Association.
If you have additional questions about the MPFS Proposed Rule and its impact on physician compensation or need assistance with any matter involving physician compensation, valuation, strategy and integration, or compliance, contact a PYA executive below at (800) 270-9629.
Prepping for CCJR: Lessons Learned in Physician Alignment and Bundled PaymentsWellbe
With CMS’ recent announcement of its Comprehensive Care for Joint Replacement (CCJR) payment model and its plan to implement in seventy-five geographic areas, hospitals must be prepared to manage the entire episode of care from the time of surgery through ninety days after discharge. CCJR presents both opportunities and challenges for hospitals. In order to achieve success, organizations must manage their system of care delivery, ensure they are aligned with their physicians and post acute providers, and master the analytics necessary for driving high quality, low cost care.
MedAssets has worked with numerous providers to implement alignment models that bring hospitals and their physicians together, evaluate, identify, and implement changes to the care delivery system to improve quality and decrease cost across the continuum, and employ meaningful analytics for managing an episode of care.
Kevin Lieb, Senior Director for MedAssets’ Physician Alignment Solutions division, will share examples demonstrating how organizations have successfully implemented Episodes of Care. Mr. Lieb will also share examples from both hospital led and specialist led programs and provide lessons learned from these experiences.
This webinar will enable attendees to do the following:
• Identify alignment models within bundled payments and understand their applicability to your organization
• Understand the analytic capabilities necessary for success in a bundled payment environment
• Identify opportunities and strategies for cost reduction and quality improvement
About the Speaker:
Mr. Lieb has more than 20 years of healthcare-related experience focusing on quality improvement, market development and cost reduction initiatives for the hospital provider market. Mr. Lieb has worked for a number of well-known healthcare companies including GE Medical Systems, HCIA and LBA in Denver, Colorado. His responsibilities included healthcare consulting with a focus on process improvement and quality initiatives.
Every hospital and health care system is significantly impacted by readmission policies mandated by new regulations.
And every facility must implement strategies to reduce the number of costly and unnecessary readmissions.
During this presentation you will discover how to decrease your readmission rates and take advantage of incentives, rather than suffer penalties that can significantly impact your bottom line.
NYU Langone Medical Center’s TJA BPCI Experience: Lessons in How to Maximize ...Wellbe
The Bundled Payments for Care Improvement (BPCI) Initiative began generating data in January of 2013. Dr. Iorio will outline the challenges and benefits of implementing BPCI for Total Joint Arthroplasty at an urban, tertiary, academic medical center with a hybrid compensation model. Early results from the implementation of a Medicare BPCI Model 2 primary TJA program demonstrate cost-savings with an improvement in quality of care metrics and continued cost savings through year 3 of our experience. Changes in patient optimization, care coordination, clinical care pathways, and evidence-based protocols are the key to improving the quality metrics and cost effectiveness within the implementation of the Bundled Payment for Care Initiative, thus bringing increased value to our TJA patients.
Maximizing Value in a Bundled Environment – Keys to Success:
• Evidence based, cost effectiveness analysis
• Standardized protocol adoption
• Transparent data
• Perioperative Patient Optimization
• Care management
• Physician-hospital alignment with Gain sharing
• Enhanced pain relief and rehabilitation protocols
• Blood management and rational VTED prophylaxis
About the Speaker:
Richard Iorio, MD, is the William and Susan Jaffe Professor of Orthopaedic Surgery at New York University Langone Medical Center Hospital for Joint Diseases and Chief of Adult Reconstruction at NYU Langone HJD. He co-founded Labrador Healthcare Consulting Services, Responsive Risk Solutions, and the Value Based Healthcare Consortium in 2015. He is a member of the Board of Directors for LIMA, the Lifetime Initiative for the Management of Arthritis. Dr. Iorio is a national expert in physician and hospital quality and safety and a leader in the implementation of alternate payment paradigms in orthopaedic surgery.
The Center for Medicare & Medicaid Innovation (CMS Innovation Center) hosted an open door forum covering the application process for the 2017 Next Generation Accountable Care Organization Model on Tuesday, March 8, 2016 from 4:00 - 5:00pm EST.
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CMS Innovation Center
http://innovation.cms.gov
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Navigating the Commercial Market & Health Insurance ExchangesAltegra Health
Implementation of the Affordable Care Act’s Market Reform Rules is rapidly transforming the commercial exchange market. Success under reform requires an emphasis on:
- Accurate eligibility, claims and coding data
- Risk intelligence under the new Hierarchical Condition Category (HCC) risk model
- Member engagement, assessment and retention
- Provider engagement and incentives
- Precise medical management
Altegra Health’s integrated suite of services assists health plans in managing the commercial market requirements and the resulting market response through:
- Data transformation and submission, risk analytics, and payment transfer reconciliation
- Diagnosis and procedure code coding and primary data validation audit support
- Member onboarding, engagement and retention
- Provider engagement and support
- Care management and medical cost reductions
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
CDSCO and Phamacovigilance {Regulatory body in India}NEHA GUPTA
The Central Drugs Standard Control Organization (CDSCO) is India's national regulatory body for pharmaceuticals and medical devices. Operating under the Directorate General of Health Services, Ministry of Health & Family Welfare, Government of India, the CDSCO is responsible for approving new drugs, conducting clinical trials, setting standards for drugs, controlling the quality of imported drugs, and coordinating the activities of State Drug Control Organizations by providing expert advice.
Pharmacovigilance, on the other hand, is the science and activities related to the detection, assessment, understanding, and prevention of adverse effects or any other drug-related problems. The primary aim of pharmacovigilance is to ensure the safety and efficacy of medicines, thereby protecting public health.
In India, pharmacovigilance activities are monitored by the Pharmacovigilance Programme of India (PvPI), which works closely with CDSCO to collect, analyze, and act upon data regarding adverse drug reactions (ADRs). Together, they play a critical role in ensuring that the benefits of drugs outweigh their risks, maintaining high standards of patient safety, and promoting the rational use of medicines.
Title: Sense of Taste
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the structure and function of taste buds.
Describe the relationship between the taste threshold and taste index of common substances.
Explain the chemical basis and signal transduction of taste perception for each type of primary taste sensation.
Recognize different abnormalities of taste perception and their causes.
Key Topics:
Significance of Taste Sensation:
Differentiation between pleasant and harmful food
Influence on behavior
Selection of food based on metabolic needs
Receptors of Taste:
Taste buds on the tongue
Influence of sense of smell, texture of food, and pain stimulation (e.g., by pepper)
Primary and Secondary Taste Sensations:
Primary taste sensations: Sweet, Sour, Salty, Bitter, Umami
Chemical basis and signal transduction mechanisms for each taste
Taste Threshold and Index:
Taste threshold values for Sweet (sucrose), Salty (NaCl), Sour (HCl), and Bitter (Quinine)
Taste index relationship: Inversely proportional to taste threshold
Taste Blindness:
Inability to taste certain substances, particularly thiourea compounds
Example: Phenylthiocarbamide
Structure and Function of Taste Buds:
Composition: Epithelial cells, Sustentacular/Supporting cells, Taste cells, Basal cells
Features: Taste pores, Taste hairs/microvilli, and Taste nerve fibers
Location of Taste Buds:
Found in papillae of the tongue (Fungiform, Circumvallate, Foliate)
Also present on the palate, tonsillar pillars, epiglottis, and proximal esophagus
Mechanism of Taste Stimulation:
Interaction of taste substances with receptors on microvilli
Signal transduction pathways for Umami, Sweet, Bitter, Sour, and Salty tastes
Taste Sensitivity and Adaptation:
Decrease in sensitivity with age
Rapid adaptation of taste sensation
Role of Saliva in Taste:
Dissolution of tastants to reach receptors
Washing away the stimulus
Taste Preferences and Aversions:
Mechanisms behind taste preference and aversion
Influence of receptors and neural pathways
Impact of Sensory Nerve Damage:
Degeneration of taste buds if the sensory nerve fiber is cut
Abnormalities of Taste Detection:
Conditions: Ageusia, Hypogeusia, Dysgeusia (parageusia)
Causes: Nerve damage, neurological disorders, infections, poor oral hygiene, adverse drug effects, deficiencies, aging, tobacco use, altered neurotransmitter levels
Neurotransmitters and Taste Threshold:
Effects of serotonin (5-HT) and norepinephrine (NE) on taste sensitivity
Supertasters:
25% of the population with heightened sensitivity to taste, especially bitterness
Increased number of fungiform papillae
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
Basavarajeeyam is a Sreshta Sangraha grantha (Compiled book ), written by Neelkanta kotturu Basavaraja Virachita. It contains 25 Prakaranas, First 24 Chapters related to Rogas& 25th to Rasadravyas.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
2. TODAY’S
PRESENTERS
2
! Wanda
Kochhar
–
President
/
Senior
Advisor,
Outcomes
• All
membership
in
coun8es
that
are
2-‐year
transi8on.
4.0
STAR
ra8ng.
No
historical
use
of
enrollee
risk
assessments.
• 3%
(Normaliza8on
factor)
-‐
1.65%
(benchmark
trend)
-‐
0%
(%
FFS
transi8on)
-‐
0.25%(coding
intensity)
–
0%
(STARs
bonus)
–
0.7%
(industry
fee)
–
0%
(enrollee
risk
assessments)
=
Total
impact
Posi2ve
0.4%
• Ms.
Kochhar
received
her
BBA
and
MBA
from
the
Hugh
McColl
School
of
Business
at
Queens
College.
! Rolland
Ho
–
SVP,
Risk
Adjustment
Solu9ons
&
Analy9cs,
Outcomes
• Rolland
Ho
leads
the
design
and
development
of
risk
adjustment
solu8ons
that
support
Commercial/Marketplace,
Medicaid
and
Medicare
Advantage
plans
• Prior
to
joining
Outcomes
Health,
Rolland
served
as
Vice
President
of
Medical
Economics
at
Arcadian
Health
Plan
overseeing
risk
adjustment,
medical
analy8cs
and
bid
development.
• Rolland
graduated
Magna
Cum
Laude
from
Harvard
University
with
an
AB
in
Economics
and
obtained
his
Master
in
Business
Administra8on
from
Stanford
University.
3. 2015
ADVANCE
NOTICE
! Con2nued
revenue
compression
for
MA
plans:
• Change
in
FFS
normaliza8on
factor
methodology
(+3.0%)
• Combined
benchmark
trend
change
of
Nega8ve
1.65-‐2.3%
(weighted
average
Neg
1.9%)
• Add’l
decline
in
average
benchmarks
with
transi8on
to
%
FFS
(weighted
average
Neg
2.3%)
• Coding
intensity
adjustment
increased
from
4.91%
to
5.16%
(Neg
0.25%)
• STAR
ra8ng
bonus
eliminated
for
<
4.0
STAR
plans
(Neg
3-‐3.5%
for
affected
plans,
weighted
average
(Neg
1.6%)
• Increased
industry
fees
(Neg
0.7%)
• Requirement
that
risk
assessment
diagnoses
be
confirmed
in
clinical
sefng
(Neg
0-‐3%
depending
on
plan
usage
of
risk
assessments)
However,
specific
impact
is
highly
variable
depending
on
plan
profile.
3
4. IMPACT
ON
TWO
DIFFERING
PLAN
PROFILES
! Plan
A
• All
membership
in
coun8es
that
are
2-‐year
transi8on.
4.0
STAR
ra8ng.
No
historical
use
of
enrollee
risk
assessments.
• 3%
(Normaliza8on
factor)
-‐
1.65%
(benchmark
trend)
-‐
0%
(%
FFS
transi8on)
-‐
0.25%(coding
intensity)
–
0%
(STARs
bonus)
–
0.7%
(industry
fee)
–
0%
(enrollee
risk
assessments)
=
Total
impact
Posi2ve
0.4%
! Plan
B
• All
membership
in
coun8es
that
are
6-‐year
transi2on.
3.5
STAR
ra2ng.
Heavy
historical
use
of
enrollee
risk
assessments.
• 3%
(Normaliza8on
factor)
–
2.3%
(benchmark
trend)
–
3.3%
(%
FFS
transi8on)
-‐
0.25%(coding
intensity)
–
3.5%
(STARs
bonus)
–
0.7%
(industry
fee)
–
3%
(enrollee
risk
assessments)
=
Total
impact
Nega2ve
10.1%
4
While
na2onal
average
impact
is
Neg
5%
on
average,
plan
specific
impact
can
range
widely
from
+0.4%
to
over
Neg
10%.
5. DANCING
WITH
THE
STARS
5
Termina2on
of
Star
bonus
demo
for
2015
may
materially
affect
the
market
compe22veness
of
many
plans
6. TRANSITION
TO
%
OF
FFS
BENCHMARKS
6
Much
less
variability
across
plans
in
terms
of
impact
from
transi2on
to
%
FFS.
7. THE
ENROLLEE
RISK
ASSESSMENT
WILDCARD
! Plans
will
likely
be
split
in
terms
of
support
for/against
new
rule
• Plans
that
are
heavily
invested
in
enrollee
risk
assessments
will
obviously
favor
con8nua8on
of
current
status
quo.
• Plans
that
currently
conduct
few
assessments
could
be
on
either
side.
Some
might
protest
rule
change
because
looking
to
counteract
benchmark
declines
with
expanded
assessment
program.
But
some
might
support
rule
change
to
cheaply
and
effec8vely
level
playing
field
against
compe8tors
who
are
more
heavily
invested
in
assessments.
! What
plans
and
vendors
are
likely
pushing
CMS
to
think
about
• Will
there
be
any
situa8ons
in
home
sefng
(POS=12)
that
qualifies
for
risk
adjustment
such
as
an
assessment
that
fulfills
Annual
Wellness
Visit
criteria?
Or
if
the
visit
is
conducted
by
member’s
assigned
Primary
Care
Physician?
• Does
each
specific
diagnosis
have
to
be
re-‐documented
in
the
subsequent
clinical
sefng
encounter?
Or
is
having
the
clinical
encounter
itself
sufficient
to
make
diagnosis
valid
for
risk
adjustment?
• What
other
place
of
service
loca8ons
might
be
specifically
excluded
or
included?
Mobile
units
(POS=15)?
Retail
health
clinics
(POS=17)?
7
8. HOW
WILL
PLANS
ADAPT?
! High
likelihood
that
final
rule
is
substan2ally
similar
to
Advance
No2ce
• Plans
and
vendors
will
need
to
develop
the
required
links
to
clinical
follow-‐up
treatment
which
will
increase
overall
assessment
costs
• Risk
adjustment
analy8cs
will
need
to
be
re-‐tooled
to
beler
stra8fy
members
by
magnitude
of
opportunity
• Plans
will
need
to
enable
and
incent
provider
partners
to
perform
beler
diagnos8c
capture
via
tools,
P4P
programs,
and
revenue
sharing
! Assuming
the
proposed
rule
stands
as-‐is,
couple
poten2al
scenarios:
• Plans
may
decide
to
subs8tute
Physician
Office
assessments
for
In-‐Home
Clinical
Care
Visits
• Or,
Vendors
may
change
process
to
u8lize
a
lower
skilled,
lower
cost
clinician
(e.g.
RN
instead
of
NP/PA/MD)
to
conduct
the
ini8al
home
assessment
and
then
channel
those
members
iden8fied
with
a
new
HCC
to
a
subsequent
clinical
office
visit
• If
retail
health
clinics
are
allowed,
perhaps
assessments
are
structured
to
occur
when
member
next
fills
their
pharmacy
scripts
8
9. THE
PROPOSED
“DELETIONS”
RULE
! A
massive
sinkhole
that
may
engulf
unwary
plans
• CMS
recently
released
a
proposed
rule
outside
of
the
Advance
No8ce
process
that
would
specifically
require
MA
plans
to
review
chart
data
against
claims
and
submit
any
unvalidated
diagnoses
for
dele8on.
• For
aggressive
plans,
chart
review
typically
delivers
5-‐6%
incremental
lin
to
risk
scores.
On
average,
claims
HCC’s
are
known
to
have
a
11-‐12%
error
rate
affec8ng
the
45-‐50%
of
revenue
derived
from
HCCs.
• As
a
result,
if
this
rule
is
implemented,
unwary
plans
may
effec8vely
eliminate
their
current
risk
adjustment
gains
from
chart
review
programs
due
to
the
high
percentage
of
unvalidated
diagnosis
data
in
claims.
! Implica2ons
for
plans
• Stra8fy
HCCs
by
dele8on
risk
and
take
dele8on
risk
into
considera8on
when
selec8ng
chart
review
targets.
• Develop
coding
systems
and
processes
that
allow
DOS-‐specific
execu8on
of
chart
reviews.
• Track
provider
level
non-‐valida8on
rates
and
incorporate
into
future
chart
targe8ng
decisions.
9
10. DELETION
RISK
BY
STRATA
ANALYSIS
–
Sample
10
! Shows
#
of
HCC
diagnosis
/
DOS
combina2ons
in
claims
! Shows
#
of
unique
HCCs
in
claims
! Shows
#
reviewed
in
charts
! Shows
#
not
validated
! Detailed
results
by
risk
strata
! Calculates
weighted
average
for
overall
valida2on
rate
11. EDS
VS
RAPS
! RAPS
will
survive
yet
another
year
as
CMS
proposes
to
use
both
EDS
and
RAPS
data
for
PY2015
risk
adjustment
• Essen8al
that
plans
use
this
coming
year
to
exhaus8vely
compare
and
test
their
EDS
risk
score
results
vs.
their
RAPS
risk
score
results.
• Any
discrepancies
need
to
be
hunted
down
and
fixed
to
ensure
that
final
switchover
to
EDS
occurs
without
a
hiccup
to
plan
risk
scores.
• EDS
rejec8on
volumes
can
quickly
overwhelm
available
resources
for
resolving.
Make
sure
analy8cs
are
in
place
to
quickly
iden8fy
those
errors
that
affect
acceptance
of
any
new/incremental
HCCs
so
that
they
receive
highest
priority
for
resolu8on.
• Plans
need
to
determine
policy
and
processes
for
submission
of
linked
vs.
unlinked
chart
reviews
11
12. WHAT
CHANGES
COULD
HAPPEN
IN
FINAL
NOTICE?
! Always
some
chance
that
one
or
more
items
may
be
revised
• CMS
could
poten8ally
announce
revised
trend
calcula8ons
that
bring
the
growth
rate
somewhat
closer
to
0%.
• Last
year,
CMS
decided
to
defer
changes
related
to
enrollee
risk
assessments.
Could
theore8cally
(though
unlikely)
do
so
again
this
year.
! But
plan
specific
factors
will
drive
substan2al
differences
in
impact
• Star
ra8ngs
(0-‐3.5%
depending
on
plan)
• Enrollee
risk
assessments
(0-‐3%
depending
on
plan)
• Distribu8on
of
membership
in
2
vs
4
vs
6
year
transi8on
coun8es
(0-‐3.3%
depending
on
plan)
Important
that
each
MA
plan
develop
a
clear
understanding
of
their
specific
circumstances
and
adjust
strategy
accordingly.
12
13. OVERALL
STRATEGIC
IMPLICATIONS
FOR
MA
PLANS
! Achieving
4
Star
Ra2ng
is
a
must
• Qualify
plan
for
a
5%
increase
in
reimbursement
benchmark
• Qualify
for
65-‐70%
rebate
instead
of
50%
rebate
in
bid
process
! Highly
accurate
risk
adjustment
is
essen2al
• Plans
can
no
longer
afford
to
leave
the
typical
20-‐30%
of
retrospec8ve
risk
adjustment
reimbursement
on
the
table
(~1.0-‐1.8%+
of
reimbursement)
• Restructured
deployment
of
prospec8ve
risk
adjustment
ini8a8ves
can
s8ll
deliver
addi8onal
risk
adjustment
reimbursement
opportuni8es
! Integra2on
of
Risk
Adjustment
and
HEDIS
Programs
will
differen2ate
the
winners
• 4-‐star
plan
ra8ngs
are
the
new
standard
• Plans
that
successfully
cross-‐leverage
risk
adjustment
ac8vi8es
to
boost
HEDIS/
Star
scores
and
vice-‐versa
will
have
a
cri8cal
compe88ve
advantage
13