Clinical chemistry estrogen
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Estrogen is an important hormone produced primarily in the ovaries that is responsible for female secondary sex characteristics and reproductive functions. It stimulates endometrial growth, suppresses FSH and stimulates LH secretion. Estrogen is synthesized from cholesterol and influences bone health, metabolism, and mood. Both low and high estrogen levels can cause physical and mental health issues and are treated through lifestyle changes or hormone replacement therapy.
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Clinical chemistry estrogen
- 1. Clinical Chemistry HLD 22103 Steroid Hormone -Estrogen-
- 2. Clinical Chemistry HLD 22103 Muhammad Fattah bin Fazel Anis Nabila binti Mohd Nor
- 3. What Is Estrogen ? (O.o) • Group of compounds named for their importance in both menstrual and reproductive cycles. • Important hormone of the females • Responsible for the secondary sexual characters in the females.
- 4. Functions of Estrogen (^_^) • Stimulate the growth of endometrium in the uterus. • It suppress the activity of FSH, and stimulate the secretion of LH. • It is responsible for the youthfullness of females and it controls the action of parathormone- hormone which intake calcium ions from bones and teeth. • After menopause estrogen will caused osteoporosis in some women due the activity of parathormones
- 5. Estrogen in Male (^_^) • In male, estrogen does not play as important a role as it does in women though men also have a small amount of estradiol normally in their bodies • The amount of testosterone that men have usually does not allow estrogen to have any significant physiological effects on the body. • If the amount of estrogen compared to testosterone increases, it will cause: - weight gain especially in the midsection -development of enlarged breasts (gynecomastia), - decreased sex drive
- 6. Secretion of Estrogen (-_- ) • Produced primarily by the ovaries. • The stimulation for secretion of estrogen comes from the Luteinizing hormone (LH) from anterior pituitary gland.
- 7. Secretion of Estrogen ( -_-) • Some of the estrogens are also produced in smaller amounts by other tissues : -liver - adrenal glands - breasts. • Fat cells are also sources of estrogen. This is the reason why underweight or overweight women are at risk of infertility.
- 8. Types of Estrogen • Estrone - Produce in menopause women • Estradiol - Produce during reproductive years • Estriol - Produce during pregnancy
- 9. Synthesis of Estrogen • Synthesized in the theca interna cells in the ovary. Aromatase enzyme Cholesterol Androstenodione Estrone Aromatase enzyme Cholesterol Androstenodione Testosterone Estrone
- 10. Synthesis of Estrogen • Estriol Sulfatase enzyme DHEA sulfate Estriol In placenta
- 13. Estrogen Imbalance High Level of Estrogen Low Level of Estrogen
- 14. Estrogen Imbalance High Level of Estrogen • Cause: 1. Natural Causes of High Estrogen Levels. 2. Induced Causes of High Estrogen Levels. 3. Other Causes of High Estrogen Levels : - Obesity - Cardiovascular disease - Digestive problems
- 15. Estrogen Imbalance High Level of Estrogen Symptoms Physical Mental -Artherosclerosis -Depression -Headaches -Panic attacks -Cramps -Low self esteem -Weight gain -Mood swings -Uterine fibroids -Memory loss -Irregular periods
- 16. Estrogen Imbalance Low Level of Estrogen • Causes: 1. Natural Causes of Low Estrogen Levels 2. Other Causes of Low Estrogen Levels: - Lifestyle • Diet • Stress • Eating disorders • Extreme exercise • Pituitary diseases
- 17. Estrogen Imbalance Low Level of Estrogen • Causes: 3. In young women: - Genetic disease, such as Turner syndrome (which leads to short stature and lack of ovulation, normal female development and menstruation) - Chemotherapy or radiation - Thyroid disorders - Insufficient body fat - Delayed development and lack of menstruation (amenorrhea)
- 18. Estrogen Imbalance Low Level of Estrogen Symptoms Physical Mental -Dry Skin -Depression -Rapid heartbeat -Panic attacks -Headaches -Low self esteem -Weight gain -Mood swings -Low back pain -Memory loss -Difficulty concentrating
- 19. Estrogen Imbalance Treatment • Same for both high and low levels of estrogen. 1. Lifestyle Changes - highest amount of self discipline. 2. Alternative Medicine - extremely effective way to treat estrogen imbalance. - Phytoestrogenic and non-phytoestrogenic 3. Hormone Replacement Therapy. - highest risk and often the highest costs.
- 20. Thank You The Sky Is NOT Your Limit You Can Go Further To Achieve The Future.
Editor's Notes
- Secondary sexual characteristic in females:BreastHip wideningincreased amounts fat in the buttock, thigh, and hip region Makes women much more hairless compare to men
- Point 2Which transforms the ruptured Graafian follicle to corpus leutem which in turn secretes progesterone another important female hormone to retain pregnancy.Youthfullness = development of female
- Point 1- They are released by the follicles on the ovaries and are also secreted by the corpus luteum after the egg has been released from the follicle and from the placenta.
- Point 1These secondary sources are important in women who have already had their menopause.Point 2Delicate balance of estrogen is important for fertility. Excess or deficiency of this hormone affects fertility adversely.
- The primary molecule that begins the synthesis of estrogen is cholesterol. It forms androstenodione. Androstenedione is a substance of moderate androgenic activity. This compound crosses the basal membrane into the surrounding granulosa cells, where it is converted to estrone or estradiol, either immediately or through testosterone.This conversion of testosterone to estradiol, and of androstenedione to estrone, is catalyzed by the enzyme aromatase. Estradiol levels vary through the menstrual cycle, with levels highest just before ovulation
- It originates from the fetal adrenal gland in the form of DHEA Sulfate and then is finally transformed to Estriol in the placenta by the sulfatase enzyme.
- Number 1 -High estrogen levels typically indicate a problem in the ovaries or the ovarian area.-Menstrual cycle cause hormone imbalance-Pre-menopause process (supressed progesterone production cause body to release high amount of estrogen)Number 2- Drugs (steroid medications, ampicillin)
- Artherosclerosis = narrowing of artery by blood clot
- Number 1- Premenstrual. ( because human do not have same metabolism, thus, varying the result of imbalance of hormone)
- Lifestyle changes.-more exercise-eat more healthy food (balance diet)Alternative medicine-Herbal remedies2 type of herbs : Phytoestrogenic herbs: Containing estrogenic components produced by plants, these herbs, at first, do treat the hormonal imbalance by introducing these plant-based estrogens into the body. Non-estrogenic herbs: They don't contain any estrogen. These herbs stimulate a woman's hormone production by nourishing the pituitary and endocrine glands, causing them to more efficiently produce natural hormones. This ultimately results in balancing not only estrogen, but also progesterone and testosterone. (Safest way)Hormonal Replacement Therapy-Last choice-In form of pills. -This may be a quick and strong way to combat hormonal imbalance; but, unfortunately, it entails serious side effects and increases the risk of different types of cancer among women