Uploaded bySherif Elbadrawy
Classical drug associations MRCP.
Dr. Sherif Badrawy presents a document listing various drug associations and their related medical risks or monitoring requirements in 3 sentences or less. It includes 129 entries describing drugs or drug classes and their potential to cause issues like increased bleeding risk, low blood pressure, or liver damage. Each association is briefly noted along with the related adverse effect or monitoring parameter to consider. The document serves as a concise reference for clinicians on important drug-drug and drug-disease interactions to be aware of in clinical practice.
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Classical drug associations MRCP.
- 1. Classic Drug associationin MRCP DR.SHERIF BADRAWY
- 2. Psychosis 1a Dr. Sherif Badrawy Digitally signedby Dr. Sherif Badrawy DN: cn=Dr. Sherif Badrawy, o=KKUH, ou=Critical Care, email=sherif_badrawy@ya hoo.com, c=SA Date: 2015.03.23 10:45:36 +03'00'
- 3.
- 4.
- 5. ◥ combined oral contraceptivepill ◥ tamoxifen ◥ antipsychotics 2b
- 6. increased risk of endometrialcancer 3a
- 7.
- 8.
- 9. ◥ amlodipine ◥ sildenafil ◥tamoxifen 4b
- 10.
- 11. ◥ methotrexate ◥ fluorouracil(5-FU) 5b
- 12.
- 13. ◥ pioglitazone ◥ ciclosporin ◥corticosteroids ◥ hydralazine 6b
- 14.
- 15. ◥ vincristine,vinblastine,cisplatin ◥ isoniazid ◥ amiodarone ◥phenytoin ◥ etanercept 7b
- 16.
- 17.
- 18.
- 19.
- 20.
- 21. haemolysis in patients withG6PD deficiency 10b
- 22. Toxicity in patients withthiopurine methyltransferase deficiency 11a
- 23.
- 24.
- 25. ◥ heparin ◥ sodiumvalproate ◥ thiazides ◥ valproic acid ◥ quinidine 12b
- 26. antagonist of the P2Y12adenosine diphosphate (ADP) receptor 13a
- 27.
- 28.
- 29. Normal anion gap metabolicacidosis 14b
- 30.
- 31.
- 32.
- 33.
- 34. acts as adecoy receptor for TNF- alpha 17a
- 35.
- 36. Prevents microtubule depolymerisation & disassembly, decreasingfree tubulin 18a
- 37.
- 38.
- 39.
- 40.
- 41.
- 42.
- 43.
- 44.
- 45.
- 46.
- 47. ◥ Pioglitazone ◥ heparin ◥bisphosphonates ◥ corticosteroids 23b
- 48.
- 49.
- 50.
- 51. ◥ sodium valproate ◥sulfonylureas ◥ pioglitazone ◥ lithium ◥ antipsychotics ◥ corticosteroids 25b
- 52. decreases IL-2 release byinhibiting calcineurin 26a
- 53.
- 54.
- 55.
- 56.
- 57.
- 58.
- 59. review if creatinineis > 130, stop metformin if > 150 29b
- 60.
- 61. Acceptable ↑ inserum creatinine , up to 50% from baseline or up to 265 (whichever is smaller) & an increase in potassium up to 5.5 30b
- 62.
- 63.
- 64.
- 65.
- 66.
- 67.
- 68. Increased risk of ischaemicstroke 34a
- 69. ◥ combined oral contraceptivepill ◥ antipsychotics 34b
- 70.
- 71.
- 72.
- 73.
- 74.
- 75.
- 76.
- 77.
- 78. Increased risk of cervicalcancer 39a
- 79. combined oral contraceptivepill 39b
- 80.
- 81.
- 82.
- 83.
- 84.
- 85.
- 86. irreversible blockade of H+/K+ATPase 43a
- 87.
- 88.
- 89.
- 90.
- 91. ◥ levodopa ◥ hydralazine ◥adenosine 45b
- 92.
- 93.
- 94.
- 95.
- 96.
- 97. ◥ isotretinoin (dt dryness) ◥warfarin 48b
- 98.
- 99. ◥ corticosteroids ◥ infliximab ◥etanercept 49b
- 100. recombinant version of urateoxidase 50a
- 101.
- 102.
- 103. ◥ isotretinoin ◥ corticosteroids ◥levodopa 51b
- 104.
- 105.
- 106.
- 107.
- 108.
- 109.
- 110.
- 111.
- 112.
- 113.
- 114.
- 115. ◥ loop diuretics ◥foscarnet 57b
- 116.
- 117.
- 118. anticoagulant which don't cross-reacté HIT Abs 59a
- 119. ◥ Danaparoid ◥ Lepirudin ◥Argatroban 59b
- 120.
- 121.
- 122.
- 123. ◥ Tricyclic antidepressants ◥ antipsychotics ◥chlorpheniramine61b
- 124.
- 125.
- 126.
- 127. ◥ amiodarone ◥ lithium ◥carbimazole 63b
- 128. Blocks T-type calcium channelsin thalamic neurons 64a
- 129.
- 130. Binds to TNF-alpha andprevents it from binding with TNF receptors 65a
- 131.
- 132.
- 133.
- 134.
- 135.
- 136.
- 137. ◥ corticosteroids ◥ heparin ◥pioglitazone 68b
- 138.
- 139.
- 140.
- 141.
- 142.
- 143.
- 144.
- 145. ◥ ropinirole ◥ apomorphine ◥bromocriptine ◥ cabergoline 72b
- 146.
- 147. ◥ donepezil ◥ pyridostigmine ◥galantamine ◥ rivastigmine ◥ edrophonium 73b
- 148. inhibits RANK ligand, whichin turn inhibits the maturation of osteoclasts 74a
- 149.
- 150.
- 151.
- 152.
- 153. ◥ isosorbide mononitrate ◥ hydralazine ◥minoxidil 76b
- 154.
- 155.
- 156.
- 157. ◥ levodopa ◥ digoxin ◥interferon-alpha 78b
- 158.
- 159.
- 160.
- 161.
- 162.
- 163.
- 164.
- 165.
- 166.
- 167.
- 168.
- 169.
- 170. Inhibits microtubule polymerization bybinding to tubulin, interfering with mitosis. Also inhibits neutrophil motility and activity 85a
- 171.
- 172. Metabolised to theactive compound mercaptopurine, a purine analogue that inhibits purine synthesis 86a
- 173.
- 174.
- 175.
- 176.
- 177.
- 178. Activates antithrombin III. Formsa complex that inhibits thrombin, factors Xa, Ixa, Xia and XIIa 89a
- 179.
- 180.
- 181.
- 182. Suppression of growth inchildren 91a
- 183.
- 184.
- 185.
- 186. Increased risk of breastcancer 93a
- 187. combined oral contraceptivepill 93b
- 188.
- 189.
- 190.
- 191.
- 192. Inhibits sodium absorption atthe beginning of the distal convoluted tubule 96a
- 193.
- 194. Blocks the actionof cyclooxygenase-1 and 2 and thromboxane A2 formation 97a
- 195.
- 196.
- 197.
- 198. Enhance the effectof the inhibitory neurotransmitter gamma- aminobutyric acid (GABA) 99a
- 199.
- 200.
- 201. ◥ sodium valproate ◥valproic acid 100b
- 202. Increased risk of myocardialinfarction 101a
- 203. combined oral contraceptivepill 101b
- 204.
- 205. ◥ antipsychotics ◥ verapamil ◥tricyclic antidepressants ◥ opioids 102b
- 206.
- 207.
- 208.
- 209.
- 210.
- 211. ◥ antipsychotics ◥ phenytoin ◥amantadine 105b
- 212.
- 213. ◥ thiazides ◥ pyrazinamide ◥loop diuretics ◥ nicotinic acid 106b
- 214.
- 215. ◥ antipsychotics ◥ tricyclicantidepressants ◥ ivabradine ◥ chlorpheniramine 107b
- 216.
- 217. ◥ phenytoin ◥ ciclosporin ◥amlodipine ◥ diltiazem ◥ verapamil 108b
- 218.
- 219. ◥ levodopa ◥ antipsychotics ◥phenytoin 109b
- 220.
- 221. ◥ amiodarone ◥ tetracyclines ◥isotretinoin ◥ thiazides 110b
- 222.
- 223.
- 224.
- 225. ◥ loop diuretics ◥aminoglycosides ◥ vancomycin 112b
- 226.
- 227. ◥ phenytoin ◥ sodiumvalproate ◥ carbamazepine ◥ amantadine 113b
- 228.
- 229. ◥ isotretinoin ◥ tricyclicantidepressants ◥ levodopa ◥ antipsychotics ◥ chlorpheniramine 114b
- 230.
- 231.
- 232.
- 233.
- 234.
- 235.
- 236.
- 237.
- 238. pyrimidine analogue which inducescell cycle arrest and apoptosis by blocking thymidylate synthase 119a
- 239.
- 240.
- 241.
- 242.
- 243.
- 244. Blocks the releaseof acetylcholine 122a
- 245.
- 246.
- 247. ◥ verapamil ◥ diltiazem ◥ivabradine ◥ adenosine ◥ digoxin 123b
- 248.
- 249.
- 250.
- 251.
- 252. agonist of theA1 receptor in the AV node 126a
- 253.
- 254.
- 255. ◥ thiazides ◥ loopdiuretics ◥ amphotericin B 127b
- 256. Stimulates alpha adrenergic, dopaminergic andserotonergic receptors resulting in uterine contractions 128a
- 257.
- 258. Blocks the uptakeof dopamine, noradrenaline and serotonin 129a
- 259.
- 260.
- 261.
- 262.
- 263. ◥ digoxin ◥ amantadine ◥phenytoin ◥ metoclopramide 131b
- 264. Haemolysis in patients withG6PD deficiency 132a
- 265. ◥ primaquine ◥ ciprofloxacin ◥sulphonamides ◥ sulphasalazine ◥ sulfonylureas 132b
- 266.
- 267.
- 268. non-specific phosphodiesterase inhibitor and decreases cellularuptake of adenosine 134a
- 269.
- 270.
- 271. ◥ corticosteroids ◥ sodiumvalproate ◥ thiazides ◥ valproic acid 135b
- 272. Facilitate GABAA action byincreasing the duration of chloride channel opening 136a
- 273.
- 274.
- 275.
- 276. Arachidonic acid product causingvasoconstriction & increased platelet aggregation 138a
- 277.
- 278.
- 279.
- 280.
- 281. ◥ lithium ◥ ciclosporin ◥sodium valproate ◥ antipsychotics 140b
- 282.
- 283.
- 284.
- 285.
- 286.
- 287.
- 288.
- 289. ◥ thiazides ◥ loopdiuretics ◥ sulfonylureas ◥ carbamazepine ◥ sodium valproate 144b
- 290. Non-specific inhibitor of phosphodiesterase resultingin an increase in cAMP 145a
- 291.
- 292. Increases cGMP leading tosmooth muscle relaxation 146a
- 293.
- 294. Antagonises the effects ofvitamin K 147a
- 295.
- 296.
- 297.
- 298.
- 299. ◥ hydralazine ◥ procainamide ◥hydralazine ◥ phenytoin ◥ carbamazepine ◥ tetracyclines ◥ isoniazid 149b
- 300.
- 301.
- 302.
- 303. ◥ ciclosporin ◥ aminoglycosides ◥amphotericin B ◥ foscarnet ◥ vancomycin ◥ loop diuretics 151b
- 304.
- 305.
- 306.
- 307.
- 308.
- 309. ◥ ciprofloxacin ◥ antipsychotics ◥foscarnet 154b
- 310.
- 311. ◥ phenytoin ◥ carbamazepine ◥amantadine ◥ nicorandil 155b
- 312.
- 313. ◥ isotretinoin ◥ corticosteroids ◥ciclosporin ◥ protease inhibitors ◥ antipsychotics 156b
- 314.
- 315. ◥ protease inhibitors ◥corticosteroids 157b
- 316.
- 317.
- 318.
- 319. ◥ amiodarone ◥ beta-blockers ◥digoxin ◥ verapamil ◥ diltiazem ◥ ivabradine 159b