Imaging features of acute and chronic osteomyelitis are described in this PPT. Infective arthritis along with fungal infections of soft tissue are also covered very well. Special emphasis is given on tubercular infection of bone.
Imaging features of acute and chronic osteomyelitis are described in this PPT. Infective arthritis along with fungal infections of soft tissue are also covered very well. Special emphasis is given on tubercular infection of bone.
The root words osteon (bone) and myelo (marrow) are combined with itis (inflammation) to define the clinical state in which bone is infected with microorganisms.
Osteomyelitis is an inflammation of bone caused by an infecting organism.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
The root words osteon (bone) and myelo (marrow) are combined with itis (inflammation) to define the clinical state in which bone is infected with microorganisms.
Osteomyelitis is an inflammation of bone caused by an infecting organism.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
NVBDCP.pptx Nation vector borne disease control programSapna Thakur
NVBDCP was launched in 2003-2004 . Vector-Borne Disease: Disease that results from an infection transmitted to humans and other animals by blood-feeding arthropods, such as mosquitoes, ticks, and fleas. Examples of vector-borne diseases include Dengue fever, West Nile Virus, Lyme disease, and malaria.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
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2. Definition
• Osteomyelitis is the infection of the bone or BM which leads to a
subsequent Inflammatory process.
• Micro-Organisms may reach bones via the Bloodstream or by Direct
Invasion. (e.g : skin puncture, operation, open fracture)
• Factors which affects it’s development
– Virulence of the organism involved
– Host Factors (Age, Immunity, Diseases)
– Local factors (site of Involvement, damaged muscle presence of
foreign material , vascularity)
3. • It is nearly always a sequel to acute osteomyelitis, generally secondary to
open fractures, bacteremia and contiguous soft tissue infection. It is
difficult to treat and is characterized with frequent relapses
• Occasionally infection is subacute or chronic from the beginning.
• Cause. As with acute osteomyelitis, the Staphylococcus is the usual
causative organism, but streptococci, pneumococci, typhoid bacilli, or other
bacteria may be responsible.
• Chronic osteomyelitis from contiguous soft tissue infection is becoming
more common due to increasing prevalence of diabetic foot infection and
peripheral vascular disease
4.
5. Pathology
1. Inflammation.
• Earliest Change
• Increase interaosseous pressure leads to Pain.
2. Suppuration
• Pus at medulla >> Volkmann canals>>Surface >> Subperiosteal Abscess>>
spread along the shaft>> burst into the soft tissue
• May extend to Epiphysis in Neonates and Children.
• May extend to Interverteberal Discs in Adults.
3. Necrosis/Sequestrum
• Begin in a week.
• causes : increase in intraosseous pressure, vascular stasis, infected
thrombosis, periosteal stripping which increasingly compromise blood
supply
6. 4. New-bone formation
• New bone formation from the stripped surface of periosteum
• Bone thickens to form an involucrum enclosing the infected tissue.
5. Resolution
bone will heal if infection is controlled and intraosseous pressure is
released, though it may remain thickened. or progress to complications
7. Pathology
• It is commonest in the long bones. It is often confined to one end of
the bone, but it may affect the whole length. The bone is thickened
and generally denser than normal, though often honeycombed with
granulation tissue, fibrous tissue, or pus. Sequestra (Fragment of dead
bone) are commonly present within cavities in the bone. Often a sinus
tract leads to the skin surface: the sinus tends to heal and break down
recurrently, but if a sequestrum is present it never heals permanently.
8.
9.
10. Investigations
1. Lab studies
• CBC: leucocytosis
• Elevated CRP & ESR (nonspecific).
• Blood Culture
• Culture & sensitivity test; by aspiration from the subperiosteal abscess,
+ve in only 50% of patients with hematogenous osteomyelitis.
2. Radiological studies
• X-ray
• MRI
• Radionuclide bone scanning
• CT scan
• US
11. X-Ray
• 1st 10 days Show No Abnormality .
Only after two or three weeks do visible changes appear, and they may never do
so if efficient treatment is started very early.
• By the end of the 2nd Week signs of rarefaction of Metaphysis and
New Bone Formation. Then sigs of healing
• Soft-tissue edema at 3-5 days after infection.
• Bony changes are not evident for 14-21 days:
– Early radiographic signs of rarefraction (thining of bony tissue
sufficient to cause decreased density of bone) of the
metaphysis and new bone formation outlining the raised
periosteum
– Sclerosis and thickening of the bone cortex at healing
• Approximately 40-50% focal bone loss is necessary to cause
detectable lucency on plain films; a negative X-Ray does not
exclude osteomyelitis
12.
13. Clinical Features
• a purulent discharge (the main symptom is usually a purulent
discharge from a sinus over the affected bone. Discharge of pus
may be continuous or intermittent)
• Pain may be the predominant feature
• ‘flare-up’, or ‘flare’, of infection (Reappearance of a sinus that
has been healed for some time and it is heralded by local pain,
pyrexia, and the formation of an abscess)
• On examination the bone is palpably thickened, and there are
nearly always a number of overlying scars or sinuses.
14. Clinical features
Non-specific and difficult to recognize. Raise suspicion :
• Persistent sinus tract
• Exposed bone
• Tissue necrosis overlying bone
• Chronic wound overlying surgical hardware
• Chronic wound overlying fracture
• May also present as recurrent condition with periods
of quiescence, with exacerbation, patient complaining
increasing pain at affected site
15.
16. DIAGNOSIS : CLINICAL
DURING PERIOD OF
INACTIVITY NO SYMPTIMS ARE
PRESENT
SKIN
THIN,DARK,SCARRED,POOR
NOURISHED, PAST DINUD.OR
ULCERATION MAY BE VISIBLE
MUSCLE WAISTING
CONTRACTURE,ATROPHY
JOINT STIFFNESS BONE THICK SCLEROTIC
ABSCESS CAVITY MAY BE
PRESENT
17. Imaging
• Radiographic examination
– The bone is often thickened and shows irregular and patchy sclerosis which
may give a honeycombed appearance. If a sequestrum is present it is seen
as a dense loose fragment, with irregular but sharply demarcated edges,
lying within a cavity in the bone
• Radioisotope scanning
– increased uptake in the vicinity of the lesion
• MRI and CT scanning
– localisation of abscess cavities and sequestra in diffuse disease, thus
allowing accurate planning of operative treatment.
24. SEQUESTERECTOMY …WHEN?????
EARLY : IF PATIENT
PRESENTS EARLY
SEQUESTERECTOMY
ERADICATES INFECTION
AND LEAVES ABETTER
ENVIORNMENT FOR
PERIOSTEUM TO
RESPOND
LATE : IN CASES OF LATE
PRESENTATION THE
PROCEDURE IS DELAYED
TILL FORMATION OF
INVOLUCRUM TO
MINIMIZE RISK OF
FRACTURE AND
SEGMENTAL LOSS
IN EITHER CASES IT IS
CRITICAL TO PRESERVE
NVOLUCRUM
3-6 MONTHS IS
CONSIDERED AS A
PREFFERABLE TIME TO
WAIT
25. POST
SEQUESTERECTOMY
NO STABILISATION NEEDED IF 70% OF THE
ORIGINAL CORTEX REMAINS INTACT
IF MORE THEN 70% LOSS IS SEEN MANY
SPLINTAG OPTIONS AS:
A) CASTING
B) EXTERNAL FIXATORS
C) IF FOCAL BONE LOSS : OPEN CANCELLOUS/
CONVENTIONAL BONE GRAFTS
D) IF SEGMENTAL BONE LOSS: BONE
TRANSPORT AS ILLIZAROV DEVICES MAY BE
USED
35. SOFT
TISSUE
COVERAGE
THREE METHODS ARE COMMONLY USED
PRIMARY CLOSURE- IF NO INFECTION
HEALING BY SEACONDRY INTENTION
SPLIT SKIN GRAFTING FOR SMALL SOFT TISSUE
DEFECTS
LOCAL MUSCLE FLAPS /FREE VASCULARIZED
MUSCLE FLAPS FOR LARGER DEFECTS
HEALING BY SEACONDRY INTENTION THOUGH
NOT PREFFERED AS SCAR TISSUE FORMED MAY
BE AVASCULAR