This document discusses sexually transmitted infections (STIs), including their causes, symptoms, and treatments. It focuses on gonorrhea, caused by Neisseria gonorrhoeae. Gonorrhea symptoms vary between males and females and can include discharge and dysuria. Complications include pelvic inflammatory disease and disseminated gonococcal infection. Treatment involves ceftriaxone or other cephalosporins. The document also briefly outlines Chlamydia trachomatis, lymphogranuloma venereum, syphilis, and neurosyphilis.
STD is an abbreviated form of Sexually transmitted diseases. The meaning of STD disease is that the disease is imparted to others through sexual contact. Apart from sexual transmission, sexually transmitted diseases are also transferred to other persons in various ways. These are- breastfeeding, sharing of infected needles, etc. There are many diseases under the class of STD, and these can be cured by maintaining proper sexual health and hygiene. The mass awareness of sexually transmitted diseases is necessary for preventing them. Social media, newspapers and journals, television broadcasting, internet sources, and medical campaigning are the ways through which the transmission, symptoms, prevention, and prospective cure of STDs are conveyed to the common people. Examples of sexually transmitted diseases are- AIDS, gonorrhea, syphilis, etc.
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary)
STD is an abbreviated form of Sexually transmitted diseases. The meaning of STD disease is that the disease is imparted to others through sexual contact. Apart from sexual transmission, sexually transmitted diseases are also transferred to other persons in various ways. These are- breastfeeding, sharing of infected needles, etc. There are many diseases under the class of STD, and these can be cured by maintaining proper sexual health and hygiene. The mass awareness of sexually transmitted diseases is necessary for preventing them. Social media, newspapers and journals, television broadcasting, internet sources, and medical campaigning are the ways through which the transmission, symptoms, prevention, and prospective cure of STDs are conveyed to the common people. Examples of sexually transmitted diseases are- AIDS, gonorrhea, syphilis, etc.
Syphilis is a sexually transmitted infection caused by the bacterium Treponema pallidum subspecies pallidum. The signs and symptoms of syphilis vary depending in which of the four stages it presents (primary, secondary, latent, and tertiary)
Download the Power Point for FREE: http://q.gs/Ea2Gx or https://clk.sh/H7Ef
IEC for STIs
A sexually transmitted infection (STI) is an infection you can get by having sex. Some STIs (such as gonorrhea and chlamydia) infect your sexual and reproductive organs. Others (such as HIV, hepatitis B, and syphilis) cause general body infections. STIs used to be called VDs, or venereal diseases. (http://www.pamf.org/teen/sex/std/)
Trichomoniasis
Causes of trichomoniasis
Infectious area
Symptoms
Risk factors
Diagnosis
Management
Trichomoniasis, or trich is a sexually transmitted infection (STI) caused by a tiny parasite called Trichomonas vaginalis (TV).
About 70% of women and men do not have symptoms when infected.
Download the Power Point for FREE: http://q.gs/Ea2Gx or https://clk.sh/H7Ef
IEC for STIs
A sexually transmitted infection (STI) is an infection you can get by having sex. Some STIs (such as gonorrhea and chlamydia) infect your sexual and reproductive organs. Others (such as HIV, hepatitis B, and syphilis) cause general body infections. STIs used to be called VDs, or venereal diseases. (http://www.pamf.org/teen/sex/std/)
Trichomoniasis
Causes of trichomoniasis
Infectious area
Symptoms
Risk factors
Diagnosis
Management
Trichomoniasis, or trich is a sexually transmitted infection (STI) caused by a tiny parasite called Trichomonas vaginalis (TV).
About 70% of women and men do not have symptoms when infected.
Yeast infections are generally caused by an organism called Candida albicans. Natural cures are simple, less expensive, and by far the most important point, they actually work. Get few tips for avoiding this disease with ease.
http://www.yeastinfectionheal.com/
Yeast infections are generally caused by an organism called Candida albicans. Natural cures are simple, less expensive, and by far the most important point, they actually work. Get few tips for avoiding this disease with ease.
http://www.yeastinfectionheal.com/
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
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We specializes in exporting high quality Research chemical, medical intermediate, Pharmaceutical chemicals and so on. Products are exported to USA, Canada, France, Korea, Japan,Russia, Southeast Asia and other countries.
2. What is a Sexually Transmitted
Infection or STI?
STI’s are infections that are spread from person to
person through intimate sexual contact.
STI’s are dangerous because they are easily spread
and it is hard to tell just by looking who has an STI.
1 in 4 sexually active teens has an STI
Common STI
Chlamydia
Gonorrhea
Genital Herpes (HSV-2)
Genital Warts (HPV)
Hepatitis B
4. Gonorrhea
Is caused by Neisseria gonorrhoeae, a Gram-negative
diplococcus.
Signs and symptoms
The manifestations in males presents more early as
compared to female.
In males.;
o A purulent discharge associated with dysuria is the first
sign of infection. The discharge, which is presumably
caused by chemotactic factors such as C5a released
when anti gonococcal antibody binds complement,
may become more profuse and blood tinged as the
infection progresses.
5. o In female
Women often are asymptomatic. So it takes so
long for gonorrhea to be diagnosed in women.
The most common symptom is vaginal
discharge. including purulent or mucopurulent
endocervical discharge,
Other cervical abnormalities., eg
erythema, friability, and edema of the zone of
ectopy.
Pelvic inflammatory disease (PID) is a serious
complication in 10% to 20% of women with acute
gonococcal infection and can lead to infertility and
6. Treatments; of uncomplicated gono..
Ceftriaxone
Ceftriaxone, a third-generation cephalosporin, is given as a
single, small-volume IM injection (e.g., 125 mg diluted with
normal saline or 1% lidocaine solution). Ceftriaxone
eradicates anal and pharyngeal gonorrhea and is also safe
in pregnancy.
Other injectable cephalosporins (notably
ceftizoxime, cefoxitin, and cefotaxime) have been found to
be safe and highly effective, although efficacy in
pharyngeal infections is not as well-established.
Because a high percentage of patients with gonorrhea are
also coinfected with C. trachomatis, a single dose of
azithromycin or a 7-day course of doxycycline is
recommended to be taken concurrently for a presumed
infection
Many strains exibit resistance to penicillin, tetracycline
, floroquinolones
7. All partners who have had sexual exposure to
patients with gonorrhea are advised, within 60
days should be treated.
This is especially true when the partner is
pregnant because gonorrhea during pregnancy is
associated with chorioamnionitis and
prematurity, as well as neonatal infection.
Pregnant women can be treated safely with
cephalosporins and azithromycin for gonorrhea
and Chlamydia. Doxycycline should be avoided
during pregnancy
8. o Anorectal and Pharyngeal Gonorrhea
The most prevalent bacterial STI among the
homosexual male population is gonorrhea
pharyngeal and anorectal gonococcal infections are
often asymptomatic, a large reservoir of carriers in
the homosexual male population may exist.
o Symptoms
Rectal gonorrhea produces the syndrome of
proctitis with anorectal pain, mucopurulent anorectal
discharge, constipation, tenesmus, and anorectal
bleeding
9. treatment
The treatment of choice for patients with
anorectal and/or pharyngeal gonorrhea is
ceftriaxone 125 mg IM as a single dose.
Azithromycin or doxycycline should be given to
those with rectal gonorrhea to treat possible
coexisting rectal chlamydial infection.
Patients should be advised to avoid further
unprotected sexual activity and should be
counseled and tested for infection with HIV.
And an altenative drug like the cephalosporins
should be given if a patient do not torelate
penicillin.
11. Pelvic Inflammatory Disease
The term pelvic inflammatory disease (PID)
commonly refers to a variety of inflammatory
disorders of the upper female reproductive tract.
PID also has been used to connote an infection
that occurs acutely when either vaginal or cervical
micro-organisms traverse the sterile endometrium
and ascend to the fallopian tubes.
Acute salpingitis also may be used to describe
an acute infection of the fallopian tubes.
Therefore, the terms PID and salpingitis are used
interchangeably in this discussion to denote an
acute infection involving the fallopian tubes.
12. Etiology
Most cases of PID are caused by C. trachomatis
and N. gonorrhoeae. Some micro-organisms that
comprise the vaginal flora are also associated
with PID, including Gardnerella vaginalis, H.
influenzae, and Streptococcus agalactiae.
Facultative enteric Gram-negative bacilli and a
variety of anaerobic bacteria have also been
isolated from the upper genital tract of up to 70%
of women with acute PID.
Women diagnosed with acute PID should be
tested for C. trachomatis and N. gonorrhoeae and
screened for HIV
13. o Symptoms
abdominal pain often occurs soon after the
menstrual period, Vaginal
discharge, menorrhagia, dysuria, and
dyspareunia
o Signs
include cervical motion tenderness, uterine
tenderness, or adnexal tenderness white blood
cells (WBC) on saline microscopy of vaginal
secretions, elevated erythrocyte sedimentation
rate, or an elevated C-reactive protein
Treatment;
14. o Disseminated Gonococcal Infection(gonorrhoea
bacteremia)
Signs and Symptoms
include fever, occasional chills, a mild tenosynovitis of
the small joints, and skin lesions
o Treatment
Patients with gonococcal arthritis and bacteremia
should be hospitalized for treatment with ceftriaxone 1
g IV daily until clinical improvement, such as
decreased fever and pain, is sustained for 24 to 48
hours, at which time therapy may be switched to an
appropriate oral agent. Symptoms and signs of
tenosynovitis should be improved markedly within 48
hours.
15. o Treatment of gonococcal endocarditis and
meningitis.
It is rare but life threatening, septic emboli, valve
damage of CHF.
Require high-dose IV therapy such as ceftriaxone
(1–2 g IV every 12 hours) for 10 days or more in the
case of meningitis and for 4 week
o Neonatal Disseminated Gonococcal Infection:
Acquired when fetus passes through infected birth
canal, leading to acute purulent, conjuctivitis 4
weeks after birth, it can lead to blindness
Treatments
Neonatal DGI and meningitis can be treated with
either ceftriaxone or cefotaxime for 7 days;
however, if meningitis is documented, 10 to 14 days
of treatment is required. Ceftriaxone is given at 25 to
50 mg/kg (IV or IM) Q 24 hr and cefotaxime is given
16. Chlamydia trachomatis
A disease caused by chlamydia trachomatis, a
gram negative intracellular bacteria this is the
main cause of non gonococcal urethrites in
males.
Has 15 serovars. Serovar d-k, are transmitted
sexually and are responsible for NGU.(urethritis,
epididymis, proctitis, cervicitis and salpingitis.)
17. o Symptoms,
Males; mucopurulent discharge, after 1-3 weeks
of intercourse, dysuria and pruritis.
Females; cervicitis, mild vaginal
discharge, salpingitis is a complication.
o Treatment
Tetracyclines are the drugs of
choice(tetracycline, minocyclines and
doxycyclines) 7-21 days., aternatively
erythromycin is used(in pregnancy or in allerge).
18.
19. Lymphogranuloma Venereum
The cause of LGV is usually C. trachomatis serovars
L1, L2, or L3, which is different from those serovars
responsible for chlamydia urethritis.
Three stages of LGV infection are recognized in
heterosexual men.
During stage I, a small genital papule or vesicle
appears between 3 and 30 days after exposure. The
patient usually is asymptomatic; the ulcer heals
rapidly and leaves no scar
Stage II is characterized by acute, painful
lymphadenitis with bubo formation (the inguinal
syndrome) it often is accompanied by pain and fever,
Without treatment, the buboes may rupture, forming
numerous sinus tracts that drain chronically
20. Late or tertiary manifestations include perirectal
abscesses, rectovaginal fistulae (in women),
rectal strictures, and genital elephantiasis.
Appropriate treatment of stage II LGV usually
prevents these late complications.
An acute anorectal syndrome of LGV occurs in
homosexual men who acquire the infection
through rectal receptive intercourse. In these
cases, a primary anal ulcer may be noted with
associated inguinal adenopathy
21. treatment
include the use of doxycycline 100 mg PO BID or
erythromycin base 500 mg PO QID for 21
days.Surgical intervention may be needed for
later forms of the disease. Azithromycin 1 g
weekly for 3 weeks may be effective, but clinical
data on its use are lacking.
22. syphilis
Def; is a chronic systemic infection due to
Treponema palidum. The microorganism
penetrate the epithelium and spread via the
lymphatic system.
Symptoms; after sexual intercourse a primary
chancre develops. This is a small macule
becoming a papule that breaks down into ulcer.
The ulcer is painless and does not bleed on
trauma.
Stages of syphilis.;
Primary stage: it is the most infectious stage,
even the superficial lesions are infectious. The
chancre heals after 6-8 weeks, leaving no scar,
23. Secondary stage; this stage is manifest by a
widespread maculopapular skin rash that
involves the palms, soles, trunks and extremities
and the mucous membrane. In adition the patient
has fatigue, malaise,headache, fever, weight loss
and general lymphadenopath. Untreated lesions
heals in 4-12 weeks,, this is the latent stage of
syphilis, the early latent is infective, bt late latent
is non infective.
Tertiary stage, this is the late stage, it involves
every organ., the skeletal
system, cardiovascular, cns . Though it is a non
infective stage, it is a very destructive stage.
26. Neurosyphilis
Neurosyphilis can present at any stage of
syphilis.
neurosyphilis may be asymptomatic or
accompanied by a variety of manifestations; the
most common syndromes are meningovascular
syphilis, general paresis, tabes dorsalis
(locomotor ataxia), and optic atrophy
Treatment
recommends treatment of neurosyphilis with
aqueous penicillin G, 3 to 4 MU IV every 4 hours,
or 18 to 24 MU/d continuous infusion, for 10 to 14
days
27. Congenial syphilis
Acquired by transplacental infection of the fetus.
Occasionally a child is born with syphilitic
penphigus, bulbous eruption, often 2-3 weeks
after birth the skin lesion erupts. The child has
severe dehydration, malnutrition, long bone
destruction. 20 yrs later CNS may be
involved, leading to deafness, blindness, or
juvenile paresis and finally death.
Treatment;
Procaine penicillin G. 1.2 mu for 10
days, tetracycline 500mg, or you can
give, erythromycin, cephalothin, cephaloridine.., i
n pregnancy, inorder to cure fetal
spirochaetemia, ppf daily 0.6 mu for 7 days is the
28.
29. Jarisch-Herxheimer Reaction
Is a benign, self-limited complication of antitreponemal
antibiotic therapy that develops in a high proportion of
patients within a few hours after treatment of secondary
syphilis and less often after primary.
The cause of JHR is not well understood, but is
probably related to release of cytokines.
Clinical manifestations include fever, chills, myalgias,
headache, tachycardia, and hypotension
Usually self-limiting in non-pregnant patients, the
primary risk of this reaction in pregnant women is
miscarriage, premature labor, or fetal distress.
Pregnant women should seek medical attention if
contractions or a change in fetal movements are noted.
Antibiotic treatment should not be discontinued.