Successfully reported this slideshow.
We use your LinkedIn profile and activity data to personalize ads and to show you more relevant ads. You can change your ad preferences anytime.
LIPIDS OF PHYSIOLOGICAL SIGNIFICANCE  &  ITS ROLE IN HEALTH AND DISEASES Presented by, Shruti Sharma (D.Phil Scholar)
Why lipids are important- <ul><li>Lipids are important to the body because;- </li></ul><ul><li>Important constituent of th...
Major lipids of physiological significance;- <ul><li>Fatty acids  ;-   basic units of fat composed of chains of carbon ato...
Classification of fatty acids;- Fatty acids Saturated FA  Unsaturated FA
Saturated fatty acids;- <ul><li>•  </li></ul><ul><li>Saturated fatty contains no double bonds (having no points of unsatur...
Unsaturated fatty acids;- Unsaturated fatty acid:  a fatty acid with one or more points of unsaturation. Unsaturated fats ...
Divisions of unsaturated fatty acids;- Unsaturated Fatty acids MUFA PUFA Eicosanoids
Monounsaturated fatty acids ;- <ul><li>Monounsaturated fatty acid:  a fatty acid containing one point of unsaturation, fou...
Cis- unsaturated fatty acids;- <ul><li>In  cis  bonds , the two pieces of the carbon chain on either side of the double bo...
Trans unsaturated fatty acids;- <ul><li>Trans fatty acids are produced by hydrogenation process. </li></ul><ul><li>Hydroge...
SERUM LIPIDS— >raises levels of low-density lipoprotein (LDL) cholesterol reduces levels of high-density lipoprotein (HDL)...
Systemic inflammation— inflammation: an independent risk factor for atherosclerosis, sudden death from cardiac causes, dia...
ENDOTHELIAL-CELL FUNCTION-- increased levels of several markers of endothelial dysfunction:  for eg;- soluble intercellula...
Polyunsaturated fatty acids;- Polyunsaturated fatty acids (sometimes abbreviated PUFA) are those fatty acids where unsatur...
<ul><li>Increase esterification process of cholesterol & prevents its absorption. </li></ul><ul><li>By  increasing the syn...
Omega-3-fatty acids- Benefits- >Lower PGE2s level >Anti-inflammatory >Lower triglyceride and cholesterol levels >Benefits ...
Omega-6 fatty acids- Linoleic fatty acid Arachidonic acid Benefits- Platelet aggregation, cardiovascular diseases, and inf...
Eicosanoids;- <ul><li>These compounds are derived from long chain polyenoic fatty acids (20-carbon). </li></ul><ul><li>Exa...
Triglycerides;- <ul><li>Structure </li></ul><ul><ul><li>Glycerol + 3 fatty acids </li></ul></ul><ul><li>Functions </li></u...
Phospholipids;-  main lipid constituent of cell membrane. <ul><li>Structure </li></ul><ul><ul><li>Glycerol + 2 fatty acids...
Sterols ;- Steroids are the compounds contains cyclic steroid nucleus namely cyclo pentanophenanthrene ring. Cholesterol- ...
Glycolipids;- <ul><li>--widely distributed in the body </li></ul><ul><li>Fatty acids + sphingosine +carbohydrate </li></ul...
Lipoproteins;- Lipoproteins are th macromolecular complex of lipids and proteins. Transportation of lipids in the blood. S...
Classes of lipoproteins ;- Chylomicrons, VLDL, LDL HDL > 30 nm 9–15 nm 20–22 nm D<1.006 g/ml D=1.019-1.063g/ml D=1.063-1.2...
<ul><li>Apolipoproteins— </li></ul><ul><li>Apo AI (liver, small intestine) </li></ul><ul><ul><li>Structural; activator of ...
<ul><li>Apoprotein continued… </li></ul><ul><li>Apo B-100 (liver) </li></ul><ul><ul><li>Structural; synthesis of VLDL; lig...
Apoprotein continued… <ul><li>Apo C-I (liver) </li></ul><ul><ul><li>Activator of LCAT, inhibitor of hepatic TGRL uptake </...
Chylomicrons ;- TG rich . Synthesized in intestine. Transports endogenous TGs. Hydrophobic Core Triglyceride (93%) Cholest...
VLDL;-  rich in CE and TGs- Surface Monolayer Phospholipids (12%) Free Cholesterol (14%) Protein (4%) Hydrophobic Core Tri...
LDL;-  cholesterol rich. Surface Monolayer Phospholipids (25%) Free Cholesterol (15%) Protein (22%) Synthesized from VLDL ...
High density lipoprotein- Surface Monolayer Phospholipids (25%) Free Cholesterol (7%) Protein (45%) Promotes re-esterifica...
HDL Subpopulations Rye et al.  Atherosclerosis  1999;145:227-238. Apolipoprotein Composition A-I HDL A-I/A-II HDL A-II HDL...
<ul><li>The Effects of Various Types of Fat on Blood Lipid Levels </li></ul><ul><li>•  Saturated Fat </li></ul><ul><li>–  ...
<ul><li>Omega-3 Fat </li></ul><ul><li>–  Decreases total cholesterol </li></ul><ul><li>–  Decreases LDL-cholesterol </li><...
Role of lipids in health and diseases  –  omega-3 FAs . Docosahexanoic acid and brain development- <ul><li>It is becoming ...
Arachidonic acid and the brain-- One of the most important changes in this field is the link between arachidonic acid (AA)...
Prevention of cancer;- Marine-derived fatty acids have been found to inhibit proliferation and promote apoptosis in breast...
Lipids related disorders ;- <ul><li>lipid disorders </li></ul>Common disorders Hypercholetrolemia Hypertriglyceridemia Hyp...
<ul><li>ATHEROSCLEROSIS :  </li></ul><ul><li>As LDL particles penetrate the walls of the arteries, they become oxidized-LD...
Diagrammatic representation of the disease (atherosclerosis)-
Metabolic disorders of cerebrosides Dermatitis,skeletal deformation,hoarseness. ceramide ceramidase Ref- Harper’s biochemi...
Lipoprotein disorders ;- Hyperlipoproteinemias- --do-- Chylomicron and VLDL Ref- Harper’s biochemistry --do-- v May/may no...
Infant repiratory distress syndrome- Caused  due to the deficiency of the lung surfactant  dipalmitoyl lecithin . It preve...
Defects in the metabolism of essential fatty acids  - Cystic fibrosis,Acrodermatitis enterohepatica,Hepato renal syndrome,...
Common Atherogenic dyslipidemias ) 􀂃  polygenic inheritance –  dietary component –  secondarily enhanced by insulin resist...
Fatty liver;- <ul><li>When lipids accumulates excessively in  liver, then it causes fatty liver. </li></ul><ul><li>Droplet...
Tangier Disease <ul><li>>Autosomal codominant disorder due to mutations in </li></ul><ul><li>both alleles of ABC1 gene </l...
References-- 1) Connell E, Darios F, Broersen K, Gatsby N, Peak-Chew SY, Rickman C, Davletov B. Mechanism of arachidonic a...
Thank you.
Upcoming SlideShare
Loading in …5
×

of

Presentation on lipid Slide 1 Presentation on lipid Slide 2 Presentation on lipid Slide 3 Presentation on lipid Slide 4 Presentation on lipid Slide 5 Presentation on lipid Slide 6 Presentation on lipid Slide 7 Presentation on lipid Slide 8 Presentation on lipid Slide 9 Presentation on lipid Slide 10 Presentation on lipid Slide 11 Presentation on lipid Slide 12 Presentation on lipid Slide 13 Presentation on lipid Slide 14 Presentation on lipid Slide 15 Presentation on lipid Slide 16 Presentation on lipid Slide 17 Presentation on lipid Slide 18 Presentation on lipid Slide 19 Presentation on lipid Slide 20 Presentation on lipid Slide 21 Presentation on lipid Slide 22 Presentation on lipid Slide 23 Presentation on lipid Slide 24 Presentation on lipid Slide 25 Presentation on lipid Slide 26 Presentation on lipid Slide 27 Presentation on lipid Slide 28 Presentation on lipid Slide 29 Presentation on lipid Slide 30 Presentation on lipid Slide 31 Presentation on lipid Slide 32 Presentation on lipid Slide 33 Presentation on lipid Slide 34 Presentation on lipid Slide 35 Presentation on lipid Slide 36 Presentation on lipid Slide 37 Presentation on lipid Slide 38 Presentation on lipid Slide 39 Presentation on lipid Slide 40 Presentation on lipid Slide 41 Presentation on lipid Slide 42 Presentation on lipid Slide 43 Presentation on lipid Slide 44 Presentation on lipid Slide 45 Presentation on lipid Slide 46 Presentation on lipid Slide 47 Presentation on lipid Slide 48 Presentation on lipid Slide 49
Upcoming SlideShare
Classification of lipids
Next
Download to read offline and view in fullscreen.

151 Likes

Share

Download to read offline

Presentation on lipid

Download to read offline

this is the brief introductory prsentation about lipids and its physiological significance.

Related Audiobooks

Free with a 30 day trial from Scribd

See all

Presentation on lipid

  1. 1. LIPIDS OF PHYSIOLOGICAL SIGNIFICANCE & ITS ROLE IN HEALTH AND DISEASES Presented by, Shruti Sharma (D.Phil Scholar)
  2. 2. Why lipids are important- <ul><li>Lipids are important to the body because;- </li></ul><ul><li>Important constituent of the cell membranes. </li></ul><ul><li>Helps in the absorption of fat soluble vitamins. </li></ul><ul><li>Maintains membrane fluidity. </li></ul><ul><li>Acts as a thermal insulator and cellular metabolic regulator. </li></ul><ul><li>Hormone synthesis. </li></ul><ul><li>Organ padding . </li></ul><ul><li>• </li></ul>
  3. 3. Major lipids of physiological significance;- <ul><li>Fatty acids ;- basic units of fat composed of chains of carbon atoms with an acid group at one end and hydrogen atoms attached all along their length. </li></ul><ul><li>Present as either esterified or unesterified form in fats and oils. </li></ul>
  4. 4. Classification of fatty acids;- Fatty acids Saturated FA Unsaturated FA
  5. 5. Saturated fatty acids;- <ul><li>• </li></ul><ul><li>Saturated fatty contains no double bonds (having no points of unsaturation ). </li></ul><ul><li>Saturated fats- considered as harmful. It increases total </li></ul><ul><li>cholesterol level and TGs level. </li></ul><ul><li>Hypercholestrolemic SFAs are-Myristic acid & Lauric acid. </li></ul>
  6. 6. Unsaturated fatty acids;- Unsaturated fatty acid: a fatty acid with one or more points of unsaturation. Unsaturated fats are found in foods from both plant and animal sources. Unsaturated fatty acids are further divided into monounsaturated fatty acids and polyunsaturated fatty acids.
  7. 7. Divisions of unsaturated fatty acids;- Unsaturated Fatty acids MUFA PUFA Eicosanoids
  8. 8. Monounsaturated fatty acids ;- <ul><li>Monounsaturated fatty acid: a fatty acid containing one point of unsaturation, found mostly in vegetable oils such as olive, canola, and peanut . </li></ul><ul><li>They are considered as beneficial for human health. </li></ul><ul><li>MUFA </li></ul>Cis FA Trans FA
  9. 9. Cis- unsaturated fatty acids;- <ul><li>In cis bonds , the two pieces of the carbon chain on either side of the double bond are either both “up” or both “down,” such that both are on the same side of the molecule. </li></ul><ul><li>Significance – </li></ul><ul><li>Decreases total cholesterol and TGs level. </li></ul><ul><li>Increases HDL level. </li></ul>
  10. 10. Trans unsaturated fatty acids;- <ul><li>Trans fatty acids are produced by hydrogenation process. </li></ul><ul><li>Hydrogen atoms are on the opposite sides of the molecule. </li></ul><ul><li>Eg.cis-oleic acid trans-elaidic acid </li></ul>PHYSIOLOGICAL EFFECTS OF TRANS FATTY ACIDS - SERUM LIPIDS -SYSTEMIC INFLAMMATION -ENDOTHELIAL-CELL FUNCTION
  11. 11. SERUM LIPIDS— >raises levels of low-density lipoprotein (LDL) cholesterol reduces levels of high-density lipoprotein (HDL) cholesterol >increases the ratio of total cholesterol to HDL cholesterol, a powerful predictor of the risk of CHD >increase the blood levels of triglycerides , of Lp(a) lipoprotein, and reduce the particle size of LDL cholesterol: further raise the risk of CHD. >trans fatty acids have markedly adverse effects on serum lipids Physiological effects of trans fatty acids continued…
  12. 12. Systemic inflammation— inflammation: an independent risk factor for atherosclerosis, sudden death from cardiac causes, diabetes, and heart failure the inflammatory effects of trans fats may account in part for their effects on cardiovascular health For example, the difference in C-reactive protein levels ; 2.1 percent vs 0.9 percent intake: an increase in cardiovascular risk of approximately 30 percent. Physiological effects of trans fatty acids continued…
  13. 13. ENDOTHELIAL-CELL FUNCTION-- increased levels of several markers of endothelial dysfunction: for eg;- soluble intercellular adhesion molecule, soluble vascular-cell adhesion molecule, and E-selectin Physiological effects of trans fatty acids continued…
  14. 14. Polyunsaturated fatty acids;- Polyunsaturated fatty acids (sometimes abbreviated PUFA) are those fatty acids where unsaturation occur more than two points, found in nuts and vegetable oils such as safflower, sunflower, and soybean, and in fatty fish. They possess protective role on human health.considered as beneficial for consumpmtion.
  15. 15. <ul><li>Increase esterification process of cholesterol & prevents its absorption. </li></ul><ul><li>By increasing the synthesis of eicosanoids. </li></ul><ul><li>Acts as an anti platelet aggregating factor, so decreases the chances of clot formation. </li></ul><ul><li>Decreases the synthesis of the precursor of VLDL AND TGs. </li></ul><ul><li>Increases clearance of LDL cholesterol. </li></ul>PUFA continued;-
  16. 16. Omega-3-fatty acids- Benefits- >Lower PGE2s level >Anti-inflammatory >Lower triglyceride and cholesterol levels >Benefits vision and >brain function >Decrease Skin >inflammation >Inhibit platelet adhesion >Increase insulin sensitivity
  17. 17. Omega-6 fatty acids- Linoleic fatty acid Arachidonic acid Benefits- Platelet aggregation, cardiovascular diseases, and inflammation. Reduce the symptoms of eczema and psoriasis. Clear up different types of acne.
  18. 18. Eicosanoids;- <ul><li>These compounds are derived from long chain polyenoic fatty acids (20-carbon). </li></ul><ul><li>Examples of eicosanoids ;- </li></ul><ul><li>Prostaglandins. </li></ul><ul><li>Prostacyclines, </li></ul><ul><li>Thromboxanes </li></ul><ul><li>Leukotrienes </li></ul><ul><li>lipoxins </li></ul><ul><ul><li>They have roles in: </li></ul></ul><ul><ul><li>Inflammation </li></ul></ul><ul><ul><li>Fever </li></ul></ul><ul><ul><li>Regulation of blood pressure </li></ul></ul><ul><ul><li>Blood viscosity </li></ul></ul><ul><ul><li>Male fertility </li></ul></ul><ul><ul><li>Female conception </li></ul></ul><ul><ul><li>Muscle cotraction </li></ul></ul><ul><ul><li>Blood clotting </li></ul></ul><ul><ul><li>Tissue growth </li></ul></ul><ul><ul><li>Regulation of sleep/wake cycle </li></ul></ul><ul><ul><li>Bronchocostriction </li></ul></ul><ul><ul><li>Asthma. </li></ul></ul>
  19. 19. Triglycerides;- <ul><li>Structure </li></ul><ul><ul><li>Glycerol + 3 fatty acids </li></ul></ul><ul><li>Functions </li></ul><ul><ul><li>Energy source--9 kcals per gram </li></ul></ul><ul><ul><li>Form of stored energy in adipose tissue. </li></ul></ul><ul><ul><li>Insulation and protection </li></ul></ul><ul><ul><li>Carrier of fat-soluble vitamins </li></ul></ul><ul><ul><li>Sensory properties in food </li></ul></ul>
  20. 20. Phospholipids;- main lipid constituent of cell membrane. <ul><li>Structure </li></ul><ul><ul><li>Glycerol + 2 fatty acids + phosphate group </li></ul></ul><ul><ul><li>also considered as derivative of ‘ phosphatidic acid ’. </li></ul></ul><ul><li>Functions </li></ul><ul><ul><li>Main lipid constituent of cell membranes </li></ul></ul><ul><ul><li>Lipid transport as part of lipoproteins </li></ul></ul><ul><ul><li>Emulsifiers </li></ul></ul><ul><ul><li>Cell signalling process. </li></ul></ul><ul><ul><li>phospholipids </li></ul></ul><ul><ul><li>Phos.choline phos.inositol cardiolipin lysophospholipid plasmalogens sphingomy. </li></ul></ul>
  21. 21. Sterols ;- Steroids are the compounds contains cyclic steroid nucleus namely cyclo pentanophenanthrene ring. Cholesterol- best known steroid because of its association with atherosclerosis and heart diseases. Contains same steroid nucleus. Exclusively present in animals . Functions;- --Bile acids – Sex hormones – Adrenal hormones – Vitamin D --Cardiac glycosides
  22. 22. Glycolipids;- <ul><li>--widely distributed in the body </li></ul><ul><li>Fatty acids + sphingosine +carbohydrate </li></ul><ul><li>Also k/a glycosphingolipids. </li></ul><ul><li>Present in cell membrane and nervous tissues. </li></ul><ul><li>It contributes to cell surface carbohydrate </li></ul><ul><li>Other glycolipids are;- </li></ul><ul><li>Cerebrosides- simplest form of glycolipids.contains ceramides. </li></ul><ul><li>eg. Galactosylcerebrosides </li></ul><ul><li>glucosylcerebrosides </li></ul><ul><li>Gangliosides – predominantly found in ganglions.Complex glycolipids </li></ul>
  23. 23. Lipoproteins;- Lipoproteins are th macromolecular complex of lipids and proteins. Transportation of lipids in the blood. Structure of lipoproteins ;- Hydrophobic lipids (TG, CE) in core; Hydrophilic lipids (UC, PL) on surface
  24. 24. Classes of lipoproteins ;- Chylomicrons, VLDL, LDL HDL > 30 nm 9–15 nm 20–22 nm D<1.006 g/ml D=1.019-1.063g/ml D=1.063-1.21 g/ml Doi H et al. Circulation 2000;102:670-676; Colome C et al. Atherosclerosis 2000; 149:295-302; Cockerill GW et al. Arterioscler Thromb Vasc Biol 1995;15:1987-1994
  25. 25. <ul><li>Apolipoproteins— </li></ul><ul><li>Apo AI (liver, small intestine) </li></ul><ul><ul><li>Structural; activator of lecithin:cholesterol acyltransferase (LCAT) </li></ul></ul><ul><li>Apo AII (liver) </li></ul><ul><ul><li>Structural; inhibitor of hepatic lipase; component of ligand for HDL binding </li></ul></ul><ul><li>Apo A-IV (small intestine) </li></ul><ul><ul><li>Activator of LCAT; modulator of lipoprotein lipase (LPL) </li></ul></ul><ul><li>Apo A-V (liver) </li></ul><ul><ul><li>Direct functional role is unknown; regulates TG levels. </li></ul></ul>
  26. 26. <ul><li>Apoprotein continued… </li></ul><ul><li>Apo B-100 (liver) </li></ul><ul><ul><li>Structural; synthesis of VLDL; ligand for LDL-receptor </li></ul></ul><ul><li>Apo B-48 (small intestine) </li></ul><ul><ul><li>Structural; synthesis of chylomicrons; derived from apo B-100 mRNA following specific mRNA editing </li></ul></ul><ul><li>Apo E (liver, macrophages, brain) </li></ul><ul><ul><li>Ligand for apoE receptor; mobilization of cellular cholesterol </li></ul></ul>
  27. 27. Apoprotein continued… <ul><li>Apo C-I (liver) </li></ul><ul><ul><li>Activator of LCAT, inhibitor of hepatic TGRL uptake </li></ul></ul><ul><li>Apo C-II (liver) </li></ul><ul><ul><li>Activator of LPL, inhibitor of hepatic TGRL uptake </li></ul></ul><ul><li>Apo C-III (liver) </li></ul><ul><ul><li>Inhibitor of LPL, inhibitor of hepatic TGRL uptake </li></ul></ul>
  28. 28. Chylomicrons ;- TG rich . Synthesized in intestine. Transports endogenous TGs. Hydrophobic Core Triglyceride (93%) Cholesteryl Esters (1%)
  29. 29. VLDL;- rich in CE and TGs- Surface Monolayer Phospholipids (12%) Free Cholesterol (14%) Protein (4%) Hydrophobic Core Triglyceride (65%) Cholesteryl Esters (8%)
  30. 30. LDL;- cholesterol rich. Surface Monolayer Phospholipids (25%) Free Cholesterol (15%) Protein (22%) Synthesized from VLDL in blood circulation. Transports cholesterol from liver and delivers to other tissues.
  31. 31. High density lipoprotein- Surface Monolayer Phospholipids (25%) Free Cholesterol (7%) Protein (45%) Promotes re-esterification process of cholesterol.
  32. 32. HDL Subpopulations Rye et al. Atherosclerosis 1999;145:227-238. Apolipoprotein Composition A-I HDL A-I/A-II HDL A-II HDL Particle Shape Discoidal Spherical Lipid Composition TG, CE, and PL Particle Size HDL 2b HDL 2a HDL 3a HDL 3b HDL 3c
  33. 33. <ul><li>The Effects of Various Types of Fat on Blood Lipid Levels </li></ul><ul><li>• Saturated Fat </li></ul><ul><li>– Increases total cholesterol </li></ul><ul><li>– Increases LDL-cholesterol </li></ul><ul><li>• Polyunsaturated Fat </li></ul><ul><li>– Decreases total cholesterol </li></ul><ul><li>– Decreases LDL-cholesterol </li></ul><ul><li>– Decreases HDL-cholesterol </li></ul><ul><li>• Monounsaturated Fat </li></ul><ul><li>– Decreases total cholesterol </li></ul><ul><li>– Decreases LDL-cholesterol </li></ul><ul><li>– Increases HDL-cholesterol </li></ul>
  34. 34. <ul><li>Omega-3 Fat </li></ul><ul><li>– Decreases total cholesterol </li></ul><ul><li>– Decreases LDL-cholesterol </li></ul><ul><li>– Increases HDL-cholesterol </li></ul><ul><li>– Decreases serum triglycerides </li></ul><ul><li>• Trans Fat </li></ul><ul><li>– Increases total cholesterol </li></ul><ul><li>– Increases LDL-cholesterol </li></ul>
  35. 35. Role of lipids in health and diseases – omega-3 FAs . Docosahexanoic acid and brain development- <ul><li>It is becoming increasingly evident that long-chain PUFA from the (n-3) family appear to be neuroprotective and that long-chain PUFA from the (n-6family) may also have unique properties in affecting neurobiology. </li></ul><ul><li>It is found in very high concentrations in the cell membranes of the retina and cerebral cortex . </li></ul><ul><li>Whelan et al,(2008) focused on docosahexaenoic acid (DHA),4 a PUFA that is preferentially deposited in brain phospholipids and has been linked to dementia, Parkinson disease, Alzheimer disease (AD),cognitive function, mental stability, suicide, depression, bipolar disorders, impulsivity, aggression, etc. (3–10). The content of DHA in the brain is 12–15%, 10- to 20-fold higher than any other (n-3) PUFA. </li></ul>
  36. 36. Arachidonic acid and the brain-- One of the most important changes in this field is the link between arachidonic acid (AA) content and brain function. The level of AA in the brain is comparable to that of DHA. At 8–11% of the fatty acid phospholipids, it is severalfold higher than any other (n-6) PUFA (by comparison, linoleic acid content is ;1%). Connell et al,(2007 ) demonstrated that dietary AA appears to influence plasticity and preserve hippocampal membrane fluidity and may provide some protection to oxidative stress via the activation of peroxisomal proliferatoractivated receptor-g (17). Furthermore, it has been shown that AA, as well as DHA, activates syntaxin-3, a critical factor in the growth and regeneration of neurons.
  37. 37. Prevention of cancer;- Marine-derived fatty acids have been found to inhibit proliferation and promote apoptosis in breast, prostate, and colon cancer cell lines cultured outside the body Studies in animal models of cancer also indicate that increased intake of EPA and DHA decreases the occurrence and progression of mammary, prostate, and intestinal tumors
  38. 38. Lipids related disorders ;- <ul><li>lipid disorders </li></ul>Common disorders Hypercholetrolemia Hypertriglyceridemia Hyperlipoproteinemia ketosis CVD Fatty liver Obesity cancer Uncommon disorders Metabolic disorders of cerebrosides. Lipidoses / lipid storage diseases Multiple sclerosis. Infant respiratory distress syndrome Xanthomatosis. Retinitis pigmentosa. Phrynoderma / Toad skin. Disorders of EFAs deficiency. Zwellweger’s disease.
  39. 39. <ul><li>ATHEROSCLEROSIS : </li></ul><ul><li>As LDL particles penetrate the walls of the arteries, they become oxidized-LDL and next are scavenged by the body’s white blood cells. </li></ul><ul><li>• These foam cells are then deposited into the </li></ul><ul><li>lining of the artery wall. </li></ul><ul><li>• This process, known as atherosclerosis, causes </li></ul><ul><li>plaque deposits to enlarge, artery walls to lose </li></ul><ul><li>elasticity, and the passage through the artery to narrow. </li></ul>
  40. 40. Diagrammatic representation of the disease (atherosclerosis)-
  41. 41. Metabolic disorders of cerebrosides Dermatitis,skeletal deformation,hoarseness. ceramide ceramidase Ref- Harper’s biochemistry Farber’s disease Enlarged liver and spleen sphingomyelin sphingomyelinase Niemann-pick disease Enlarged liver and spleen, eroison of long bones ,mental retardation glucosylceramide B-glucosidase Gaucher’s disease Mental retardation,complete loss of myelin sheath. galactosylceramide B-galactosidase Krabbe’s disease Skin rashes,kidney failure galactosylceramide A-galactosidase. Fabry;’s disease Mentalretardation,blindness,muscular weakness. symptoms gangliosides Lipid accumulating hexosaminidase Enzyme deficiency Tay –sachs disease diseases
  42. 42. Lipoprotein disorders ;- Hyperlipoproteinemias- --do-- Chylomicron and VLDL Ref- Harper’s biochemistry --do-- v May/may not increase TGs Overproduction of TGs lv high TGs and cholesterol Abnormality in apo -e lll high TGs and cholesterol Overproduction of apo-b llb Very high cholesterol Deficiency of LDLreceptors lla increase Risk of athersclerosis chylomicrons Increased plasma lipid most Deficiency of lipoproteinlipase Metabolic defect l Hy. Lipo.types
  43. 43. Infant repiratory distress syndrome- Caused due to the deficiency of the lung surfactant dipalmitoyl lecithin . It prevents collapsing of the alveoli and also decreases the surface tension . Deficiency is common in young infants. Xanthomatosis;- Deposition of yellow-orange colours lipids occurs in the liver ,spleen and flat bones. Usually related with severe hypercholesterolemia and hyperlipidemia. Phrynoderma or Toad skin ;- Caused due to the deficiency of essential fatty acids. Horny eruptions occurs on posterior and lateral limbs.poor wound healing. Multiple sclerosis;- It is a demyelinating condition. loss of both phospholipids and sphingolipids occurs from white matter. Neurodegeneration is common.
  44. 44. Defects in the metabolism of essential fatty acids - Cystic fibrosis,Acrodermatitis enterohepatica,Hepato renal syndrome, Crohn’s disease,Cirrhosis, Alcoholism, Reye's syndrome etc. Zwellweger’s disease;- Rare disorder. occurs due to the accumulation of long chain polyenoic fatty acids in the brain. Causes loss of functions and neural degeneration . Dicarboxylic aciduria- It is characterized by the excretion of C6-C10 dicarboxylic acid due to the lack of mitochondrial acyl coA dehydrogenase enzyme.
  45. 45. Common Atherogenic dyslipidemias ) 􀂃 polygenic inheritance – dietary component – secondarily enhanced by insulin resistance (see further why) 􀂃 prognosis of combined hyperlipidemia is worse than that of hypercholesterolemia 􀂃 main features – impaired clearance of TAG by LPL (􀀪 insulin) from chylomicrons -> increased TAG and increased delivery of TAG for liver – increased production of VLDL by liver (􀀪 insulin) from TAG, FFA from adipose tissue (􀀪 insulin) and glucose (􀀪 insulin) – therefore increased conversion of VLDL to LDL – low HDL
  46. 46. Fatty liver;- <ul><li>When lipids accumulates excessively in liver, then it causes fatty liver. </li></ul><ul><li>Dropletes of TGs are found in the entire hepatic cytoplasm, </li></ul><ul><li>this causes impairment in liver function. </li></ul><ul><li>Fatty liver may occur due to two main reason- </li></ul><ul><li>Increased synthesis of TGs. </li></ul><ul><li>Impairment in lipoprotein synthesis. </li></ul><ul><li>Fatty liver is associated with the fibrotic changes and cirrhosis. </li></ul>
  47. 47. Tangier Disease <ul><li>>Autosomal codominant disorder due to mutations in </li></ul><ul><li>both alleles of ABC1 gene </li></ul><ul><li>• Extremely marked reduction in HDL-C and apoA-I </li></ul><ul><li>• Markedly accelerated catabolism of apoA-I and </li></ul><ul><li>>apoA-II </li></ul><ul><li>• Cholesterol accumulation: </li></ul><ul><li>− Enlarged orange tonsils </li></ul><ul><li>− Hepatosplenomegaly </li></ul><ul><li>− Peripheral neuropathy </li></ul>
  48. 48. References-- 1) Connell E, Darios F, Broersen K, Gatsby N, Peak-Chew SY, Rickman C, Davletov B. Mechanism of arachidonic acid action on syntaxin- Munc18. EMBO Rep. 2007;8:414–9 2) Granner,K. and Robert,K.(2006). Harper’s illustrated biochemistry .27 th edition.Tata McGraw Hills publication. 3)Satyanarayan,U. (2006). Biochemistry .3 rd edition. Books and Allied (P)Ltd. 4) Whelan ,J.(2008 ).(n-6) and (n-3) Polyunsaturated Fatty Acids and the Aging Brain: Food for Thought. Abstract J. Nutr. 138: 2521–2522.
  49. 49. Thank you.
  • AsmitaDuragkar1

    Apr. 27, 2021
  • NishaPrasad27

    Jan. 22, 2021
  • leduabugale

    Oct. 1, 2020
  • VibhorThaokar

    Sep. 30, 2020
  • MDSHAKILSARKER2

    Aug. 10, 2020
  • ssuser2f2e3b1

    Apr. 10, 2020
  • MudasarIqbal10

    Apr. 7, 2020
  • spandanabanerji

    Mar. 21, 2020
  • neerugattibanerji

    Mar. 13, 2020
  • RiwajBhandari

    Feb. 26, 2020
  • ToufiqElahi1

    Feb. 15, 2020
  • MaimoonaGull

    Nov. 20, 2019
  • EbsaTofik

    Nov. 14, 2019
  • MdHafijulIslam3

    Nov. 6, 2019
  • kanchanraut3

    Nov. 5, 2019
  • RonDeLeon5

    Nov. 5, 2019
  • EricaOclos

    Nov. 5, 2019
  • DhonnaMaeSonido

    Nov. 5, 2019
  • DrshivamDixit

    Oct. 31, 2019
  • NirmalChandra3

    Oct. 22, 2019

this is the brief introductory prsentation about lipids and its physiological significance.

Views

Total views

82,538

On Slideshare

0

From embeds

0

Number of embeds

9,669

Actions

Downloads

3,682

Shares

0

Comments

0

Likes

151

×