A chemical substance is a form of matter that has a definite chemical composition and characteristic properties. It cannot be separated into its constituent elements by physical separation methods alone. Chemical substances exist as solids, liquids, gases, or plasma and may change between these states. They can be combined or converted through chemical reactions to form other substances. A chemical substance may be a pure chemical element or compound. An element is made of a single type of atom and cannot be broken down further, while a compound is formed when two or more elements are chemically bonded together. There are millions of possible chemical compounds due to combinations of the known chemical elements. Chemists use chemical formulae and molecular structures to refer to compounds. Pure substances are often isolated