Henrietta Lacks' immortal HeLa cells are used widely in medical research to study cancer, viruses, and other cell processes. Cells reproduce through mitosis, which duplicates DNA and divides the cell into two identical daughter cells. Mitosis maintains the chromosome number while meiosis halves it, producing gametes for sexual reproduction. Meiosis involves two nuclear divisions, mixing parental chromosomes and alleles in offspring.
-Cell Division Process In Prokaryotes & Eukaryotes
-Compacting DNA into Chromosomes
-Types of Cell Reproduction
-Phases of the Cell Cycle
-Mitosis
-Meiosis
-Oogenesis & Spermatogenesis
-Comparison of Divisions
Mitosis and meosis are two common phenomenons, one can get plenty information about these two but its significance is very rarely provided on social networks. Here is its significance, have a look.
-Cell Division Process In Prokaryotes & Eukaryotes
-Compacting DNA into Chromosomes
-Types of Cell Reproduction
-Phases of the Cell Cycle
-Mitosis
-Meiosis
-Oogenesis & Spermatogenesis
-Comparison of Divisions
Mitosis and meosis are two common phenomenons, one can get plenty information about these two but its significance is very rarely provided on social networks. Here is its significance, have a look.
Chapter-6Cell Cycle and DivisionCell Divisio.docxchristinemaritza
Chapter-6
Cell Cycle and Division
Cell Division
Cells reproduce by cell division, in which a parent cell normally gives rise to two daughter cells
Each daughter cell receives a complete set of hereditary information (DNA) from the parent cell and about half its cytoplasm
The hereditary information DNA is usually identical with that of the parent cell
The cell division of eukaryotic cells by which organisms grow or increase in number is called mitotic cell division
After cell division, the daughter cells may differentiate, becoming specialized for specific functions
The repeating pattern of divide, grow, and differentiate, then divide again is called the cell cycle
Most multicellular organisms have three categories of cells
1. stem cells
2. Other cells capable of dividing
3. Permanently differentiated cells
1.Stem cells :
- have two important characteristics: self-renewal, and the ability to differentiate into a variety of cell types
-Stem cells self-renew because they retain the ability to divide, perhaps for the entire life of the organism
-Some stem cells in early embryos can produce any of the specialized cell types of the entire body
2. Other cells capable of dividing
-Some cells other than stem cells are capable of continuing to divide, but typically differentiate into only one or two different cell types
-Dividing liver cells, for example, can only become more liver cells
3. Permanently differentiated cells
-Permanently differentiated cells differentiate and never divide again
-For example, most heart and brain cells cannot divide
CELL CYCLE
Both prokaryotic and eukaryotic cells have cell cycles that include growth, metabolic activity, DNA replication, and cell division
However, they have major structural and functional differences
Eukaryotic chromosome
Eukaryotic chromosomes are separated from the cytoplasm by a membrane-bound nucleus
Eukaryotic cells always have multiple chromosomes
Eukaryotic chromosomes are longer and have more DNA than prokaryotic chromosomes (human chromosomes are 10 to 80 times longer and have 10 to 50 times more DNA)
Genes
Genes are segments of the DNA of a chromosome
Genes are sequences of DNA from hundreds to thousands of nucleotides long
Each gene occupies a specific place, or locus (plural, loci) on the chromosome
Two important parts of chromosome
Two telomeres
One centromere
It temporarily holds two daughter DNA double helices together after DNA replication
It is the attachment site for microtubules that move the chromosomes during cell division
Homologous
11
Chromosomes that contain the same genes are called homologous chromosomes, or homologues
Cells with pairs of homologous chromosomes are called diploid, which means “double”
Cells with half the number of chromosomes are called haploid
Human Chromosomes
A typical human cell has ...
The Legacy of Breton In A New Age by Master Terrance LindallBBaez1
Brave Destiny 2003 for the Future for Technocratic Surrealmageddon Destiny for Andre Breton Legacy in Agenda 21 Technocratic Great Reset for Prison Planet Earth Galactica! The Prophecy of the Surreal Blasphemous Desires from the Paradise Lost Governments!
2137ad - Characters that live in Merindol and are at the center of main storiesluforfor
Kurgan is a russian expatriate that is secretly in love with Sonia Contado. Henry is a british soldier that took refuge in Merindol Colony in 2137ad. He is the lover of Sonia Contado.
Explore the multifaceted world of Muntadher Saleh, an Iraqi polymath renowned for his expertise in visual art, writing, design, and pharmacy. This SlideShare delves into his innovative contributions across various disciplines, showcasing his unique ability to blend traditional themes with modern aesthetics. Learn about his impactful artworks, thought-provoking literary pieces, and his vision as a Neo-Pop artist dedicated to raising awareness about Iraq's cultural heritage. Discover why Muntadher Saleh is celebrated as "The Last Polymath" and how his multidisciplinary talents continue to inspire and influence.
thGAP - BAbyss in Moderno!! Transgenic Human Germline Alternatives ProjectMarc Dusseiller Dusjagr
thGAP - Transgenic Human Germline Alternatives Project, presents an evening of input lectures, discussions and a performative workshop on artistic interventions for future scenarios of human genetic and inheritable modifications.
To begin our lecturers, Marc Dusseiller aka "dusjagr" and Rodrigo Martin Iglesias, will give an overview of their transdisciplinary practices, including the history of hackteria, a global network for sharing knowledge to involve artists in hands-on and Do-It-With-Others (DIWO) working with the lifesciences, and reflections on future scenarios from the 8-bit computer games of the 80ies to current real-world endeavous of genetically modifiying the human species.
We will then follow up with discussions and hands-on experiments on working with embryos, ovums, gametes, genetic materials from code to slime, in a creative and playful workshop setup, where all paticipant can collaborate on artistic interventions into the germline of a post-human future.
2137ad Merindol Colony Interiors where refugee try to build a seemengly norm...luforfor
This are the interiors of the Merindol Colony in 2137ad after the Climate Change Collapse and the Apocalipse Wars. Merindol is a small Colony in the Italian Alps where there are around 4000 humans. The Colony values mainly around meritocracy and selection by effort.
1. BIOLOGY: Today and Tomorrow, 4e
starr evers starr
Chapter 8
How Cells Reproduce
2. 8.1 Henrietta’s Immortal Cells
Henrietta Lacks died of cervical cancer more than 50 years
ago, but her cells live on in research laboratories
HeLa cells are widely used to investigate cancer, viral growth,
protein synthesis, effects of radiation, and many other
processes important in medicine and research
Understanding why cancer cells are immortal – and we are
not – begins with understanding the structures and
mechanisms that cells use to divide
4. 8.2 Multiplication by Division
A cell reproduces by dividing in two
Each descendant cell receives a full set of chromosomes and
some cytoplasm
Before the cell’s cytoplasm divides, it must first replicate its
chromosomes
Duplicated chromosomes are separated and packaged into
new nuclei by one of two mechanisms: mitosis or meiosis
5. Mitosis and Meiosis
Mitosis is a nuclear division mechanism that maintains the
chromosome – used in growth, development, replacement of
damaged or dead cells, or as part of asexual reproduction
Meiosis is a nuclear division mechanism that halves the
chromosome number – used in sexual reproduction, in
which two parents contribute genes to offspring
8. 8.3 Mitosis and the Cell Cycle
Cell cycle
A series of events from the time a cell forms until its
cytoplasm divides
Includes three phases: interphase, mitosis, and
cytoplasmic division
9. Interphase
Most of a cell’s activities occur in interphase
Interphase
In a eukaryotic cell cycle, the interval between mitotic
divisions when a cell grows, roughly doubles the number
of its cytoplasmic components, and replicates its DNA
Three stages:
G1, 1st interval (gap) of growth before DNA replication
S, interval of synthesis (DNA replication)
G2, 2nd interval (gap) when the cell prepares to divide
11. Controls Over the Cell Cycle
When a cell divides—and when it does not—is determined by
gene expression controls
Products of “checkpoint genes” monitor whether a cell’s
DNA has been copied completely, whether it is damaged, and
whether enough nutrients are available
If a problem remains uncorrected, other checkpoint proteins
may cause the cell to self-destruct
12. Homologous Chromosomes
Human body cells have 23 chromosome pairs
Except for a pairing of sex chromosomes (XY) in males, the
chromosomes of each pair are homologous
Homologous chromosomes are members of a pair of
chromosomes with the same length, shape, and genes
One member of a homologous pair was inherited from the
female parent, and the other from the male parent
13. How Mitosis Maintains Chromosome Number
Mitosis distributes a complete set of chromosomes into two
new nuclei
In G2, each chromosomes consists of two replicated DNA
molecules attached at the centromere (sister chromatids)
When sister chromatids are pulled apart, each becomes an
individual chromosome in a new nucleus
When the cytoplasm divides, the two nuclei are packaged into
two separate cells
14. How Mitosis Maintains Chromosome Number
A) An unduplicated
pair of chromosomes
in a cell in G1.
B) By G2, each
chromosome has been
duplicated.
C) Mitosis and cytoplasmic
division package one copy of
each chromosome into each
of two new cells.
15. Figure 8-4 p135
A) An unduplicated
pair of chromosomes
in a cell in G1.
Stepped Art
B) By G2, each
chromosome has
been duplicated.
C) Mitosis and
cytoplasmic division
package one copy of each
chromosome into each of
two new cells.
16. The Process of Mitosis
Prophase
Chromosomes condense and spindle forms
Nuclear envelope breaks up
Spindle microtubules attach to chromosomes
Spindle
Moves chromosomes during nuclear division
Dynamically assembled and disassembled microtubules
17. The Process of Mitosis
Metaphase
Duplicated homologous chromosomes line up at the
spindle equator (halfway between spindle poles)
Sister chromatids begin to move apart toward opposite
spindle poles
Anaphase
Microtubules separate sister chromatids of each
chromosome and pull them toward opposite spindle poles
Each DNA molecule is now a separate chromosome
18. The Process of Mitosis
Telophase
Two clusters of chromosomes arrive at the spindle poles
and decondense; new nuclei form
End of mitosis
Nuclear envelopes form around the two clusters of
chromosomes, forming two new nuclei with the parental
chromosome number
19. Mitosis in a plant cell Mitosis in an animal cell
pair of
centrioles
1 Interphase
Interphase cells are shown for comparison, but interphase is not part of mitosis.
The red spots in the plant cell nucleus are areas where ribosome subunits are
being transcribed and assembled.
Mitosis
20. Mitosis in a plant cell Mitosis in an animal cell
2 Early prophase
Mitosis begins. Transcription stops, and the DNA begins to appear grainy as it
starts to condense. The centriole pair gets duplicated.
Mitosis
21. Mitosis in a plant cell Mitosis in an animal cell
microtubule of spindle
3 Prophase
The duplicated chromosomes become visible as they condense. One of the two
centriole pairs moves to the opposite side of the cell. The nuclear envelope
breaks up. Spindle microtubules assemble and bind to chromosomes at the
centromere. Sister chromatids become attached to opposite centriole pairs.
Mitosis
22. Mitosis in a plant cell Mitosis in an animal cell
4 Metaphase
All of the chromosomes are aligned in the middle of the cell.
Mitosis
23. Mitosis in a plant cell Mitosis in an animal cell
5 Anaphase
Spindle microtubules separate the sister chromatids and move them toward
opposite sides of the cell. Each sister chromatid has now become an individual,
unduplicated chromosome.
Mitosis
24. Mitosis in a plant cell Mitosis in an animal cell
6 Telophase
The chromosomes reach opposite sides of the cell and decondense. Mitosis ends
when a new nuclear envelope forms around each cluster of chromosomes.
Mitosis
25. ANIMATED FIGURE: Random alignment
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
26. ANIMATED FIGURE: The cell cycle
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
28. 8.4 Cytoplasmic Division Mechanisms
A cell’s cytoplasm divides between late anaphase and the
end of telophase, forming two cells, each with its own nucleus
Mechanisms of cytoplasmic division differ between animal
cells and plant cells
29. Cytoplasmic Division in Animal Cells
In animal cells, a contractile ring pinches the cytoplasm in two
A contractile ring of microfilaments contracts when its
component proteins are energized by ATP
The cleavage furrow produced deepens until the cytoplasm
(and the cell) is pinched in two
Each new cell has its own nucleus, cytoplasm, and is
enclosed by a plasma membrane
31. Cytoplasmic Division in Plant Cells
In plant cells, microtubules guide vesicles from Golgi bodies
and the cell surface to the division plane
Vesicles and their wall-building contents fuse into a disk-
shaped cell plate
The cell plate grows and forms a cross-wall between the two
new nuclei
The cell plate develops into two new cell walls, separating the
descendant cells
33. ANIMATED FIGURE: Cytoplasmic division
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
34. 8.5 When Mitosis Becomes Pathological
When checkpoint mechanisms fail, the cell may skip
interphase and keep dividing with no resting period
Signaling mechanisms that make an abnormal cell die may
stop working
Mutations are passed along to the cell’s descendants, which
form a neoplasm, an accumulation of cells that lost control
over how they grow and divide
35. Tumors and Oncogenes
A neoplasm that forms a lump is a tumor
An oncogene is any gene that helps transform a normal cell
into a tumor cell
Genes for proteins that promote mitosis are called proto-
oncogenes because mutations can turn them into oncogenes
Example: Genes that code for receptors for growth factors
37. Tumor Suppressors
Checkpoint gene products that inhibit mitosis are called tumor
suppressors because tumors form when they are missing
Example: Products of BRCA1 and BRCA2 genes
Viruses such as HPV cause a cell to make proteins that
interfere with its own tumor suppressors
39. Cancer
A benign neoplasm such as a mole is noncancerous; a
malignant neoplasm is dangerous to health
Cancer occurs when abnormally dividing cells of a malignant
neoplasm disrupt body tissues, physically and metabolically
Malignant neoplasms can break free and invade other tissues
(metastasis)
40. Metastasis
Benign neoplasms
grow slowly and stay
in their home tissue.
Cells of a malignant
neoplasm can break away
from their home tissue.
Malignant cells can become attached to the wall
of a blood vessel or lymph vessel. They release
enzymes that create an opening in the wall, then
enter the vessel.
The cells creep or tumble along in blood vessels,
then leave the bloodstream the same way they got
in. They may start growing in other tissues, a
process called metastasis.
1
4
3
2
41. Three Characteristics of Cancer Cells
1. Grow and divide abnormally
2. Abnormal plasma membrane, cytoskeleton, chromosome
number, and metabolism
3. Cells do not stay anchored properly in tissues because
plasma membrane adhesion proteins are defective or missing
42. Detecting Skin Cancer
C) Melanoma, a malignant
neoplasm of skin cells, spreads
fastest. Cells form
dark, encrusted lumps that may
itch or bleed easily.
B) The second most common
form of skin cancer is a
squamous cell carcinoma.
This pink growth, firm to the
touch, grows under the surface
of skin.
A) Basal cell carcinoma is the
most common type of skin
cancer. This slow growing,
raised lump may be
uncolored, reddish brown, or
black.
43. ANIMATED FIGURE: Cancer and metastasis
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
47. 8.6 Sex and Alleles
Asexual reproduction
Offspring arise from one parent
Offspring are genetic clones
Sexual reproduction
Offspring inherit genes from two parents
Diversity offers a better chance of surviving an
environmental challenge or harmful mutations
Beneficial mutations spread quickly
48. Introducing Alleles
Paired genes on homologous chromosomes often vary
slightly in DNA sequence
Alleles are forms of a gene that encode slightly different
versions of the gene’s product
Offspring of sexual reproducers inherit new combinations of
alleles, which is the basis of new combinations of traits
49. A) Corresponding colored patches in this
fluorescence micrograph indicate
corresponding DNA sequences in
a homologous chromosome pair. These
chromosomes carry the same set of genes.
Alleles
50. Genes occur in pairs on
homologous
chromosomes.
The members of each
pair of genes may be
identical, or they may
differ slightly, as alleles.
B) Homologous chromosomes carry the
same series of genes, but the DNA
sequence of any one of those genes
might differ just a bit from that of its
partner on the homologous chromosome.
Alleles
51. ANIMATED FIGURE: Genetic terms
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
52. 8.7 Meiosis and the Life Cycle
Meiosis halves the parental chromosome number by sorting
the chromosomes into new nuclei twice (meiosis I and
meiosis II)
Duplicated chromosomes of a diploid nucleus (2n) are
distributed into four haploid nuclei (n)
54. Meiosis
Meiosis I
In the first nuclear division, duplicated homologous
chromosomes line up and cross over, then move apart,
toward opposite spindle poles
Two new nuclear envelopes form around the two clusters
of still-duplicated chromosomes
Meiosis II
The second nuclear division separates sister chromatids
Four haploid nuclei typically form, each with one complete
set of unduplicated chromosomes
55. Meiosis I One diploid nucleus to two haploid nuclei
1 2 3 4Prophase I Metaphase I Anaphase I Telophase I
plasma
membrane
spindle
nuclear
envelope breaking up
centiole pair one pair of
homologous chromosomes
Meiosis
56. No DNA
replication
Meiosis II Two haploid nuclei to four haploid nuclei
5 6 7 8Prophase II Metaphase II Anaphase II Telophase II
Meiosis
57. Meiosis Mixes Alleles
Meiosis shuffles parental combinations of alleles, introducing
variation in offspring
Crossing over in prophase I
Random assortment in metaphase I
Crossing over is recombination between nonsister
chromatids of homologous chromosomes which produces
new combinations of parental alleles
58. A) Here, we focus on only two of the many genes on a chromosome. In this example, one
gene has alleles A and a; the other has alleles B and b.
Crossing Over
59. crossover
B) Close contact between homologous chromosomes promotes crossing over between
nonsister chromatids, which exchange corresponding pieces.
Crossing Over
60. C) Crossing over mixes up paternal and maternal alleles on homologous chromosomes.
Crossing Over
61. From Gametes to Offspring
Sexual reproduction involves the fusion of reproductive cells
(gametes) from two parents
All gametes are haploid, and they arise by division of
immature reproductive cells (germ cells)
At fertilization, two haploid gametes fuse and produce a
diploid zygote, which is the first cell of a new individual
62. Gametes in Animals and Plants
In animals, meiosis of germ cells in the reproductive organs
give rise to sperm (male gametes) or eggs (female gametes)
In plants, two kinds of multicelled bodies form:
A diploid sporophyte produces spores by meiosis
Gametes form in a haploid gametophyte
65. ANIMATED FIGURE: Crossing over
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
66. ANIMATED FIGURE: Generalized life cycles
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
67. ANIMATION: Meiosis I and II
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
69. ANIMATION: Crossover review
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
70. ANIMATION: Stages of Mitosis and Meiosis
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
71. ANIMATION:
Meiosis and Mitosis Drag and Drop
To play movie you must be in Slide Show Mode
PC Users: Please wait for content to load, then click to play
Mac Users: CLICK HERE
72. 8.8 Henrietta’s Immortal Cells (revisited)
HeLa cells were used in early tests of taxol, a drug that keeps
microtubules from disassembling and interferes with mitosis
The HeLa cell line was established more than 50 years ago
without Henrietta Lacks knowledge or consent
Today, consent forms are required to take tissue samples
Figure 8.1 Dividing HeLa cells (above), a cellular legacy of Henrietta Lacks (left), who was a young casualty of cancer.
Figure 8.2 A multicelled animal develops from
a fertilized egg by repeated cell divisions. These early
frog embryos have undergone three divisions.
Figure 8.4 How mitosis maintains the chromosome number.
For clarity, only one chromosome pair is shown.
Figure 8.4 How mitosis maintains the chromosome number.
For clarity, only one chromosome pair is shown.
Figure 8.5 Animated! Mitosis. Micrographs show mitosis in the nucleus of a plant cell (onion root, left), and
an animal cell (fertilized egg of a roundworm, right). A diploid (2n) animal cell with two chromosome pairs is illustrated.
1 Interphase
Interphase cells are shown for comparison,
but interphase is not part of mitosis.
The red spots in the plant cell nucleus
are areas where ribosome subunits are
being transcribed and assembled.
3 Prophase
The duplicated chromosomes become
visible as they condense. One of the two
centriole pairs moves to the opposite side
of the cell. The nuclear envelope breaks
up. Spindle microtubules assemble and
bind to chromosomes at the centromere.
Sister chromatids become attached to
opposite centriole pairs.
4 Metaphase
All of the chromosomes are aligned
in the middle of the cell.
5 Anaphase
Spindle microtubules separate the sister
chromatids and move them toward
opposite sides of the cell. Each sister
chromatid has now become an individual,
unduplicated chromosome.
6 Telophase
The chromosomes reach opposite
sides of the cell and decondense.
Mitosis ends when a new nuclear
envelope forms around each cluster
of chromosomes.
Figure 8.5 Animated! Mitosis. Micrographs show mitosis in the nucleus of a plant cell (onion root, left), and
an animal cell (fertilized egg of a roundworm, right). A diploid (2n) animal cell with two chromosome pairs is illustrated.
1 Interphase
Interphase cells are shown for comparison,
but interphase is not part of mitosis.
The red spots in the plant cell nucleus
are areas where ribosome subunits are
being transcribed and assembled.
3 Prophase
The duplicated chromosomes become
visible as they condense. One of the two
centriole pairs moves to the opposite side
of the cell. The nuclear envelope breaks
up. Spindle microtubules assemble and
bind to chromosomes at the centromere.
Sister chromatids become attached to
opposite centriole pairs.
4 Metaphase
All of the chromosomes are aligned
in the middle of the cell.
5 Anaphase
Spindle microtubules separate the sister
chromatids and move them toward
opposite sides of the cell. Each sister
chromatid has now become an individual,
unduplicated chromosome.
6 Telophase
The chromosomes reach opposite
sides of the cell and decondense.
Mitosis ends when a new nuclear
envelope forms around each cluster
of chromosomes.
Figure 8.5 Animated! Mitosis. Micrographs show mitosis in the nucleus of a plant cell (onion root, left), and
an animal cell (fertilized egg of a roundworm, right). A diploid (2n) animal cell with two chromosome pairs is illustrated.
1 Interphase
Interphase cells are shown for comparison,
but interphase is not part of mitosis.
The red spots in the plant cell nucleus
are areas where ribosome subunits are
being transcribed and assembled.
3 Prophase
The duplicated chromosomes become
visible as they condense. One of the two
centriole pairs moves to the opposite side
of the cell. The nuclear envelope breaks
up. Spindle microtubules assemble and
bind to chromosomes at the centromere.
Sister chromatids become attached to
opposite centriole pairs.
4 Metaphase
All of the chromosomes are aligned
in the middle of the cell.
5 Anaphase
Spindle microtubules separate the sister
chromatids and move them toward
opposite sides of the cell. Each sister
chromatid has now become an individual,
unduplicated chromosome.
6 Telophase
The chromosomes reach opposite
sides of the cell and decondense.
Mitosis ends when a new nuclear
envelope forms around each cluster
of chromosomes.
Figure 8.5 Animated! Mitosis. Micrographs show mitosis in the nucleus of a plant cell (onion root, left), and
an animal cell (fertilized egg of a roundworm, right). A diploid (2n) animal cell with two chromosome pairs is illustrated.
1 Interphase
Interphase cells are shown for comparison,
but interphase is not part of mitosis.
The red spots in the plant cell nucleus
are areas where ribosome subunits are
being transcribed and assembled.
3 Prophase
The duplicated chromosomes become
visible as they condense. One of the two
centriole pairs moves to the opposite side
of the cell. The nuclear envelope breaks
up. Spindle microtubules assemble and
bind to chromosomes at the centromere.
Sister chromatids become attached to
opposite centriole pairs.
4 Metaphase
All of the chromosomes are aligned
in the middle of the cell.
5 Anaphase
Spindle microtubules separate the sister
chromatids and move them toward
opposite sides of the cell. Each sister
chromatid has now become an individual,
unduplicated chromosome.
6 Telophase
The chromosomes reach opposite
sides of the cell and decondense.
Mitosis ends when a new nuclear
envelope forms around each cluster
of chromosomes.
Figure 8.5 Animated! Mitosis. Micrographs show mitosis in the nucleus of a plant cell (onion root, left), and
an animal cell (fertilized egg of a roundworm, right). A diploid (2n) animal cell with two chromosome pairs is illustrated.
1 Interphase
Interphase cells are shown for comparison,
but interphase is not part of mitosis.
The red spots in the plant cell nucleus
are areas where ribosome subunits are
being transcribed and assembled.
3 Prophase
The duplicated chromosomes become
visible as they condense. One of the two
centriole pairs moves to the opposite side
of the cell. The nuclear envelope breaks
up. Spindle microtubules assemble and
bind to chromosomes at the centromere.
Sister chromatids become attached to
opposite centriole pairs.
4 Metaphase
All of the chromosomes are aligned
in the middle of the cell.
5 Anaphase
Spindle microtubules separate the sister
chromatids and move them toward
opposite sides of the cell. Each sister
chromatid has now become an individual,
unduplicated chromosome.
6 Telophase
The chromosomes reach opposite
sides of the cell and decondense.
Mitosis ends when a new nuclear
envelope forms around each cluster
of chromosomes.
.
Figure 8.5 Animated! Mitosis. Micrographs show mitosis in the nucleus of a plant cell (onion root, left), and
an animal cell (fertilized egg of a roundworm, right). A diploid (2n) animal cell with two chromosome pairs is illustrated.
1 Interphase
Interphase cells are shown for comparison,
but interphase is not part of mitosis.
The red spots in the plant cell nucleus
are areas where ribosome subunits are
being transcribed and assembled.
3 Prophase
The duplicated chromosomes become
visible as they condense. One of the two
centriole pairs moves to the opposite side
of the cell. The nuclear envelope breaks
up. Spindle microtubules assemble and
bind to chromosomes at the centromere.
Sister chromatids become attached to
opposite centriole pairs.
4 Metaphase
All of the chromosomes are aligned
in the middle of the cell.
5 Anaphase
Spindle microtubules separate the sister
chromatids and move them toward
opposite sides of the cell. Each sister
chromatid has now become an individual,
unduplicated chromosome.
6 Telophase
The chromosomes reach opposite
sides of the cell and decondense.
Mitosis ends when a new nuclear
envelope forms around each cluster
of chromosomes.
Figure 8.6 Animated! Cytoplasmic division of an animal cell.
1 After mitosis is
completed, the spindle
begins to disassemble.
4 The ring contracts
until it pinches the
cell in two.
3 This contractile ring
pulls the cell surface
inward as it shrinks.
2 At the midpoint of
the former spindle, a
ring of microfilaments
attached to the plasma
membrane contracts.
Figure 8.7 Animated! Cytoplasmic division of a plant cell.
5 The future plane of division
was established beforeå
mitosis began. Vesicles cluster
here before mitosis ends.
6 The vesicles fuse
with each other, forming
a cell plate along
the plane of division.
7 The cell plate expands
outward along the plane
of division. When it
reaches the plasma membrane,
it attaches to the
membrane and partitions
the cytoplasm.
8 The cell plate matures
as two new cell walls.
These walls join with the
parent cell wall, so each
descendant cell becomes
enclosed by its own wall.
Figure 8.8 An oncogene causing a neoplasm. In this
section of human breast tissue, activated growth factor
receptor is stained brown. Normal cells are the ones with
lighter staining. The heavily stained cells have formed a
neoplasm; the abnormal overabundance of the activated
receptor means that mitosis is being continually stimulated
in these cells. Cells of most neoplasms have mutations
that cause this receptor to be overproduced or overactive.
Figure 8.9 Checkpoint genes putting the brakes on cell division. Both of
these images show the same nucleus, which has been exposed to radiation that
damaged the DNA inside of it (compare Figure 6.8A). A Green dots pinpoint the
location of the product of a gene called 53BP1; B red dots show the location of
the BRCA1 gene product. Both proteins have clustered around the same chromosome
breaks in the same nucleus; both function to recruit DNA repair enzymes.
The integrated action of these and other checkpoint gene products blocks mitosis
until the DNA breaks are fixed.
Figure 8.11 Skin cancer can be detected and treated early with periodic screening.
Figure 8.12 Animated! Genes on chromosomes.
Different forms of a gene are called alleles.
Figure 8.12 Animated! Genes on chromosomes.
Different forms of a gene are called alleles.
Figure 8.13 Animated! Meiosis.
The micrographs show meiosis in a lily cell. The illustrations
show two pairs of chromosomes in a diploid (2n)
animal cell; homologous chromosomes are indicated in
blue and pink.
Figure 8.13 Animated! Meiosis.
The micrographs show meiosis in a lily cell. The illustrations
show two pairs of chromosomes in a diploid (2n)
animal cell; homologous chromosomes are indicated in
blue and pink.
Figure 8.14 Crossing over.
Blue signifies a paternal chromosome, and pink, its
maternal homologue. For clarity, we show only one
pair of homologous chromosomes and one crossover,
but more than one crossover may occur in
each chromosome pair.
Figure 8.14 Crossing over.
Blue signifies a paternal chromosome, and pink, its
maternal homologue. For clarity, we show only one
pair of homologous chromosomes and one crossover,
but more than one crossover may occur in
each chromosome pair.
Figure 8.14 Crossing over.
Blue signifies a paternal chromosome, and pink, its
maternal homologue. For clarity, we show only one
pair of homologous chromosomes and one crossover,
but more than one crossover may occur in
each chromosome pair.