Hypersensitivity reactions for Medical StudentsNCRIMS, Meerut
Hypersensitivity (animated) for MBBS Students
Hypersensitivity refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system.
Hypersensitivity reactions require a pre-sensitized state of the host.
Four types of hypersensitivity
Type I – anaphylactic
Type II – cytotoxic
Type III – immune complex mediated
Type IV – contact, tuberculin and granulomatous
Anaphylaxis is defined as a life-threatening allergic reaction set in action by a wide range of antigens and involving multiple organ systems.
The true incidence is difficult to estimate, but in 1973 the Boston Collaborative Drug Surveillance Program reported six anaphylactic reactions and 0.87 deaths from anaphylaxis per 10,000 patients.
Reactions to insect stings alone are responsible for at least 50 deaths in the United States each year.
These figures reveal the importance of continued research into the biology of anaphylaxis along with developing new (and improving existing) therapies.
Hypersensitivity (Allergy) - Drug allergy, Contact dermatitis, Allergic asthmaAvinandan Jana
A condition in which the immune system reacts abnormally to a foreign substance.
Drug allergy
An abnormal reaction of the immune system to a medication.
Food allergies
An unpleasant or dangerous immune system reaction after a certain food is eaten.
Contact dermatitis
A skin rash caused by contact with a certain substance.
Latex allergy
An allergic reaction to certain proteins found in natural rubber latex.
Allergic asthma
Asthma triggered by exposure to the same substances that trigger allergy symptoms.
Seasonal allergies
An allergic response causing itchy, watery eyes, sneezing and other similar symptoms.
Animal allergy
An abnormal immune reaction to proteins in an animal's skin cells, saliva or urine.
Anaphylaxis
A severe, potentially life-threatening allergic reaction.
Allergy to mold
An abnormal allergic reaction to mould spores.
Hypersensitivity reactions for Medical StudentsNCRIMS, Meerut
Hypersensitivity (animated) for MBBS Students
Hypersensitivity refers to undesirable (damaging, discomfort-producing and sometimes fatal) reactions produced by the normal immune system.
Hypersensitivity reactions require a pre-sensitized state of the host.
Four types of hypersensitivity
Type I – anaphylactic
Type II – cytotoxic
Type III – immune complex mediated
Type IV – contact, tuberculin and granulomatous
Anaphylaxis is defined as a life-threatening allergic reaction set in action by a wide range of antigens and involving multiple organ systems.
The true incidence is difficult to estimate, but in 1973 the Boston Collaborative Drug Surveillance Program reported six anaphylactic reactions and 0.87 deaths from anaphylaxis per 10,000 patients.
Reactions to insect stings alone are responsible for at least 50 deaths in the United States each year.
These figures reveal the importance of continued research into the biology of anaphylaxis along with developing new (and improving existing) therapies.
Hypersensitivity (Allergy) - Drug allergy, Contact dermatitis, Allergic asthmaAvinandan Jana
A condition in which the immune system reacts abnormally to a foreign substance.
Drug allergy
An abnormal reaction of the immune system to a medication.
Food allergies
An unpleasant or dangerous immune system reaction after a certain food is eaten.
Contact dermatitis
A skin rash caused by contact with a certain substance.
Latex allergy
An allergic reaction to certain proteins found in natural rubber latex.
Allergic asthma
Asthma triggered by exposure to the same substances that trigger allergy symptoms.
Seasonal allergies
An allergic response causing itchy, watery eyes, sneezing and other similar symptoms.
Animal allergy
An abnormal immune reaction to proteins in an animal's skin cells, saliva or urine.
Anaphylaxis
A severe, potentially life-threatening allergic reaction.
Allergy to mold
An abnormal allergic reaction to mould spores.
PREPARED BY DR MUHAMMAD MUQEEM MANGI BASED ON GUYTON AND HALL 14TH EDITION WITH NET HELP, FOR THE MEDICAL STUDENTS OF FIRST YEAR MBBS ,DENTAL STUDENTS , DOCTORS OF PHYSIOTHERAPY AND PARAMEDICAL PERSONEL
The symptoms resulting from allergic responses are known as anaphylaxis.
Mediated by IgE attached to Mast cells.
Includes: Hay fever, asthma, eczema, bee stings, food allergies.
Hypersensitivity/ Allergy ppt by DR.C.P.PRINCEDR.PRINCE C P
Hypersensitivity refers to undesirable reactions produced by the normal immune system, including allergies .
These reactions may be damaging, uncomfortable, or occasionally fatal.
ALLERGEN: non-parasite antigens that can stimulate a hypersensitivity response
Occurs in two stages : sensitization phase and shocking phase
Classified into Immediate and Delayed hypersensitivity based on time required to develop the symptoms
Type I hypersensitivity is also known as immediate or anaphylactic hypersensitivity.
The reaction may involve skin(urticaria and eczema), eyes(conjunctivitis), nasopharynx (rhinorrhea, rhinitis), bronchopulmonary tissues(asthma) and gastrointestinal tract (gastroenteritis).
Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity.
PREPARED BY DR MUHAMMAD MUQEEM MANGI BASED ON GUYTON AND HALL 14TH EDITION WITH NET HELP, FOR THE MEDICAL STUDENTS OF FIRST YEAR MBBS ,DENTAL STUDENTS , DOCTORS OF PHYSIOTHERAPY AND PARAMEDICAL PERSONEL
The symptoms resulting from allergic responses are known as anaphylaxis.
Mediated by IgE attached to Mast cells.
Includes: Hay fever, asthma, eczema, bee stings, food allergies.
Hypersensitivity/ Allergy ppt by DR.C.P.PRINCEDR.PRINCE C P
Hypersensitivity refers to undesirable reactions produced by the normal immune system, including allergies .
These reactions may be damaging, uncomfortable, or occasionally fatal.
ALLERGEN: non-parasite antigens that can stimulate a hypersensitivity response
Occurs in two stages : sensitization phase and shocking phase
Classified into Immediate and Delayed hypersensitivity based on time required to develop the symptoms
Type I hypersensitivity is also known as immediate or anaphylactic hypersensitivity.
The reaction may involve skin(urticaria and eczema), eyes(conjunctivitis), nasopharynx (rhinorrhea, rhinitis), bronchopulmonary tissues(asthma) and gastrointestinal tract (gastroenteritis).
Hypersensitivity (also called hypersensitivity reaction or intolerance) refers to undesirable reactions produced by the normal immune system, including allergies and autoimmunity.
Ozempic: Preoperative Management of Patients on GLP-1 Receptor Agonists Saeid Safari
Preoperative Management of Patients on GLP-1 Receptor Agonists like Ozempic and Semiglutide
ASA GUIDELINE
NYSORA Guideline
2 Case Reports of Gastric Ultrasound
Recomendações da OMS sobre cuidados maternos e neonatais para uma experiência pós-natal positiva.
Em consonância com os ODS – Objetivos do Desenvolvimento Sustentável e a Estratégia Global para a Saúde das Mulheres, Crianças e Adolescentes, e aplicando uma abordagem baseada nos direitos humanos, os esforços de cuidados pós-natais devem expandir-se para além da cobertura e da simples sobrevivência, de modo a incluir cuidados de qualidade.
Estas diretrizes visam melhorar a qualidade dos cuidados pós-natais essenciais e de rotina prestados às mulheres e aos recém-nascidos, com o objetivo final de melhorar a saúde e o bem-estar materno e neonatal.
Uma “experiência pós-natal positiva” é um resultado importante para todas as mulheres que dão à luz e para os seus recém-nascidos, estabelecendo as bases para a melhoria da saúde e do bem-estar a curto e longo prazo. Uma experiência pós-natal positiva é definida como aquela em que as mulheres, pessoas que gestam, os recém-nascidos, os casais, os pais, os cuidadores e as famílias recebem informação consistente, garantia e apoio de profissionais de saúde motivados; e onde um sistema de saúde flexível e com recursos reconheça as necessidades das mulheres e dos bebês e respeite o seu contexto cultural.
Estas diretrizes consolidadas apresentam algumas recomendações novas e já bem fundamentadas sobre cuidados pós-natais de rotina para mulheres e neonatos que recebem cuidados no pós-parto em unidades de saúde ou na comunidade, independentemente dos recursos disponíveis.
É fornecido um conjunto abrangente de recomendações para cuidados durante o período puerperal, com ênfase nos cuidados essenciais que todas as mulheres e recém-nascidos devem receber, e com a devida atenção à qualidade dos cuidados; isto é, a entrega e a experiência do cuidado recebido. Estas diretrizes atualizam e ampliam as recomendações da OMS de 2014 sobre cuidados pós-natais da mãe e do recém-nascido e complementam as atuais diretrizes da OMS sobre a gestão de complicações pós-natais.
O estabelecimento da amamentação e o manejo das principais intercorrências é contemplada.
Recomendamos muito.
Vamos discutir essas recomendações no nosso curso de pós-graduação em Aleitamento no Instituto Ciclos.
Esta publicação só está disponível em inglês até o momento.
Prof. Marcus Renato de Carvalho
www.agostodourado.com
micro teaching on communication m.sc nursing.pdfAnurag Sharma
Microteaching is a unique model of practice teaching. It is a viable instrument for the. desired change in the teaching behavior or the behavior potential which, in specified types of real. classroom situations, tends to facilitate the achievement of specified types of objectives.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
- Video recording of this lecture in English language: https://youtu.be/lK81BzxMqdo
- Video recording of this lecture in Arabic language: https://youtu.be/Ve4P0COk9OI
- Link to download the book free: https://nephrotube.blogspot.com/p/nephrotube-nephrology-books.html
- Link to NephroTube website: www.NephroTube.com
- Link to NephroTube social media accounts: https://nephrotube.blogspot.com/p/join-nephrotube-on-social-media.html
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These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
Acute scrotum is a general term referring to an emergency condition affecting the contents or the wall of the scrotum.
There are a number of conditions that present acutely, predominantly with pain and/or swelling
A careful and detailed history and examination, and in some cases, investigations allow differentiation between these diagnoses. A prompt diagnosis is essential as the patient may require urgent surgical intervention
Testicular torsion refers to twisting of the spermatic cord, causing ischaemia of the testicle.
Testicular torsion results from inadequate fixation of the testis to the tunica vaginalis producing ischemia from reduced arterial inflow and venous outflow obstruction.
The prevalence of testicular torsion in adult patients hospitalized with acute scrotal pain is approximately 25 to 50 percent
2. Dr Sonal Saxena, MD
Director Professor and Head of the Department of Microbiology
Maulana Azad Medical College,
New Delhi
and
Dr Amala A Andrews, MD
Maulana Azad Medical College,
New Delhi
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3. INTRODUCTION
Hypersensitivity refers to the undesirable injurious
consequences in a sensitised host following contact with
specific antigens
Allergy refers to all immune processes harmful to the host
such as hypersensitivity and autoimmunity
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4. CLASSIFICATION
Based on time
Immediate
Delayed
Based on mechanism (Coombs and Gell)
Type I (immediate anaphylactic hypersensitivity)
Type II (cytolytic/cytotoxic hypersensitivity)
Type III (immune complex-mediated hypersensitivity)
Type IV (delayed type T-cell mediated
hypersensitivity)
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5. Table 16.1 Distinguishing features of immediate and
delayed types of hypersensitivity
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CLASSIFICATION
6. Table 16.2 Types of hypersensitivity reactions and their
features
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CLASSIFICATION
7. TYPE I
(ANAPHYLACTIC
HYPERSENSITIVITY)
Within minutes after exposure to the antigen
Mediated by IgE and involves degranulation of mast cells or
basophils.
Occurs in two forms:
- Anaphylaxis: Acute, potentially fatal with systemic
manifestation
- Atopy: Chronic or recurrent, non-fatal and typically localised
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8. TYPE I
(ANAPHYLACTIC
HYPERSENSITIVITY)
Anaphylaxis
Acute, fatal, systemic
Sensitizing dose Shocking dose
Mediated by cytotropic IgE antibody
Antigen combining with IgE bind to mast cells and
basophils leading to degranulation and release of
biologically active substances
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9. ANAPHYLAXIS:
SIGNS AND
SYMPTOMS
Usually caused by drugs and insect stings
Occurs in seconds
Itching of the scalp and tongue
Flushing of the skin
Difficulty in breathing
Nausea, vomiting, abdominal pain and diarrhea
Hypotension, loss of consciousness and death
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10. TYPES OF
ANAPHYLAXIS
1. Cutaneous anaphylaxis
Antigen given intradermally to a sensitised host
Local wheal-and-flare response (local
anaphylaxis)
2. Passive cutaneous anaphylaxis (PCA)
- In vivo method
- To detect antibodies that can passively lead to
cutaneous anaphylaxis
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11. TYPES OF
ANAPHYLAXIS
3. Anaphylaxis in vitro
Schultz–Dale phenomenon
Intestinal/uterine muscle strips from sensitised guinea
pigs, held in a bath of Ringer’s solution will contract
vigorously on the addition of the specific antigen to the
bath
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12. MECHANISM OF ANAPHYLAXIS
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Fig. 16.1 Type I reaction: Immediate anaphylactic hypersensitivity reaction mediated
by IgE (Source: https://openstax.org/books/ microbiology/pages/19-1
hypersensitivities-19-3)
13. MECHANISM
OF
ANAPHYLAXIS
Pharmacological mediators
Primary mediators
◦ Histamine
◦ Serotonin (5-hydroxytryptamine)
◦ Chemotactic factors
◦ Enzymatic mediators
Secondary mediators
◦ Platelet-activating factor (PAF)
◦ Leukotrienes and prostaglandins
◦ Cytokines, bradykinin and other kinins
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14. ANAPHYLAXIS
Treatment
Prompt
0.5 mL of a 1-in-1000 solution, subcutaneously or
intramuscularly
Anaphylactoid reaction: The intravenous injection of
peptone, trypsin and certain other substances provokes a
clinical reaction resembling anaphylactic shock; this is
termed an anaphylactoid reaction
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15. ATOPY
Genetically determined familial hypersensitivities
Hay fever and asthma
Antigens commonly involved
◦ Environmental inhalants like pollens and house dust
◦ Ingestants like eggs and milk
◦ Contact allergens
Preponderant IgE response
Symptoms depends on portal of entry: E.g., conjunctivitis,
rhinitis, gastrointestinal symptoms and dermatitis
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16. DETECTION OF TYPE I
HYPERSENSITIVITY
Skin test
RAST
Radioimmunosorbent test (RIST)
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Fig. 16.2 (a)Skin test to demonstrate
immediate hypersensitivity, and (b) wheal-
and-flare reaction on the forearm seen in
an individual allergic to pollen, and cat fur;
seen within 30 minutes of injecting minute
doses of the allergens (Source: Dr Reba
Kanungo, personal collection)
17. TREATMENT OF
TYPE 1
HYPERSENSITIVITY
Acute anaphylaxis or allergy
Epinephrine (adrenalin)
Antihistamines (block H1 and H2 receptors)
Corticosteroids (reduce histamine levels).
Atopic persons can be treated by desensitisation
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18. TYPE II
REACTIONS:
CYTOLYTIC AND
CYTOTOXIC
Antigenic determinants on the surface of cells
or
Free antigen or hapten absorbed on to cell surfaces
Activation of IgG (or rarely IgM) antibodies
Complement activation
Cytotoxic or cytolytic effects
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19. TYPE II REACTIONS: CYTOLYTIC AND
CYTOTOXIC
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Hemolytic anemia, agranulocytosis and thrombocytopenic purpura
Erythroblastosis fetalis, transfusion reactions
Autoimmune and drug-induced hemolytic anemia
Pernicious anemia
Autoimmune thrombocytopenic purpura , myasthenia gravis
20. TYPE II
REACTIONS:
CYTOLYTIC AND
CYTOTOXIC
Antibody-dependent cell cytotoxicity (ADCC)
Cytotoxic cells may be stimulated by the antigen–
antibody complex
Stimulatory type
Type V hypersensitivity
Subtype of type II
IgG binds to the cell surface antigen receptors
Graves’ disease
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21. TYPE III REACTIONS: IMMUNE COMPLEX-MEDIATED
HYPERSENSITIVITY
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Stimulate an inflammatory reaction
Immune complex formation and deposition
Complement activation
Antigen and antibody combine
22. TYPE III REACTIONS:
IMMUNE COMPLEX-
MEDIATED
HYPERSENSITIVITY
Types
i) Serum sickness: Systemic
form
ii) Local Type III reaction
Arthus reaction
Autoimmune disorders
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Fig. 16.3 Type III reaction (mechanism of
immune complex-mediated
hypersensitivity)
23. ANTIBODY
DEPENDENT
ENHANCEMENT
• Antibodies to a number of viruses cause enhanced virus
entry and replication in some cells
• Virus–antibody immune complexes interact with cells
bearing complement or fc receptors
• Internalisation of the virus is enhanced, leading to
increasing infection
• This results in exacerbation of viral disease
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24. TYPE IV REACTIONS:
T CELL-MEDIATED
HYPERSENSITIVITY
(DELAYED TYPE)
Delayed cell-mediated immune response
Provoked by
◦ Intracellular microbial infections
◦ Hapten-like simple chemicals applied on the skin
Induced by sensitised T cells (Tdth, Th1, Th2, Tc)
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25. UNIVERSITIES PRESS PVT LTD.
TYPE IV REACTIONS: T CELL-MEDIATED
HYPERSENSITIVITY
Types
1. Tuberculin (infection)
Prior infection or immunisation shows positive tuberculin test
Cutaneous basophil hypersensitivity: A local reaction resembling the tuberculin
response produced by the intradermal injection of some protein antigens
2. Contact dermatitis: Contact with chemicals such as nickel and chromium, dyes,
dinitrochlorobenzene, drugs such as penicillin, plant allergen and toiletries
26. TYPE IV
REACTIONS: T
CELL-MEDIATED
HYPERSENSITIVITY
Mechanism of contact dermatitis
Langerhans’ cells capture hapten along with the
modified tissue proteins to draining lymph nodes
Present processed antigen along with MHC molecules to
T cells
The sensitised T cells to the skin site release various
lymphokines
Th1 cells secrete IFN-γ and IL-2activate macrophages
and other lymphocytes
Activated Tc cells mediate the killing of target cells
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27. TYPE IV REACTIONS: T
CELL-MEDIATED
HYPERSENSITIVITY
Symptoms of contact dermatitis
- Macules and papules to vesicles
- Break down, leaving behind raw, weeping areas
Detection using ‘patch test’
- Allergen is applied to the skin
- Itchiness in 4–5 hours, and local reaction
- From erythema to vesicle or blister formation, after
24–28 hours
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