This chapter discusses security vulnerabilities, threats, and countermeasures related to hardware, firmware, memory, input/output devices, client-based systems, server-based systems, database systems, distributed systems, cloud-based systems, mobile systems, embedded devices, and cyber-physical systems. It covers protection mechanisms, common architecture flaws, and methods to assess and mitigate risks like injections, cross-site scripting, and covert channels. The chapter emphasizes principles like layering, abstraction, data hiding, and least privilege to inform security policies and architecture design.