This chapter discusses two-sample hypothesis tests for comparing means and proportions between two independent populations or between paired/dependent samples. It provides examples of hypothesis tests to compare the means of two independent samples using the z-test if populations are normal and sample sizes are large, or the t-test if populations are normal but sample sizes are small. Tests are also shown to compare proportions between two independent populations using the z-test, and to compare means between paired samples using the t-test.