SlideShare a Scribd company logo
Chapter 3: Pharmaceutical
            Measurement
                        Dr. Bridg’ette Israel
                bridgette.israel@famu.edu
Chapter 3: Objectives
    Describe instruments for volumetric measurement
     and characterize their differences in application and
     accuracy.

    Describe the correct procedure when using a
     pharmaceutical balance.

    Define sensitivity requirement and apply it in
     calculations.

    Perform calculations by the aliquot method.

    Demonstrate an understanding of percentage of error
     in pharmaceutical measurement.
Vocabulary
   Compound or Compounding

   Sensitivity Requirement (SR)

   Aliquot

   Percentage of Error
Measurement of Volume
Measurement of Volume
Measurement of Weight
Measurement of Weight
Weighing by the Aliquot
               Method
     Preliminary Step: Calculate the smallest quantity of
      a substance that can be weighed on the balance
      with the desired precision.

     Step 1: Select a multiple of the desired quantity
      that can be weighed with the required precision.

     Step 2: Dilute the multiple quantity with an inert
      substance.

     Step 3: Weigh the aliquot portion of the dilution
      that contains the desired quantity.
Preliminary Step
   Calculate the smallest quantity of a substance that
    can be weighed on the balance with the desired
    precision.
Preliminary Step
   Calculate the smallest quantity of a substance that
    can be weighed on the balance with the desired
    precision.
Preliminary Step
   Calculate the smallest quantity of a substance that
    can be weighed on the balance with the desired
    precision.
Step One
   Select a multiple of the desired quantity that can
    be weighed with the required precision.
Step Two
   Dilute the multiple quantity with an inert substance.
Step Three
   Weigh the aliquot portion of the dilution that
    contains the desired quantity.
Step Three
   Weigh the aliquot portion of the dilution that
    contains the desired quantity.
Weighing by the Aliquot
               Method
Weighing Accuracy
Least Weighable Quantity
     Method of Weighing
       Step1: Weigh an amount of the drug substance
        that is equal to or greater than the least weighable
        quantity.

       Step2: Dilute the drug substance with a calculated
        quantity of inert diluent such that a predetermined
        quantity of the drug-diluent mixture will contain the
        desired quantity of drug.
Least Weighable Quantity
     Method of Weighing
       Example:
Least Weighable Quantity
     Method of Weighing
       Example:
Least Weighable Quantity
     Method of Weighing
       Example:
Least Weighable Quantity
     Method of Weighing
       Example:
Percent Error
Percent Error
   Example:
Percent Error
   Example:
Percent Error
   Example:

More Related Content

What's hot

4.limit test for iron
4.limit test for iron4.limit test for iron
4.limit test for iron
DR.Gopinathan Narasimhan
 
over view of pharmaceutical analysis
over view of pharmaceutical analysisover view of pharmaceutical analysis
over view of pharmaceutical analysis
Avishake Sengupta
 
Pharmaceutical Numeracy
Pharmaceutical NumeracyPharmaceutical Numeracy
7.limit test for arsenic
7.limit test for arsenic7.limit test for arsenic
7.limit test for arsenic
DR.Gopinathan Narasimhan
 
Limit test
Limit testLimit test
Limit test
Revathi Gnanavelou
 
Alcohol content
Alcohol contentAlcohol content
Alcohol content
Khalid Hussain
 
Isotonic solutions
Isotonic solutionsIsotonic solutions
Isotonic solutions
Medical Knowledge
 
Introduction to liniment and turpentine liniment
Introduction to liniment and turpentine linimentIntroduction to liniment and turpentine liniment
Introduction to liniment and turpentine liniment
kopalsharma85
 
Pharmaceutical incompatibilities by monia jannatul kubra
Pharmaceutical incompatibilities by monia jannatul kubraPharmaceutical incompatibilities by monia jannatul kubra
Pharmaceutical incompatibilities by monia jannatul kubra
MoniaJanmatulKubra
 
Levigation & trituration
Levigation & triturationLevigation & trituration
Levigation & trituration
khuram sajjad
 
Volhard`s Method
Volhard`s MethodVolhard`s Method
Volhard`s Method
Aimun Altaf
 
Posology Posology: Definition, Factors affecting dose selection. Calculation ...
Posology Posology: Definition, Factors affecting dose selection. Calculation ...Posology Posology: Definition, Factors affecting dose selection. Calculation ...
Posology Posology: Definition, Factors affecting dose selection. Calculation ...
PranatiChavan
 
Pharmaceutical calculations
Pharmaceutical calculationsPharmaceutical calculations
Pharmaceutical calculations
Reshma Fathima .K
 
compounding and good practice
compounding and good practicecompounding and good practice
compounding and good practice
ShaikhSaniya2
 
Pharmacy calculations
Pharmacy calculationsPharmacy calculations
Pharmacy calculations
Diana Rangaves, PharmD, CEO
 
Errors - pharmaceutical analysis -1
Errors -  pharmaceutical analysis -1Errors -  pharmaceutical analysis -1
Errors - pharmaceutical analysis -1
Kumaran Rx
 
General introduction of limit test and limit test for chloride.
General introduction of limit test and limit test for chloride.General introduction of limit test and limit test for chloride.
General introduction of limit test and limit test for chloride.
Mahima Dubey
 
limit test for lead
limit test for leadlimit test for lead
limit test for lead
TAUFIK MULLA
 
Powders
PowdersPowders
Lec 6 isotonic solutions
Lec 6 isotonic solutionsLec 6 isotonic solutions
Lec 6 isotonic solutions
Dr Ahmad Abdulhusiaan Yosef
 

What's hot (20)

4.limit test for iron
4.limit test for iron4.limit test for iron
4.limit test for iron
 
over view of pharmaceutical analysis
over view of pharmaceutical analysisover view of pharmaceutical analysis
over view of pharmaceutical analysis
 
Pharmaceutical Numeracy
Pharmaceutical NumeracyPharmaceutical Numeracy
Pharmaceutical Numeracy
 
7.limit test for arsenic
7.limit test for arsenic7.limit test for arsenic
7.limit test for arsenic
 
Limit test
Limit testLimit test
Limit test
 
Alcohol content
Alcohol contentAlcohol content
Alcohol content
 
Isotonic solutions
Isotonic solutionsIsotonic solutions
Isotonic solutions
 
Introduction to liniment and turpentine liniment
Introduction to liniment and turpentine linimentIntroduction to liniment and turpentine liniment
Introduction to liniment and turpentine liniment
 
Pharmaceutical incompatibilities by monia jannatul kubra
Pharmaceutical incompatibilities by monia jannatul kubraPharmaceutical incompatibilities by monia jannatul kubra
Pharmaceutical incompatibilities by monia jannatul kubra
 
Levigation & trituration
Levigation & triturationLevigation & trituration
Levigation & trituration
 
Volhard`s Method
Volhard`s MethodVolhard`s Method
Volhard`s Method
 
Posology Posology: Definition, Factors affecting dose selection. Calculation ...
Posology Posology: Definition, Factors affecting dose selection. Calculation ...Posology Posology: Definition, Factors affecting dose selection. Calculation ...
Posology Posology: Definition, Factors affecting dose selection. Calculation ...
 
Pharmaceutical calculations
Pharmaceutical calculationsPharmaceutical calculations
Pharmaceutical calculations
 
compounding and good practice
compounding and good practicecompounding and good practice
compounding and good practice
 
Pharmacy calculations
Pharmacy calculationsPharmacy calculations
Pharmacy calculations
 
Errors - pharmaceutical analysis -1
Errors -  pharmaceutical analysis -1Errors -  pharmaceutical analysis -1
Errors - pharmaceutical analysis -1
 
General introduction of limit test and limit test for chloride.
General introduction of limit test and limit test for chloride.General introduction of limit test and limit test for chloride.
General introduction of limit test and limit test for chloride.
 
limit test for lead
limit test for leadlimit test for lead
limit test for lead
 
Powders
PowdersPowders
Powders
 
Lec 6 isotonic solutions
Lec 6 isotonic solutionsLec 6 isotonic solutions
Lec 6 isotonic solutions
 

Recently uploaded

Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance PanelsNorthern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving
 
Day 2 - Intro to UiPath Studio Fundamentals
Day 2 - Intro to UiPath Studio FundamentalsDay 2 - Intro to UiPath Studio Fundamentals
Day 2 - Intro to UiPath Studio Fundamentals
UiPathCommunity
 
GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...
GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...
GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...
GlobalLogic Ukraine
 
Dandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity serverDandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity server
Antonios Katsarakis
 
Lee Barnes - Path to Becoming an Effective Test Automation Engineer.pdf
Lee Barnes - Path to Becoming an Effective Test Automation Engineer.pdfLee Barnes - Path to Becoming an Effective Test Automation Engineer.pdf
Lee Barnes - Path to Becoming an Effective Test Automation Engineer.pdf
leebarnesutopia
 
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
DanBrown980551
 
MySQL InnoDB Storage Engine: Deep Dive - Mydbops
MySQL InnoDB Storage Engine: Deep Dive - MydbopsMySQL InnoDB Storage Engine: Deep Dive - Mydbops
MySQL InnoDB Storage Engine: Deep Dive - Mydbops
Mydbops
 
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectorsConnector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
DianaGray10
 
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...
AlexanderRichford
 
PRODUCT LISTING OPTIMIZATION PRESENTATION.pptx
PRODUCT LISTING OPTIMIZATION PRESENTATION.pptxPRODUCT LISTING OPTIMIZATION PRESENTATION.pptx
PRODUCT LISTING OPTIMIZATION PRESENTATION.pptx
christinelarrosa
 
Leveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and StandardsLeveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and Standards
Neo4j
 
"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota
Fwdays
 
From Natural Language to Structured Solr Queries using LLMs
From Natural Language to Structured Solr Queries using LLMsFrom Natural Language to Structured Solr Queries using LLMs
From Natural Language to Structured Solr Queries using LLMs
Sease
 
Y-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PPY-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PP
c5vrf27qcz
 
AWS Certified Solutions Architect Associate (SAA-C03)
AWS Certified Solutions Architect Associate (SAA-C03)AWS Certified Solutions Architect Associate (SAA-C03)
AWS Certified Solutions Architect Associate (SAA-C03)
HarpalGohil4
 
AI in the Workplace Reskilling, Upskilling, and Future Work.pptx
AI in the Workplace Reskilling, Upskilling, and Future Work.pptxAI in the Workplace Reskilling, Upskilling, and Future Work.pptx
AI in the Workplace Reskilling, Upskilling, and Future Work.pptx
Sunil Jagani
 
Biomedical Knowledge Graphs for Data Scientists and Bioinformaticians
Biomedical Knowledge Graphs for Data Scientists and BioinformaticiansBiomedical Knowledge Graphs for Data Scientists and Bioinformaticians
Biomedical Knowledge Graphs for Data Scientists and Bioinformaticians
Neo4j
 
Must Know Postgres Extension for DBA and Developer during Migration
Must Know Postgres Extension for DBA and Developer during MigrationMust Know Postgres Extension for DBA and Developer during Migration
Must Know Postgres Extension for DBA and Developer during Migration
Mydbops
 
Apps Break Data
Apps Break DataApps Break Data
Apps Break Data
Ivo Velitchkov
 
Christine's Supplier Sourcing Presentaion.pptx
Christine's Supplier Sourcing Presentaion.pptxChristine's Supplier Sourcing Presentaion.pptx
Christine's Supplier Sourcing Presentaion.pptx
christinelarrosa
 

Recently uploaded (20)

Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance PanelsNorthern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
Northern Engraving | Modern Metal Trim, Nameplates and Appliance Panels
 
Day 2 - Intro to UiPath Studio Fundamentals
Day 2 - Intro to UiPath Studio FundamentalsDay 2 - Intro to UiPath Studio Fundamentals
Day 2 - Intro to UiPath Studio Fundamentals
 
GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...
GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...
GlobalLogic Java Community Webinar #18 “How to Improve Web Application Perfor...
 
Dandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity serverDandelion Hashtable: beyond billion requests per second on a commodity server
Dandelion Hashtable: beyond billion requests per second on a commodity server
 
Lee Barnes - Path to Becoming an Effective Test Automation Engineer.pdf
Lee Barnes - Path to Becoming an Effective Test Automation Engineer.pdfLee Barnes - Path to Becoming an Effective Test Automation Engineer.pdf
Lee Barnes - Path to Becoming an Effective Test Automation Engineer.pdf
 
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
LF Energy Webinar: Carbon Data Specifications: Mechanisms to Improve Data Acc...
 
MySQL InnoDB Storage Engine: Deep Dive - Mydbops
MySQL InnoDB Storage Engine: Deep Dive - MydbopsMySQL InnoDB Storage Engine: Deep Dive - Mydbops
MySQL InnoDB Storage Engine: Deep Dive - Mydbops
 
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectorsConnector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
Connector Corner: Seamlessly power UiPath Apps, GenAI with prebuilt connectors
 
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...
QR Secure: A Hybrid Approach Using Machine Learning and Security Validation F...
 
PRODUCT LISTING OPTIMIZATION PRESENTATION.pptx
PRODUCT LISTING OPTIMIZATION PRESENTATION.pptxPRODUCT LISTING OPTIMIZATION PRESENTATION.pptx
PRODUCT LISTING OPTIMIZATION PRESENTATION.pptx
 
Leveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and StandardsLeveraging the Graph for Clinical Trials and Standards
Leveraging the Graph for Clinical Trials and Standards
 
"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota"Choosing proper type of scaling", Olena Syrota
"Choosing proper type of scaling", Olena Syrota
 
From Natural Language to Structured Solr Queries using LLMs
From Natural Language to Structured Solr Queries using LLMsFrom Natural Language to Structured Solr Queries using LLMs
From Natural Language to Structured Solr Queries using LLMs
 
Y-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PPY-Combinator seed pitch deck template PP
Y-Combinator seed pitch deck template PP
 
AWS Certified Solutions Architect Associate (SAA-C03)
AWS Certified Solutions Architect Associate (SAA-C03)AWS Certified Solutions Architect Associate (SAA-C03)
AWS Certified Solutions Architect Associate (SAA-C03)
 
AI in the Workplace Reskilling, Upskilling, and Future Work.pptx
AI in the Workplace Reskilling, Upskilling, and Future Work.pptxAI in the Workplace Reskilling, Upskilling, and Future Work.pptx
AI in the Workplace Reskilling, Upskilling, and Future Work.pptx
 
Biomedical Knowledge Graphs for Data Scientists and Bioinformaticians
Biomedical Knowledge Graphs for Data Scientists and BioinformaticiansBiomedical Knowledge Graphs for Data Scientists and Bioinformaticians
Biomedical Knowledge Graphs for Data Scientists and Bioinformaticians
 
Must Know Postgres Extension for DBA and Developer during Migration
Must Know Postgres Extension for DBA and Developer during MigrationMust Know Postgres Extension for DBA and Developer during Migration
Must Know Postgres Extension for DBA and Developer during Migration
 
Apps Break Data
Apps Break DataApps Break Data
Apps Break Data
 
Christine's Supplier Sourcing Presentaion.pptx
Christine's Supplier Sourcing Presentaion.pptxChristine's Supplier Sourcing Presentaion.pptx
Christine's Supplier Sourcing Presentaion.pptx
 

Chap3 calculation

  • 1. Chapter 3: Pharmaceutical Measurement Dr. Bridg’ette Israel bridgette.israel@famu.edu
  • 2. Chapter 3: Objectives  Describe instruments for volumetric measurement and characterize their differences in application and accuracy.  Describe the correct procedure when using a pharmaceutical balance.  Define sensitivity requirement and apply it in calculations.  Perform calculations by the aliquot method.  Demonstrate an understanding of percentage of error in pharmaceutical measurement.
  • 3. Vocabulary  Compound or Compounding  Sensitivity Requirement (SR)  Aliquot  Percentage of Error
  • 8. Weighing by the Aliquot Method  Preliminary Step: Calculate the smallest quantity of a substance that can be weighed on the balance with the desired precision.  Step 1: Select a multiple of the desired quantity that can be weighed with the required precision.  Step 2: Dilute the multiple quantity with an inert substance.  Step 3: Weigh the aliquot portion of the dilution that contains the desired quantity.
  • 9. Preliminary Step  Calculate the smallest quantity of a substance that can be weighed on the balance with the desired precision.
  • 10. Preliminary Step  Calculate the smallest quantity of a substance that can be weighed on the balance with the desired precision.
  • 11. Preliminary Step  Calculate the smallest quantity of a substance that can be weighed on the balance with the desired precision.
  • 12. Step One  Select a multiple of the desired quantity that can be weighed with the required precision.
  • 13. Step Two  Dilute the multiple quantity with an inert substance.
  • 14. Step Three  Weigh the aliquot portion of the dilution that contains the desired quantity.
  • 15. Step Three  Weigh the aliquot portion of the dilution that contains the desired quantity.
  • 16. Weighing by the Aliquot Method
  • 18. Least Weighable Quantity Method of Weighing  Step1: Weigh an amount of the drug substance that is equal to or greater than the least weighable quantity.  Step2: Dilute the drug substance with a calculated quantity of inert diluent such that a predetermined quantity of the drug-diluent mixture will contain the desired quantity of drug.
  • 19. Least Weighable Quantity Method of Weighing  Example:
  • 20. Least Weighable Quantity Method of Weighing  Example:
  • 21. Least Weighable Quantity Method of Weighing  Example:
  • 22. Least Weighable Quantity Method of Weighing  Example:
  • 24. Percent Error  Example:
  • 25. Percent Error  Example:
  • 26. Percent Error  Example: