Cerebral palsy (CP) is a physical impairment that affects movement and motor skills. It is caused by abnormalities in the developing brain, often before birth. Common causes include low birth weight, premature birth, infections, and lack of oxygen. CP affects areas like the cortex, basal ganglia, and cerebellum. It can cause spasticity, ataxia, or dyskinesia. Symptoms vary from mild to severe and may include issues with mobility, muscle tone, coordination, speech, and secondary effects like pain, fatigue, and depression. As people with CP age, secondary effects can worsen earlier than normal. Challenging behaviors are also common, especially for those with intellectual disabilities or
Presentation by Pre-Med (2013) Students of Penang Medical College. This presentation is based on a mini research paper on Multidisciplinary Management of Cerebral Palsy. Group members consist of Nurul Najihah,Daniel Koshy & Maheshwaran
Ataxic cerebral palsy is a rare form of cerebral palsy affecting around 5% to 10% of all people diagnosed. It gets its name from the word ataxia, which means lack of coordination and without order.
A group of motor impairment syndromes resulting from disorders of early brain development and often associated with epilepsy and abnormalities of speech, vision and intellect
Children's cerebral palsy is diagnosed at Trishla Foundation by parent and doctor observation, or by analyzing deficiencies in motor skill skills or evaluating medical history. Trishla Foundation is the greatest and has been in operation since 2014. Along with India, they are assisting other countries in the fight against cerebral palsy.
Presentation by Pre-Med (2013) Students of Penang Medical College. This presentation is based on a mini research paper on Multidisciplinary Management of Cerebral Palsy. Group members consist of Nurul Najihah,Daniel Koshy & Maheshwaran
Ataxic cerebral palsy is a rare form of cerebral palsy affecting around 5% to 10% of all people diagnosed. It gets its name from the word ataxia, which means lack of coordination and without order.
A group of motor impairment syndromes resulting from disorders of early brain development and often associated with epilepsy and abnormalities of speech, vision and intellect
Children's cerebral palsy is diagnosed at Trishla Foundation by parent and doctor observation, or by analyzing deficiencies in motor skill skills or evaluating medical history. Trishla Foundation is the greatest and has been in operation since 2014. Along with India, they are assisting other countries in the fight against cerebral palsy.
Habilitation Perspective in the management of Cerebral Palsy.pptxICDDelhi
Institute for Child Development (ICD) is a private company registered under section 25 of company registration act, 1956. ICD is the brain child of Dr. Mansoor Alam, a pediatric developmental specialist who has treated more than 50,000 children with special needs during the last 25 years. ICD is a premier organization which provides the best treatment to children with complex health issues, developmental delay, neurodevelopmental disorders and childhood onset disabilities. ICD’s facility is available to children from birth to 21 years of age. Adult with disabilities are specially supported in case of need. ICD is the only organization in India which practices integrated approach of treatment, named as Multimodal treatment / Combination Therapy for children with developmental disorders. Combination Therapy combines the best available treatments into one treatment plan to get the best result. Researches have proved that combination therapy is better than isolated therapy. In fact, pediatric developmental disorders cannot be treated in isolation. It requires a team of professionals with varied specialization.
Presently ICD has its model centre named as “PediaMed” in Malviya Nagar (South Delhi), New Delhi. The model centre has capacity to treat 100 children in daily basis.
ICD is going to have its branches in the following places
North Delhi
West Delhi
East Delhi
Noida ( UP)
Ghaziabad (UP)
Faridabad (Haryana)
Gurugram /Gurgaon (Haryana)
Bahadurgarh (Haryana)
ICD is open to collaborate with other organizations with similar interests in rest of India
CP-Care curriculum, training course and assessment mechanism (ECVET based)
Website: http://cpcare.eu/en/
This project (CP-CARE - 2016-1-TR01-KA202-035094) has been funded with support from the European Commission. This communication reflects the views only of the author, and the Commission cannot be held responsible for any use which may be made of the information contained therein.
New Directions in Targeted Therapeutic Approaches for Older Adults With Mantl...i3 Health
i3 Health is pleased to make the speaker slides from this activity available for use as a non-accredited self-study or teaching resource.
This slide deck presented by Dr. Kami Maddocks, Professor-Clinical in the Division of Hematology and
Associate Division Director for Ambulatory Operations
The Ohio State University Comprehensive Cancer Center, will provide insight into new directions in targeted therapeutic approaches for older adults with mantle cell lymphoma.
STATEMENT OF NEED
Mantle cell lymphoma (MCL) is a rare, aggressive B-cell non-Hodgkin lymphoma (NHL) accounting for 5% to 7% of all lymphomas. Its prognosis ranges from indolent disease that does not require treatment for years to very aggressive disease, which is associated with poor survival (Silkenstedt et al, 2021). Typically, MCL is diagnosed at advanced stage and in older patients who cannot tolerate intensive therapy (NCCN, 2022). Although recent advances have slightly increased remission rates, recurrence and relapse remain very common, leading to a median overall survival between 3 and 6 years (LLS, 2021). Though there are several effective options, progress is still needed towards establishing an accepted frontline approach for MCL (Castellino et al, 2022). Treatment selection and management of MCL are complicated by the heterogeneity of prognosis, advanced age and comorbidities of patients, and lack of an established standard approach for treatment, making it vital that clinicians be familiar with the latest research and advances in this area. In this activity chaired by Michael Wang, MD, Professor in the Department of Lymphoma & Myeloma at MD Anderson Cancer Center, expert faculty will discuss prognostic factors informing treatment, the promising results of recent trials in new therapeutic approaches, and the implications of treatment resistance in therapeutic selection for MCL.
Target Audience
Hematology/oncology fellows, attending faculty, and other health care professionals involved in the treatment of patients with mantle cell lymphoma (MCL).
Learning Objectives
1.) Identify clinical and biological prognostic factors that can guide treatment decision making for older adults with MCL
2.) Evaluate emerging data on targeted therapeutic approaches for treatment-naive and relapsed/refractory MCL and their applicability to older adults
3.) Assess mechanisms of resistance to targeted therapies for MCL and their implications for treatment selection
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Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
The prostate is an exocrine gland of the male mammalian reproductive system
It is a walnut-sized gland that forms part of the male reproductive system and is located in front of the rectum and just below the urinary bladder
Function is to store and secrete a clear, slightly alkaline fluid that constitutes 10-30% of the volume of the seminal fluid that along with the spermatozoa, constitutes semen
A healthy human prostate measures (4cm-vertical, by 3cm-horizontal, 2cm ant-post ).
It surrounds the urethra just below the urinary bladder. It has anterior, median, posterior and two lateral lobes
It’s work is regulated by androgens which are responsible for male sex characteristics
Generalised disease of the prostate due to hormonal derangement which leads to non malignant enlargement of the gland (increase in the number of epithelial cells and stromal tissue)to cause compression of the urethra leading to symptoms (LUTS
These lecture slides, by Dr Sidra Arshad, offer a quick overview of physiological basis of a normal electrocardiogram.
Learning objectives:
1. Define an electrocardiogram (ECG) and electrocardiography
2. Describe how dipoles generated by the heart produce the waveforms of the ECG
3. Describe the components of a normal electrocardiogram of a typical bipolar leads (limb II)
4. Differentiate between intervals and segments
5. Enlist some common indications for obtaining an ECG
Study Resources:
1. Chapter 11, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 9, Human Physiology - From Cells to Systems, Lauralee Sherwood, 9th edition
3. Chapter 29, Ganong’s Review of Medical Physiology, 26th edition
4. Electrocardiogram, StatPearls - https://www.ncbi.nlm.nih.gov/books/NBK549803/
5. ECG in Medical Practice by ABM Abdullah, 4th edition
6. ECG Basics, http://www.nataliescasebook.com/tag/e-c-g-basics
Ethanol (CH3CH2OH), or beverage alcohol, is a two-carbon alcohol
that is rapidly distributed in the body and brain. Ethanol alters many
neurochemical systems and has rewarding and addictive properties. It
is the oldest recreational drug and likely contributes to more morbidity,
mortality, and public health costs than all illicit drugs combined. The
5th edition of the Diagnostic and Statistical Manual of Mental Disorders
(DSM-5) integrates alcohol abuse and alcohol dependence into a single
disorder called alcohol use disorder (AUD), with mild, moderate,
and severe subclassifications (American Psychiatric Association, 2013).
In the DSM-5, all types of substance abuse and dependence have been
combined into a single substance use disorder (SUD) on a continuum
from mild to severe. A diagnosis of AUD requires that at least two of
the 11 DSM-5 behaviors be present within a 12-month period (mild
AUD: 2–3 criteria; moderate AUD: 4–5 criteria; severe AUD: 6–11 criteria).
The four main behavioral effects of AUD are impaired control over
drinking, negative social consequences, risky use, and altered physiological
effects (tolerance, withdrawal). This chapter presents an overview
of the prevalence and harmful consequences of AUD in the U.S.,
the systemic nature of the disease, neurocircuitry and stages of AUD,
comorbidities, fetal alcohol spectrum disorders, genetic risk factors, and
pharmacotherapies for AUD.
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Anti ulcer drugs and their Advance pharmacology ||
Anti-ulcer drugs are medications used to prevent and treat ulcers in the stomach and upper part of the small intestine (duodenal ulcers). These ulcers are often caused by an imbalance between stomach acid and the mucosal lining, which protects the stomach lining.
||Scope: Overview of various classes of anti-ulcer drugs, their mechanisms of action, indications, side effects, and clinical considerations.
Title: Sense of Smell
Presenter: Dr. Faiza, Assistant Professor of Physiology
Qualifications:
MBBS (Best Graduate, AIMC Lahore)
FCPS Physiology
ICMT, CHPE, DHPE (STMU)
MPH (GC University, Faisalabad)
MBA (Virtual University of Pakistan)
Learning Objectives:
Describe the primary categories of smells and the concept of odor blindness.
Explain the structure and location of the olfactory membrane and mucosa, including the types and roles of cells involved in olfaction.
Describe the pathway and mechanisms of olfactory signal transmission from the olfactory receptors to the brain.
Illustrate the biochemical cascade triggered by odorant binding to olfactory receptors, including the role of G-proteins and second messengers in generating an action potential.
Identify different types of olfactory disorders such as anosmia, hyposmia, hyperosmia, and dysosmia, including their potential causes.
Key Topics:
Olfactory Genes:
3% of the human genome accounts for olfactory genes.
400 genes for odorant receptors.
Olfactory Membrane:
Located in the superior part of the nasal cavity.
Medially: Folds downward along the superior septum.
Laterally: Folds over the superior turbinate and upper surface of the middle turbinate.
Total surface area: 5-10 square centimeters.
Olfactory Mucosa:
Olfactory Cells: Bipolar nerve cells derived from the CNS (100 million), with 4-25 olfactory cilia per cell.
Sustentacular Cells: Produce mucus and maintain ionic and molecular environment.
Basal Cells: Replace worn-out olfactory cells with an average lifespan of 1-2 months.
Bowman’s Gland: Secretes mucus.
Stimulation of Olfactory Cells:
Odorant dissolves in mucus and attaches to receptors on olfactory cilia.
Involves a cascade effect through G-proteins and second messengers, leading to depolarization and action potential generation in the olfactory nerve.
Quality of a Good Odorant:
Small (3-20 Carbon atoms), volatile, water-soluble, and lipid-soluble.
Facilitated by odorant-binding proteins in mucus.
Membrane Potential and Action Potential:
Resting membrane potential: -55mV.
Action potential frequency in the olfactory nerve increases with odorant strength.
Adaptation Towards the Sense of Smell:
Rapid adaptation within the first second, with further slow adaptation.
Psychological adaptation greater than receptor adaptation, involving feedback inhibition from the central nervous system.
Primary Sensations of Smell:
Camphoraceous, Musky, Floral, Pepperminty, Ethereal, Pungent, Putrid.
Odor Detection Threshold:
Examples: Hydrogen sulfide (0.0005 ppm), Methyl-mercaptan (0.002 ppm).
Some toxic substances are odorless at lethal concentrations.
Characteristics of Smell:
Odor blindness for single substances due to lack of appropriate receptor protein.
Behavioral and emotional influences of smell.
Transmission of Olfactory Signals:
From olfactory cells to glomeruli in the olfactory bulb, involving lateral inhibition.
Primitive, less old, and new olfactory systems with different path
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Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
ARTIFICIAL INTELLIGENCE IN HEALTHCARE.pdfAnujkumaranit
Artificial intelligence (AI) refers to the simulation of human intelligence processes by machines, especially computer systems. It encompasses tasks such as learning, reasoning, problem-solving, perception, and language understanding. AI technologies are revolutionizing various fields, from healthcare to finance, by enabling machines to perform tasks that typically require human intelligence.
1. CEREBRAL PALSY
SUMMARY
What is it?
How common is it?
The development of cerebral palsy.
Why does it happen?
Contributing factors or cause.
What happens physically.
The main effects.
How cp affect development.
Areas of the brain affected.
Parts of the body affected.
Getting older.
Secondary ageing effects.
Depression and cp.
Challenging behaviour and cp.
Risk factors.
2. What is it?
Cerebral palsy (cp) is not a disease or an illness.
It is the description of a physical impairment that
affects movement.
The movement problems vary from barely
noticeable to extremely severe.
It is as individual as people themselves.
3. How common is it?
In recent years there has been a slight increase
in the proportion of children who have cp.
Currently about one in every 400 child is
affected.
Among these, the percentage of severely and
multiply disabled people needing support is
growing.
those people will need continue need support
throughout their lives.
4. How common is it?
There has never been a single explanation of
what cerebral palsy is.
1984 P. Scrutton wrote, “The almost infinite
variety (and the lack of common language to
describe this variety accurately) makes learning
about it very difficult indeed.”
It is not specific condition - unlike Down’s
Syndrome for example, which is an identifiable
chromosomal disorder.
5. How common is it?
Cerebral palsy can be defined as “a
persistent disorder of movement and
posture, as the result of one or more non-
progressive abnormalities in the brain.”
6. The development of cp
The characteristics of the motor disorder, the way
the person is affected and muscle tone may alter
significantly, particularly during the early years of
life.
In the first few months any potential difficulties
may not be immediately obvious.
It is possible for some signs not to show until the
child is between 12 and 18 months or older.
7. Why does it happen?
Studies suggest that cerebral palsy is due
mostly to factors affecting the brain before
birth.
It is commonly the result of one or more
abnormalities in the brain, before growth
and development are complete.
8. Contributing factors or cause
Some of the factors associated with the incidence of
cerebral palsy are:
• Low birth-weight
• Premature birth
• Multiple births
• Asphyxia (lack of oxygen)
• Infection
• Cerebral bleed
• Infection in the early part of pregnancy;
• Infection or accident in the early years of a child’s life.
There may also be a genetic link, but this is quite rare.
9. What happens physically?
The brain impairment is
non-progressive.
It is not necessarily that
the physical capacity and
function will remain the
same throughout the life.
Can be maturational,
developmental or aging
changes, that can affect
the individual’s ability.
10. What are the main effects?
Cerebral palsy is primarily a disorder of voluntary
movement and co-ordination, due to a defect or
lesion of the immature brain.
Because of other areas of the brain may also
have been affected there is a possibility of
‘associated’ or ‘related’ difficulties such as
sensory or perceptual impairment.
Other associated difficulties may include learning
difficulties or epilepsy (seizures).
11. How can cp affect development
The brain ‘learn’ how to position and focus the
eyes, make noises and sounds, chew food,
control the muscle used when going to the toilet
and those used for breathing.
Growing babies and children have to learn to use
many other muscle besides those concerned with
the co-ordination and movement of arms, legs,
trunk, and so on.
12. Areas of the brain affected
Cortex:
Spastic cerebral palsy
(spasticity). Disorder
control of movements.
• Increase muscle tone
or hypertonia.
• Some muscle become
very stiff and weak.
13. Areas of the brain affected
Basal Ganglia:
Athetoid cerebral palsy
(athetosis).
• Also called Dyskinetic cerebral
palsy.
• Usually comprises slow
writhing.
• Loss of control of the posture.
• Tend to make unwanted
movements.
• Involuntary spasms,
• jerky arm and leg
movements.
14. Areas of the brain affected
Cerebellum:
Ataxia cerebral palsy (ataxia).
• Disordered movements.
• Short and jerky movements.
• Often muscle tone is normal
or decreased.
• Shaky hand movements.
• irregular speech.
• Unsteady walking.
• Problem with balance.
• Spatial awareness.
15. Parts of the body affected:
Diplegia
Is where both legs are
affected more than
the hands and arms.
16. Parts of the body affected:
Hemiplegia
One side of the body
(including arm and
leg) is affected.
17. Parts of the body affected:
Quadriplegia/Tetraplegia
All four limbs are involved, usually trunk and
neck.
18. Getting Older
For those who have lived a lifetime with a
physical impairment, the effects of ageing
can become apparent earlier than
expected.
Cerebral palsy is an example of
developmental disorder in which physical
functioning can deteriorate with ageing as
a result of poor mechanical efficiency.
19. Getting Older
What is clear is that people with cerebral
palsy age in the same way as non-disable
people (primary ageing) but some people
with cerebral palsy may also experience
secondary ageing effects.
These are likely to be long-term effects of
the original impairment.
20. Secondary Ageing Effects
Unfortunately the effects of cp can bring
problems of secondary ageing much
earlier than in the general population.
Following are some of the more common
problems reported by people in their
thirties and forties or, sometimes, a little
earlier.
21. Secondary Ageing effect in cp
Increased levels of pain and discomfort.
Osteoarthritis (pain and stiffness in the joints).
Increase in spasms.
Increase in contractures (shortening of muscles).
Less efficient motor control (body parts involved in
movements).
Joint problems.
Tight muscles.
Gastro-intestinal (digestive system) problems.
New back pain and increase in back pain.
Emergence / increase in incontinence.
Loss of joint flexibility.
Reduced energy levels and fatigue.
22. Depression and cp
Sometimes changes of mood can be related to
depression in a person who has cerebral palsy.
Depression is twice as common in women, with
men being more likely to show anti-social
behaviour.
In some cases of depression a review of the
person’s lifestyle can be helpful but for others,
anti-depressant drugs or counselling may be
necessary.
23. Challenging behaviour an cp
There are four main categories of challenging behaviour and
actions can range from moderate to severe.
Self-injurious behaviour includes had-banging, scratching, pulling, eye
poking, picking, grinding teeth, eating non-foodstuffs.
Aggressive behaviour toward others includes biting and scratching,
hitting , pinching, grabbing, hair pulling, throwing objects, verbal abuse,
screaming, spitting.
Stereotyped behaviour including repetitive movements, rocking,
repetitive speech, and repetitive manipulation of objects.
Non-person directed behaviour includes damage to property,
hyperactivity, stealing, inappropriate sexualised behaviour, destruction of
clothing, incontinence, temper tantrums, lack of awareness of danger
withdrawal.
24. The link between cp and challenging
behaviour
A large proportion of people with cerebral palsy also have a learning
disability.
Many people will also have a severe cognitive impairment, which means
they cannot reason well or understand their environment fully.
The most common aims of challenging behaviour are:
Self-stimulation
Gaining the attention of others
Avoidance
In most people who have severe learning disability, these behaviour are
not premeditated and are not designed to purposely upset.
25. Risk Factors
Three significant indicators for challenging
behaviour in cerebral palsy can be indentified.
These are:
Damage to the nervous system
Learning disability
Epilepsy (especially if poorly controlled)
26. Risk Factors
Additional factors are:
Age (reaching a peak between age 15 – 34 with a reduction in challenging
behaviour in the mid-thirties).
Gender (men exhibit more challenging behaviour than women).
Multiple disabilities.
Communication difficulties.
Challenging behaviour is not unusual especially where someone cannot
communicate effectively.
Challenging behaviour can, however, occur across the whole range of
intelligence and can be severe in people with mild or no intellectual
disability with cp, mainly out of sheer frustration.