Cephalosporin
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Cephalosporin is a class of β-lactam antibiotic that is closely related to penicillin both structurally and functionally. It inhibits bacterial cell wall synthesis by interfering with transpeptidase. Cephalosporin is classified into five generations based on their spectrum of activity and resistance. It is administered orally or parentally, excreted renally, and has a plasma half-life of 30-90 minutes. Some potential adverse effects include hypersensitivity, nephrotoxicity, thrombophlebitis, superinfections, and diarrhea.
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A. Discuss history and Mechanism of action of Cephalosporin
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For 2+ video lecture series on Pharmacoeconomics refer link given below: https://www.youtube.com/playlist?list=PLBVbJ9HCa1BY8U1TnlcHttsRB8hwpoJRL
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Facebook Page: https://www.facebook.com/asacademylearningforever
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These simplified slides by Dr. Sidra Arshad present an overview of the non-respiratory functions of the respiratory tract.
Learning objectives:
1. Enlist the non-respiratory functions of the respiratory tract
2. Briefly explain how these functions are carried out
3. Discuss the significance of dead space
4. Differentiate between minute ventilation and alveolar ventilation
5. Describe the cough and sneeze reflexes
Study Resources:
1. Chapter 39, Guyton and Hall Textbook of Medical Physiology, 14th edition
2. Chapter 34, Ganong’s Review of Medical Physiology, 26th edition
3. Chapter 17, Human Physiology by Lauralee Sherwood, 9th edition
4. Non-respiratory functions of the lungs https://academic.oup.com/bjaed/article/13/3/98/278874
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Cephalosporin
- 1. CEPHALOSPORIN Motiur Rahman Bappy ID: 1501144 Faculty of Veterinary Science , BAU
- 2. CONTENTS • Cephalosporin • Structure • Classification • Mechanism of Action • Pharmacokinetics • Adverse Effects
- 3. Cephalosporin • A class of β-lactam antibiotic • Inhibit Bacterial cell wall synthesis • Closely related to Penicillin both structurally and functionally • First isolated from Cephalosporium acremonium
- 4. Structure Cephalosporin Nucleus: 7- amino cephalosporanic Acid Dihydrothiazine ring β-lactam ring Side chain Attachment Side chain Attachment
- 5. Classification • Cephalexin • Cefazolin1st Generation • Cefotetan • Cefuroxime2nd Generation • Ceftriaxone • Ceftazidime3rd Generation • Cefepime4rth Generation • Ceftaroline5th Generation
- 6. Mechanism of Action Peptide chain N- acetylmuramic acid N- acetylglucosa mine Transpeptidase
- 7. Pharmacokinetics • Route of Administration : Oral , Parental • Relatively lipid insoluble ( like penicillins ) • Dont penetrate cells or CNS, except for third generations • Excretion : -Mostly renal -Very few through bile • Plasma half life : 30-90 min
- 8. Adverse Effects • Hypersensitivity • Nephrotoxicity • Thrombophlebitis • Superinfections • Diarrhea