The cavernous sinus is located in the middle cranial fossa on either side of the body of the sphenoid bone and sella turcica. It contains the internal carotid artery and cranial nerves III, IV, V1, and VI. The cavernous sinus drains into the angular vein, pterygoid venous plexus, and intercavernous sinuses which connect the two cavernous sinuses. Clinical implications include spread of infection or thrombosis from the face into the cavernous sinus via connections to facial veins.