Carbohydrate Metabolism
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Glycolysis Citric Acid Cycle Gluconeogenesis Glycogenesis Glycogenolysis Hexose monophosphate shunt Uronic acid pathway Galactose metabolism Fructose metabolism Amino sugar & mucopolysaccharide metabolism
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Carbohydrate Metabolism
- 1. DR. SIDDHARTH DUTTA (PGT) CARBOHYDRATE METABOLISM
- 3. Carbohydrate Metabolism The Major Pathways: Glycolysis Citric Acid Cycle Gluconeogenesis Glycogenesis Glycogenolysis Hexose monophosphate shunt Uronic acid pathway Galactose metabolism Fructose metabolism Amino sugar & mucopolysaccharide metabolism
- 4. GLYCOLYSIS
- 5. GYLCOLYSIS (C6H12O6) 2 x (CH3-CO-COOH) Krebs Cycle Fermentation Aerobic condition Anaerobic condition
- 11. CARBOHYDRATEMETABOLISM 2ATP (-) 2ATP (+) X 2 2ATP NET OUTPUT X 2 [NADH + H+] X 2 6ATP 0ATP Aerobic condition Anaerobic condition(when in mitochondria)
- 12. Krebs Cycle
- 13. CoA CO2 NAD [NADH + H+] Acetyl-CoA 2C CARBOHYDRATEMETABOLISM Pyruvate dehydrogenase (PDH)
- 14. Fumerase NAD+ Acetyl-CoA 2C CARBOHYDRATEMETABOLISM [NADH + H+] Citrate Synthase CoA Isocitrate dehydrogenase FADH2 FAD Krebs Cycle CoA H2O Succinate dehydrogenase Alphaketoglutarate dehydrogenase Succinyl CoA synthase Malate dehydrogenase Aconitase
- 15. Gluconeogenesis
- 16. Gluconeogenesis CARBOHYDRATE ENZYMES BREAKDOWN GLUCOSE FAT AMINO ACIDS PYRUVATE (Non Carb Sources)
- 17. CARBOHYDRATEMETABOLISM GLYCOGEN Blood Glucose Levels 100-200 MG/DL FASTING
- 19. CARBOHYDRATEMETABOLISM BLOOD GLUCOSE (6C) PYRUVATE (3C) PYRUVATE GLUCOSE 3 irreversible reactions GLYCOLYSIS 10 REACTIONS SPECIFIC ENZYMES can reverse these reactions under special circumstances like FASTING
- 21. CARBOHYDRATEMETABOLISM OXALOACETATE Phosphoenol-pyruvate Carboxylase CO2 GTP Fructose 1,6 Bisphosphate Phosphofructokinase Pi ATP ADP REVERSIBLE REACTIONS Mitochondria OXALOACETATE CO2 ATP Pyruvate carboxylase
- 23. Propionate Glycerol CARBOHYDRATEMETABOLISM Succinyl CoA KREBS CYCLE Lactate Lactate Dehydrogenase Reversal process continues as explained before. Glycerol 3-phosphate
- 24. 1 23 4 5 O O 1 2 34 5 6 6 P P Glucose 6-phosphate Fructose 6-phosphate