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Moderator:
Professor Nancy J. Devlin
Director of Research, OHE
ISPOR European Congress, Vienna, 2016
Can we really compare and aggregate PRO
data between people and setting?
Implications for clinical trials and HTA
ISPOR European Congress, Vienna, 2016
Can we safely assume comparability of
PRO data?
• Use of PRO instruments to measure health within and between
populations, and the aggregation of those data (e.g. in RCTs)
relies on their strict comparability.
Two aspects to this:
(i) Properties of the instruments themselves: conceptual (what
attributes of health matter) and linguistic/semantic issues (how
to describe health).
(ii) How people respond to the instruments in self-reporting health.
Self-perception of health and health problems may depend on:
• Their perception of what is ‘normal’ and expectations
regarding health
• Conditioned by social context, education, literacy, income,
availability of health care facilities, public health education etc.
ISPOR European Congress, Vienna, 2016
Does ‘no problems’ mean
different things
to different people?
Might ‘the best health you
can imagine’ (and the
worst) differ between
different sorts of people?
ISPOR European Congress, Vienna, 2016
LifeexpectancySelf-reported
morbidity
Sen (2002) Self reported
morbidity has severe
limitations and can be
extremely misleading BMJ
“The internal (self-reported)
view of health deserves
attention, but relying on it
in assessing health care or
in evaluating medical
strategy can be extremely
misleading”
ISPOR European Congress, Vienna, 2016
Nancy Devlin (Moderator):
Introduction
Mike Herdman: Conceptual and
linguistic issues in cross-cultural
comparability of PROs
Paula Lorgelly: Addressing differences
in use of PRO response categories:
anchoring vignettes
Andrea Manca: Methods for
addressing heterogeneity in PRO data
NANCY DEVLIN
The Office of Health Economics
Registered address Southside, 7th Floor, 105 Victoria Street,
London SW1E 6QT
Website: www.ohe.org
Email: ndevlin@ohe.org
THANK YOU FOR YOUR ATTENTION

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Can we really compare and aggregate PRO data between people and setting

  • 1. Moderator: Professor Nancy J. Devlin Director of Research, OHE ISPOR European Congress, Vienna, 2016 Can we really compare and aggregate PRO data between people and setting? Implications for clinical trials and HTA
  • 2. ISPOR European Congress, Vienna, 2016 Can we safely assume comparability of PRO data? • Use of PRO instruments to measure health within and between populations, and the aggregation of those data (e.g. in RCTs) relies on their strict comparability. Two aspects to this: (i) Properties of the instruments themselves: conceptual (what attributes of health matter) and linguistic/semantic issues (how to describe health). (ii) How people respond to the instruments in self-reporting health. Self-perception of health and health problems may depend on: • Their perception of what is ‘normal’ and expectations regarding health • Conditioned by social context, education, literacy, income, availability of health care facilities, public health education etc.
  • 3. ISPOR European Congress, Vienna, 2016 Does ‘no problems’ mean different things to different people? Might ‘the best health you can imagine’ (and the worst) differ between different sorts of people?
  • 4. ISPOR European Congress, Vienna, 2016 LifeexpectancySelf-reported morbidity Sen (2002) Self reported morbidity has severe limitations and can be extremely misleading BMJ “The internal (self-reported) view of health deserves attention, but relying on it in assessing health care or in evaluating medical strategy can be extremely misleading”
  • 5. ISPOR European Congress, Vienna, 2016 Nancy Devlin (Moderator): Introduction Mike Herdman: Conceptual and linguistic issues in cross-cultural comparability of PROs Paula Lorgelly: Addressing differences in use of PRO response categories: anchoring vignettes Andrea Manca: Methods for addressing heterogeneity in PRO data
  • 6. NANCY DEVLIN The Office of Health Economics Registered address Southside, 7th Floor, 105 Victoria Street, London SW1E 6QT Website: www.ohe.org Email: ndevlin@ohe.org THANK YOU FOR YOUR ATTENTION