Perspective on Large Animal Biomedical Research
F. Claire Hankenson, DVM, MS, DACLAM
Director, Campus Animal Resources;
Professor, Pathology & Diagnostic Investigation, CVM;
Michigan State University
January 21, 2016
Shelia R. Cotten, PhD Director, Sparrow/MSU Center for Innovation and Research Director, Trifecta Professor and Associate Chair for Research, Department of Media & Information Michigan State University cotten@msu.edu
9/17/2015
Liam Cleere University College Dublin’s Senior Manager for Research Analytics...IrishHumanitiesAlliance
From the IHA Impact in the Humanities event 8 June held in QUB and co-sponsored by InterTradeIreland
Panel Three Impact: How should we capture it?
From the perspectives of analytics, science and policy: how should we capture and measure Impact, how should the definition of Impact incorporate academic perspectives and what role can the humanities play in policy?
Implementing a Scholarly Impact Program for Faculty and Graduate StudentsBrenna Helmstutler
In academic institutions today, there are greater expectations of accountability requiring tenure-track faculty to substantively demonstrate scholarly impact for annual reporting, benchmarking, and promotion and tenure. Database vendors and other content providers are creating robust, yet user-friendly, scholarly impact tools within current products. In response, institutional libraries are offering workshops, individual assistance, research guides, and other activities to promote the value and usage of these tools. However, there is no dedicated scholarly impact outreach program yet documented in the library literature. This poster will discuss developing, implementing, and assessing an innovative scholarly impact outreach program based on the author's experience as a librarian at Georgia State University.
Shelia R. Cotten, PhD Director, Sparrow/MSU Center for Innovation and Research Director, Trifecta Professor and Associate Chair for Research, Department of Media & Information Michigan State University cotten@msu.edu
9/17/2015
Liam Cleere University College Dublin’s Senior Manager for Research Analytics...IrishHumanitiesAlliance
From the IHA Impact in the Humanities event 8 June held in QUB and co-sponsored by InterTradeIreland
Panel Three Impact: How should we capture it?
From the perspectives of analytics, science and policy: how should we capture and measure Impact, how should the definition of Impact incorporate academic perspectives and what role can the humanities play in policy?
Implementing a Scholarly Impact Program for Faculty and Graduate StudentsBrenna Helmstutler
In academic institutions today, there are greater expectations of accountability requiring tenure-track faculty to substantively demonstrate scholarly impact for annual reporting, benchmarking, and promotion and tenure. Database vendors and other content providers are creating robust, yet user-friendly, scholarly impact tools within current products. In response, institutional libraries are offering workshops, individual assistance, research guides, and other activities to promote the value and usage of these tools. However, there is no dedicated scholarly impact outreach program yet documented in the library literature. This poster will discuss developing, implementing, and assessing an innovative scholarly impact outreach program based on the author's experience as a librarian at Georgia State University.
At Cure Brain Cancer Foundation we are not accepting the typical timeframe of 50 years to find a cure – we want to do it in 10 – and passionately believe this is achievable – the talent, ingenuity and will are there - if we are bold enough to do things differently and follow the right strategy.
Using system dynamics for ex-ante impact assessment of food safety policies i...ILRI
Presentation by Karl M. Rich, Nguyen Thi Thu Huyen, Duong Nam Ha, Nguyen Thi Duong Nga, Vu Khac Xuan, Ninh Xuan Trung, Tran Van Long, Pham Van Hung, Fred Unger, Kanar Hamza and Lucy Lapar at the Safe Pork conference, Porto, Portugal, 7-10 September 2015.
Looking at implementation: how useful is realist evaluation?valéry ridde
Presentation by Emilie Robert (McGill University).
Global Health Workshop: Methods For Implementation Science in Global Health.
http://www.equitesante.org/implementation-science-methods-in-global-health/
Looking at how health research impacts health programming and policy-making in international development, the African Medical and Research Foundation hosted a discussion highlighting some of the themes laid out in this slideshow.
INTRODUCTION - Global Health Workshop: Methods for implementation science in ...valéry ridde
Introduction by Valéry Ridde (Université de Montréal) to the Global Health Workshop: Methods For Implementation Science in Global Health (2017, April 20th).
http://www.equitesante.org/implementation-science-methods-in-global-health/
A case study approach to comprehend sustainability's framework valéry ridde
Presentation by Mathieu Seppey (Université de Montréal).
Global Health Workshop: Methods For Implementation Science in Global Health.
http://www.equitesante.org/implementation-science-methods-in-global-health/
A reflection on frameworks to assess implementation fidelity of an adaptive d...valéry ridde
Presentation by Dennis Pérez Chacón (Université de Montréal).
Global Health Workshop: Methods For Implementation Science in Global Health.
http://www.equitesante.org/implementation-science-methods-in-global-health/
Apresentação IV EBPC do artigo Participação Social na Cultura: Análise da ele...Drica Veloso
O trabalho tem o objetivo de endereçar a participação social no Brasil, a partir do estudo de caso das eleições do Conselho Nacional de Políticas Culturais (CNPC), ocorrido em 2015. A metodologia parte da revisão bibliográfica e adota a técnica da observação participante e análise documental. Investiga-se a composição de gênero e raça dos atuais conselheiros do CNPC, dado que o edital do processo eleitoral previu cotas para mulheres e afro brasileiros, apontando conclusões.
Artigo completo em: https://goo.gl/Lw43Gq
Basis of immunodeficiency: Defective VDJ Recombination
Presented by Katheryn Meek, DVM
College of Veterinary Medicine
Michigan State University
January 21, 2016
At Cure Brain Cancer Foundation we are not accepting the typical timeframe of 50 years to find a cure – we want to do it in 10 – and passionately believe this is achievable – the talent, ingenuity and will are there - if we are bold enough to do things differently and follow the right strategy.
Using system dynamics for ex-ante impact assessment of food safety policies i...ILRI
Presentation by Karl M. Rich, Nguyen Thi Thu Huyen, Duong Nam Ha, Nguyen Thi Duong Nga, Vu Khac Xuan, Ninh Xuan Trung, Tran Van Long, Pham Van Hung, Fred Unger, Kanar Hamza and Lucy Lapar at the Safe Pork conference, Porto, Portugal, 7-10 September 2015.
Looking at implementation: how useful is realist evaluation?valéry ridde
Presentation by Emilie Robert (McGill University).
Global Health Workshop: Methods For Implementation Science in Global Health.
http://www.equitesante.org/implementation-science-methods-in-global-health/
Looking at how health research impacts health programming and policy-making in international development, the African Medical and Research Foundation hosted a discussion highlighting some of the themes laid out in this slideshow.
INTRODUCTION - Global Health Workshop: Methods for implementation science in ...valéry ridde
Introduction by Valéry Ridde (Université de Montréal) to the Global Health Workshop: Methods For Implementation Science in Global Health (2017, April 20th).
http://www.equitesante.org/implementation-science-methods-in-global-health/
A case study approach to comprehend sustainability's framework valéry ridde
Presentation by Mathieu Seppey (Université de Montréal).
Global Health Workshop: Methods For Implementation Science in Global Health.
http://www.equitesante.org/implementation-science-methods-in-global-health/
A reflection on frameworks to assess implementation fidelity of an adaptive d...valéry ridde
Presentation by Dennis Pérez Chacón (Université de Montréal).
Global Health Workshop: Methods For Implementation Science in Global Health.
http://www.equitesante.org/implementation-science-methods-in-global-health/
Apresentação IV EBPC do artigo Participação Social na Cultura: Análise da ele...Drica Veloso
O trabalho tem o objetivo de endereçar a participação social no Brasil, a partir do estudo de caso das eleições do Conselho Nacional de Políticas Culturais (CNPC), ocorrido em 2015. A metodologia parte da revisão bibliográfica e adota a técnica da observação participante e análise documental. Investiga-se a composição de gênero e raça dos atuais conselheiros do CNPC, dado que o edital do processo eleitoral previu cotas para mulheres e afro brasileiros, apontando conclusões.
Artigo completo em: https://goo.gl/Lw43Gq
Basis of immunodeficiency: Defective VDJ Recombination
Presented by Katheryn Meek, DVM
College of Veterinary Medicine
Michigan State University
January 21, 2016
Adam Moeser, DVM PhD
Associate Professor
Matilda R. Wilson Endowed Chair
Large Animal Clinical Sciences
College of Veterinary Medicine
January 21, 2016
Connie Sung, PhD
Assistant Professor of Rehabilitation Counseling
Department Counseling, Educational Psychology & Special Education
June Chen, PhD
Former Hegarty Fellow in MSU-DOCTRID Program
NIH/Career Development Award Workshop
Leslie Raffel, MD
Associate Director and Cedars-Sinai Site Director
UCLA Clinical and Translational Science Institute
5th Tumor Models Boston July 2017 BrochureDiane McKenna
Tumor Models Boston 2017 will address the preclinical & clinical developments of the most promising therapies including targeted therapies, check-point inhibitors & CAR-T therapies and how these findings can be utilized to bridge the gap between preclinical and clinical studies.
Holistic Review in Graduate Admissions: What we need to KnowJulia Michaels
The pathway to becoming a scientist leads through graduate school, and graduate admissions committees are the gatekeepers. This webinar will, co-hosted by the Council of Graduate Schools (CGS), the Coalition of Urban Serving Universities (USU), and the Association of Public and Land-grant Universities (APLU), will explore existing evidence for holistic review in graduate admissions and critical gaps in evidence that need to be addressed before implementing the practice broadly across programs.
Impact of mass gatherings on emergency departmentsJamie Ranse
Ranse J, Hutton A, Crilly J, Johnston A. (2017). Impact of mass gatherings on emergency departments: A free workshop for emergency doctors, nurses and paramedics, Adelaide, SA, 16th March.
Involucrar a los responsables políticos para priorizar proyectos de investiga...investenisciii
XVI Encuentro Internacional de Investigación en Cuidados
CONFERENCIA CLAUSURA:
Alba DiCenso: Involucrar a los responsables políticos para priorizar proyectos de investigación que influyan en las políticas de salud
Welcome Remarks and Overview of CTSI ResourcesUCLA CTSI
Welcome Remarks and Overview of CTSI Resources
Steven Dubinett, MD
Director, UCLA Clinical and Translational Science Institute
President/CEO, Los Angeles Biomedical Research Institute, Harbor-UCLA Medical Center
January 26, 2018
In the United States, two major federal laws apply to vertebrate animals used in laboratory research. The first of these two statutes, the Animal Welfare Act (AWA, under the US Department of Agriculture), celebrated its fiftieth anniversary in 2016. The second statute, the Health Research Extension Act of 1985 (also referred to as the Public Health Services Act, or PHS Act), which is similar to the AWA, applies specifically to work funded by the US Public Health Service (i.e., agencies under the Department of Health and Human Services). Understanding laboratory animal law is necessary and fundamental for all researchers relying on results from animal research, laboratory animal veterinarians, institutional officials, Institutional Animal Care and Use Committee (IACUC) members and veterinarians in training. They require familiarity with both the scope and particulars of these laws. Different parties interested in or impacted by laboratory animal laws can have significantly different perspectives about the scope or efficiency of the regulations or their implementation.
The Roundtable on Science and Welfare in Laboratory Animal Use of the Institute for Laboratory Animal Research, the Petrie-Flom Center for Health Law Policy, Biotechnology and Bioethics, and the Animal Law and Policy Program of Harvard Law School convened this pre-workshop webcast and a workshop to discuss the future of federal laboratory animal law in the United States.
For more information, visit our website at: http://petrieflom.law.harvard.edu/events/details/future-directions-for-laboratory-animal-law-in-the-united-states
Welcome Remarks and Overview of CTSI Resources
Steven Dubinett, MD
Director, UCLA Clinical and Translational Science Institute
Senior Associate Dean and Associate Vice Chancellor for Research
Bruno Basso, of the department of Environmental Science at MSU, illustrates the important work pertaining to crop and corn data being used throughout a digital landscape.
Advanced Genome Engineering Services and Transgenic Model Generation
at MSU’s Transgenic and Genome Editing Facility
Huirong Xie, Elena Demireva, Nate Kauffman, Richard Neubig
Back to the Future: Plastics from Plants and Cars that Run on Electricity, presented by Thomas Gregory, owner/consultant for Borealis Technology Solutions at the Michigan State University Bioeconomy Institute on 10-12-16.
Arend Hintze, Department of Integrative Biology, Department of Computer Science and Engineering, and BEACON Center for the Study of Evolution in Action at Michigan State University, presents his computational analysis of evolutionary processes at the Michigan State University Bioeconomy Institute on 10-12-16.
Presentation by Michaela TerAvest, assistant professor of Biochemistry and Molecular Biology at Michigan State University, at the MSU Bioeconomy Institute in Holland, Mich., on Mar. 16, 2016.
Presentation by John Frost, University Distinguished Professor of Chemistry, Michigan State University, at the MSU Bioeconomy Institute, Holland, Mich., Feb. 10, 2016
Comparing Evolved Extractive Text Summary Scores of Bidirectional Encoder Rep...University of Maribor
Slides from:
11th International Conference on Electrical, Electronics and Computer Engineering (IcETRAN), Niš, 3-6 June 2024
Track: Artificial Intelligence
https://www.etran.rs/2024/en/home-english/
Slide 1: Title Slide
Extrachromosomal Inheritance
Slide 2: Introduction to Extrachromosomal Inheritance
Definition: Extrachromosomal inheritance refers to the transmission of genetic material that is not found within the nucleus.
Key Components: Involves genes located in mitochondria, chloroplasts, and plasmids.
Slide 3: Mitochondrial Inheritance
Mitochondria: Organelles responsible for energy production.
Mitochondrial DNA (mtDNA): Circular DNA molecule found in mitochondria.
Inheritance Pattern: Maternally inherited, meaning it is passed from mothers to all their offspring.
Diseases: Examples include Leber’s hereditary optic neuropathy (LHON) and mitochondrial myopathy.
Slide 4: Chloroplast Inheritance
Chloroplasts: Organelles responsible for photosynthesis in plants.
Chloroplast DNA (cpDNA): Circular DNA molecule found in chloroplasts.
Inheritance Pattern: Often maternally inherited in most plants, but can vary in some species.
Examples: Variegation in plants, where leaf color patterns are determined by chloroplast DNA.
Slide 5: Plasmid Inheritance
Plasmids: Small, circular DNA molecules found in bacteria and some eukaryotes.
Features: Can carry antibiotic resistance genes and can be transferred between cells through processes like conjugation.
Significance: Important in biotechnology for gene cloning and genetic engineering.
Slide 6: Mechanisms of Extrachromosomal Inheritance
Non-Mendelian Patterns: Do not follow Mendel’s laws of inheritance.
Cytoplasmic Segregation: During cell division, organelles like mitochondria and chloroplasts are randomly distributed to daughter cells.
Heteroplasmy: Presence of more than one type of organellar genome within a cell, leading to variation in expression.
Slide 7: Examples of Extrachromosomal Inheritance
Four O’clock Plant (Mirabilis jalapa): Shows variegated leaves due to different cpDNA in leaf cells.
Petite Mutants in Yeast: Result from mutations in mitochondrial DNA affecting respiration.
Slide 8: Importance of Extrachromosomal Inheritance
Evolution: Provides insight into the evolution of eukaryotic cells.
Medicine: Understanding mitochondrial inheritance helps in diagnosing and treating mitochondrial diseases.
Agriculture: Chloroplast inheritance can be used in plant breeding and genetic modification.
Slide 9: Recent Research and Advances
Gene Editing: Techniques like CRISPR-Cas9 are being used to edit mitochondrial and chloroplast DNA.
Therapies: Development of mitochondrial replacement therapy (MRT) for preventing mitochondrial diseases.
Slide 10: Conclusion
Summary: Extrachromosomal inheritance involves the transmission of genetic material outside the nucleus and plays a crucial role in genetics, medicine, and biotechnology.
Future Directions: Continued research and technological advancements hold promise for new treatments and applications.
Slide 11: Questions and Discussion
Invite Audience: Open the floor for any questions or further discussion on the topic.
Earliest Galaxies in the JADES Origins Field: Luminosity Function and Cosmic ...Sérgio Sacani
We characterize the earliest galaxy population in the JADES Origins Field (JOF), the deepest
imaging field observed with JWST. We make use of the ancillary Hubble optical images (5 filters
spanning 0.4−0.9µm) and novel JWST images with 14 filters spanning 0.8−5µm, including 7 mediumband filters, and reaching total exposure times of up to 46 hours per filter. We combine all our data
at > 2.3µm to construct an ultradeep image, reaching as deep as ≈ 31.4 AB mag in the stack and
30.3-31.0 AB mag (5σ, r = 0.1” circular aperture) in individual filters. We measure photometric
redshifts and use robust selection criteria to identify a sample of eight galaxy candidates at redshifts
z = 11.5 − 15. These objects show compact half-light radii of R1/2 ∼ 50 − 200pc, stellar masses of
M⋆ ∼ 107−108M⊙, and star-formation rates of SFR ∼ 0.1−1 M⊙ yr−1
. Our search finds no candidates
at 15 < z < 20, placing upper limits at these redshifts. We develop a forward modeling approach to
infer the properties of the evolving luminosity function without binning in redshift or luminosity that
marginalizes over the photometric redshift uncertainty of our candidate galaxies and incorporates the
impact of non-detections. We find a z = 12 luminosity function in good agreement with prior results,
and that the luminosity function normalization and UV luminosity density decline by a factor of ∼ 2.5
from z = 12 to z = 14. We discuss the possible implications of our results in the context of theoretical
models for evolution of the dark matter halo mass function.
Nutraceutical market, scope and growth: Herbal drug technologyLokesh Patil
As consumer awareness of health and wellness rises, the nutraceutical market—which includes goods like functional meals, drinks, and dietary supplements that provide health advantages beyond basic nutrition—is growing significantly. As healthcare expenses rise, the population ages, and people want natural and preventative health solutions more and more, this industry is increasing quickly. Further driving market expansion are product formulation innovations and the use of cutting-edge technology for customized nutrition. With its worldwide reach, the nutraceutical industry is expected to keep growing and provide significant chances for research and investment in a number of categories, including vitamins, minerals, probiotics, and herbal supplements.
Richard's entangled aventures in wonderlandRichard Gill
Since the loophole-free Bell experiments of 2020 and the Nobel prizes in physics of 2022, critics of Bell's work have retreated to the fortress of super-determinism. Now, super-determinism is a derogatory word - it just means "determinism". Palmer, Hance and Hossenfelder argue that quantum mechanics and determinism are not incompatible, using a sophisticated mathematical construction based on a subtle thinning of allowed states and measurements in quantum mechanics, such that what is left appears to make Bell's argument fail, without altering the empirical predictions of quantum mechanics. I think however that it is a smoke screen, and the slogan "lost in math" comes to my mind. I will discuss some other recent disproofs of Bell's theorem using the language of causality based on causal graphs. Causal thinking is also central to law and justice. I will mention surprising connections to my work on serial killer nurse cases, in particular the Dutch case of Lucia de Berk and the current UK case of Lucy Letby.
1. Campus Animal Resources:
Perspective on Large Animal
Biomedical Research
F. Claire Hankenson, DVM, MS, DACLAM
Director, Campus Animal Resources;
Professor, Pathology & Diagnostic Investigation, CVM;
Michigan State University
fclaire@ora.msu.edu
January 21, 2016
2. Campus Animal Resources (CAR) Mission
Provide high quality veterinary care, animal husbandry and
regulatory support services for the academic colleges that
conduct biomedical research
Initiatives:
Preserve animal health and welfare
Provide best possible approach to regulatory oversight of animals in
biomedical research
Maintain, improve and guide construction of animal housing facilities
Streamline billing and ordering services for research personnel
Deliver training opportunities (in person, hands on) for working with
rodents and other species in research
Modernize animal facilities and operations (to be competitive in
comparison to other research institutions)
3. Cohorts Impacted by MSU
Large Animal Research Support
MSU
Principal Investigators
Mission for
‘Global Impact’ Hiring
Targeted
Recruitments
• Concerted movement
to translational work
in larger animals from
rodent models:
surgery
neoplasia
reproduction
cardiovascular
• Interest from faculty
that want to explore
ex vivo bioengineering
concepts in large
animal models
• 100 proposed hires to
MSU in next 5 years
Assumption that
percentage will be
animal researchers
that will transfer
programs to MSU
• Requests from
existing faculty to
known colleagues at
other institutions
Relocation of
significant animal
research programs
from originating
institutions
Must take into consideration the
current limitations….
Facilities, surgical and veterinary support,
technical expertise, etc