This document discusses the need for research into aging to improve patient care and test interventions for older populations. It notes that older adults have historically been excluded from clinical trials due to ageism and practical barriers. This can lead to a lack of evidence about treatments for older patient groups. It then outlines existing support for aging research from organizations like the UK Clinical Research Network and its East Midlands division. Finally, it proposes possible roles for an East Midlands Research into Aging Network in coordinating aging research efforts through navigation, connection, peer support, and maintaining institutional memory.

1. www.le.ac.uk
Why do we need an EM research into
ageing network?
Simon Conroy
Geriatrician & Honorary Senior Lecturer

2. Outline
• Why ageing research at all?
• Existing support for research & delivery
• UK Clinical Research Network
• Ageing speciality group
• Possible roles for EMRAN

3. Why do we need research into older people?
• To improve patient care
• To test interventions
– Valid findings
– Intervention effect & health economics
– Generalisability
• Old & frail vs. old & fit

4. Why do we need research into older people?
• Historically older people have been excluded from
clinical trials (PREDICT study)
– Ageism – societal & clinicians/researchers
– Practical features to support participation
– Study design – excluding people who can’t give
consent
 Leading to treatments that are not tested in the
populations for whom they are given (OR not given)

5. Older people & research participation
• http://www.crn.nihr.ac.uk/ageing/pcpie/

6. Traditional evidence base

7. Frailty related evidence base

9. Existing support - EM
• Support for portfolio development
– http://www.rds-eastmidlands.nihr.ac.uk/
• Funding for portfolio development
– http://www.clahrc-em.nihr.ac.uk/clahrc-em-
nihr/index.aspx
• Research delivery
– http://www.enrich.dendron.nihr.ac.uk/news-
item.php?ID=141
– http://www.crn.nihr.ac.uk/ageing/

10. Existing support - EM
• Translating research into practice
– http://emahsn.org.uk/
• Patient & public involvement
– http://emahsn.org.uk/public-involvement/
– Local groups

11. UK Clinical Research Network
• Recruited over 600k study participants in 2013/14
• Infrastructure
– Set up clinical studies
– Support delivery
– Research training
– Patient & public involvement

13. NIHR CRN: East Midlands
• Population: 4.5 M
• Derbyshire, Lincolnshire, Nottinghamshire,
Leicestershire & Rutland, Northamptonshire
• 10 NIHR hosted research networks
• 15 NHS Trusts
• 19 CCGs
• 8 universities
• Budget £23 M

14. UK CRN divisional structure

15. 0 2000 4000 6000 8000 10000 12000
Ageing
Dermatology
Health services and delivery research
Musculoskeletal disorders
Oral and Dental Health
Primary Care
Public Health
Recruitment by County & Specialty in 21014-15
Derby City & County Lincolnshire
LLR Leicester City & County & Rutland Northamptonshire
Notts City & County Non-NHS - East Midlands LCRN

16. Ageing speciality group - remit
• Healthy ageing and frailty
• Organising and delivering interventions for health
promotion
• Ageing process and early markers of ill health
• Modelling links between disease and functioning
• Education and lifelong learning
• Environmental conditions for ageing well
• Effectiveness of clinical and social care

17. Acronym Active Status Trust Name Local Investigator Lead
CLOTS-3
Closed - in follow-
up
Chesterfield Royal Hospital NHS Foundation
Trust Dennis, Prof M Strok
CLOTS-3
Closed - in follow-
up
Sherwood Forest Hospitals NHS Foundation
Trust Cooke, Dr Justin Strok
CLOTS-3
Closed - in follow-
up United Lincolnshire Hospitals NHS Trust
Leach, Dr Simon; Mangion, Dr
David Strok
PD REHAB
Closed - in follow-
up University Hospitals of Leicester NHS Trust
Deme
neuro
Survey of Older Adults' views on Advance Care Planning in UK &
Japan
Closed - in follow-
up University Hospitals of Leicester NHS Trust Musa, Irfan Prima
Survey of Older Adults' views on Advance Care Planning in UK &
Japan
Closed - in follow-
up Formerly Nottingham City PCT Musa, Dr Irfana Prima
Survey of Older Adults' views on Advance Care Planning in UK &
Japan
Closed - in follow-
up Formerly Nottinghamshire County Teaching PCT Musa, Dr Irfana Prima
Hypertension in Dementia - Feasibility Study In Set-Up Nottingham University Hospitals NHS Trust Van Der Wardt, Dr Veronika Prima
The FINOF Study Open Nottingham University Hospitals NHS Trust Sahota, Prof Opinder Muscu
IVANOF1 Study Open Nottingham University Hospitals NHS Trust Moppett, Dr Iain K Injuri
The effect (s) of routine administration of Fluoxetine in patients
with a recent stroke - FOCUS Open United Lincolnshire Hospitals NHS Trust
Mangion, Dr David; Leach, Dr
Simon Strok
PRoBaND: Parkinson's Repository of Biosamples and Network
Datasets Open University Hospitals of Leicester NHS Trust Critchley, Peter
Deme
neuro
PRoBaND: Parkinson's Repository of Biosamples and Network
Datasets Open Derby Hospitals NHS Foundation Trust Bajaj, Dr Nin
Deme
neuro
PRoBaND: Parkinson's Repository of Biosamples and Network
Datasets Open United Lincolnshire Hospitals NHS Trust Sharma, Prof Jagdish
Deme
neuro
Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open Formerly Lincolnshire Teaching PCT
Siriwardena, Prof Aloysius
Niroshan Respi
Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open NHS Lincolnshire East CCG
Siriwardena, Prof Aloysius
Niroshan Respi
Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open NHS Lincolnshire West CCG
Siriwardena, Prof Aloysius
Niroshan Respi
Clinical Trial for Elderly Patients with Multiple Diseases (CHROMED) Open NHS South Lincolnshire CCG
Siriwardena, Prof Aloysius
Niroshan Respi
Increasing physical activity in older adults Open Lincolnshire Partnership NHS Foundation Trust Collins, Dr Iheanyichukwu Esiwe Prima
Hypertension in Dementia - Feasibility Study Open Leicester City PCT Prima
Hypertension in Dementia - Feasibility Study Open Formerly Derby City PCT Van Der Wardt, Dr Veronika Prima
Hypertension in Dementia - Feasibility Study Open Formerly Derbyshire County PCT Van Der Wardt, Dr Veronika Prima
Hypertension in Dementia - Feasibility Study Open Formerly Lincolnshire Teaching PCT Van Der Wardt, Dr Veronika Prima
Hypertension in Dementia - Feasibility Study Open Formerly Nottinghamshire County Teaching PCT Van Der Wardt, Dr V Prima
Hypertension in Dementia - Feasibility Study Open NHS Mansfield and Ashfield CCG Van Der Wardt, Dr V Prima
Hypertension in Dementia - Feasibility Study Open NHS Nottingham City CCG Van Der Wardt, Dr V Prima
OPTIMAL: Better health for care homes Open NHS Nottingham City CCG Pitchford, Russell
Deme
neuro
OPTIMAL: Better health for care homes Open Nottinghamshire Healthcare NHS Trust Pithford, Richard
Deme
neuro

19. Possible roles for EMRAN
• Navigation & translation
• Connection & coordination
• Peer-support
• ‘Memory’

20. Summary
• ‘We’ve never had it so good’
• Opportunities
• Mechanisms
• Collaboration key