This document discusses the challenges healthcare CIOs face in calculating return on investment (ROI) for IT projects and gaining approval from leadership. It provides an overview of why ROI must be calculated, challenges in technology appraisal and deployment, and proposes using a 10 step economic analysis approach involving identifying costs and benefits to develop a business case. Key challenges include intangible benefits, long timeframes for returns, and skepticism from management. The document recommends CIOs use frameworks to convert intangible benefits to tangible factors and account for risks to more accurately assess potential ROI and impacts of IT projects.