This document discusses how human factors requirements influenced rocket design for the Constellation Program (CxP). It describes how requirements were developed based on crew health, safety, and performance. It then discusses how a requirement around human tolerance for vibration led to further analysis showing gaps in knowledge about crew performance during and after vibration. This prompted the formation of a Thrust Oscillation Focus Team to analyze thrust oscillation issues and identify mitigation strategies to reduce predicted vibration responses and risks to the vehicle, spacecraft, and crew from vibration.