Structural aberrations including deletions, insertions, inversions, tandem duplications, translocations, and more complex rearrangements constitute a frequent type of alteration in human tumors. Here, we sought to explore the potential to discover such events from targeted DNA sequence data in our CLIA-compliant molecular diagnostics laboratory. To detect somatic structural aberrations in individual tumors, we have developed an analytic framework in Perl & Python to detect these events in data generated by a hybridization capture-based, targeted sequencing clinical assay (MSK-IMPACT), which can reveal structural rearrangements as small as 500bp.