This document discusses septic shock and its management. It covers: - The pathophysiology of septic shock including absolute and relative hypovolemia, distributive shock, and impaired oxygen extraction. - The history of managing septic shock from focusing on normalizing blood pressure in the 1960s to measuring oxygen delivery and consumption in later decades. - Guidelines for initial resuscitation of septic shock patients, including targeting a MAP ≥65 mmHg, CVP of 8-12 mmHg, and ScvO2 ≥70%. - Use of fluid challenges to guide fluid resuscitation and options for vasopressors like norepinephrine if needed to support blood pressure.