The biomechanical frame of reference views the body as a machine made up of parts that can be impaired by disease or injury. It focuses on structural stability, range of motion, endurance, edema control, and strength through purposeful activities. The assumptions of this frame of reference are that purposeful activities can treat impairments, regaining function follows regaining impairments, the body needs rest then stress, and it is best suited for patients with an intact central nervous system.