This document summarizes current status of biomarkers for potentially malignant oral disorders (PMODs) and oral squamous cell carcinomas (OSCCs), with an emphasis on the specificity and sensitivity of serum and salivary biomarkers. It discusses that traditional diagnosis has limitations and biomarkers can help overcome these issues. The document defines biomarkers and describes different types, including tumor markers. It evaluates several potential salivary and serum biomarkers for PMODs and OSCCs, finding that many lack sufficient specificity or sensitivity for clinical use. Overall biomarkers show promise for non-invasive screening and diagnosis but further validation is still needed.
A tumor marker is a substance present in or produced by a tumor or by the tumor’s host in response to the tumor’s presence that can be used to differentiate a tumor from normal tissue or to determine the presence of a tumor based on measurement in the blood or secretions.
MAIN MOLECULAR MARKERS OF ORAL SQUAMOUS CELL CARCINOMA / dental implant cour...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
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describes various clear cell lesions of head and neck region, its classification, origin, their immunohistochemistry profiles, various clear cell types, physiological and pathological clear cells, their causes.with histopathological images.
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Ameloblastoma is benign slow-growing but locally invasive neoplasm of odontogenic origin. In 2005, the WHO has classified ameloblastomas into multi cystic, unicystic and peripheral subtypes. The clinical picture, radiographic findings and differential diagnosis are presented. Treatment of ameloblastomas is primarily surgical. There has been some debate regarding the most appropriate method for removing. These range from conservative to radical modes. Some authors advocate conservative approach and thought that ameloblastoma are essentially benign in nature and should be treated as such. However, this conservative approach result in recurrence rates of 55% to 90%of the cases. Currently, the standard of care for ameloblastoma includes en bloc resection with 1-2 combine margin and immediate bone reconstruction. Despite the medical nature of a surgical resection, it may actually involve less morbidity than extensive hard and soft tissue resection with associated extensive morbidity that may be warranted in case of recurrence following inadequate primary treatment.
A tumor marker is a substance present in or produced by a tumor or by the tumor’s host in response to the tumor’s presence that can be used to differentiate a tumor from normal tissue or to determine the presence of a tumor based on measurement in the blood or secretions.
MAIN MOLECULAR MARKERS OF ORAL SQUAMOUS CELL CARCINOMA / dental implant cour...Indian dental academy
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.for more details please visit
www.indiandentalacademy.com
describes various clear cell lesions of head and neck region, its classification, origin, their immunohistochemistry profiles, various clear cell types, physiological and pathological clear cells, their causes.with histopathological images.
Dr. Ahmed M. Adawy, Professor Emeritus, Dep. Oral & Maxillofacial Surgery. Former Dean, Faculty of Dental Medicine, Al-Azhar University. Ameloblastoma is benign slow-growing but locally invasive neoplasm of odontogenic origin. In 2005, the WHO has classified ameloblastomas into multi cystic, unicystic and peripheral subtypes. The clinical picture, radiographic findings and differential diagnosis are presented. Treatment of ameloblastomas is primarily surgical. There has been some debate regarding the most appropriate method for removing. These range from conservative to radical modes. Some authors advocate conservative approach and thought that ameloblastoma are essentially benign in nature and should be treated as such. However, this conservative approach result in recurrence rates of 55% to 90%of the cases. Currently, the standard of care for ameloblastoma includes en bloc resection with 1-2 combine margin and immediate bone reconstruction. Despite the medical nature of a surgical resection, it may actually involve less morbidity than extensive hard and soft tissue resection with associated extensive morbidity that may be warranted in case of recurrence following inadequate primary treatment.
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Introduction
Prevention of caries
Brief introduction about types of Immunity
Causative factors of dental caries
Virulance of S mutans
Natural immune barriers
Salivary secretion and its composition
Natural barriers
Innate immune responses of dental pulp to caries
Acquisition of oral microbes
Factors affecting oral microbial colonization
Innate salivary factors found in oral cavity
Adaptive immunity
Secretary IgA
Types of Immunization
Routes of Immunization
Conclusion
Fibro-osseous lesions of the jaws
Fibrous dysplasia
Cemento-osseous dysplasia
Focal cemento-osseous dysplasia
Periapical cemento-osseous dysplasia
Florid cemento-osseous dysplasia
Ossifying fibroma
Juvenile aggressive ossifying fibroma
Cherubism
Fibro-osseous lesions (FOL) are characterized by replacement of normal bone architecture by collagen fibers and fibroblasts containing calcified tissue.
They include a wide variety of lesions of developmental, dysplastic and neoplastic origins with clinical and radiographic presentation and behavior.
Because of the histological similarities between diverse diseases, proper diagnosis requires correlation of history, clinical and radiographic findings.Fibrous Dysplasia
2. Reactive (dysplastic lesions arising in the tooth-bearing area (presumably of periodontal origin).
a. Periapical cemento-osseous dysplasia
b. Focal cemento-osseous dysplasia
c. Florid cemento-osseous dysplasia
3. Fibro-osseous neoplasms (widely designated as cementifying fibroma, ossifying fibroma or cemento-ossifying fibroma.Bone dysplasias
a. Fibrous dyspla i. Monostoticii. Polyostotic
iii. Polyostotic with endocrinopathy (McCune-Albright)
iv Osteofibrous dysplasia
b. Osteitis deformansc. Pagetoid heritable bone dysplasias of childhood
d. Segmental odontomaxillary dysplasia
2. Cemento-osseous dysplasias
a. Focal cemento-osseous dysplasia b. Florid cemento-osseous dysplasia
3.Inflammatory/reactive processes
a. Focal sclerosing osteomyelitisb. Diffuse sclerosing osteomyelitis
c. Proliferative periostitis
4. Metabolic Disease: hyperparathyroidism
5. Neoplastic lesions (Ossifying fibromas)
a. Ossifying fibromab. Hyperparathyroidism jaw lesion syndrome
c. Juvenile ossifying fibroma i. Trabecular typeii. Psammomatoid type
d. Gigantiform cementomas
The role of the psychogenic factor in the development of malignant tumoursNata Chalanskaya
Oleg Buchtoyarov, m.d., Chief Physician and Head of the Laboratory of Psychoimmunology of the Medical Center 39 (Kaliningrad, Russia), member of the Russian Scientific Society of Immunologists, member of the Editorial Board of the American Journal of International Journal of Clinical Oncology and Cancer Research, presentation at the Second International Scientific and Practical Conference «Improving the quality of life of cancer patients through the development of cooperation between state, commercial and non-profit organizations».
2018-01-24, Minsk. Belarus
http://oncopatient.by/category/konferencija-23-24-01-2018/
The Indian Dental Academy is the Leader in continuing dental education , training dentists in all aspects of dentistry and
offering a wide range of dental certified courses in different formats.
Introduction
Prevention of caries
Brief introduction about types of Immunity
Causative factors of dental caries
Virulance of S mutans
Natural immune barriers
Salivary secretion and its composition
Natural barriers
Innate immune responses of dental pulp to caries
Acquisition of oral microbes
Factors affecting oral microbial colonization
Innate salivary factors found in oral cavity
Adaptive immunity
Secretary IgA
Types of Immunization
Routes of Immunization
Conclusion
Fibro-osseous lesions of the jaws
Fibrous dysplasia
Cemento-osseous dysplasia
Focal cemento-osseous dysplasia
Periapical cemento-osseous dysplasia
Florid cemento-osseous dysplasia
Ossifying fibroma
Juvenile aggressive ossifying fibroma
Cherubism
Fibro-osseous lesions (FOL) are characterized by replacement of normal bone architecture by collagen fibers and fibroblasts containing calcified tissue.
They include a wide variety of lesions of developmental, dysplastic and neoplastic origins with clinical and radiographic presentation and behavior.
Because of the histological similarities between diverse diseases, proper diagnosis requires correlation of history, clinical and radiographic findings.Fibrous Dysplasia
2. Reactive (dysplastic lesions arising in the tooth-bearing area (presumably of periodontal origin).
a. Periapical cemento-osseous dysplasia
b. Focal cemento-osseous dysplasia
c. Florid cemento-osseous dysplasia
3. Fibro-osseous neoplasms (widely designated as cementifying fibroma, ossifying fibroma or cemento-ossifying fibroma.Bone dysplasias
a. Fibrous dyspla i. Monostoticii. Polyostotic
iii. Polyostotic with endocrinopathy (McCune-Albright)
iv Osteofibrous dysplasia
b. Osteitis deformansc. Pagetoid heritable bone dysplasias of childhood
d. Segmental odontomaxillary dysplasia
2. Cemento-osseous dysplasias
a. Focal cemento-osseous dysplasia b. Florid cemento-osseous dysplasia
3.Inflammatory/reactive processes
a. Focal sclerosing osteomyelitisb. Diffuse sclerosing osteomyelitis
c. Proliferative periostitis
4. Metabolic Disease: hyperparathyroidism
5. Neoplastic lesions (Ossifying fibromas)
a. Ossifying fibromab. Hyperparathyroidism jaw lesion syndrome
c. Juvenile ossifying fibroma i. Trabecular typeii. Psammomatoid type
d. Gigantiform cementomas
The role of the psychogenic factor in the development of malignant tumoursNata Chalanskaya
Oleg Buchtoyarov, m.d., Chief Physician and Head of the Laboratory of Psychoimmunology of the Medical Center 39 (Kaliningrad, Russia), member of the Russian Scientific Society of Immunologists, member of the Editorial Board of the American Journal of International Journal of Clinical Oncology and Cancer Research, presentation at the Second International Scientific and Practical Conference «Improving the quality of life of cancer patients through the development of cooperation between state, commercial and non-profit organizations».
2018-01-24, Minsk. Belarus
http://oncopatient.by/category/konferencija-23-24-01-2018/
Robert Anders, MD, PhD, Julie R. Brahmer, MD, MSc, and Christopher D. Gocke, MD, prepared useful Practice Aids pertaining to immunotherapy and biomarker testing for this CME/MOC/CC activity titled "Keeping Up With Advances in Cancer Immunotherapy and Biomarker Testing: Implications for Pathologists at the Forefront of the Emerging Precision Immuno-Oncology Era." For the full presentation, monograph, complete CME/MOC/CC information, and to apply for credit, please visit us at http://bit.ly/2L7zlSy. CME/MOC/CC credit will be available until May 2, 2020.
Naiyer Rizvi, MD, Omid Hamid, MD, Solange Peters, MD, PhD, Thomas Powles, MBBS, MRCP, MD, and Nadeem Riaz, MD, MSc, prepared useful Practice Aids pertaining to immuno-oncology for this CME activity titled "Emerging Biomarkers, New Targets, and Rational Combinations: Are We on the Verge of the Next Generation of Immuno-Oncology?" For the full presentation, monograph, complete CME information, and to apply for credit, please visit us at http://bit.ly/2H2s92Y. CME credit will be available until June 17, 2019.
Explore natural remedies for syphilis treatment in Singapore. Discover alternative therapies, herbal remedies, and lifestyle changes that may complement conventional treatments. Learn about holistic approaches to managing syphilis symptoms and supporting overall health.
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Ve...kevinkariuki227
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
TEST BANK for Operations Management, 14th Edition by William J. Stevenson, Verified Chapters 1 - 19, Complete Newest Version.pdf
New Drug Discovery and Development .....NEHA GUPTA
The "New Drug Discovery and Development" process involves the identification, design, testing, and manufacturing of novel pharmaceutical compounds with the aim of introducing new and improved treatments for various medical conditions. This comprehensive endeavor encompasses various stages, including target identification, preclinical studies, clinical trials, regulatory approval, and post-market surveillance. It involves multidisciplinary collaboration among scientists, researchers, clinicians, regulatory experts, and pharmaceutical companies to bring innovative therapies to market and address unmet medical needs.
Couples presenting to the infertility clinic- Do they really have infertility...Sujoy Dasgupta
Dr Sujoy Dasgupta presented the study on "Couples presenting to the infertility clinic- Do they really have infertility? – The unexplored stories of non-consummation" in the 13th Congress of the Asia Pacific Initiative on Reproduction (ASPIRE 2024) at Manila on 24 May, 2024.
Report Back from SGO 2024: What’s the Latest in Cervical Cancer?bkling
Are you curious about what’s new in cervical cancer research or unsure what the findings mean? Join Dr. Emily Ko, a gynecologic oncologist at Penn Medicine, to learn about the latest updates from the Society of Gynecologic Oncology (SGO) 2024 Annual Meeting on Women’s Cancer. Dr. Ko will discuss what the research presented at the conference means for you and answer your questions about the new developments.
Pulmonary Thromboembolism - etilogy, types, medical- Surgical and nursing man...VarunMahajani
Disruption of blood supply to lung alveoli due to blockage of one or more pulmonary blood vessels is called as Pulmonary thromboembolism. In this presentation we will discuss its causes, types and its management in depth.
Knee anatomy and clinical tests 2024.pdfvimalpl1234
This includes all relevant anatomy and clinical tests compiled from standard textbooks, Campbell,netter etc..It is comprehensive and best suited for orthopaedicians and orthopaedic residents.
Prix Galien International 2024 Forum ProgramLevi Shapiro
June 20, 2024, Prix Galien International and Jerusalem Ethics Forum in ROME. Detailed agenda including panels:
- ADVANCES IN CARDIOLOGY: A NEW PARADIGM IS COMING
- WOMEN’S HEALTH: FERTILITY PRESERVATION
- WHAT’S NEW IN THE TREATMENT OF INFECTIOUS,
ONCOLOGICAL AND INFLAMMATORY SKIN DISEASES?
- ARTIFICIAL INTELLIGENCE AND ETHICS
- GENE THERAPY
- BEYOND BORDERS: GLOBAL INITIATIVES FOR DEMOCRATIZING LIFE SCIENCE TECHNOLOGIES AND PROMOTING ACCESS TO HEALTHCARE
- ETHICAL CHALLENGES IN LIFE SCIENCES
- Prix Galien International Awards Ceremony
Flu Vaccine Alert in Bangalore Karnatakaaddon Scans
As flu season approaches, health officials in Bangalore, Karnataka, are urging residents to get their flu vaccinations. The seasonal flu, while common, can lead to severe health complications, particularly for vulnerable populations such as young children, the elderly, and those with underlying health conditions.
Dr. Vidisha Kumari, a leading epidemiologist in Bangalore, emphasizes the importance of getting vaccinated. "The flu vaccine is our best defense against the influenza virus. It not only protects individuals but also helps prevent the spread of the virus in our communities," he says.
This year, the flu season is expected to coincide with a potential increase in other respiratory illnesses. The Karnataka Health Department has launched an awareness campaign highlighting the significance of flu vaccinations. They have set up multiple vaccination centers across Bangalore, making it convenient for residents to receive their shots.
To encourage widespread vaccination, the government is also collaborating with local schools, workplaces, and community centers to facilitate vaccination drives. Special attention is being given to ensuring that the vaccine is accessible to all, including marginalized communities who may have limited access to healthcare.
Residents are reminded that the flu vaccine is safe and effective. Common side effects are mild and may include soreness at the injection site, mild fever, or muscle aches. These side effects are generally short-lived and far less severe than the flu itself.
Healthcare providers are also stressing the importance of continuing COVID-19 precautions. Wearing masks, practicing good hand hygiene, and maintaining social distancing are still crucial, especially in crowded places.
Protect yourself and your loved ones by getting vaccinated. Together, we can help keep Bangalore healthy and safe this flu season. For more information on vaccination centers and schedules, residents can visit the Karnataka Health Department’s official website or follow their social media pages.
Stay informed, stay safe, and get your flu shot today!
Lung Cancer: Artificial Intelligence, Synergetics, Complex System Analysis, S...Oleg Kshivets
RESULTS: Overall life span (LS) was 2252.1±1742.5 days and cumulative 5-year survival (5YS) reached 73.2%, 10 years – 64.8%, 20 years – 42.5%. 513 LCP lived more than 5 years (LS=3124.6±1525.6 days), 148 LCP – more than 10 years (LS=5054.4±1504.1 days).199 LCP died because of LC (LS=562.7±374.5 days). 5YS of LCP after bi/lobectomies was significantly superior in comparison with LCP after pneumonectomies (78.1% vs.63.7%, P=0.00001 by log-rank test). AT significantly improved 5YS (66.3% vs. 34.8%) (P=0.00000 by log-rank test) only for LCP with N1-2. Cox modeling displayed that 5YS of LCP significantly depended on: phase transition (PT) early-invasive LC in terms of synergetics, PT N0—N12, cell ratio factors (ratio between cancer cells- CC and blood cells subpopulations), G1-3, histology, glucose, AT, blood cell circuit, prothrombin index, heparin tolerance, recalcification time (P=0.000-0.038). Neural networks, genetic algorithm selection and bootstrap simulation revealed relationships between 5YS and PT early-invasive LC (rank=1), PT N0—N12 (rank=2), thrombocytes/CC (3), erythrocytes/CC (4), eosinophils/CC (5), healthy cells/CC (6), lymphocytes/CC (7), segmented neutrophils/CC (8), stick neutrophils/CC (9), monocytes/CC (10); leucocytes/CC (11). Correct prediction of 5YS was 100% by neural networks computing (area under ROC curve=1.0; error=0.0).
CONCLUSIONS: 5YS of LCP after radical procedures significantly depended on: 1) PT early-invasive cancer; 2) PT N0--N12; 3) cell ratio factors; 4) blood cell circuit; 5) biochemical factors; 6) hemostasis system; 7) AT; 8) LC characteristics; 9) LC cell dynamics; 10) surgery type: lobectomy/pneumonectomy; 11) anthropometric data. Optimal diagnosis and treatment strategies for LC are: 1) screening and early detection of LC; 2) availability of experienced thoracic surgeons because of complexity of radical procedures; 3) aggressive en block surgery and adequate lymph node dissection for completeness; 4) precise prediction; 5) adjuvant chemoimmunoradiotherapy for LCP with unfavorable prognosis.
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Biomarkers for pmo ds and oscc
1. Current status of biomarkers for
PMODs and OSCCs with emphasis on
specificity and sensitivity of serum and
salivary biomarkers.
Dr. Preethi.A.
PG Student
Dept. Of Oral Pathology
SRM Dental College
2. CONTENT
• INTRODUCTION
• WHAT ARE PMODs AND OSCCs
• PATHOLOGIC DIAGNOSIS
• BIOMARKERS
• CURRENT STATUS
• RECENT ADVANCES
• CONCLUSION
3. INTRODUCTION
OPMD is a clinical diagnosis for which the histological diagnosis may be hyperplasia,
hyperkeratosis, oral epithelial dysplasia (OED) or oral squamous cell carcinoma (OSCC).
Leukoplakia – 1.49 – 2.60. Erythroplakia – 0.02%
Oral cancer – 11th most common cancer in the world (30 % of all cancers). Most lesions
of Oral cancer (80%)– preceded by clinically observable precursor lesions.
Traditional therapeutics have encountered a bottleneck caused by diagnosis delay and
subjective and unreliable assessment.
Biomarkers can overcome this bottleneck and guide us toward precision medicine.
4. POTENTIALLY MALGINANT ORAL
DISORDERS
WHO
1978
•Pre-malignant lesion is “a
morphologically altered
tissue in which
oral cancer is more likely
to occur than its
apparently normal
counterpart.”
•Pre-malignant condition
is “a generalized state
associated with a
significantly increased
risk of cancer.”
Oral
oncology
Journal,
2012
•OPMD
•It is a group of disorders
of varying etiologies,
usually tobacco
characterized by mutagen
associated, spontaneous
or hereditary alterations
or mutations in the
genetic material of oral
epithelial cells with or
without clinical and histo-
morphological alterations
that may lead to oral
squamous cell carcinoma
transformation.
OOOO
journal
,
June
2018
•Potentially premalignant
oral epithelial lesions.
•These lesions have the
potential to become
malignant and that in
their current status, that
is, before malignant
transformation, they may
represent an actual
premalignant state
5.
6. CLINICAL PRESENTATION OF POTENTIALLY
PREMALIGNANT LESIONS
COMMON LESIONS
• Leukoplakia
• PVL
• Erythroplakia
• Erythroleukoplakia
• OSMF
• OLP
LESS COMMON LESIONS
• Palatal lesions in reverse smokers
• Discoid lupus erythematosus
• Epidermolysis bullosa
• Actinitc chelitis
• Oral lichenoid reactions
• Graft-versus-host disease (GvHD)
7. • About 5-18% of epithelial dysplasias become malignant.
• OSCC -62% high mortality rate.
• PMODs are the first indications of micro- and macroscopic alterations of possible
malignant transformations
• The estimated median time for this progression depends on the histologic severity of
the epithelial dysplasia: 58 months for mild, 38 months for moderate, and 12 months
for severe.
11. WHAT ARE BIOMARKERS.??
A characteristic that is objectively measured and
evaluated as an indicator of normal biological processes,
pathogenic processes or pharmacological responses to a
therapeutic intervention.
Any substance, structure or process that can be measured
in the body or its products and influence or predict the
incidence or outcome of disease.
• [Strimbu et al: What are biomarkers?; 2011]
LIQUID BIOPSY
14. BASED ON CLINICAL APPLICATION
Diagnostic
marker
Prognostic
marker
Predictive
marker
Therapeutic
marker
To determine if a cancer is likely in
some patients and helps to diagnose
the origin of the cancer in advanced
widespread disease
To assess how aggressive a cancer is
likely to be or even how well it
might respond to certain drugs
To detect cancers that recur
after initial treatment
To monitor patients being
treated for cancer.
16. TUMOR MARKERS
• Specific, novel or structurally altered cellular
macromolecule or temporarily, spatially or
quantitatively altered molecules associated with
malignant or in some benign neoplastic cells.
[Madhav Nagpal et al: Tumor markers: A diagnostic tool; 2016]
Cancer biomarkers are usually proteins
detected in the fluids that are either produced
by the tumor itself or in response to the
presence of cancer.
17. BASIC DIAGNOSTIC TERMINOLOGIES
SPECIFICITY
The ability of the test to correctly
identify those without the
disease (true negative rate)
If 100 with no disease are tested
and 96 return a completely
negative result, then the test has
96% specificity
SENSITIVITY
The ability of a test to correctly
identify those with the disease
(true positive rate)
If 100 patients known to have a
disease were tested, and 43 test
positive, then the test has 43%
sensitivity
18. POSITIVE PREDICITIVE VALUE
• It is the percentage of
patients with a positive test
who actually have the
disease
NEGATIVE PREDICITIVE VALUE
• It is the percentage of
patients with a negative test
who do not have the
disease
Positive and negative predictive values are directly related to the prevalence of
the disease in the population
19. Ideal requisites of tumor marker
It should be highly sensitive and should have low false negatives.
It should be highly specific and should have low false positives.
It should have high positive and negative predictive value.
100% accuracy in differentiating between healthy individuals and tumor patients.
It should be able to differentiate between neoplastic and non-neoplastic disease and show positive correlation with tumor volume and
extent.
It should be clinically sensitive i.e. detectable at early stage of tumor.
It should either be a universal marker for all types of malignancies or specific to one type of malignancy.
It should be easily assayable and be able to indicate all changes in cancer patients receiving treatment.
20. TYPES OF TUMOR MARKERS
Tumor
derived
markers
• Originate from neoplastic cells
Tumor
associated
markers
• Produced by cells of un involved
organs ( plasma, enzymes,
proteins etc).
24. S.NO MARKERS DESCRIPTION TYPE OF SPECIMEN INFERENCE
1. MMPs (3,9) Family of enzymes. Helps in regulating cell growth, angiogenesis, and invasiveness. Saliva Poor sensitivity
2. ILs Sub group of cytokines. Important in stimulating immune responses, such as inflammation. Saliva Lack of specificity and sensitivity
3. CD44 An adhesion/homing molecule. Regulates cell migration, growth and differentiation and cell
adhesion.
Saliva and serum Lacks specificity
4. mRNA Molecule that links genes to proteins. Helps in Efficient and smooth interactions of the molecules. Saliva No clinical validation
5. Melanoma associated
antigen gene
Play important roles during embryogenesis, which later deactivated by a genetic mechanism such as
methylation. In the case of tumor formation, these genes are reactivated and the resultant proteins
may be recognized and attacked by the immune system.
Saliva No clinical validation
6. Actin and myosin Key cytoskeletal proteins that facilitate cell motility and invasion, behaviour central to epithelial
tumorigenesis
Saliva Lack of sensitivity and specificity
7. CKs (8,18, CRP) Intracytoplasmic cytoskeleton of epithelial tissue. They are an important component of intermediate
filaments, which help cells resist mechanical stress and are used clinically to identify the cell of origin
of various human tumors.
Saliva and serum No clinical validation
8. Cytokines (Tissue
polypeptide antigen,
leptin, VEGF)
Signalling molecules that mediate and regulate immunity, inflammation and hematopoiesis. Serum Lacks specificity
9. Adiponectine Produced by adipocytes. Acts as anti-diabetic, anti-atherogenic, anti-inflammatory and anti-
angiogenic hormone.
Serum Lack of sensitivity and specificity
10. CYFRA 21-1 Cytokeratin 19 fragment Saliva and serum Lacks specificity
11. TNF-alpha and DCR3 Tumor necrosis factor Serum Lacks sensitivity
12. Big endothelin-1 Vasoactive peptide associated with the development and spread of tumors Serum Lacks specificity and sensitivity
13. miRNAs Able to target multiple mRNAs and, thereby, potentially affect several important cellular pathways
involved in tumorigenic processes.
Saliva and serum High sensitivity in saliva
14. Vitamin D Anti-neoplastic activity Serum Lacks specificity and sensitivity
15. Melondialdehyde MDA, an end product of lipid peroxidation, is widely used as an index for oxidative stress in different
pathological conditions. Particularly, MDA’s high reactivity and capability to form adducts with
multiple biological molecules such as proteins or DNA shows its physiological relevance in cancerous
lesions. MDA–DNA adducts have been detected in oral mucosal cells as a marker for oral cancer risk.
Serum Significant rise in OMPD & OSCC
25. CONCLUSION
• The evaluation of these cancer biomarkers in liquid
biopsy has the advantage of providing a,
– Real-time picture of primary and metastatic tumors at
different time points,
– Giving information about tumor and tumor burden and
– Early evidence of drug resistance and tumor recurrence.