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The Gateway to Health and Disease: the oral microbiome, autoimmune, and personalized nutrition - TRICON 2017

The Gateway to Health and Disease: the oral microbiome, autoimmune, and personalized nutrition - TRICON 2017

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Did you know, the health state of your mouth could influence and possibly determine the health of the rest of your body? First exploring the relationship of the gut microbiome and disease, at the 2017 Tri-Conference in San Francisco (Feb 2017), Bonnie explores the recent connections and research around the impact of the oral microbiome.

Carefully curating the latest research around the oral microbiome, autoimmune disease, and personalized nutrition, we present to you our hyperlinked slides. Enjoy!

Did you know, the health state of your mouth could influence and possibly determine the health of the rest of your body? First exploring the relationship of the gut microbiome and disease, at the 2017 Tri-Conference in San Francisco (Feb 2017), Bonnie explores the recent connections and research around the impact of the oral microbiome.

Carefully curating the latest research around the oral microbiome, autoimmune disease, and personalized nutrition, we present to you our hyperlinked slides. Enjoy!

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The Gateway to Health and Disease: the oral microbiome, autoimmune, and personalized nutrition - TRICON 2017

  1. 1. Your Autoimmunity ConnectionYour Autoimmunity Connection The Gateway to Health and Disease the oral microbiome, autoimmunity, and personalized nutrition
  2. 2. Your Autoimmunity Connection Bonnie Feldman, DDS, MBA DrBonnie360’s mission is to create a digitally connected world of personalized care for autoimmune patients. We consult with start-up companies and entrepreneurs who are bringing new products and services that will improve research, diagnosis, and treatment for autoimmunity The Gateway to Health and Disease +1.310.666.5312 drbonnie360@gmail.com www.drbonnie360.com @DrBonnie360 www.facebook.com/YourAutoimmunityConnection Content and Visual Design by Tiffany Simms
  3. 3. Your Autoimmunity Connection Special Thanks To: Cindy Crowninshield, Ellen M Martin, and Tiffany Simms
  4. 4. Your Autoimmunity ConnectionYour Autoimmunity Connection Did You Know? Microbial DNA can represent 30-60% of total saliva DNA Over 700 different species of bacteria can live in your mouth Nearly Half of American adults have periodontitis, (most severe form of periodontal disease) 93% of people with gum disease are at risk for diabetes Doi: 10.1177/0022034512457373 Doi: 10.1111/j.1752-7325.2009.00157.x Doi: 10.1186/s40064-016-3728-6 Doi: 10.1128/JCM.43.11.5721-5732.2005
  5. 5. Your Autoimmunity Connection What is the Microecology of the Oral Cavity?
  6. 6. Your Autoimmunity Connection Pubmed Health Glossary
  7. 7. Your Autoimmunity Connection -Omics Research Sets the Stage for a New View of the Oral Ecosystem Doi: 10.3402/jom.v7.28223
  8. 8. Your Autoimmunity Connection Where Do We Find the Microbiome in the Body? The Scientist: The Body’s Ecosystem
  9. 9. Your Autoimmunity Connection What is the Body’s Microbiome Composed of? Doi: 10.1038/nrg3182
  10. 10. Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017 What Characterizes the Oral Microbiome?
  11. 11. Your Autoimmunity Connection Doi: 10.1111/j.1601-0825.2011.01851.x The Oral Microbiome’s Impact on Personalized Health
  12. 12. Your Autoimmunity Connection Doi: 10.5772/63492 What’s the Functional Profile of Saliva Microbiome?
  13. 13. Your Autoimmunity Connection Doi: 10.1038/sj.bdj.2016.865 Can We Identify Which Bacterial Phyla Characterize the Caries Prone Person?
  14. 14. Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017 The Oral Microbiome in Periodontal Disease
  15. 15. Your Autoimmunity Connection Doi: 10.1016/j.it.2013.09.001 Periodontitis (bone resorption) inflammation Immunomicrobial Pathogenesis of Periodontitis
  16. 16. Your Autoimmunity Connection Doi: 10.1016/j.imlet.2014.08.017 Oral Microbiome Changes in Periodontal Disease
  17. 17. Your Autoimmunity Connection Doi: 10.1038/nri7385 Periodontitis and Systemic Disease
  18. 18. Your Autoimmunity Connection Doi: 10.1111/odi.12589 Autoimmunity & the Oral Microbiome
  19. 19. Your Autoimmunity Connection Doi: 10.1038/nrmicro.2016.83 The Oral Microbiome in Rheumatoid Arthritis
  20. 20. Your Autoimmunity Connection Doi: 10.1016/j.cell.2015.11.001 Personalized Nutrition
  21. 21. Your Autoimmunity Connection Defining the Spectrum of Personalized Nutriton Solutions
  22. 22. Your Autoimmunity Connection Company What How For Whom Predicts blood sugar responses to thousands of different foods based on analysis of individual’s microbiome. Personalize nutrition by rating different foods through app. Stool samples Blood test DNA sequence of gut microbiome Analysis using patented algorithm Consumers Uses certified coaches to develop personalized nutrition plans that help meet your goals while chefs prepare personalized meals delivered to your door. Home biomarker test kit Questionaire Patent pending engine determines foods/nutrients Coaching and Chefs Consumers Cognitive enhancing compounds that produce minimal side effects. Manufacture unique combinations of supplements to enhance cognition Consumers Discovers natural active ingredients that come from food sources AI & DNA analysis to access most health-benefitting components in foods (Bioactive Peptides) Business
  23. 23. Your Autoimmunity Connection Our Body’s Immune System Starts in the Mouth Your Autoimmunity Connection Exploring the Link between the Oral Microbiome and Systemic Disease
  24. 24. Your Autoimmunity Connection Devine, Deirdre A., Philip D. Marsh, and Josephine Meade. "Modulation of host responses by oral commensal bacteria." Journal of oral microbiology 7 (2015). <http://www.journaloforalmicrobiology.net/index.php/jom/article/view/26941>. The Overlooked Microbes in Your Mouth What is the Oral Microbiome? Oral vs Gut Microbiome Dewhirst, Floyd E., et al. "The human oral microbiome." Journal of bacteriology 192.19 (2010): 5002-5017. <http://jb.asm.org/content/192/19/5002.short>. Krzyściak, Wirginia, Anna Jurczak, and Jakub Piątkowski. "The Role of Human Oral Microbiome in Dental Biofilm Formation." InTech. N.p., n.d. Web. <http://www.intechopen.com/books/microbial-biofilms-importance-and-applications/the-role-of-human- oral-microbiome-in-dental-biofilm-formation>. Lloyd-Price, Jason, Galeb Abu-Ali, and Curtis Huttenhower. "The healthy human microbiome." Genome medicine 8.1 (2016): 1. <https://genomemedicine.biomedcentral.com/articles/10.1186/s13073-016-0307-y>. Nelson-Dooley, Cass. "The Mouth, the Oral Microbiome, and Systemic Inflammation." Institute for Functional Medicine. N.p., n.d. Web. 18 Jan. 2017. <https://www.functionalmedicine.org/home/focus_on/oral_microbiome/>. What is the Oral Microbiome
  25. 25. Your Autoimmunity Connection Nelson-Dooley, Cass, and Stephen F. Olmstead. "The Microbiome and Overall Health Part 5: The Oropharyngeal Microbiota's Far-Reaching Role in Immunity, Gut Health, and Cardiovascular Disease." Complementary Prescriptions. N.p., n.d. Web. 19 Jan. 2017. <http://www.cpmedical.net/newsletter/the-microbiome-and-overall-health-part-5-the-oropharyngeal>. Zarco, Vess, and Ginsburg. “The Oral Microbiome in Health and Disease and the Potential Impact on Personalized Dental Medicine.” Oral Diseases 18.2 (2012): 109–120. <http://onlinelibrary.wiley.com/doi/10.1111/j.1601-0825.2011.01851.x/full>. The Hidden Gold Mine: Saliva’s Importance Glurich, Ingrid et al. “Progress in Oral Personalized Medicine: Contribution of ‘omics.’” Journal of Oral Microbiology 7.0 (2015): 28223. <https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4561229/>. Yang, Fang et al. “Characterization of Saliva Microbiota’s Functional Feature Based on Metagenomic Sequencing.” SpringerPlus 5.1 (2016): 2098. PMC. Web. 18 Jan. 2017. <http://link.springer.com/article/10.1186/s40064-016-3728-6>. Zaura, Egija, et al. "On the ecosystemic network of saliva in healthy young adults." The ISME Journal (2017). <http://www.nature.com/ismej/journal/vaop/ncurrent/full/ismej2016199a.html>.
  26. 26. Your Autoimmunity Connection Costalonga, Massimo, and Mark C. Herzberg. "The oral microbiome and the immunobiology of periodontal disease and caries." Immunology letters 162.2 (2014): 22-38. <http://www.sciencedirect.com/science/article/pii/S0165247814001874>. Dewhirst, Floyd E. “The Oral Microbiome: Critical for Understanding Oral Health and Disease.” Journal of the California Dental Association 44.7 (2016): 409–10. <https://www.ncbi.nlm.nih.gov/pubmed/27514152>. Kilian, M., et al. "The oral microbiome–an update for oral healthcare professionals." British Dental Journal 221.10 (2016): 657-666. <http://www.nature.com/bdj/journal/v221/n10/abs/sj.bdj.2016.865.html>. Liu, Bo, et al. "Deep sequencing of the oral microbiome reveals signatures of periodontal disease." PloS one 7.6 (2012): e37919. <http://journals.plos.org/plosone/article?id=10.1371/journal.pone.0037919>. Our Disease Barometer The Oral Microbiome in Caries & Periodontal Disease Chicken or the Egg? The Oral Microbiome & Systemic Disease Nikitakis, N. G., et al. "The autoimmunity–oral microbiome connection." Oral diseases (2016). <http://onlinelibrary.wiley.com/doi/10.1111/odi.12589/full>. Scher, Jose U., et al. "Periodontal disease and the oral microbiota in new‐onset rheumatoid arthritis." Arthri & Rheumatism 64.10 (2012): 3083-3094. <http://onlinelibrary.wiley.com/doi/10.1002/art.34539/full>. Zhang, Xuan et al. “The Oral and Gut Microbiomes Are Perturbed in Rheumatoid Arthritis and Partly Normalized after Treatment.” Nature Medicine 21.8 (2015): 895–905. <http://www.nature.com/nm/journal/v21/n8/abs/nm.3914.html>.
  27. 27. Your Autoimmunity Connection Biesalski, Hans K. “Nutrition Meets the Microbiome: Micronutrients and the Microbiota.” Annals of the New York Academy of Sciences 1372.1 (2016): 53–64. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.13145/full>. Marshall, Lisa. "The Personalized-Nutrition Boom." Nutrition Business Journal XX.4 (2015): 1-4. PLM Institute. Apr. 2015. Web. 21 Jan. 2017. <http://plminstitute.org/wp-content/uploads/2015/05/NBJ-Personalized-Nutrition_final_April-2015-_Pages-1- 4.pdf>. Shoaie, Saeed et al. “Quantifying Diet-Induced Metabolic Changes of the Human Gut Microbiome.” Cell metabolism 22.2 (2015): 320–331. <http://www.sciencedirect.com/science/article/pii/S1550413115003307>. vel Szic, Katarzyna Szarc, et al. "From inflammaging to healthy aging by dietary lifestyle choices: is epigenetics the key to personalized nutrition?." Clinical epigenetics 7.1 (2015): 33. <https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-015-0068-2>. Wasielewski, Helen, Joe Alcock, and Athena Aktipis. “Resource Conflict and Cooperation between Human Host and Gut Microbiota: Implications for Nutrition and Health.” Annals of the New York Academy of Sciences 1372.1 (2016): 20–8. <http://onlinelibrary.wiley.com/doi/10.1111/nyas.13118/full>. Zeevi, David, et al. "Personalized nutrition by prediction of glycemic responses." Cell 163.5 (2015): 1079-1094. <http://www.sciencedirect.com/science/article/pii/S0092867415014816>. Zmora, Niv, et al. "Taking it personally: personalized utilization of the human microbiome in health and disease." Cell host & microbe 19.1 (2016): 12-20. <http://www.sciencedirect.com/science/article/pii/S1931312815005089>. Dinnertime! The Personalized Nutrition Boom

Editor's Notes

  • Title: The Gateway to Health and Disease OR Unlocking the Gateway to Health and Disease
  • https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4346134/

    High diversity and richness in health, with low diversity and richness in disease


    Microorganisms growing around the tool surfaces are divided into supragingival and subgingival plaques

    Periodontal disease is a microbial shift with massive reorganization of the microbiota residing in the gingival crevice= region between the tooth surface and the gingival epithelium.
    While marked changes in microbial population

    Key ponints with microbiome shift from health to periodontitis
    Community biomass increase at 3 log
    microbiome diversity and community complexity increases
    Health associated species
     
    Microbiome shifts in peridontitis not only includes changes in the microbiome species, but also changes in biomass.

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